Find 4 Star Hotels in Seneca, SC from $161

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Our top choices for Seneca 4-star hotels

The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
4.0 star property
Clemson
9.8 out of 10, Exceptional, (769 reviews)
"Excellent stay, I highly recommend! Accommodations, location, overall vibe, great food and drinks! "
United States
Julie
$229 nightly
The price is $254
Apr 6 - Apr 7
Total with taxes and fees
The Shepherd Hotel Downtown Clemson

The Abernathy of Clemson

The Abernathy of Clemson
4.0 star property
Clemson
9.6 out of 10, Exceptional, (574 reviews)
"Great staff who demonstrates true southern hospitality. Five minute walk to campus and 10 minutes to downtown - could not be me more convenient. Also cozy bar allowed us to relax after a long day on the road. Nice to see them hiring Clemson students as my daughter who was there for a college tour got some great insights on life at Clemson."
United States
Walter
$170 nightly
The price is $189
Apr 15 - Apr 16
Total with taxes and fees
The Abernathy of Clemson

Liberty Hall Bed and Breakfast

Liberty Hall Bed and Breakfast
4.0 star property
Pendleton
10.0 out of 10, Exceptional, (84 reviews)
"The was by far one of the best bed and breakfast places that I have ever stayed in. The house is beautiful, the rooms and spotless and the breakfast is amazing. "
United States
Jennifer Ann
$145 nightly
The price is $161
Mar 23 - Mar 24
Total with taxes and fees
Liberty Hall Bed and Breakfast

Luxe Keowee Key Living: Golf Views & Resort Pool

Luxe Keowee Key Living: Golf Views & Resort Pool
4.0 star property
Salem
Luxe Keowee Key Living: Golf Views & Resort Pool

Lake Keowee Condo: Resort Pools & Lake Access!

Lake Keowee Condo: Resort Pools & Lake Access!
4.0 star property
Salem
10.0 out of 10, Exceptional, (1 review)
Lake Keowee Condo: Resort Pools & Lake Access!

Lake Hartwell Frank Howard Home Clemson

Lake Hartwell Frank Howard Home Clemson
4.0 star property
Anderson
$273 nightly
The price is $303
Mar 17 - Mar 18
Total with taxes and fees
Lake Hartwell Frank Howard Home Clemson

Private Balcony: Lake Keowee Home w/ Pool Access

Private Balcony: Lake Keowee Home w/ Pool Access
4.0 star property
Salem
Private Balcony: Lake Keowee Home w/ Pool Access

Belvedere

Belvedere
4.0 star property
Anderson
8.0 out of 10, Very Good, (1 review)
"Bring everything. Including hangers for your clothes, salt and pepper, etc. it is like staying at a place that has one purpose, to rent out. Beds are uncomfortable. Nice big closets with one wire hanger. Why??? "
United States
CANDACE
Belvedere

Views, Pools & Marina: Lake Keowee Condo!

Views, Pools & Marina: Lake Keowee Condo!
4.0 star property
Salem
Views, Pools & Marina: Lake Keowee Condo!

5 Mi to Memorial Stadium & Beach: Modern Townhome

5 Mi to Memorial Stadium & Beach: Modern Townhome
4.0 star property
Central
5 Mi to Memorial Stadium & Beach: Modern Townhome

Designer Retreat w/ Pool, Golf + Beach Access!

Designer Retreat w/ Pool, Golf + Beach Access!
4.0 star property
Salem
10.0 out of 10, Exceptional, (1 review)
"Property is in a great community, and it was very clean and beautifully decorated."
United States
Anonymous traveler
Designer Retreat w/ Pool, Golf + Beach Access!

Salem Vacation Rental w/ Lake Keowee Access!

Salem Vacation Rental w/ Lake Keowee Access!
4.0 star property
Salem
Salem Vacation Rental w/ Lake Keowee Access!

Lake Keowee Resort Condo: Waterfront Balcony

Lake Keowee Resort Condo: Waterfront Balcony
4.0 star property
Salem
10.0 out of 10, Exceptional, (1 review)
"Very clean. Amazing amenities. Lake view that takes your breath away."
United States
Tiffany
Lake Keowee Resort Condo: Waterfront Balcony

Keowee Key Condo w/ Lake Access & Community Pools!

