Panacea Vacations from $1,272

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Your Panacea Vacation

When you book a vacation package to Panacea, you can relax and enjoy your getaway knowing that all your travel plans have been worked out ahead of time. Discover the wonders of this city while based in a neighborhood like Ochlockonee Bay, which is great for nature. Up for some sightseeing? A trip to Panacea isn't complete without visiting Mashes Sand Beach, Ochlockonee River State Park and other popular attractions. Check out Expedia's wide range of travel options and start organizing your ideal vacation to Panacea now.

The Latest Panacea vacation packages

Price found within the past 48 hours. Click for updated prices.
Home2 Suites by Hilton Tallahassee State Capitol

Home2 Suites by Hilton Tallahassee State Capitol

3 out of 5
Price was $1,497, price is now $1,272 per person
$1,272
per person
Apr 30 - May 4
found 1 day ago
Roundtrip flight included
Des Moines (DSM) to Tallahassee (TLH)
8.4/10 Very Good! (1,004 reviews)
Outdated room. Shower was gross. Room was big. Beds were clean. Staff was good

Reviewed on Jan 18, 2026

Wyndham Garden Tallahassee Capitol

Wyndham Garden Tallahassee Capitol

3 out of 5
Price was $1,689, price is now $1,402 per person
$1,402
per person
Apr 30 - May 4
found 1 day ago
Roundtrip flight included
Des Moines (DSM) to Tallahassee (TLH)
5.8/10 (1,185 reviews)
The facility is definitely showing its age. Staff was very polite and accommodating.

Reviewed on Jan 28, 2026

TRYP by Wyndham Tallahassee North I-10 Capital Circle

TRYP by Wyndham Tallahassee North I-10 Capital Circle

3 out of 5
Price was $1,760, price is now $1,465 per person
$1,465
per person
Apr 30 - May 4
found 1 day ago
Roundtrip flight included
Des Moines (DSM) to Tallahassee (TLH)
8/10 Very Good! (1,175 reviews)
Everything was great, very comfy room. Squeaky clean. Friendly staff. Breakfast was one of the better ones considering it was the standard "free breakfast " everyone serves. Hot, not overcooked eggs, etc. Will definitely stay again when in the area.

Reviewed on Feb 2, 2026

Alluxsuites at 1876, an Ascend Collection Hotel

Alluxsuites at 1876, an Ascend Collection Hotel

2.5 out of 5
Price was $1,787, price is now $1,519 per person
$1,519
per person
Apr 30 - May 4
found 1 day ago
Roundtrip flight included
Des Moines (DSM) to Tallahassee (TLH)
8.2/10 Very Good! (681 reviews)
Spotless, Good staff, very nice room, and very quiet.

Reviewed on Jan 26, 2026

La Familia Stay Inn

La Familia Stay Inn

2 out of 5
Price was $1,659, price is now $1,420 per person
$1,420
per person
Apr 30 - May 4
found 1 day ago
Roundtrip flight included
Des Moines (DSM) to Tallahassee (TLH)
5.4/10 (20 reviews)
Room was clean and staff was super nice. Really enjoyed my stay.

Reviewed on Dec 16, 2025

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Discover the most popular places to visit in Panacea

Bald Point State Park

You can take time to visit Bald Point State Park during your travels to Alligator Point. Stroll along the beaches in this relaxing area, or seek out the fishing spots.

Bald Point State Park

Panacea Hotel Deals

5 Bedroom Beach House Slps 12 - Private Beach - Shells - Fishing -Screened porch

5 Bedroom Beach House Slps 12 - Private Beach - Shells - Fishing -Screened porch

Panacea FL
9.8/10 Exceptional! (80 reviews)
The sunrise from this porch is breath taking. The house is well equipped and the the porch is simply amazing. Host was quick to respond and we will be renting this home again!

Reviewed on Dec 19, 2025

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5 Bedroom Beach House Slps 12 - Private Beach - Shells - Fishing -Screened porch
7 Bedroom Beach House with POOL!! Gulf Front and Bay Front

7 Bedroom Beach House with POOL!! Gulf Front and Bay Front

Alligator Point FL
$1,733 nightly
The price is $1,898 total per night from Feb 4 to Feb 5
$1,898 total
Feb 4 - Feb 5
Total with taxes and fees
10/10 Exceptional! (101 reviews)
Our family had a great time. There was plenty of space for everyone to be alone when they needed it, but absolutely plenty of space to come together. Kitchen was fully stocked with all of the pots/pans/utensils needed. The house is right on the water with convenient access. The front yard was perfect ...

Reviewed on Nov 10, 2025

7 Bedroom Beach House with POOL!! Gulf Front and Bay Front
Tiki House is a Unique Beach Front gathering spot for family, friends and PUPs.

Tiki House is a Unique Beach Front gathering spot for family, friends and PUPs.

Alligator Point FL
9.8/10 Exceptional! (42 reviews)
We LOVED our stay at the Tiki House. The location is on our favorite part of Alligator Point (Mud Cove). Our son loves to cast the net for the Mullet and Shrimp that come into the Mud Cove area during this time of year. Loved the large kitchen bar that was perfect for our traditional Thanksgiving ...

Reviewed on Dec 2, 2025

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Tiki House is a Unique Beach Front gathering spot for family, friends and PUPs.
See all 506 properties in Panacea
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Panacea Vacation Packages

Panacea Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Tallahassee Intl. Airport (TLH)
Population
820
Top Sights
Shell Point Beach, Alligator Point Beach and Bald Point State Park

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Frequently asked questions

How much does a Panacea vacation package cost?
Offering great value package deals from $1,272 on Expedia, you'll be pleasantly surprised at how much a vacation to Panacea costs! Expedia's packages make travel planning easier and your savings go further.
What are the cheapest months to go to Panacea?
If you're hoping to book a cheap Panacea vacation package, consider visiting in July, October and November. You're likely to find better prices on hotels and flights during these quieter months — perfect for budget-conscious travelers.
How many days is enough for Panacea?
The ideal length of your Panacea vacation depends on what you'd like to see and do. Typically, a few days to a week will give you plenty of time to tick off all the major attractions and discover some hidden spots along the way.
How to find the best Panacea package deals?
Landing a cheap Panacea package deal is easy with Expedia. Once you've entered your preferred dates and destination under our "Packages" tab, set your maximum budget, apply a couple of filters and see what's available. You can tailor your search by "Amenities," "Property type," "Traveler experience" and more. Order the results by "Price: low to high" to discover the most wallet-friendly Panacea package deals. Want a simple trick to score even more savings? Be flexible with your departure dates and consider traveling on a weekday, when prices are usually lower.
Is it cheaper to book a Panacea vacation as a package?
An Expedia vacation package could land you significant savings when compared to arranging flights and hotels individually. Better still, you can customize your Panacea escape to match your exact needs. Pick your preferred flight time, select the hotel type and add a rental car. Browse our bundle deals and find out how much you can save.
When to book a vacation package to Panacea?
If you have your Panacea travel dates locked in, book as early as you can to grab some terrific deals. With Expedia, you can typically reserve some flights up to one year ahead of time. Prefer spontaneous adventures? Our last-minute deals are ideal for setting off on a whim.
Does Expedia offer Book Now, Pay Later Panacea vacation packages?
Jet off on your dream trip to Panacea with help from Expedia's Book Now, Pay Later vacations. No need to save like crazy or wait for the next payday — we've teamed up with online lender Affirm to give you more flexibility with your finances. Our vacation packages with payment plans allow you to spread the total cost across 3, 6 or 12 months. With no late payment fees or extra charges, it's easy to stick to your budget and snap up travel deals while they last.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.