Plan your trip

A calm river with a boat docked on the right, surrounded by dense foliage and a clear blue sky with scattered clouds.

Search Inns in Opelousas

  • Bundle & Save

    Get more, spend less whenever you see Bundle & Save deals

  • OneKeyCash

    Earn OneKeyCash on all your eligible bookings

  • Upfront pricing

    We are not like the others - we include taxes and fees

    • Check prices for these dates

    Check prices for these dates, December 12 – 13, 2026

    View in a map

    Our top choices for Opelousas inns

    1. St Charles

    A modern living room with a beige sofa, a round wooden coffee table, and a patterned rug.

    2. Claiborne Inn

    A modern kitchen with white cabinets, stainless steel appliances, and a central island with stools.

    3. Frenchman Inn

    A modern living room with a brown leather sofa, a wooden coffee table, and a gray armchair.

    4. University Inn

    A spacious living area with a round wooden table, beige sofa, and two armchairs.

    5. Baronne Inn

    A kitchen with white cabinets, a black stove, a microwave, and a gold faucet.

    Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

    View all properties

    Learn more about Opelousas

    Spice up your visit to the Zydeco Capital with live music venues and the annual Zydeco Festival in late August. Explore Cajun food history at the Opelousas Museum, then sample authentic boudin and crawfish at family-owned restaurants locals recommend.

    See all hotels in Opelousas

    A calm river with a boat docked on the right, surrounded by dense foliage and a clear blue sky with scattered clouds.

    Top reviews in Opelousas

    Hotel Klaus

    A spacious room with a blue sofa, leather armchairs, and a round table.

    Hampton Inn Opelousas

    A Hampton Inn hotel with a clear entrance, a flagpole with the American flag, and a parking area.

    Drury Inn & Suites Lafayette, LA

    A modern lobby with grey upholstered armchairs, a round wooden ottoman, and a patterned rug.

    Home2 Suites By Hilton Lafayette I-10

    A modern outdoor seating area with fire pit, chairs, and a covered patio.

    Holiday Inn & Suites Lafayette North by IHG

    An indoor swimming pool with clear water, surrounded by lounge chairs and a brick wall.

    Holiday Inn Express Breaux Bridge by IHG

    A buffet with various food items and utensils, including a sign indicating a cheese omelet option.

    Comfort Inn & Suites Scott-West Lafayette

    A hotel lobby with a reception desk, seating area, and a large framed picture on the wall.

    Spark by Hilton Opelousas

    A hotel room with a bed, bedside tables, a TV, a wardrobe, and a large window with curtains.

    Maison D'Memoire Bed & Breakfast Cottages

    A small, single-story house with a porch and a wooden fence.

    La Quinta Inn & Suites by Wyndham Lafayette Oil Center

    A modern hotel with a prominent logo, a covered entrance, and a landscaped front area.

    DoubleTree by Hilton Hotel Lafayette

    A spacious lobby with a staircase, seating area, and a reception desk.

    Mouton Plantation

    An outdoor patio with brick flooring, metal tables and chairs, potted plants, and a building with large windows in the background.

    Holiday Inn Express Hotel & Suites Lafayette by IHG

    A buffet with various food items, including omelets and baked goods, served in metal containers.

    Enclave 2 Bedroom Luxury Homes

    A modern kitchen with white cabinets, a central island with bar stools, a stainless steel refrigerator, and a brick backsplash.

    Home2 Suites by Hilton Parc Lafayette

    An outdoor seating area with wicker furniture, a fire pit, and ambient lighting.

    Homewood Suites by Hilton Lafayette, LA

    A hotel entrance with a covered driveway, palm trees, and a sign for Homewood Suites.

    Staybridge Suites Lafayette by IHG

    A building with a stone facade, a covered entrance with a wooden arch, and a seating area with chairs.

    Explore a world of travel with Expedia