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Our top choices for Cape Girardeau vacation homes
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer PoolCape Girardeau
8.6 out of 10, Excellent, (37)
"Very nice house. The pool and hot tub were perfect for a short getaway. Tons of activities and games to keep the fanily entertained. Will definitely come back! "
Emily D.
$209 nightly
The price is $217
Dec 23 - Dec 24
Total with taxes and fees
Serenity South -- Gardens, River-Views, and Refreshing Space
Serenity South -- Gardens, River-Views, and Refreshing SpaceCape Girardeau
10.0 out of 10, Exceptional, (149)
"Such a great place and location"
Tracy H.
$229 nightly
The price is $245
Dec 23 - Dec 24
Total with taxes and fees
Next Door to Mercy Hospital - Pet Friendly - Fast Wifi
Next Door to Mercy Hospital - Pet Friendly - Fast WifiCape Girardeau
8.0 out of 10, Very Good, (5)
"Great place for our family to have a quick get together in short notice."
Red Bear Den
$382 nightly
The price is $397
Dec 23 - Dec 24
Total with taxes and fees
4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + MoreCape Girardeau
9.6 out of 10, Exceptional, (7)
"Nice place, great times"
Jace W.
$422 nightly
The price is $438
Dec 23 - Dec 24
Total with taxes and fees
Beautiful location in the secluded woods
Beautiful location in the secluded woodsPomona
10.0 out of 10, Exceptional, (61)
"It was very nice and clean. We really enjoyed staying there. We would love to rent this place again. "
susan B.
$154 nightly
The price is $163
Dec 25 - Dec 26
Total with taxes and fees
$139 nightly
The price is $148
Dec 23 - Dec 24
Total with taxes and fees
Magical Victorian near hiking / wine trail
Magical Victorian near hiking / wine trailAnna
10.0 out of 10, Exceptional, (4)
"The house was beautiful! We were in awe of the decor and layout. This is a must-stay if you are in southern Illinois!"
Lori C.
$351 nightly
The price is $397
Dec 30 - Dec 31
Total with taxes and fees
Historic Farm Cottage on 800-Acre Orchard
Historic Farm Cottage on 800-Acre OrchardAlto Pass
9.8 out of 10, Exceptional, (8)
"Awesome"
Luke K.
$186 nightly
The price is $205
Jan 12 - Jan 13, 2026
Total with taxes and fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Cape Girardeau Hotel Reviews
The Twisted Sassafras Treehouse
10/10 Excellent
Find out more about Cape Girardeau
Cape Girardeau Vacation Homes information
Number of reviews | 267 |
|---|---|
Accommodation | 66 Vacation Homes |
Lowest Price | $148 |
Highest Price | $611 |
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