Keowee Key Condo w/ Lake Access & Community Pools!
4.0 star property
Salem
Keowee Key Condo w/ Lake Access & Community Pools!

Keowee Keys Home w/ Mountains View & Lake Access!

Keowee Keys Home w/ Mountains View & Lake Access!
4.0 star property
Salem
8.0 out of 10, Very Good, (1 review)
"upstairs guestroom has difficult ceiling and space for taller person. Property is in great condition. Wish the queen bed was a king."
United States
KURT
Keowee Keys Home w/ Mountains View & Lake Access!

Clemson Game Retreat: Lakefront Keowee Key Condo

Clemson Game Retreat: Lakefront Keowee Key Condo
4.0 star property
Salem
Clemson Game Retreat: Lakefront Keowee Key Condo

Charming Seneca Home - 3 Mi to Memorial Stadium!

Charming Seneca Home - 3 Mi to Memorial Stadium!
4.0 star property
Seneca
Charming Seneca Home - 3 Mi to Memorial Stadium!

Lakefront Seneca Vacation Rental w/ Shared Dock!

Lakefront Seneca Vacation Rental w/ Shared Dock!
4.0 star property
Seneca
Lakefront Seneca Vacation Rental w/ Shared Dock!

Lake Keowee Condo w/ Balcony & Resort Amenities!

Lake Keowee Condo w/ Balcony & Resort Amenities!
4.0 star property
Salem
Lake Keowee Condo w/ Balcony & Resort Amenities!

Marina Villa Condo at Lake Keowee w/ Fireplace

Marina Villa Condo at Lake Keowee w/ Fireplace
4.0 star property
Salem
Marina Villa Condo at Lake Keowee w/ Fireplace
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Learn more about Seneca

Nestled along Lake Keowee's shoreline, this charming town offers spectacular waterfront activities from kayaking to fishing at South Cove County Park. Nearby Stumphouse Tunnel and Issaqueena Falls provide fascinating historical exploration and refreshing natural beauty, especially during summer's humid afternoons.

Lake Keowee South Carolina

Top Seneca Hotel Reviews

Find out more about Seneca

Seneca Four Star Hotel Information

When you need to book a room with luxurious amazing amenities and the best rates, the 4 star hotels in Seneca, South Carolina are incredible options. Known for their extra perks, first-rate service, and fantastic locations, each of the Seneca 4 star hotels offers the ultimate experience for globe-trotting travelers. Relax in your expertly designed room. Kick back with around-the-clock room service.

Get a good night’s sleep with the ultra-plush bedding, and freshen up in the morning with designer-inspired body products. It’s all available when you stay at one of the top book a four star hotels in Seneca. What’s more, thanks to Expedia you might even score a cheap great deal on a 4 star hotel in Seneca, South Carolina, areas near the hottest attractions, so you can plan a sightseeing adventure and take advantage of unbeatable discounts in one fell swoop.

Whether you’re putting together a serene getaway or want to revel in the most vibrant entertainment district, 4 star Seneca hotels offer everything your heart desires.

Frequently asked questions

How much does it cost to stay in a 4-star hotel in Seneca?
With Expedia's filter tool, scoring a top deal on a 4-star hotel in Seneca just got simpler. Start by entering your chosen arrival date and length of your escape. Then list the results by price and choose a property that best fits your budget and style.

  • Search for the lowest price from $161

What's the difference between 5-star and 4-star hotels in Seneca?
Treat yourself to refined living during your Seneca getaway by staying at a 4-star hotel. As well as featuring upmarket surroundings, these properties are usually filled with amenities, including complimentary bathrobes, large beds and plenty more. A 5-star hotel will go above and beyond to make your stay an even more indulgent and special one. Round-the-clock concierge assistance, luxurious spas and world-class dining are only the start of the superior services and conveniences you'll likely be able to enjoy.
Does Seneca have any 4-star all-inclusive resorts?
Finding your dream resort in Seneca is as simple as entering your dates and destination, and selecting our "All inclusive" filter. Stay and play where everything is already taken care of like your accommodations, food, activities and entertainment, or go for a standard 4-star resort in or around this much-loved destination.

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