Title: The Best 4 Star Hotels in Opelousas, LA from $104 | Expedia.com [Opelousas Travel Guide](https://expedia.com/Opelousas.dx9235)[Hotels in Opelousas](https://expedia.com/Opelousas-Hotels.d9235.Travel-Guide-Hotels)[Vacation Rentals in Opelousas](https://expedia.com/Opelousas-Vacation-Rentals.d9235.Travel-Guide-VacationRentals)[Flights to Opelousas](https://expedia.com/Cheap-Flights-To-Opelousas.d9235.Travel-Guide-Flights)[Car Rentals in Opelousas](https://expedia.com/Car-Rentals-In-Opelousas.d9235.Car-Rental-Guide)[Opelousas Vacation Packages](https://expedia.com/Opelousas.d9235.Destination-Travel-Guides) ![The historic Dutch Romanesque Revival style Cathedral of Saint John the Evangelist or La Cathedrale St-Jean built in 1916 on Cathedral Street in downtown Lafayette, Louisiana, USA](https://images.trvl-media.com/place/9235/0930b9c0-a21c-4193-a87e-9efe9ae4e660.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/9235/0930b9c0-a21c-4193-a87e-9efe9ae4e660.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Upfront pricing Our total price for your stay includes taxes and fees - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save 10% or more on over 100,000 hotels worldwide with Member Prices [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Opelousas 4 Star Hotels Tonight [Mar 6 - Mar 7](https://www.expedia.com/Hotel-Search?regionId=9235&startDate=2026-03-06&endDate=2026-03-07&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Mar 7 - Mar 8](https://www.expedia.com/Hotel-Search?regionId=9235&startDate=2026-03-07&endDate=2026-03-08&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Mar 6 - Mar 8](https://www.expedia.com/Hotel-Search?regionId=9235&startDate=2026-03-06&endDate=2026-03-08&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Mar 13 - Mar 15](https://www.expedia.com/Hotel-Search?regionId=9235&startDate=2026-03-13&endDate=2026-03-15&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Opelousas 4-star hotels ![Reception](https://images.trvl-media.com/lodging/1000000/10000/3800/3724/3eb25caa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Nightclub](https://images.trvl-media.com/lodging/1000000/10000/3800/3724/37f8434e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/3800/3724/ed80f161.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/10000/3800/3724/54ea0bc4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### DoubleTree by Hilton Hotel Lafayette [](https://www.expedia.com/Lafayette-Hotels-DoubleTree-By-Hilton-Hotel-Lafayette.h3724.Hotel-Information) Lafayette 8.4/10 Very Good (1,008 reviews) "Nice, clean, safe, excellent staff!!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) ROY $90 nightly $104 total Apr 5 - Apr 6 Total with taxes and fees [](https://www.expedia.com/Lafayette-Hotels-DoubleTree-By-Hilton-Hotel-Lafayette.h3724.Hotel-Information) ![Room, Private Bathroom (Country Garden Cottage) | Individually decorated, individually furnished, laptop workspace](https://images.trvl-media.com/lodging/20000000/19440000/19439500/19439467/d6d4049a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, Private Bathroom (Sweet Surrender Cottage) | In-room dining](https://images.trvl-media.com/lodging/20000000/19440000/19439500/19439467/f846f690.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, Private Bathroom (Autumn Cottage) | Living area | TV, DVD player](https://images.trvl-media.com/lodging/20000000/19440000/19439500/19439467/f986faaf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, Private Bathroom (Autumn Cottage) | In-room dining](https://images.trvl-media.com/lodging/20000000/19440000/19439500/19439467/541db756.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Maison D'Memoire Bed & Breakfast Cottages [](https://www.expedia.com/Lafayette-Hotels-Maison-DMemoire-Bed-Breakfast-Cottages.h19439467.Hotel-Information) Rayne 9.6/10 Exceptional (95 reviews) "We enjoy the history of the property. Hosts are such delightful people!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Susan $189 nightly $215 total Mar 12 - Mar 13 Total with taxes and fees [](https://www.expedia.com/Lafayette-Hotels-Maison-DMemoire-Bed-Breakfast-Cottages.h19439467.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/27100/27016/92389f54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/30000/27100/27016/d00b3d08.