Santa Ana Vacations from $597

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Your Santa Ana Vacation

Come and discover this wonderful city for yourself with a Santa Ana vacation package. Consider spending some time in the neighborhood of Villa Nueva, which is great for history and culture, and your time here will be nothing short of unforgettable. Every trip to Santa Ana needs a well-planned itinerary. Fill yours with famous sights like Casa Santo Domingo Museum, Central Park and Santa Catalina Arch. Check out Expedia's extensive range of travel options and begin planning your perfect vacation to Santa Ana today.

The Latest Santa Ana Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Atitlan Oasis Eco Hotel and Spa Kaalpul

Atitlan Oasis Eco Hotel and Spa Kaalpul

3.5 out of 5
Save 100% on your flight
Price was $978, price is now $597 per person
$597
per person
Nov 6 - Nov 12
found 1 day ago
Roundtrip non-stop flight included
New York (JFK) to Guatemala City (GUA)
8.8/10 Excellent! (72 reviews)
A magical spot! Totally secluded with stunning views of Lake Atitlan. Alexis is extraordinarily kind.

Reviewed on Mar 18, 2025

Kula Maya Boutique Hotel & Spa

Kula Maya Boutique Hotel & Spa

3 out of 5
Save 100% on your flight
Price was $1,333, price is now $809 per person
$809
per person
Oct 25 - Oct 31
found 1 day ago
Roundtrip flight included
New York (JFK) to Guatemala City (GUA)
9.6/10 Exceptional! (92 reviews)
Loved EVERYTHING about this hotel ! My view was amazing and the staff was top tier ! Loved it

Reviewed on Aug 29, 2025

Casa Santa Margarita

Casa Santa Margarita

4.5 out of 5
Save 100% on your flight
Price was $2,824, price is now $1,734 per person
$1,734
per person
Nov 19 - Nov 23
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Guatemala City (GUA)
10/10 Exceptional! (13 reviews)
We enjoyed the setting and very spacious garden in the front. The staff were very friendly and it was a great time for my girlfriend and me.

Reviewed on Sep 2, 2025

Hotel Soleil La Antigua

Hotel Soleil La Antigua

4 out of 5
Save 100% on your flight
Price was $1,125, price is now $717 per person
$717
per person
Oct 5 - Oct 12
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Guatemala City (GUA)
8.6/10 Excellent! (1,009 reviews)
This place was amazing and i enjoyed my stay . Staff was good , breakfast was off the chain. They offer transportation to and from the airport for 70us for 3 peoples. I hate the fact that we couldn’t get outfood or drink. I don’t think its fair .

Reviewed on Aug 25, 2025

El Carmen Hotel

El Carmen Hotel

3 out of 5
Historic Center
Save 100% on your flight
Price was $1,382, price is now $886 per person
$886
per person
Nov 19 - Nov 23
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Guatemala City (GUA)
8.8/10 Excellent! (636 reviews)
La Mejor Vista y el Mejor desayuno Volveremos

Reviewed on Sep 1, 2025

Santa Ana Hotel Deals

Barceló Guatemala City

Barceló Guatemala City

4.5 out of 5
7 Avenida 15-45, Zona 9, Guatemala City, Guatemala
Fully refundableReserve now, pay when you stay
$85 nightly
The price is $103 total per night from Sep 14 to Sep 15
$103 total
Sep 14 - Sep 15
Total with taxes and fees
Barceló Guatemala City
Tikal Futura Hotel & Convention Center

Tikal Futura Hotel & Convention Center

4.5 out of 5
Calzada Roosevelt 22-43, Zona 11, Guatemala City, Guatemala
Fully refundableReserve now, pay when you stay
$116 nightly
The price is $142 total per night from Oct 3 to Oct 4
$142 total
Oct 3 - Oct 4
Total with taxes and fees
8.8/10 Excellent! (990 reviews)
"Love this place!"

Reviewed on Aug 26, 2025

Tikal Futura Hotel & Convention Center
Hotel Museo Spa Casa Santo Domingo

Hotel Museo Spa Casa Santo Domingo

4.5 out of 5
3a Calle Oriente No 28 A, Antigua Guatemala, Sacatepequez
Fully refundableReserve now, pay when you stay
$210 nightly
The price is $256 total per night from Sep 9 to Sep 10
$256 total
Sep 9 - Sep 10
Total with taxes and fees
Hotel Museo Spa Casa Santo Domingo
See all 1,154 properties in Santa Ana
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Santa Ana

Ruins of Old Mayan Monastery destroyed during earthquake in 15th century !

Casa Santo Domingo Museum

4.5/5(223 reviews)

You can browse the exhibits at Casa Santo Domingo Museum, a museum with a story of its own, during your travels to Antigua Guatemala. Discover the volcano viewpoints and shops in this romantic area.

Casa Santo Domingo Museum
Central Park

Central Park

4.5/5(493 reviews)

Enjoy the volcano viewpoints and explore Central Park, a lovely green space in Antigua Guatemala. Discover the area's shops, or seek out its local tours.

Central Park
Vue du volcan de Fuego

Antigua Guatemala Cathedral

4.5/5(423 reviews)

After visiting Antigua Guatemala Cathedral, make a plan to see the other sights and activities in Antigua Guatemala. Discover the area's volcano viewpoints, or seek out its local tours.

Antigua Guatemala Cathedral

Things to do

From Antigua: Pacaya Volcano Trek

From Antigua: Pacaya Volcano Trek

$23
per adult
86% of travellers recommend
From Antigua: Pacaya Volcano Trek
Altamira Park.

Hoobitenango and Altamira From Antigua or Guatemala city

$125
per adult
98% of travellers recommend
Hoobitenango and Altamira From Antigua or Guatemala city
Guided Tour to Altamira by ATV or UTV

Guided Tour to Altamira by ATV or UTV

$75
per adult
Guided Tour to Altamira by ATV or UTV
See all activities in Antigua Guatemala
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.