St. Nicholas Vacations from $290

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Your St. Nicholas Vacation

Book a St. Nicholas vacation package and experience the way of life and rhythm of this unique neighborhood. With all your travel plans taken care of, the only thing you need to concentrate on here is living it up. Your trip to St. Nicholas wouldn't be complete without a stop at big-name attractions nearby such as Jacksonville Museum of Modern Art, TIAA Bank Field and Museum of Science and History. Expedia will help turn your dream St. Nicholas vacation into reality, no matter your travel plans or budget.

The Latest St. Nicholas Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Windsor Inn of Jacksonville

Windsor Inn of Jacksonville

2.5 out of 5
Northside
Save 100% on your flight
Price was $439, price is now $290 per person
$290
per person
Nov 13 - Nov 20
found 14 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Jacksonville (JAX)
7.2/10 Good! (1,011 reviews)
Clean and friendly place. Will definitely choose them again if we go back to Jacksonville.

Reviewed on Oct 9, 2025

DoubleTree by Hilton Hotel Jacksonville Riverfront

DoubleTree by Hilton Hotel Jacksonville Riverfront

4 out of 5
Downtown Jacksonville
Save 100% on your flight
Price was $966, price is now $613 per person
$613
per person
Nov 13 - Nov 20
found 14 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Jacksonville (JAX)
6.6/10 (1,383 reviews)
The room was clean, however, things were rusted. It appeared that they were in the process of renovations. The room had peeling wallpaper, rusted sprinkler, rusted tp dispenser, and oddly, a new sink in the bathroom, but the base was chipped/rickety and one could see spray foam( I think?) where the base and sink came together. The towels were clean and the bed was very comfortable. There was some noise from the hallway. The staff was great! Not the best overall, but you pay for what you get.

Reviewed on Oct 12, 2025

Comfort Suites Baymeadows Near Butler Blvd

Comfort Suites Baymeadows Near Butler Blvd

3 out of 5
Save 100% on your flight
Price was $554, price is now $377 per person
$377
per person
Nov 13 - Nov 20
found 14 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Jacksonville (JAX)
8/10 Very Good! (1,005 reviews)
Hotel is outdated. Bathroom door didn't close all the way. Key cards worked about half the time. Staff was friendly and helpful. Was welcomed every time we entered the hotel. Had to ask for more towels and toilet paper. Room AC was good and cold. Good location to do a variety of tourist stops without being an hour or more away from them.

Reviewed on Oct 11, 2025

Hilton Jacksonville At Mayo Clinic

Hilton Jacksonville At Mayo Clinic

4.5 out of 5
Save 100% on your flight
Price was $1,062, price is now $728 per person
$728
per person
Nov 13 - Nov 20
found 14 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Jacksonville (JAX)
No reviews
Wyndham Garden Jacksonville

Wyndham Garden Jacksonville

3 out of 5
Southside
Save 100% on your flight
Price was $498, price is now $342 per person
$342
per person
Nov 13 - Nov 20
found 14 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Jacksonville (JAX)
7.8/10 Good! (1,744 reviews)
Clean room . Very friendly staff also very accommodating

Reviewed on Oct 6, 2025

Where to stay in St. Nicholas

Find the best St. Nicholas areas and neighborhoods for the activities you enjoy most. Learn more about St. Nicholas
Default Image

Southside

1 out of top 10 points of interest in this area
4/5(912 area reviews)

If you're spending some time in Southside, St. Johns Town Center and The Avenues are top sights worth seeing.

Find hotels in Southside

St. Nicholas Hotel Deals

Hyatt Regency Jacksonville

Hyatt Regency Jacksonville

4 out of 5
225 E Coastline Dr, Jacksonville, FL
Fully refundableReserve now, pay when you stay
$164 nightly
The price is $186 total per night from Oct 24 to Oct 25
$186 total
Oct 24 - Oct 25
Total with taxes and fees
8.8/10 Excellent! (1,312 reviews)
"Very clean hotel with a wonderful, helpful staff."

Reviewed on Oct 7, 2025

Hyatt Regency Jacksonville
Embassy Suites by Hilton Jacksonville Baymeadows

Embassy Suites by Hilton Jacksonville Baymeadows

3.5 out of 5
9300 Baymeadows Road, Jacksonville, FL
Fully refundableReserve now, pay when you stay
$114 nightly
The price is $129 total per night from Oct 19 to Oct 20
$129 total
Oct 19 - Oct 20
Total with taxes and fees
8.4/10 Very Good! (1,168 reviews)
"Hotel was great. Had trouble getting hot water from the shower, that’s my only complaint. Patrick at the front desk and April on the omelettes in the kitchen both were amazing and the manager even came by at breakfast to see how everything was. Pool was awesome and kids had a great time."

Reviewed on Oct 11, 2025

Embassy Suites by Hilton Jacksonville Baymeadows
Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach

2.5 out of 5
715 1st St N, Jacksonville Beach, FL
Fully refundableReserve now, pay when you stay
$174 nightly
The price is $197 total per night from Oct 14 to Oct 15
$197 total
Oct 14 - Oct 15
Total with taxes and fees
8.8/10 Excellent! (3,257 reviews)
"Clean room with partial ocean view. Area was quite and staff were all friendly and helpful. Would definately recommend. Beach access was pwrfect and made it easy to fet to and from."

Reviewed on Oct 10, 2025

Margaritaville Jacksonville Beach
See all 2,853 properties in St. Nicholas
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
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Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in St. Nicholas

Pretty

Mayo Clinic Florida

Though Mayo Clinic Florida might be what brings you to town, perhaps you'll have a chance to explore more of Jacksonville while you are here.

Mayo Clinic Florida
Jacksonville Naval Air Station

Jacksonville Naval Air Station

After visiting Jacksonville Naval Air Station, make a plan to see the other sights and activities in Jacksonville. Experience the lively festivals or attend a sporting event in this family-friendly area.

Jacksonville Naval Air Station
EverBank Field which includes a lake or waterhole

EverBank Stadium

Capable of seating over 80,000 fans, this modern football stadium is the exciting home of the Jacksonville Jaguars, international soccer games and music events.

EverBank Stadium

Things to do

Chocolate Bar Class

Chocolate Bar Class - Hands on class

$20
per adult
Chocolate Bar Class - Hands on class
1 Hour Jet Ski Rental in Jacksonville, FL Evolution Jetsports

1 Hour Jet Ski Rental in Jacksonville, FL Evolution Jetsports

$140
per traveler
90% of travellers recommend
1 Hour Jet Ski Rental in Jacksonville, FL Evolution Jetsports
See all activities in Jacksonville
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.