Santa Maria Vacations from $646

Book a Hotel + Flight or Car together to unlock savings

Your Santa Maria Vacation

Come and experience this captivating city for yourself with a Santa Maria vacation package. Think about staying in the neighborhood of Marciano della Chiana, which is good for views and nature, and your time here is sure to be unforgettable. Church of S. Francesco is just one of the famous attractions to add to your itinerary during a trip to Santa Maria. Check out Expedia's extensive range of travel options and start planning your perfect vacation to Santa Maria now.

The Latest Santa Maria vacation packages

Price found within the past 48 hours. Click for updated prices.
Eurostars Florence Boutique

Eurostars Florence Boutique

4 out of 5
Historic Centre of Florence
Price was $939, price is now $646 per person
$646
per person
Jan 14 - Jan 20
found 18 hours ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Florence (FLR)
17.2/10 Exceptional! (476 reviews)
Great little hotel. Everything is within walking distance. The view from the terrace was amazing.

Reviewed on Aug 6, 2025

Villa Cora

Villa Cora

5 out of 5
Oltrarno
Save 100% on your flight
Price was $3,265, price is now $2,209 per person
$2,209
per person
Jan 3 - Jan 9
found 1 day ago
Roundtrip flight included
Los Angeles (LAX) to Florence (FLR)
19.6/10 Exceptional! (467 reviews)
Nice property and staff.

Reviewed on Nov 13, 2025

Aurum Uffizi

Aurum Uffizi

4 out of 5
Historic Centre of Florence
Price was $1,350, price is now $916 per person
$916
per person
Jan 3 - Jan 9
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Florence (FLR)
15.6/10 Exceptional! (1,000 reviews)
Breakfast was good. Staff super friendly. Overall the expected quality for the paid price.

Reviewed on Nov 20, 2025

Hotel Palazzo San niccolò & Spa

Hotel Palazzo San niccolò & Spa

4 out of 5
Price was $937, price is now $653 per person
$653
per person
Jan 14 - Jan 20
found 18 hours ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Florence (FLR)
18.4/10 Exceptional! (175 reviews)
The property is beautifully old but be careful how much luggage you bring as there is no elevator, Only stairs. Room is nice. Bathrooms nicely updated. No complaints!

Reviewed on Sep 30, 2025

Aurum Firenze

Aurum Firenze

4 out of 5
Historic Centre of Florence
Price was $1,248, price is now $877 per person
$877
per person
Jan 3 - Jan 9
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Florence (FLR)
15.2/10 Exceptional! (1,002 reviews)
Convenient location to fast food and train station

Reviewed on Nov 7, 2025

Don't see what you're looking for?
See all available trips from Columbus to Santa Maria
View all trips

Black Friday Sale

Limited-time deals: Save up to 50% on select hotels.
Book now

Discover the most popular places to visit in Santa Maria

Church of S. Francesco

Church of S. Francesco is just one of the places to see in Lucignano, so why not enjoy the other things to explore during your travels? Discover the area's countryside and spas.

Church of S. Francesco

Piazza del Tribunal

Learn about the local history of Lucignano when you spend time at Piazza del Tribunal. Discover the area's countryside and wineries.

Piazza del Tribunal

Museum of Lucignano

You can spend an afternoon studying the exhibits at Museum of Lucignano during your travels in Lucignano. Visit the area's spas, or simply enjoy its wineries.

Museum of Lucignano

What to do in Santa Maria

Montepulciano Wine Tasting in the Tuscan Countryside

Montepulciano Wine Tasting in the Tuscan Countryside

$29
per adult
Montepulciano Wine Tasting in the Tuscan Countryside
Oil museum and oil mill in Tuscany: tour and tasting

Oil museum and oil mill in Tuscany: tour and tasting

$23
per adult
Oil museum and oil mill in Tuscany: tour and tasting
Tasting and Tour Vino Nobile di Montepulciano

Tasting and Tour Vino Nobile di Montepulciano

$46
per adult
Tasting and Tour Vino Nobile di Montepulciano
See all activities in Santa Maria

Santa Maria Hotel Deals

Monastero di Cortona Hotel & Spa

Monastero di Cortona Hotel & Spa

5 out of 5
Via del Salvatore Cortona AR
Fully refundableReserve now, pay when you stay
$291 nightly
The price is $324 total per night from Nov 30 to Dec 1
$324 total
Nov 30 - Dec 1
Total with taxes and fees
9.8/10 Exceptional! (250 reviews)
What a unique place. Near the top of the hill. Staff service and amenities were all great. Not an easy place to drive to. The taxis drive-in backwards the last eighth of a mile.

