Santi Cosma e Damiano Vacations from $736

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Your Santi Cosma e Damiano Vacation

An easy way to experience this unique city is with a custom-made Santi Cosma e Damiano vacation package. Stay in the neighborhood of Gianola, which is good for walking, families and watersports or go someplace else — our package deals are all about you. Fill your spare time with visits to Marina di Minturno Beach, Archaeological Area of Minturnae and Ponte Real Ferdinando Il di Borbone, some of the attractions you should see during your trip to Santi Cosma e Damiano. Expedia has what you need to escape your routine. Tailor your vacation to Santi Cosma e Damiano to suit your travel style, whatever that may look like.

The Latest Santi Cosma e Damiano vacation packages

Price found within the past 48 hours. Click for updated prices.
Relais de la Poste

Relais de la Poste

3 out of 5
Rome City Centre
Save 100% on your flight
Price was $1,264, price is now $736 per person
$736
per person
Jan 17 - Jan 21
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Rome (FCO)
9.2/10 Wonderful! (593 reviews)
Staff were nice and this place was close to everything! Loved it!

Reviewed on Nov 6, 2025

Albergo Etico Roma

Albergo Etico Roma

3 out of 5
Flaminio
Save 100% on your flight
Price was $1,201, price is now $740 per person
$740
per person
Jan 16 - Jan 21
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Rome (FCO)
9.6/10 Exceptional! (319 reviews)
Very clean, incredible cleaning staff, good location

Reviewed on Nov 8, 2025

Grand Hotel Olympic

Grand Hotel Olympic

4 out of 5
Rome City Centre
Price was $2,890, price is now $1,806 per person
$1,806
per person
Dec 29 - Jan 4
found 3 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Rome (FCO)
7.4/10 Good! (1,018 reviews)
The hotel is very close to the Vatican. St. Peter's Basilica is just a 5-8 minute walk away. Unfortunately, the hotel is undergoing renovations and has several issues. We experienced annoying noises, no hot water in the shower, and very inattentive staff. Breakfast was the best part of our stay. They should inform guests about the renovations so they can make an informed decision when choosing a hotel.

Reviewed on Nov 6, 2025

ROMEO Roma

ROMEO Roma

5 out of 5
Rome City Centre
Save 100% on your flight
Price was $4,565, price is now $2,867 per person
$2,867
per person
Jan 17 - Jan 21
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Rome (FCO)
No reviews
Hotel Delle Civette

Hotel Delle Civette

3 out of 5
Nomentano
Price was $1,481, price is now $957 per person
$957
per person
Jan 6 - Jan 11
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Rome (FCO)
9.6/10 Exceptional! (256 reviews)
We just left Rome and our Hotel was in very nice neighborhood close to Metro line B Bologna which is 9 min walk from hotel to connect us to city center. Beds were very comfortable we had 3 twin bed room with 2 long closets for all three of our clothes nice medium size bathroom and staff at front desk GREAT CREW

Reviewed on Nov 7, 2025

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Santi Cosma e Damiano Hotel Deals

Edra Palace

Edra Palace

4 out of 5
Via Ausonia angolo via Cerro, Cassino, FR
Fully refundableReserve now, pay when you stay
$84 nightly
The price is $96 total per night from Nov 26 to Nov 27
$96 total
Nov 26 - Nov 27
Total with taxes and fees
9/10 Wonderful! (158 reviews)
Exceeded expectations. Very classy inside. Great breakfast.

Reviewed on Oct 19, 2025

Edra Palace
Hotel Mirasole International

Hotel Mirasole International

4 out of 5
Via Firenze, 5, Gaeta, LT
$112 nightly
The price is $133 total per night from Nov 13 to Nov 14
$133 total
Nov 13 - Nov 14
Total with taxes and fees
8.4/10 Very Good! (285 reviews)
The hotel is modern and the staff are very accommodating. It’s also right next to the beach. If you are going out of season be aware lots of things are closed, especially the restaurants. They only open two days a week out of season. Don’t let this put you off though. It’s a beautiful location. We ...

Reviewed on Sep 30, 2025

Hotel Mirasole International
Virgilio Grand Hotel

Virgilio Grand Hotel

4 out of 5
Viale Primo Romita 33, Sperlonga, LT
$126 nightly
The price is $139 total per night from Dec 7 to Dec 8
$139 total
Dec 7 - Dec 8
Total with taxes and fees
8.4/10 Very Good! (288 reviews)
Staff was very helpful. Breakfast was amazing

Reviewed on Oct 8, 2025

Virgilio Grand Hotel
See all 978 properties in Santi Cosma e Damiano
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Santi Cosma e Damiano Vacation Packages

Santi Cosma e Damiano Essential Information

Language
Italian
Currency
Euros
Local Welcome
Ciao
Local Goodbye
Ciao
Population
750
Top Sights
Sassolini Beach, Park of Gianola and Monte di Scauri - Info Point and Park of Gianola

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Frequently asked questions

How much does a Santi Cosma e Damiano vacation package cost?
You can grab a vacation package to this top destination from $736 on Expedia. However, how much your vacation to Santi Cosma e Damiano costs will depend on the season, length of stay and hotel choice.
What are the cheapest months to go to Santi Cosma e Damiano?
You can typically find lower prices and better availability in November, December and January. Explore our cheap Santi Cosma e Damiano vacation packages and you could score some great off-season deals.
How many days is enough for Santi Cosma e Damiano?
The ideal duration of your Santi Cosma e Damiano vacation depends on what you'd like to do. Typically, a few days to a week will give you enough time to hit all the leading sights and explore some hidden gems along the way.
How to find the best Santi Cosma e Damiano package deals?
Use Expedia's filter tool to help you find some fabulous Santi Cosma e Damiano package deals. When you begin your search, just set your maximum budget and then sort the results by "Price: low to high." If you want to save, plan your break for midweek, or look for Santi Cosma e Damiano package deals in the off-season. Play around with your travel dates and you may land even bigger discounts. As a rule of thumb, it's typically best to book your vacation package as early as possible.
Is it cheaper to book a Santi Cosma e Damiano vacation as a package?
An Expedia vacation package could save you hundreds of dollars when compared to arranging stays and flights individually. Better still, you can customize your Santi Cosma e Damiano escape to match your exact style. Pick your preferred flight time, select the hotel type and add a car rental. Check out our great deals to see how much you can save.
When to book a vacation package to Santi Cosma e Damiano?
If you're considering a spontaneous Santi Cosma e Damiano vacation, check out our last-minute deals that can be booked up to a week before you take off. Don't want to leave things to the last minute? You can score incredible deals on your flights and hotels by booking well in advance.
Does Expedia offer Book Now, Pay Later Santi Cosma e Damiano vacation packages?
Your Santi Cosma e Damiano getaway is meant to be an escape from your busy life, not a source of money-related stress. So to give you extra flexibility, we've teamed up with online lender Affirm to bring you our Book Now, Pay Later vacations. Choose one of our vacation packages with payment plans and spread the cost over 3, 6 or 12 months. Plus, there are no late payment fees or hidden costs to worry about.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.