St. Nicholas Vacations from $372

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Your St. Nicholas Vacation

Book a St. Nicholas vacation package and experience the way of life and rhythm of this unique neighborhood. With all your travel plans taken care of, the only thing you need to concentrate on here is living it up. Your trip to St. Nicholas wouldn't be complete without a stop at big-name attractions nearby such as Jacksonville Museum of Modern Art, TIAA Bank Field and Museum of Science and History. Expedia will help turn your dream St. Nicholas vacation into reality, no matter your travel plans or budget.

The Latest St. Nicholas Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach

2.5 out of 5
Price was $506, price is now $372 per person
$372
per person
Jan 16 - Jan 19
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Jacksonville (JAX)
9/10 Wonderful! (3,345 reviews)
The room was decorated nice. Mattresses were not very good. Bathroom sink drain was very slow. The late night employee checking us in was very unpleasant. Not only to us, but to a guest that called on the phone with a question while we were standing there. Unless you want to valet, parking was iffy.

Reviewed on Dec 11, 2025

Amelia by the South

Amelia by the South

4 out of 5
Save 100% on your flight
Price was $5,413, price is now $3,358 per person
$3,358
per person
Feb 15 - Feb 19
found 8 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Jacksonville (JAX)
No reviews
Amelia by the Sea

Amelia by the Sea

4 out of 5
Save 100% on your flight
Price was $5,440, price is now $3,385 per person
$3,385
per person
Feb 15 - Feb 19
found 8 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Jacksonville (JAX)
No reviews
Hampton Inn Jacksonville Beach/Oceanfront

Hampton Inn Jacksonville Beach/Oceanfront

3 out of 5
Save 100% on your flight
Price was $630, price is now $452 per person
$452
per person
Jan 16 - Jan 19
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Jacksonville (JAX)
9.2/10 Wonderful! (2,552 reviews)
The staff was very nice and helpful

Reviewed on Dec 9, 2025

Jekyll Ocean Club

Jekyll Ocean Club

4 out of 5
Beach Village
Price was $712, price is now $512 per person
$512
per person
Jan 28 - Jan 31
found 17 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Jacksonville (JAX)
9.4/10 Exceptional! (229 reviews)
Staff were fantastic. Restaurant food was delicious. Room was nice, but the bed mattress was way to old and very uncomfortable. They need to be replaced!

Reviewed on Nov 23, 2025

Where to stay in St. Nicholas

Find the best St. Nicholas areas and neighborhoods for the activities you enjoy most. Learn more about St. Nicholas
Downtown Jacksonville which includes skyline, a city and a river or creek

Downtown Jacksonville

2 out of top 10 points of interest in this area
4/5(845 area reviews)

Historic core with major corporations, Downtown Jacksonville offers diverse culinary and nightlife experiences at The Elbow. Explore attractions like Florida Theatre, TIAA Bank Field, and museums, while enjoying convenient transportation options.

Find hotels in Downtown Jacksonville

St. Nicholas Hotel Deals

Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach

2.5 out of 5
715 1st St N Jacksonville Beach FL
Fully refundableReserve now, pay when you stay
$159 nightly
The price is $180 total per night from Dec 14 to Dec 15
$180 total
Dec 14 - Dec 15
Total with taxes and fees
8.8/10 Excellent! (3,426 reviews)
Room overlooked the water and was an amazing sunrise

Reviewed on Dec 9, 2025

Margaritaville Jacksonville Beach
Hyatt Regency Jacksonville

Hyatt Regency Jacksonville

4 out of 5
225 E Coastline Dr Jacksonville FL
Fully refundableReserve now, pay when you stay
$162 nightly
The price is $183 total per night from Dec 19 to Dec 20
$183 total
Dec 19 - Dec 20
Total with taxes and fees
8.8/10 Excellent! (1,374 reviews)
Loved

Reviewed on Dec 8, 2025

Hyatt Regency Jacksonville
DoubleTree by Hilton Hotel Jacksonville Riverfront

DoubleTree by Hilton Hotel Jacksonville Riverfront

4 out of 5
1201 Riverplace Boulevard Jacksonville FL
Fully refundableReserve now, pay when you stay
$91 nightly
The price is $103 total per night from Dec 21 to Dec 22
$103 total
Dec 21 - Dec 22
Total with taxes and fees
6.6/10 (1,468 reviews)
View was beautiful

Reviewed on Dec 7, 2025

DoubleTree by Hilton Hotel Jacksonville Riverfront
See all 2,937 properties in St. Nicholas
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in St. Nicholas

Pretty

Mayo Clinic Florida

4.5/5(433 reviews)

Though Mayo Clinic Florida might be what brings you to town, perhaps you'll have a chance to explore more of Jacksonville while you are here.

Mayo Clinic Florida
Jacksonville Naval Air Station

Jacksonville Naval Air Station

4/5(300 reviews)

After visiting Jacksonville Naval Air Station, make a plan to see the other sights and activities in Jacksonville. Experience the lively festivals or attend a sporting event in this family-friendly area.

Jacksonville Naval Air Station
Jacksonville Zoo and Gardens showing zoo animals

Jacksonville Zoo and Gardens

4.5/5(463 reviews)

Admire thousands of animals and plants across entertaining exhibits in this family-friendly zoo that also has a children’s play area and a 4-D experience.

Jacksonville Zoo and Gardens

Things to do

Chocolate Bar Class

Chocolate Bar Class - Hands on class

$14
per adult
Chocolate Bar Class - Hands on class
1 Hour Jet Ski Rental in Jacksonville, FL Evolution Jetsports

1 Hour Jet Ski Rental in Jacksonville, FL Evolution Jetsports

$140
per traveler
90% of travellers recommend
1 Hour Jet Ski Rental in Jacksonville, FL Evolution Jetsports
Architecture and History Tour in San Marco

Architecture and History Tour in San Marco

$96
per adult
Architecture and History Tour in San Marco
See all activities in Jacksonville
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.