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite (Parlor) | 1 bedroom, premium bedding, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/30000/27100/27016/0a5ec1e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Gym](https://images.trvl-media.com/lodging/1000000/30000/27100/27016/5aa934fb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Wyndham Garden Lafayette [](https://www.expedia.com/Lafayette-Hotels-Wyndham-Garden-Lafayette.h27016.Hotel-Information) Lafayette 5.4/10 (548 reviews) "The carpets need to be steamed clean . The housekeeper didn’t gave us towels like they was supposed to . We had to call like 3x before the front desk had to come bring the towels . They never emptied the garbage the whole two days we was there. The air condition needed to be turned up . They need microwaves in the rooms. The rooms are nice besides no microwave. I enjoyed my stay but they need to upgrade the freshness and upgrade on their housekeeping service" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Anonymous traveler [](https://www.expedia.com/Lafayette-Hotels-Wyndham-Garden-Lafayette.h27016.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/127000000/126690000/126683800/126683792/8d2da575_edited_b1bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Luxury Townhome, Kitchen | Private kitchen | Full-size fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/127000000/126690000/126683800/126683792/b6ececa9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Luxury Townhome, Kitchen | Iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/127000000/126690000/126683800/126683792/cc6f2d6d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/127000000/126690000/126683800/126683792/0f2c82fd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Enclave 3 Bedroom Luxury Homes [](https://www.expedia.com/Lafayette-Hotels-Enclave-3-Bedroom-Luxury-Homes.h126683792.Hotel-Information) Lafayette [](https://www.expedia.com/Lafayette-Hotels-Enclave-3-Bedroom-Luxury-Homes.h126683792.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F4Star-Opelousas-Hotels.s40-0-d9235.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F4Star-Opelousas-Hotels.s40-0-d9235.Travel-Guide-Filter-Hotels) ## Learn more about Opelousas Spice up your visit to the Zydeco Capital with live music venues and the annual Zydeco Festival in late August. Explore Cajun food history at the Opelousas Museum, then sample authentic boudin and crawfish at family-owned restaurants locals recommend. [See all hotels in Opelousas](https://www.expedia.com/Hotel-Search?startDate=2026-03-20&endDate=2026-03-21&adults=2®ionId=9235) ![The historic Dutch Romanesque Revival style Cathedral of Saint John the Evangelist or La Cathedrale St-Jean built in 1916 on Cathedral Street in downtown Lafayette, Louisiana, USA](https://images.trvl-media.com/place/9235/0930b9c0-a21c-4193-a87e-9efe9ae4e660.jpg?impolicy=fcrop&w=900&h=600&p=1&q=high) ## Top Opelousas Hotel Reviews ![DoubleTree by Hilton Hotel Lafayette](https://images.trvl-media.com/lodging/1000000/10000/3800/3724/3eb25caa_y.jpg) ### DoubleTree by Hilton Hotel Lafayette 8/10 Good "Good" [](https://expedia.com/Lafayette-Hotels-DoubleTree-By-Hilton-Hotel-Lafayette.h3724.Hotel-Information) ## Find out more about Opelousas ## Opelousas Four Star Hotel Information When you need to book a room with luxurious amazing amenities and the best rates, the 4 star hotels in Opelousas, Louisiana are incredible options. Known for their extra perks, first-rate service, and fantastic locations, each of the Opelousas 4 star hotels offers the ultimate experience for globe-trotting travelers. Relax in your expertly designed room. Kick back with around-the-clock room service. Get a good night’s sleep with the ultra-plush bedding, and freshen up in the morning with designer-inspired body products. It’s all available when you stay at one of the top book a four star hotels in Opelousas. What’s more, thanks to Expedia you might even score a cheap great deal on a 4 star hotel in Opelousas, Louisiana, areas near the hottest attractions, so you can plan a sightseeing adventure and take advantage of unbeatable discounts in one fell swoop. Whether you’re putting together a serene getaway or want to revel in the most vibrant entertainment district, 4 star Opelousas hotels offer everything your heart desires. ## Frequently asked questions ### How much does it cost to stay in a 4-star hotel in Opelousas? > - Search for the lowest price from $104 ### What's the difference between 5-star and 4-star hotels in Opelousas? ### Does Opelousas have any 4-star all-inclusive resorts? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - [Hotels near Louisiana Orphan Train Museum ](https://www.expedia.com/Louisiana-Orphan-Train-Museum-Hotels.0-l553248621532644536-0.Travel-Guide-Filter-Hotels) - [Hotels near St. Landry Catholic Church ](https://www.expedia.com/St-Landry-Catholic-Church-Hotels.0-l553248621532644537-0.Travel-Guide-Filter-Hotels) - [Washington Hotels ](https://www.expedia.com/Washington-Hotels.d553248634999415279.Travel-Guide-Hotels) - [Lawtell Hotels ](https://www.expedia.com/Lawtell-Hotels.d3000439412.Travel-Guide-Hotels) - 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