Panacea Vacations from $444

Book a Hotel + Flight or Car together to unlock savings

Photo by Barbara Brogdon

Your Panacea Vacation

When you book a vacation package to Panacea, you can relax and enjoy your getaway knowing that all your travel plans have been worked out ahead of time. Discover the wonders of this city while based in a neighborhood like Ochlockonee Bay, which is great for nature. Up for some sightseeing? A trip to Panacea isn't complete without visiting Mashes Sand Beach, Ochlockonee River State Park and other popular attractions. Check out Expedia's wide range of travel options and start organizing your ideal vacation to Panacea now.

The Latest Panacea vacation packages

Price found within the past 48 hours. Click for updated prices.
Daffodale House B&B

Daffodale House B&B

4 out of 5
Price was $527, price is now $444 per person
$444
per person
Feb 6 - Feb 9
found 1 day ago
Roundtrip non-stop flight included
Miami (MIA) to Tallahassee (TLH)
9.6/10 Exceptional! (110 reviews)
The house was amazing with antiques. The owners were delightful. Definitely will stay there again!

Reviewed on Nov 21, 2025

Alluxsuites at 1876, an Ascend Collection Hotel

Alluxsuites at 1876, an Ascend Collection Hotel

2.5 out of 5
Price was $755, price is now $617 per person
$617
per person
Feb 13 - Feb 16
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Tallahassee (TLH)
8.2/10 Very Good! (698 reviews)
My complete stay and accommodations were good. Nothing really that I did not like about my stay.

Reviewed on Dec 1, 2025

Hampton Inn & Suites Tallahassee Capitol - University

Hampton Inn & Suites Tallahassee Capitol - University

2.5 out of 5
Railroad Square Art District
Price was $1,464, price is now $1,218 per person
$1,218
per person
Feb 2 - Feb 6
found 4 hours ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Tallahassee (TLH)
9.2/10 Wonderful! (1,004 reviews)
Very clean. By far one of the best hotels we’ve stayed at. Comfortable.

Reviewed on Dec 20, 2025

Country Inn & Suites by Radisson, Tallahassee-University Area, FL

Country Inn & Suites by Radisson, Tallahassee-University Area, FL

2.5 out of 5
Price was $671, price is now $581 per person
$581
per person
Feb 13 - Feb 16
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Tallahassee (TLH)
8.2/10 Very Good! (1,424 reviews)
Great room, very clean, decent breakfast. Recommend placing soap or at least body wash dispenser by sink to clean hands rather than body lotion.

Reviewed on Dec 19, 2025

Quality Inn Quincy - Tallahassee West

Quality Inn Quincy - Tallahassee West

2.5 out of 5
Price was $603, price is now $531 per person
$531
per person
Jan 23 - Jan 27
found 1 day ago
Roundtrip non-stop flight included
San Francisco (SFO) to Tallahassee (TLH)
7.6/10 Good! (497 reviews)
Staff very nice. Bed very good. Quiet location. Breakfast up to expectations. Beyond that, not worth it cost. An old place and shows it.

Reviewed on Dec 13, 2025

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Discover the most popular places to visit in Panacea

Bald Point State Park

Bald Point State Park

4.5/5(6 reviews)

You can take time to visit Bald Point State Park during your travels to Alligator Point. Stroll along the beaches in this relaxing area, or seek out the fishing spots.

Bald Point State Park

Panacea Hotel Deals

Skipper-extends from Beach Front to Harbor with Kayaks, Pickleball & Dock

Skipper-extends from Beach Front to Harbor with Kayaks, Pickleball & Dock

Panacea FL
$383 nightly
The price is $418 total per night from Jan 3 to Jan 4
$418 total
Jan 3 - Jan 4, 2026
Total with taxes and fees
9.6/10 Exceptional! (93 reviews)
We really enjoyed our time at Skipper! It's location on the west end of Alligator Point is perfect for walking the beach for miles in either direction. With so many shells to search for and so many dolphins to watch, our time there was so relaxing that we can't wait to go back!

Reviewed on Dec 3, 2025

Skipper-extends from Beach Front to Harbor with Kayaks, Pickleball & Dock
The Panacea Motel

The Panacea Motel

2 out of 5
1545 Coastal Hwy Panacea FL
$116 nightly
The price is $130 total per night from Dec 31 to Jan 1
$130 total
Dec 31 - Jan 1, 2026
Total with taxes and fees
9/10 Wonderful! (139 reviews)
Excellent stay! Very clean and spacious room! Staff was friendly and helpful

Reviewed on Dec 3, 2025

The Panacea Motel
"Shifting Sands" Private Beach Front 3 Bd, 2 Bath, sleeps 8

"Shifting Sands" Private Beach Front 3 Bd, 2 Bath, sleeps 8

Alligator Point FL
9.8/10 Exceptional! (97 reviews)
This is our 2nd time visiting. We absolutely love this house and the view!

Reviewed on Nov 5, 2025

Get rates
"Shifting Sands" Private Beach Front 3 Bd, 2 Bath, sleeps 8
See all 500 properties in Panacea
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Panacea Vacation Packages

Panacea Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Tallahassee Intl. Airport (TLH)
Population
820
Top Sights
Shell Point Beach, Alligator Point Beach and Bald Point State Park

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Frequently asked questions

How much does a Panacea vacation package cost?
Offering great value package deals from $444 on Expedia, you'll be pleasantly surprised at how much a vacation to Panacea costs! Expedia's packages make travel planning easier and your savings go further.
What are the cheapest months to go to Panacea?
If you're hoping to book a cheap Panacea vacation package, consider visiting in July, October and November. You're likely to find better prices on hotels and flights during these quieter months — perfect for budget-conscious travelers.
How many days is enough for Panacea?
The ideal length of your Panacea vacation depends on what you'd like to see and do. Typically, a few days to a week will give you plenty of time to tick off all the major attractions and discover some hidden spots along the way.
How to find the best Panacea package deals?
Landing a cheap Panacea package deal is easy with Expedia. Once you've entered your preferred dates and destination under our "Packages" tab, set your maximum budget, apply a couple of filters and see what's available. You can tailor your search by "Amenities," "Property type," "Traveler experience" and more. Order the results by "Price: low to high" to discover the most wallet-friendly Panacea package deals. Want a simple trick to score even more savings? Be flexible with your departure dates and consider traveling on a weekday, when prices are usually lower.
Is it cheaper to book a Panacea vacation as a package?
An Expedia vacation package could land you significant savings when compared to arranging flights and hotels individually. Better still, you can customize your Panacea escape to match your exact needs. Pick your preferred flight time, select the hotel type and add a rental car. Browse our bundle deals and find out how much you can save.
When to book a vacation package to Panacea?
If you have your Panacea travel dates locked in, book as early as you can to grab some terrific deals. With Expedia, you can typically reserve some flights up to one year ahead of time. Prefer spontaneous adventures? Our last-minute deals are ideal for setting off on a whim.
Does Expedia offer Book Now, Pay Later Panacea vacation packages?
Jet off on your dream trip to Panacea with help from Expedia's Book Now, Pay Later vacations. No need to save like crazy or wait for the next payday — we've teamed up with online lender Affirm to give you more flexibility with your finances. Our vacation packages with payment plans allow you to spread the total cost across 3, 6 or 12 months. With no late payment fees or extra charges, it's easy to stick to your budget and snap up travel deals while they last.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.