Isle of Palms Vacations from $317

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Your Isle of Palms Vacation

Your next big adventure beckons with a vacation package to Isle of Palms. Food, fun and nothing but good times — you're bound to find it in this neighborhood. Not sure what to do during your trip to Isle of Palms? Nearby attractions like Jacksonville Beach Pier, Oceanfront Park and Adventure Landing are good places to start. Expedia can put your plans into action. Book your dream Isle of Palms vacation today.

The Latest Isle of Palms Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Tricove Inn & Suites

Tricove Inn & Suites

2.5 out of 5
Southside
Price was $411, price is now $317 per person
$317
per person
Oct 2 - Oct 5
found 24 hours ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Jacksonville (JAX)
7/10 Good! (1,003 reviews)
Away from most noise. Like the business area.

Reviewed on Aug 11, 2025

Hammock Beach Golf Resort & Spa

Hammock Beach Golf Resort & Spa

4 out of 5
Save 100% on your flight
Price was $1,314, price is now $843 per person
$843
per person
Nov 5 - Nov 9
found 21 hours ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Daytona Beach (DAB)
8.6/10 Excellent! (1,006 reviews)
We have a great family time

Reviewed on Aug 25, 2025

Vintage Amelia Island Apartments

Vintage Amelia Island Apartments

3.5 out of 5
Save 100% on your flight
Price was $642, price is now $450 per person
$450
per person
Nov 10 - Nov 15
found 5 hours ago
Roundtrip flight included
New York (JFK) to Jacksonville (JAX)
7.6/10 Good! (52 reviews)
The apartment was, clean, comfortable and well equipped. The guest support staff was extremely helpful and responsive. Would definitely recommend

Reviewed on Aug 15, 2025

DoubleTree by Hilton Hotel Jacksonville Riverfront

DoubleTree by Hilton Hotel Jacksonville Riverfront

4 out of 5
Downtown Jacksonville
Price was $665, price is now $504 per person
$504
per person
Oct 3 - Oct 6
found 1 day ago
Roundtrip flight included
Baltimore (BWI) to Jacksonville (JAX)
6.6/10 (1,373 reviews)
I liked the view from river side balcony. The room was okay but the m

Reviewed on Sep 1, 2025

Hoyt House Amelia Island

Hoyt House Amelia Island

3.5 out of 5
Fernandina Beach Historic District
Save 100% on your flight
Price was $1,319, price is now $1,034 per person
$1,034
per person
Oct 10 - Oct 15
found 5 hours ago
Roundtrip flight included
New York (JFK) to Jacksonville (JAX)
9.4/10 Exceptional! (568 reviews)
Great place near downtown district.

Reviewed on Aug 25, 2025

Where to stay in Isle of Palms

Find the best Isle of Palms areas and neighborhoods for the activities you enjoy most. Learn more about Isle of Palms
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Southside

3 out of top 10 points of interest in this area
4/5(912 area reviews)

If you're spending some time in Southside, St. Johns Town Center and The Avenues are top sights worth seeing.

Find hotels in Southside

Isle of Palms Hotel Deals

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

3 out of 5
4905 SAN PABLO ROAD SOUTH, Jacksonville, FL
Fully refundableReserve now, pay when you stay
$175 nightly
The price is $199 total per night from Sep 12 to Sep 13
$199 total
Sep 12 - Sep 13
Total with taxes and fees
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach

2.5 out of 5
715 1st St N, Jacksonville Beach, FL
Fully refundableReserve now, pay when you stay
$174 nightly
The price is $197 total per night from Sep 3 to Sep 4
$197 total
Sep 3 - Sep 4
Total with taxes and fees
9/10 Wonderful! (3,031 reviews)
"The property was so beautiful, so relaxing and such a breathe of fresh air. It was a well needed Mom-daughter getaway that was so beautiful. The staff was lovely and so kind and there were plenty of dinner options in the area, just be weary there’s no microwave on the property so don’t bring too ..."

Reviewed on Sep 1, 2025

Margaritaville Jacksonville Beach
Hyatt Regency Jacksonville

Hyatt Regency Jacksonville

4 out of 5
225 E Coastline Dr, Jacksonville, FL
Fully refundableReserve now, pay when you stay
$162 nightly
The price is $183 total per night from Sep 3 to Sep 4
$183 total
Sep 3 - Sep 4
Total with taxes and fees
Hyatt Regency Jacksonville
See all 3,113 properties in Isle of Palms
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Isle of Palms

Pretty

Mayo Clinic Florida

Though Mayo Clinic Florida might be what brings you to town, perhaps you'll have a chance to explore more of Jacksonville while you are here.

Mayo Clinic Florida
Jacksonville Naval Air Station

Jacksonville Naval Air Station

After visiting Jacksonville Naval Air Station, make a plan to see the other sights and activities in Jacksonville. Experience the great live music or attend a sporting event in this family-friendly area.

Jacksonville Naval Air Station
EverBank Field which includes a lake or waterhole

EverBank Stadium

Capable of seating over 80,000 fans, this modern football stadium is the exciting home of the Jacksonville Jaguars, international soccer games and music events.

EverBank Stadium

Things to do

3 Hour Coastal Fun Cruise

3 Hour Coastal Fun Cruise

$150
per adult
3 Hour Coastal Fun Cruise
1 Hour Jet Ski Rental in Jacksonville, FL Evolution Jetsports

1 Hour Jet Ski Rental in Jacksonville, FL Evolution Jetsports

$140
per traveler
90% of travellers recommend
1 Hour Jet Ski Rental in Jacksonville, FL Evolution Jetsports
Chocolate Bar Class

Chocolate Bar Class - Hands on class

$20
per adult
Chocolate Bar Class - Hands on class
See all activities in Jacksonville
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.