Isle of Palms Vacations from $622

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Your Isle of Palms Vacation

Your next big adventure beckons with a vacation package to Isle of Palms. Food, fun and nothing but good times — you're bound to find it in this neighborhood. Not sure what to do during your trip to Isle of Palms? Nearby attractions like Jacksonville Beach Pier, Oceanfront Park and Adventure Landing are good places to start. Expedia can put your plans into action. Book your dream Isle of Palms vacation today.

The Latest Isle of Palms Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Legacy Vacation Resorts Palm Coast

Legacy Vacation Resorts Palm Coast

3 out of 5
Save 100% on your flight
per person
Sep 17 - Sep 24
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Daytona Beach (DAB)
8.8/10 Excellent! (1,447 reviews)
Been nice if there was a tiki bar on property, but the room was great

Reviewed on Jul 9, 2025

Barsala At Artea At Southbank

Barsala At Artea At Southbank

3.5 out of 5
Downtown Jacksonville
Save 100% on your flight
per person
Aug 25 - Sep 1
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Jacksonville (JAX)
No reviews
The Villas of Amelia Island

The Villas of Amelia Island

4 out of 5
Save 100% on your flight
per person
Sep 14 - Sep 18
found 8 hours ago
Roundtrip flight included
Boston (BOS) to Jacksonville (JAX)
8.4/10 Very Good! (1,025 reviews)
Everything was lovely except the cigarette smokers somewhere near our condo made sitting on the patio difficult and cigarette smoke coming into the bedroom. I would definitely make this a smoke free property.

Reviewed on Jul 9, 2025

Barsala At Corner On Main

Barsala At Corner On Main

2.5 out of 5
Urban Core
Save 100% on your flight
per person
Aug 25 - Sep 1
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Jacksonville (JAX)
No reviews
The Ritz-Carlton, Amelia Island

The Ritz-Carlton, Amelia Island

5 out of 5
Save 100% on your flight
per person
Sep 14 - Sep 18
found 8 hours ago
Roundtrip flight included
Boston (BOS) to Jacksonville (JAX)
9.2/10 Wonderful! (365 reviews)
Amazing property! Only needs better food

Reviewed on Jul 2, 2025

Where to stay in Isle of Palms

Find the best Isle of Palms areas and neighborhoods for the activities you enjoy most. Learn more about Isle of Palms
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Southside

3 out of top 10 points of interest in this area
4/5(912 area reviews)

If you're spending some time in Southside, St. Johns Town Center and The Avenues are top sights worth seeing.

Find hotels in Southside

Isle of Palms Hotel Deals

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
3 out of 5
4905 SAN PABLO ROAD SOUTH, Jacksonville, FL
Fully refundableReserve now, pay when you stay
$162 nightly
The price is $184 total per night from Aug 2 to Aug 3
$184 total
Aug 2 - Aug 3
Total includes taxes and fees
9.4/10 Exceptional! (406 reviews)
"Loved very"

Reviewed on Jul 7, 2025

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
Margaritaville Jacksonville Beach
Margaritaville Jacksonville Beach
2.5 out of 5
715 1st St N, Jacksonville Beach, FL
Fully refundableReserve now, pay when you stay
$156 nightly
The price is $178 total per night from Aug 3 to Aug 4
$178 total
Aug 3 - Aug 4
Total includes taxes and fees
9/10 Wonderful! (2,964 reviews)
"Great location. Would definitely return in the future."

Reviewed on Jul 10, 2025

Margaritaville Jacksonville Beach
Embassy Suites by Hilton Jacksonville Baymeadows
Embassy Suites by Hilton Jacksonville Baymeadows
3.5 out of 5
9300 Baymeadows Road, Jacksonville, FL
Fully refundableReserve now, pay when you stay
$105 nightly
The price is $120 total per night from Jul 20 to Jul 21
$120 total
Jul 20 - Jul 21
Total includes taxes and fees
8.4/10 Very Good! (1,002 reviews)
"Great breakfast!"

Reviewed on Jul 9, 2025

Embassy Suites by Hilton Jacksonville Baymeadows
See all 3,137 properties in Isle of Palms
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

All Inclusive Vacations

All Inclusive Vacations

Beach Vacations

Beach Vacations

Kid Friendly Vacations

Kid Friendly Vacations

Discover the most popular places to visit in Isle of Palms

Pretty

Mayo Clinic Florida

4.5/5(433 reviews)

Though Mayo Clinic Florida might be what brings you to town, perhaps you'll have a chance to explore more of Jacksonville while you are here.

Mayo Clinic Florida
Jacksonville Naval Air Station

Jacksonville Naval Air Station

4/5(300 reviews)

After visiting Jacksonville Naval Air Station, make a plan to see the other sights and activities in Jacksonville. Experience the great live music or attend a sporting event in this family-friendly area.

Jacksonville Naval Air Station
EverBank Field which includes a lake or waterhole

EverBank Stadium

4/5(386 reviews)

Capable of seating over 80,000 fans, this modern football stadium is the exciting home of the Jacksonville Jaguars, international soccer games and music events.

EverBank Stadium

Things to do

3 Hour Coastal Fun Cruise

3 Hour Coastal Fun Cruise

$150
per adult
3 Hour Coastal Fun Cruise
1 Hour Jet Ski Rental in Jacksonville, FL Evolution Jetsports

1 Hour Jet Ski Rental in Jacksonville, FL Evolution Jetsports

$140
per traveler
1 Hour Jet Ski Rental in Jacksonville, FL Evolution Jetsports
Learn what lurks beneath the waves.

Jacksonville Ghosts and Ghouls Tour By US Ghost Adventures

$32
per adult
100% of travellers recommend
Jacksonville Ghosts and Ghouls Tour By US Ghost Adventures
See all activities in Jacksonville
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.