Otay Mesa West Vacations from $317

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Your Otay Mesa West Vacation

Otay Mesa West is beckoning! Whatever type of adventure you're planning, you can discover more of this neighborhood with an Otay Mesa West vacation package. Plan enough time on your itinerary to see leading nearby sights such as Kaiser Permanente Otay Mesa Medical Offices during your trip to Otay Mesa West. Whatever your dream Otay Mesa West vacation may look like, you can turn it into reality with Expedia.

The Latest Otay Mesa West Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Quiet Mind Mountain Lodge, Retreat and Spa

Quiet Mind Mountain Lodge, Retreat and Spa

4.5 out of 5
Price was $633, price is now $317 per person
$317
per person
Jan 22 - Jan 28
found 21 hours ago
Roundtrip flight included
Denver (DEN) to San Diego (SAN)
9.2/10 Wonderful! (558 reviews)
The room has a nice calm and peaceful vibe. Overall, liked the stay.

Reviewed on Nov 25, 2025

Hyatt Vacation Club at The Welk, San Diego Area

Hyatt Vacation Club at The Welk, San Diego Area

3.5 out of 5
Lawrence Welk Resort Village
Price was $822, price is now $349 per person
$349
per person
Feb 7 - Feb 14
found 1 hour ago
Roundtrip flight included
Denver (DEN) to San Diego (SAN)
8.2/10 Very Good! (1,508 reviews)
No hot water on second day.

Reviewed on Nov 24, 2025

The Bristol Hotel San Diego

The Bristol Hotel San Diego

3.5 out of 5
Downtown San Diego
Price was $1,209, price is now $563 per person
$563
per person
Feb 18 - Feb 25
found 1 day ago
Roundtrip flight included
Chicago (CHI) to San Diego (SAN)
8.6/10 Excellent! (1,428 reviews)
So clean, Very Nice staff, convenient location !

Reviewed on Nov 25, 2025

The Sofia Hotel

The Sofia Hotel

3.5 out of 5
Downtown San Diego
Save 100% on your flight
Price was $1,092, price is now $557 per person
$557
per person
Feb 18 - Feb 25
found 1 day ago
Roundtrip flight included
Chicago (CHI) to San Diego (SAN)
8.4/10 Very Good! (1,627 reviews)
Clean room and hotel over all. Loved that there is a Starbucks pick up store front right on the bottom floor just adjacent from the lobby.

Reviewed on Nov 27, 2025

La Jolla Beach and Tennis Club

La Jolla Beach and Tennis Club

4 out of 5
La Jolla Shores
Save 100% on your flight
Price was $1,101, price is now $581 per person
$581
per person
Feb 2 - Feb 6
found 1 day ago
Roundtrip flight included
Chicago (CHI) to San Diego (SAN)
8.8/10 Excellent! (485 reviews)
Fabulous place. Marine Room dining exquisite. Breakfast at the restaurant was only a “C”.

Reviewed on Nov 23, 2025

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Where to stay in Otay Mesa West

Find the best Otay Mesa West areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa West
US Grant Hotel

Downtown San Diego

3 out of top 10 points of interest in this area
4.5/5(8,497 area reviews)

Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.

Find hotels in Downtown San Diego

Otay Mesa West Hotel Deals

Hotel del Coronado, Curio Collection by Hilton

Hotel del Coronado, Curio Collection by Hilton

4 out of 5
1500 Orange Ave Coronado CA
Fully refundableReserve now, pay when you stay
$432 nightly
The price is $479 total per night from Dec 15 to Dec 16
$479 total
Dec 15 - Dec 16
Total with taxes and fees
8.4/10 Very Good! (1,014 reviews)
Room was nice, walkability was great. On site amenities made the stay easy traveling with a toddler.

Reviewed on Nov 18, 2025

Hotel del Coronado, Curio Collection by Hilton
Hilton San Diego Mission Valley

Hilton San Diego Mission Valley

4 out of 5
901 Camino Del Rio S San Diego CA
Fully refundableReserve now, pay when you stay
$114 nightly
The price is $131 total per night from Dec 7 to Dec 8
$131 total
Dec 7 - Dec 8
Total with taxes and fees
8/10 Very Good! (2,203 reviews)
Room was excellent, clean and friendly staff at all times of the day

Reviewed on Nov 24, 2025

Hilton San Diego Mission Valley
Legacy Resort Hotel & Spa

Legacy Resort Hotel & Spa

4 out of 5
875 Hotel Circle South San Diego CA
Fully refundableReserve now, pay when you stay
$125 nightly
The price is $144 total per night from Nov 30 to Dec 1
$144 total
Nov 30 - Dec 1
Total with taxes and fees
9/10 Wonderful! (2,967 reviews)
I had an amazing time at the hotel. The room was spacious and comfortable, and the staff was incredibly friendly and helpful. The restaurant there served delicious food that was a highlight of my stay.

Reviewed on Nov 27, 2025

Legacy Resort Hotel & Spa
See all 6,840 properties in Otay Mesa West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Discover the most popular places to visit in Otay Mesa West

San Diego Zoo featuring landscape views, zoo animals and a pond

San Diego Zoo

4.5/5(3,565 reviews)

See nature up-close and personal at one of the country’s largest and most educational zoos.

San Diego Zoo
San Diego Convention Center

San Diego Convention Center

4.5/5(1,297 reviews)

Whether you come for Comic-Con or a medical convention, this huge gathering place in the Marina District of San Diego will more than satisfy your needs.

San Diego Convention Center
Mission Bay featuring a sandy beach

Mission Bay

4.5/5(2,386 reviews)

Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.

Mission Bay

Things to do

San Diego Whale Watching Tour

San Diego Whale Watching & Dolphin Cruise

$71
per adult
86% of travellers recommend
San Diego Whale Watching & Dolphin Cruise
San Diego Old Town Trolley Hop-On Hop-Off Tour

San Diego Old Town Trolley Hop-On Hop-Off Tour

$55
per adult
94% of travellers recommend
San Diego Old Town Trolley Hop-On Hop-Off Tour
Great Scenery

San Diego Sunset Cruise from Mission Bay

$40
per adult
78% of travellers recommend
San Diego Sunset Cruise from Mission Bay
See all activities in San Diego
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.