Title: Top America's Best Inns in Central, SC - Expedia.com [Central Travel Guide](https://expedia.com/Central.dx10503)[Hotels in Central](https://expedia.com/Central-Hotels.d10503.Travel-Guide-Hotels)[Vacation Rentals in Central](https://expedia.com/Central-Vacation-Rentals.d10503.Travel-Guide-VacationRentals)[Flights to Central](https://expedia.com/Cheap-Flights-To-Central.d10503.Travel-Guide-Flights)[Car Rentals in Central](https://expedia.com/Car-Rentals-In-Central.d10503.Car-Rental-Guide)[Central Vacation Packages](https://expedia.com/Central.d10503.Destination-Travel-Guides) ![Todd Creek Falls](https://images.trvl-media.com/place/10503/baefe116-5881-466e-b320-6ded2828ee1d.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/10503/baefe116-5881-466e-b320-6ded2828ee1d.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ## Check prices for these dates Tonight [Apr 3 - Apr 4](https://www.expedia.com/Hotel-Search?regionId=10503&startDate=2026-04-03&endDate=2026-04-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Apr 4 - Apr 5](https://www.expedia.com/Hotel-Search?regionId=10503&startDate=2026-04-04&endDate=2026-04-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Apr 3 - Apr 5](https://www.expedia.com/Hotel-Search?regionId=10503&startDate=2026-04-03&endDate=2026-04-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Apr 10 - Apr 12](https://www.expedia.com/Hotel-Search?regionId=10503&startDate=2026-04-10&endDate=2026-04-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FCentral-Hotels-Americas-Best-Inns.0-0-d10503--bAmericasBestInns.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FCentral-Hotels-Americas-Best-Inns.0-0-d10503--bAmericasBestInns.Travel-Guide-Filter-Hotels) ## Top Central Hotel Reviews ![Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy](https://images.trvl-media.com/lodging/111000000/110490000/110487400/110487306/d7c06df6_y.jpg) ### Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy 10/10 Excellent "Great spot for couples wanting to connect or a solo trip. " [](https://expedia.com/Postcard-Cabins-Lake-Hartwell.h110487306.Hotel-Information) ![The Abernathy of Clemson](https://images.trvl-media.com/lodging/18000000/17230000/17229400/17229377/ead974b7_y.jpg) ### The Abernathy of Clemson 10/10 Excellent "Welcoming staff, spacious room, great amenities, close to campus " [](https://expedia.com/Anderson-Hotels-The-Abernathy-Of-Clemson.h17229377.Hotel-Information) ![Tru by Hilton Seneca Clemson](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323330/83732283_y.jpg) ### Tru by Hilton Seneca Clemson 10/10 Excellent "The breakfast menu was fresh and the parking felt safe and easy. Staff were extremely helpful. " [](https://expedia.com/Anderson-Hotels-Tru-By-Hilton-Seneca-Clemson.h34323330.Hotel-Information) ![Best Western Plus Clemson Hotel & Conference Center](https://images.trvl-media.com/lodging/1000000/10000/1400/1370/w3837h2558x3y3-4efd29d6_y.jpg) ### Best Western Plus Clemson Hotel & Conference Center 6/10 Okay "Older building, clean, but you can tell that things are older in the bathroom and guest rooms. The atrium where breakfast was, is nice, modern, must be an update." [](https://expedia.com/Anderson-Hotels-Best-Western-Plus-University-Inn-Conference-Center.h1370.Hotel-Information) ![Days Inn by Wyndham Anderson](https://images.trvl-media.com/lodging/1000000/10000/6400/6344/bea0c9d1_y.jpg) ### Days Inn by Wyndham Anderson 10/10 Excellent "I had the business suite and it was worth the price " [](https://expedia.com/Anderson-Hotels-Days-Inn-By-Wyndham-Anderson.h6344.Hotel-Information) ![Lakeside Lodge Clemson](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/db449d90_y.jpg) ### Lakeside Lodge Clemson 8/10 Good "The property is next to railroad. A train woke us up during the night because it was so loud." [](https://expedia.com/Anderson-Hotels-Lakeside-Lodge-Clemson.h40217319.Hotel-Information) ![The Inn at Patrick Square](https://images.trvl-media.com/lodging/20000000/19520000/19511400/19511329/4d00561c_y.jpg) ### The Inn at Patrick Square 10/10 Excellent "Clean room and lobby, friendly staff." [](https://expedia.com/Anderson-Hotels-The-Inn-At-Patrick-Square.h19511329.Hotel-Information) ![Clemson University's James F. Martin Inn](https://images.trvl-media.com/lodging/9000000/8480000/8475000/8474950/ad943919_y.jpg) ### Clemson University's James F. Martin Inn 10/10 Excellent "Love this place. We stay here every time we come to the area. " [](https://expedia.com/Anderson-Hotels-Clemson-Universitys-James-F-Martin-Inn.h8474950.Hotel-Information) ![The Shepherd Hotel Downtown Clemson](https://images.trvl-media.com/lodging/88000000/87690000/87688200/87688155/bd45b45c_y.jpg) ### The Shepherd Hotel Downtown Clemson 10/10 Excellent "Limited menu available on site but many places nearby in walking distance." [](https://expedia.com/Clemson-Hotels-The-Shepherd-Hotel-Downtown-Clemson.h87688155.Hotel-Information)