Isle of Palms Vacations from $427

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Your Isle of Palms Vacation

Your next big adventure beckons with a vacation package to Isle of Palms. Food, fun and nothing but good times — you're bound to find it in this neighborhood. Not sure what to do during your trip to Isle of Palms? Nearby attractions like Jacksonville Beach Pier, Oceanfront Park and Adventure Landing are good places to start. Expedia can put your plans into action. Book your dream Isle of Palms vacation today.

The Latest Isle of Palms Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hampton Inn Jacksonville Beach/Oceanfront

Hampton Inn Jacksonville Beach/Oceanfront

3 out of 5
Save 100% on your flight
Price was $615, price is now $427 per person
$427
per person
Dec 12 - Dec 15
found 2 hours ago
Roundtrip flight included
Boston (BOS) to Jacksonville (JAX)
9.2/10 Wonderful! (2,500 reviews)
This is always where I reserve for guests when extra room is needed

Reviewed on Oct 28, 2025

Legacy Vacation Resorts Palm Coast

Legacy Vacation Resorts Palm Coast

3 out of 5
Save 100% on your flight
Price was $823, price is now $553 per person
$553
per person
Dec 6 - Dec 13
found 18 hours ago
Roundtrip flight included
Boston (BOS) to Daytona Beach (DAB)
8.8/10 Excellent! (1,499 reviews)
Safe area and security, staff was friendly and accommodating. They communicated regular to make sure everything was ok and if qe had any issues.

Reviewed on Oct 20, 2025

Omni Amelia Island Resort & Spa

Omni Amelia Island Resort & Spa

4 out of 5
Save 100% on your flight
Price was $870, price is now $586 per person
$586
per person
Dec 7 - Dec 11
found 18 hours ago
Roundtrip flight included
Boston (BOS) to Jacksonville (JAX)
8.6/10 Excellent! (1,008 reviews)
Very cool self contained resort

Reviewed on Oct 23, 2025

Hammock Beach Golf Resort & Spa

Hammock Beach Golf Resort & Spa

4 out of 5
Save 100% on your flight
Price was $1,083, price is now $735 per person
$735
per person
Dec 1 - Dec 5
found 1 day ago
Roundtrip flight included
Boston (BOS) to Daytona Beach (DAB)
8.6/10 Excellent! (1,004 reviews)
place is just fine. a bit dated but great location. nice people

Reviewed on Oct 20, 2025

The Ritz-Carlton, Amelia Island

The Ritz-Carlton, Amelia Island

5 out of 5
Amelia City
Save 100% on your flight
Price was $1,723, price is now $1,175 per person
$1,175
per person
Dec 7 - Dec 11
found 18 hours ago
Roundtrip flight included
Boston (BOS) to Jacksonville (JAX)
9.2/10 Wonderful! (372 reviews)
Leticia at the front desk was fantastic! I had a health related attack on the way back from Atlanta and we decided to stay at the Ritz so I could rest. We stayed at this Ritz on our honeymoon over 30 years ago, had my 50th birthday party at Salt with guests for a weekend, stayed there for our 30th wedding anniversary and had dinner at Salt also (I highly recommend Salt), stayed many holidays with our children and friends, car shows, and it is still such a wonderful resort. You cannot go wrong staying at this beautiful resort. We have loved it for over 30 years and hope to keep going there for many more years to come. All of the staff is great, but a special shout out to Leticia. Thank you for helping us.

Reviewed on Sep 6, 2025

Where to stay in Isle of Palms

Find the best Isle of Palms areas and neighborhoods for the activities you enjoy most. Learn more about Isle of Palms
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Southside

1 out of top 10 points of interest in this area
4/5(912 area reviews)

If you're spending some time in Southside, St. Johns Town Center and Orange Park Place Shopping Center are top sights worth seeing.

Find hotels in Southside

Isle of Palms Hotel Deals

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

3 out of 5
4905 SAN PABLO ROAD SOUTH, Jacksonville, FL
Fully refundableReserve now, pay when you stay
$158 nightly
The price is $179 total per night from Nov 7 to Nov 8
$179 total
Nov 7 - Nov 8
Total with taxes and fees
9.4/10 Exceptional! (433 reviews)
Always comfortable, beautiful rooms, great beds, great service, spotless clean

Reviewed on Oct 21, 2025

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
Hyatt Regency Jacksonville

Hyatt Regency Jacksonville

4 out of 5
225 E Coastline Dr, Jacksonville, FL
Fully refundableReserve now, pay when you stay
$145 nightly
The price is $165 total per night from Nov 23 to Nov 24
$165 total
Nov 23 - Nov 24
Total with taxes and fees
8.8/10 Excellent! (1,347 reviews)
Everything was amazing. We got a room with the river view and loved it!

Reviewed on Oct 26, 2025

Hyatt Regency Jacksonville
Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach

2.5 out of 5
715 1st St N, Jacksonville Beach, FL
Fully refundableReserve now, pay when you stay
$174 nightly
The price is $197 total per night from Oct 30 to Oct 31
$197 total
Oct 30 - Oct 31
Total with taxes and fees
8.8/10 Excellent! (3,303 reviews)
The hotel staff was very kind and professional. The hotel was clean and well decorated

Reviewed on Oct 29, 2025

Margaritaville Jacksonville Beach
See all 3,152 properties in Isle of Palms
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Isle of Palms

Pretty

Mayo Clinic Florida

4.5/5(433 reviews)

Though Mayo Clinic Florida might be what brings you to town, perhaps you'll have a chance to explore more of Jacksonville while you are here.

Mayo Clinic Florida
Jacksonville Naval Air Station

Jacksonville Naval Air Station

4/5(300 reviews)

After visiting Jacksonville Naval Air Station, make a plan to see the other sights and activities in Jacksonville. Experience the lively festivals or attend a sporting event in this family-friendly area.

Jacksonville Naval Air Station
EverBank Field which includes a lake or waterhole

EverBank Stadium

4/5(386 reviews)

Capable of seating over 80,000 fans, this modern football stadium is the exciting home of the Jacksonville Jaguars, international soccer games and music events.

EverBank Stadium

Things to do

Chocolate Bar Class

Chocolate Bar Class - Hands on class

$20
per adult
Chocolate Bar Class - Hands on class
1 Hour Jet Ski Rental in Jacksonville, FL Evolution Jetsports

1 Hour Jet Ski Rental in Jacksonville, FL Evolution Jetsports

$140
per traveler
90% of travellers recommend
1 Hour Jet Ski Rental in Jacksonville, FL Evolution Jetsports
Architecture and History Tour in San Marco

Architecture and History Tour in San Marco

$96
per adult
Architecture and History Tour in San Marco
See all activities in Jacksonville
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.