Title: Top Independent in Los Osos, CA - Expedia.com [Los Osos Travel Guide](https://expedia.com/Los-Osos.dx9873)[Hotels in Los Osos](https://expedia.com/Los-Osos-Hotels.d9873.Travel-Guide-Hotels)[Vacation Rentals in Los Osos](https://expedia.com/Los-Osos-Vacation-Rentals.d9873.Travel-Guide-VacationRentals)[Flights to Los Osos](https://expedia.com/Cheap-Flights-To-Los-Osos.d9873.Travel-Guide-Flights)[Things to do in Los Osos](https://expedia.com/Things-To-Do-In-Los-Osos.d9873.Travel-Guide-Activities)[Car Rentals in Los Osos](https://expedia.com/Car-Rentals-In-Los-Osos.d9873.Car-Rental-Guide)[Los Osos Vacation Packages](https://expedia.com/Los-Osos.d9873.Destination-Travel-Guides) ![Such a nice place!](https://images.trvl-media.com/place/553248621532639980/2c5ca4d7-c91a-4938-ad4a-7fa3b4914016.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Lisa Travelfeet ![](https://images.trvl-media.com/place/553248621532639980/2c5ca4d7-c91a-4938-ad4a-7fa3b4914016.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Upfront pricing Our total price for your stay includes taxes and fees - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save 10% or more on over 100,000 hotels worldwide with Member Prices [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Mar 5 - Mar 6](https://www.expedia.com/Hotel-Search?regionId=9873&startDate=2026-03-05&endDate=2026-03-06&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Mar 6 - Mar 7](https://www.expedia.com/Hotel-Search?regionId=9873&startDate=2026-03-06&endDate=2026-03-07&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Mar 6 - Mar 8](https://www.expedia.com/Hotel-Search?regionId=9873&startDate=2026-03-06&endDate=2026-03-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Mar 13 - Mar 15](https://www.expedia.com/Hotel-Search?regionId=9873&startDate=2026-03-13&endDate=2026-03-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FLos-Osos-Hotels-Independent.0-0-d9873--bIndependent.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FLos-Osos-Hotels-Independent.0-0-d9873--bIndependent.Travel-Guide-Filter-Hotels) ## Top Los Osos Hotel Reviews ![Quality Suites Downtown San Luis Obispo](https://images.trvl-media.com/lodging/1000000/10000/3200/3138/b42da2cd_y.jpg) ### Quality Suites Downtown San Luis Obispo 10/10 Excellent "Excellent " [](https://expedia.com/San-Luis-Obispo-Hotels-Quality-Suites-Downtown-San-Luis-Obispo.h3138.Hotel-Information) ![Madonna Inn](https://images.trvl-media.com/lodging/2000000/1200000/1191000/1190976/63206dec_y.jpg) ### Madonna Inn 10/10 Excellent "It was very relaxing at the pool. The service at the steak house was 5 stars Everyone was friendly " [](https://expedia.com/San-Luis-Obispo-Hotels-Madonna-Inn.h1190976.Hotel-Information) ![La Quinta Inn & Suites by Wyndham San Luis Obispo Downtown](https://images.trvl-media.com/lodging/28000000/27200000/27194600/27194534/d050f4c6_y.jpg) ### La Quinta Inn & Suites by Wyndham San Luis Obispo Downtown 10/10 Excellent "Rooms are clean, and nicely furnished with new, modern, and comfortable beds and furniture." [](https://expedia.com/San-Luis-Obispo-Hotels-La-Quinta-Inn-Suites-By-Wyndham-San-Luis-Obispo-Downtown.h27194534.Hotel-Information) ![Back Bay Inn](https://images.trvl-media.com/lodging/9000000/8170000/8168200/8168192/d28a5ac2_y.jpg) ### Back Bay Inn 10/10 Excellent "Wonderful. If you’ve never been to Baywood, you should go" [](https://expedia.com/San-Luis-Obispo-Hotels-Back-Bay-Inn.h8168192.Hotel-Information) ![Apple Farm](https://images.trvl-media.com/lodging/1000000/40000/39500/39435/880cde75_y.jpg) ### Apple Farm 10/10 Excellent "I love this place. It's so charming. " [](https://expedia.com/San-Luis-Obispo-Hotels-Apple-Farm.h39435.Hotel-Information) ![Best Western Plus Royal Oak Hotel](https://images.trvl-media.com/lodging/1000000/10000/3900/3864/8d25ff25_y.jpg) ### Best Western Plus Royal Oak Hotel 10/10 Excellent "Rooms are spacious and very clean. The gym is nice." [](https://expedia.com/San-Luis-Obispo-Hotels-Best-Western-Plus-Royal-Oak-Hotel.h3864.Hotel-Information) ![Harbor House Inn Morro Bay](https://images.trvl-media.com/lodging/1000000/80000/79600/79558/0ef1fb39_y.jpg) ### Harbor House Inn Morro Bay 10/10 Excellent "Room was clean great staff!" [](https://expedia.com/San-Luis-Obispo-Hotels-Harbor-House-Inn-Morro-Bay.h79558.Hotel-Information) ![Best Western Casa Grande Inn](https://images.trvl-media.com/lodging/1000000/30000/23100/23008/4cda8af4_y.jpg) ### Best Western Casa Grande Inn 10/10 Excellent "First time here it was a very clean place room was very clean had everything we needed we stayed in the suite had 2 bedrooms n two beds very comfy place staff was wonderful and polite to us the young man with glasses was very sweet my key card wasn't working and was very nice to go with me and recheck my keys to the room hot tub was nice and clean breakfast was super duper delicious they had waffles juices bagels bacon egg oatmeal ECT very delicious " [](https://expedia.com/San-Luis-Obispo-Hotels-Best-Western-Casa-Grande-Inn.h23008.Hotel-Information) ![SeaCrest OceanFront Hotel](https://images.trvl-media.com/lodging/2000000/1370000/1365400/1365352/b40c24d9_y.jpg) ### SeaCrest OceanFront Hotel 10/10 Excellent "Was best experience in pismo" [](https://expedia.com/San-Luis-Obispo-Hotels-SeaCrest-OceanFront-Hotel.h1365352.Hotel-Information) ## Explore a world of travel with Expedia - 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