Isle of Palms Vacations from $870
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Your Isle of Palms Vacation
Your next big adventure beckons with a vacation package to Isle of Palms. Food, fun and nothing but good times — you're bound to find it in this neighborhood. Not sure what to do during your trip to Isle of Palms? Nearby attractions like Jacksonville Beach Pier, Oceanfront Park and Adventure Landing are good places to start. Expedia can put your plans into action. Book your dream Isle of Palms vacation today.
The Latest Isle of Palms Vacation Packages
Legacy Vacation Resorts Palm Coast
Reviewed on Dec 15, 2025
Hampton Inn Jacksonville Beach/Oceanfront
Reviewed on Dec 13, 2025
Where to stay in Isle of Palms
Downtown Jacksonville
Historic core with major corporations, Downtown Jacksonville offers diverse culinary and nightlife experiences at The Elbow. Explore attractions like Florida Theatre, TIAA Bank Field, and museums, while enjoying convenient transportation options.
Isle of Palms Hotel Deals
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
Clean, convenient to interstate, Mayo Hospital, 10 minutes from numerous restaurants and shopping. The staff was friendly.
Reviewed on Dec 10, 2025
Margaritaville Jacksonville Beach
Staff were very friendly, the restaurant had amazing food and the view was perfect! Loved staying here! Would highly recommend!
Reviewed on Dec 12, 2025
Hyatt Regency Jacksonville
This is a lovely hotel. The location is beautiful on the water, the restaurants and staff were awesome, the front desk was helpful and friendly and the rooms are comfortable and clean. The pet situation is great too. There is easy access to a nice grass area for the dogs too. I don’t know how we ...
Reviewed on Dec 14, 2025
Discover the most popular places to visit in Isle of Palms
Mayo Clinic Florida
Though Mayo Clinic Florida might be what brings you to town, perhaps you'll have a chance to explore more of Jacksonville while you are here.
Jacksonville Naval Air Station
After visiting Jacksonville Naval Air Station, make a plan to see the other sights and activities in Jacksonville. Experience the lively festivals or attend a sporting event in this family-friendly area.
Jacksonville Zoo and Gardens
Admire thousands of animals and plants across entertaining exhibits in this family-friendly zoo that also has a children’s play area and a 4-D experience.
Things to do
