Otay Mesa West Vacations from $424

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Your Otay Mesa West Vacation

Otay Mesa West is beckoning! Whatever type of adventure you're planning, you can discover more of this neighborhood with an Otay Mesa West vacation package. Plan enough time on your itinerary to see leading nearby sights such as Kaiser Permanente Otay Mesa Medical Offices during your trip to Otay Mesa West. Whatever your dream Otay Mesa West vacation may look like, you can turn it into reality with Expedia.

The Latest Otay Mesa West Vacation Packages

Price found within the past 48 hours. Click for updated prices.
The Sofia Hotel

The Sofia Hotel

3.5 out of 5
Downtown San Diego
Save 100% on your flight
Price was $714, price is now $424 per person
$424
per person
Sep 28 - Oct 2
found 1 day ago
Roundtrip flight included
Chicago (CHI) to San Diego (SAN)
8.4/10 Very Good! (1,543 reviews)
I stayed at The Sofia Hotel in downtown San Diego and loved its mix of historic charm and modern comfort. The location is excellent—just steps from the Gaslamp Quarter, the waterfront, and conveniently close to the Santa Fe train station, making travel super easy.

Reviewed on Aug 28, 2025

Margaritaville Hotel San Diego Gaslamp Quarter

Margaritaville Hotel San Diego Gaslamp Quarter

4 out of 5
Downtown San Diego
Price was $1,723, price is now $876 per person
$876
per person
Nov 3 - Nov 10
found 1 day ago
Roundtrip non-stop flight included
Chicago (CHI) to San Diego (SAN)
9/10 Wonderful! (993 reviews)
You get wristbands for your hotel keys

Reviewed on Aug 28, 2025

La Jolla Cove Suites

La Jolla Cove Suites

3 out of 5
Village of La Jolla
Save 100% on your flight
Price was $1,043, price is now $619 per person
$619
per person
Nov 1 - Nov 6
found 1 day ago
Roundtrip flight included
Denver (DEN) to San Diego (SAN)
7/10 Good! (1,013 reviews)
I enjoyed the quietness of the terrace room and how close the shopping area and park are. Great location, simple check in, would love to visit again

Reviewed on Aug 26, 2025

Sand Castle Inn

Sand Castle Inn

2.5 out of 5
Save 100% on your flight
Price was $1,127, price is now $676 per person
$676
per person
Nov 3 - Nov 10
found 1 day ago
Roundtrip non-stop flight included
Chicago (CHI) to San Diego (SAN)
8.2/10 Very Good! (477 reviews)
Wasn't looking for anything fancy; this was just right. And right across the street from the beach!

Reviewed on Jul 21, 2025

The Wayfarer San Diego

The Wayfarer San Diego

4 out of 5
Mission Beach
Save 100% on your flight
Price was $1,598, price is now $971 per person
$971
per person
Nov 3 - Nov 10
found 1 day ago
Roundtrip non-stop flight included
Chicago (CHI) to San Diego (SAN)
9.4/10 Exceptional! (1,579 reviews)
Property was well kept and clean. Pool and hot tub were convenient. Location is awesome.

Reviewed on Aug 28, 2025

Where to stay in Otay Mesa West

Find the best Otay Mesa West areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa West
US Grant Hotel

Downtown San Diego

2 out of top 10 points of interest in this area
4.5/5(8,497 area reviews)

Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.

Find hotels in Downtown San Diego

Otay Mesa West Hotel Deals

Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N, San Diego, CA
Fully refundableReserve now, pay when you stay
$111 nightly
The price is $128 total per night from Sep 16 to Sep 17
$128 total
Sep 16 - Sep 17
Total with taxes and fees
8/10 Very Good! (1,998 reviews)
"Good location staff great pooland bar"

Reviewed on Aug 25, 2025

Handlery Hotel
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive, San Diego, CA
Fully refundableReserve now, pay when you stay
$174 nightly
The price is $201 total per night from Sep 1 to Sep 2
$201 total
Sep 1 - Sep 2
Total with taxes and fees
Wyndham San Diego Bayside
Bay Club Hotel & Marina

Bay Club Hotel & Marina

3.5 out of 5
2131 Shelter Island Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
$173 nightly
The price is $199 total per night from Sep 8 to Sep 9
$199 total
Sep 8 - Sep 9
Total with taxes and fees
9/10 Wonderful! (2,838 reviews)
"A great property that is well taken care of. The staff care about the customers and the location is beautiful. It is a small hotel near the water, away from the crazy traffic, bustle of downtown, noise. We have stayed here 3 times already and will definitely stay again. A great value for the ..."

Reviewed on Aug 25, 2025

Bay Club Hotel & Marina
See all 6,614 properties in Otay Mesa West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Otay Mesa West

San Diego Zoo featuring landscape views, zoo animals and a pond

San Diego Zoo

4.5/5(3,565 reviews)

See nature up-close and personal at one of the country’s largest and most educational zoos.

San Diego Zoo
San Diego Convention Center

San Diego Convention Center

4.5/5(1,297 reviews)

Whether you come for Comic-Con or a medical convention, this huge gathering place in the Marina District of San Diego will more than satisfy your needs.

San Diego Convention Center
Mission Bay featuring a sandy beach

Mission Bay

4.5/5(2,386 reviews)

Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.

Mission Bay

Things to do

San Diego Explorer Pass: Save up to 50 Percent - Includes USS Midway

San Diego Explorer Pass: Save up to 50 Percent - Includes USS Midway

$124
per adult
88% of travellers recommend
San Diego Explorer Pass: Save up to 50 Percent - Includes USS Midway
Great Scenery

San Diego Sunset Cruise from Mission Bay

$40
per adult
80% of travellers recommend
San Diego Sunset Cruise from Mission Bay
San Diego Whale Watching Tour

San Diego Whale Watching Tour

$71
per adult
86% of travellers recommend
San Diego Whale Watching Tour
See all activities in San Diego
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.