Santa Ana Vacations from $637

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Your Santa Ana Vacation

Come and discover this wonderful city for yourself with a Santa Ana vacation package. Consider spending some time in the neighborhood of Villa Nueva, which is great for history and culture, and your time here will be nothing short of unforgettable. Every trip to Santa Ana needs a well-planned itinerary. Fill yours with famous sights like Casa Santo Domingo Museum, Central Park and Santa Catalina Arch. Check out Expedia's extensive range of travel options and begin planning your perfect vacation to Santa Ana today.

The Latest Santa Ana Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hot Chipilin

Hot Chipilin

2 out of 5
Historic Center
Save 100% on your flight
Price was $1,041, price is now $637 per person
$637
per person
Feb 11 - Feb 18
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Guatemala City (GUA)
8.2/10 Very Good! (42 reviews)
Great staff and service. Very convenient location. Air conditioning works great and the breakfast is surprisingly good. Only issue I see is the bathroom has a weird layout but overall, great stay thanks to the friendly staff.

Reviewed on Dec 7, 2025

Aviva Hotel

Aviva Hotel

3 out of 5
Price was $1,976, price is now $977 per person
$977
per person
Feb 11 - Feb 18
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Guatemala City (GUA)
9.8/10 Exceptional! (14 reviews)
This spot was booked for our honeymoon. The lake town is vibrant and full of energy. We loved this establishment because it captured the beauty of the lake while allowing us to enjoy our time away from all the noise. The staff here made us feel fantastic and knowing they have a restaurant on site where all the staff get to know your name was fantastic. We went from town to town after our stay here and I wish we stayed in this hotel for the whole time.

Reviewed on Dec 3, 2025

Hotel Soleil La Antigua

Hotel Soleil La Antigua

4 out of 5
Save 100% on your flight
Price was $1,916, price is now $1,038 per person
$1,038
per person
Feb 11 - Feb 18
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Guatemala City (GUA)
8.6/10 Excellent! (1,001 reviews)
Love this hotel!! Need more food option or at least vending machines, because you’re not allowed to bring food from outside. But overall it is ⭐️⭐️⭐️⭐️⭐️

Reviewed on Dec 3, 2025

Atitlan Oasis Eco Hotel and Spa Kaalpul

Atitlan Oasis Eco Hotel and Spa Kaalpul

3.5 out of 5
Save 100% on your flight
Price was $1,320, price is now $733 per person
$733
per person
Feb 11 - Feb 18
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Guatemala City (GUA)
8.6/10 Excellent! (73 reviews)
A magical spot! Totally secluded with stunning views of Lake Atitlan. Alexis is extraordinarily kind.

Reviewed on Mar 18, 2025

Hotel Soleil Pacifico

Hotel Soleil Pacifico

3.5 out of 5
Save 100% on your flight
Price was $1,146, price is now $725 per person
$725
per person
Feb 28 - Mar 7
found 9 hours ago
Roundtrip non-stop flight included
New York (NYC) to Guatemala City (GUA)
7/10 Good! (360 reviews)
Great customer service!

Reviewed on Sep 24, 2025

Santa Ana Hotel Deals

Barceló Guatemala City

Barceló Guatemala City

4.5 out of 5
7 Avenida 15-45, Zona 9 Guatemala City Guatemala
Fully refundableReserve now, pay when you stay
$66 nightly
The price is $81 total per night from Jan 4 to Jan 5
$81 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
9/10 Wonderful! (3,095 reviews)
The staff was to great for words. I love the barcelo

Reviewed on Dec 5, 2025

Barceló Guatemala City
Tikal Futura Hotel & Convention Center

Tikal Futura Hotel & Convention Center

4.5 out of 5
Calzada Roosevelt 22-43 Guatemala City Guatemala
Fully refundableReserve now, pay when you stay
$96 nightly
The price is $118 total per night from Jan 4 to Jan 5
$118 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
9/10 Wonderful! (1,003 reviews)
Excellent!

Reviewed on Dec 4, 2025

Tikal Futura Hotel & Convention Center
Porta Hotel Antigua

Porta Hotel Antigua

4.5 out of 5
8va Calle Poniente No1 Antigua Guatemala Sacatepequez
Fully refundableReserve now, pay when you stay
$185 nightly
The price is $226 total per night from Dec 9 to Dec 10
$226 total
Dec 9 - Dec 10
Total with taxes and fees
9.2/10 Wonderful! (1,001 reviews)
Nice place to stay.

Reviewed on Nov 28, 2025

Porta Hotel Antigua
See all 1,225 properties in Santa Ana
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Santa Ana

Ruins of Old Mayan Monastery destroyed during earthquake in 15th century !

Casa Santo Domingo Museum

4.5/5(223 reviews)

You can browse the exhibits at Casa Santo Domingo Museum, a museum with a story of its own, during your travels to Antigua Guatemala. Discover the volcano viewpoints and shops in this family-friendly area.

Casa Santo Domingo Museum
Vue du volcan de Fuego

Antigua Guatemala Cathedral

4.5/5(423 reviews)

After visiting Antigua Guatemala Cathedral, make a plan to see the other sights and activities in Antigua Guatemala. Discover the area's volcano viewpoints, or seek out its local tours.

Antigua Guatemala Cathedral
Central Park

Central Park

4.5/5(493 reviews)

Enjoy the volcano viewpoints and explore Central Park, a lovely green space in Antigua Guatemala. Discover the area's shops, or seek out its local tours.

Central Park

Things to do

Acatenango Volcano Tour with Overnight from Antigua

Acatenango Volcano Overnight Tour

$99
per adult
Acatenango Volcano Overnight Tour
From Antigua: Pacaya Volcano Trek

From Antigua: Pacaya Volcano Trek

$23
per adult
86% of travellers recommend
From Antigua: Pacaya Volcano Trek
Overnight Adventure !!Hike Acatenango Volcano

Overnight Adventure Hike Acatenango Volcano

$85
per adult
Overnight Adventure Hike Acatenango Volcano
See all activities in Antigua Guatemala
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.