Reviewed on Nov 4, 2025

Monastero di Cortona Hotel & Spa
B&B Hotel Arezzo

B&B Hotel Arezzo

3 out of 5
Via Einstein, 4 Arezzo AR
Fully refundableReserve now, pay when you stay
$71 nightly
The price is $85 total per night from Dec 3 to Dec 4
$85 total
Dec 3 - Dec 4
Total with taxes and fees
8.4/10 Very Good! (335 reviews)
Nice hotel.
Nice hotel. Well located near Arezzo.

Reviewed on Feb 1, 2025

B&B Hotel Arezzo
Hotel Continentale

Hotel Continentale

4 out of 5
Piazza Guido Monaco, 7 Arezzo AR
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $151 total per night from Dec 3 to Dec 4
$151 total
Dec 3 - Dec 4
Total with taxes and fees
8.4/10 Very Good! (449 reviews)
We had a last-minute stay there due to the train strike, and it was a great evening after all… The hotel was right there in the main Square plus near the train station. The staff was lovely and they have the most beautiful rooftop patio and bar. you have to check out.

Reviewed on Oct 17, 2025

Hotel Continentale
See all 5,218 properties in Santa Maria
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Santa Maria Vacation Packages

Santa Maria Essential Information

Language
Italian
Currency
Euros
Local Welcome
Ciao
Local Goodbye
Ciao

More vacations you might like

All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Frequently asked questions

How much does a Santa Maria vacation package cost?
You'll find cheap prices from $646 on Expedia for your Santa Maria getaway. However, a range of factors like the season, choice of hotel and length of stay will determine how much your vacation to Santa Maria costs.
What are the cheapest months to go to Santa Maria?
November, December and January are the best times to search for cheap Santa Maria vacation packages. Choosing to travel in quieter periods means you can usually find reduced prices on flights and accommodations.
How many days is enough for Santa Maria?
Generally, a handful of days is enough to see the major attractions during your Santa Maria vacation. But if you prefer to have time to relax or go on day trips, consider extending your itinerary.
How to find the best Santa Maria package deals?
Use Expedia's filter tool to help you find some fabulous Santa Maria package deals. When you start your search, just set your maximum budget and then order the results by "Price: low to high." If you're looking to save, plan your break for midweek, or browse for Santa Maria package deals in the off-season. Play around with your travel dates and you may score even bigger discounts. As a rule of thumb, it's typically best to book your vacation package well in advance.
Is it cheaper to book a Santa Maria vacation as a package?
Expedia vacation packages are designed to give you more bang for your buck. Bundle your flight, hotel and car rental into one great-value price and enjoy significant savings. You'll typically score a better deal than booking each component individually. And you'll still enjoy the freedom to create a tailored Santa Maria vacation by choosing your favorite type of stay, airline and car class.
When to book a vacation package to Santa Maria?
If you've got your Santa Maria vacation dates finalized, book early to grab some terrific deals. With Expedia, you can typically reserve some flights up to a year in advance. Prefer spontaneous trips? Our last-minute deals are great for quick escapes.
Does Expedia offer Book Now, Pay Later Santa Maria vacation packages?
Your Santa Maria trip is meant to be an escape from your daily routine, not a source of money-related stress. So to give you more flexibility, we've partnered with online lender Affirm to offer our Book Now, Pay Later vacations. Pick one of our vacation packages with payment plans and break down the total cost over 3, 6 or 12 months. Plus, there aren't any hidden or late payment fees to worry about.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.