Title: Top America's Best Inns in Central, SC - Expedia.com [Central Travel Guide](https://expedia.com/Central.dx10503)[Hotels in Central](https://expedia.com/Central-Hotels.d10503.Travel-Guide-Hotels)[Vacation Rentals in Central](https://expedia.com/Central-Vacation-Rentals.d10503.Travel-Guide-VacationRentals)[Flights to Central](https://expedia.com/Cheap-Flights-To-Central.d10503.Travel-Guide-Flights)[Car Rentals in Central](https://expedia.com/Car-Rentals-In-Central.d10503.Car-Rental-Guide)[Central Vacation Packages](https://expedia.com/Central.d10503.Destination-Travel-Guides) ![Todd Creek Falls](https://images.trvl-media.com/place/10503/baefe116-5881-466e-b320-6ded2828ee1d.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/10503/baefe116-5881-466e-b320-6ded2828ee1d.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Upfront pricing Our total price for your stay includes taxes and fees - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save 10% or more on over 100,000 hotels worldwide with Member Prices [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Apr 7 - Apr 8](https://www.expedia.com/Hotel-Search?regionId=10503&startDate=2026-04-07&endDate=2026-04-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Apr 8 - Apr 9](https://www.expedia.com/Hotel-Search?regionId=10503&startDate=2026-04-08&endDate=2026-04-09&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Apr 10 - Apr 12](https://www.expedia.com/Hotel-Search?regionId=10503&startDate=2026-04-10&endDate=2026-04-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Apr 17 - Apr 19](https://www.expedia.com/Hotel-Search?regionId=10503&startDate=2026-04-17&endDate=2026-04-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FCentral-Hotels-Americas-Best-Inns.0-0-d10503--bAmericasBestInns.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FCentral-Hotels-Americas-Best-Inns.0-0-d10503--bAmericasBestInns.Travel-Guide-Filter-Hotels) ## Top Central Hotel Reviews ![Comfort Inn & Suites Clemson - University Area](https://images.trvl-media.com/lodging/1000000/20000/19100/19019/60d71ae1_y.jpg) ### Comfort Inn & Suites Clemson - University Area 8/10 Good "Good place to stay for a quick trip" [](https://expedia.com/Anderson-Hotels-Comfort-Inn-Suites-Clemson-University-Area.h19019.Hotel-Information) ![Hilton Garden Inn Anderson](https://images.trvl-media.com/lodging/2000000/1350000/1340700/1340606/5902a5ae_y.jpg) ### Hilton Garden Inn Anderson 10/10 Excellent "Room was large and clean. Grounds were well Maintained. " [](https://expedia.com/Anderson-Hotels-Hilton-Garden-Inn-Anderson.h1340606.Hotel-Information) ![Hampton Inn & Suites Seneca-Clemson Area](https://images.trvl-media.com/lodging/7000000/6700000/6696900/6696886/8f736b3a_y.jpg) ### Hampton Inn & Suites Seneca-Clemson Area 10/10 Excellent "Only 7 miles from Clemson. Quiet and enjoyable place to stay! " [](https://expedia.com/Anderson-Hotels-Hampton-Inn-Suites-Seneca-Clemson-Area.h6696886.Hotel-Information) ![The Shepherd Hotel Downtown Clemson](https://images.trvl-media.com/lodging/88000000/87690000/87688200/87688155/bd45b45c_y.jpg) ### The Shepherd Hotel Downtown Clemson 10/10 Excellent "hotel was great, modern, clean gorgeous" [](https://expedia.com/Clemson-Hotels-The-Shepherd-Hotel-Downtown-Clemson.h87688155.Hotel-Information) ![Days Inn by Wyndham Anderson](https://images.trvl-media.com/lodging/1000000/10000/6400/6344/bea0c9d1_y.jpg) ### Days Inn by Wyndham Anderson 8/10 Good "Room was clean " [](https://expedia.com/Anderson-Hotels-Days-Inn-By-Wyndham-Anderson.h6344.Hotel-Information) ![Quality Inn Clemson near University](https://images.trvl-media.com/lodging/1000000/10000/2600/2544/269fcec4_y.jpg) ### Quality Inn Clemson near University 10/10 Excellent "Yes " [](https://expedia.com/Anderson-Hotels-Quality-Inn-Clemson-Near-University.h2544.Hotel-Information) ![Best Western Plus Clemson Hotel & Conference Center](https://images.trvl-media.com/lodging/1000000/10000/1400/1370/w3837h2558x3y3-4efd29d6_y.jpg) ### Best Western Plus Clemson Hotel & Conference Center 10/10 Excellent "N/A" [](https://expedia.com/Anderson-Hotels-Best-Western-Plus-University-Inn-Conference-Center.h1370.Hotel-Information) ![The Abernathy of Clemson](https://images.trvl-media.com/lodging/18000000/17230000/17229400/17229377/ead974b7_y.jpg) ### The Abernathy of Clemson 8/10 Good "I wanted to get coffee upon waking up in the morning. I went down in the morning and ther person behind the counter told me she needed to finish counting the drawer before she could help me. So I needed to wait there about 10-15 mins until the drawer was counted. Seems like the customer should be served first, pause the drawer counting until after. " [](https://expedia.com/Anderson-Hotels-The-Abernathy-Of-Clemson.h17229377.Hotel-Information) ![Horizon Inn & Suites](https://images.trvl-media.com/lodging/1000000/10000/6500/6496/020b11bb_y.jpg) ### Horizon Inn & Suites 10/10 Excellent "This property is pet friendly as well as convenient to everywhere. " [](https://expedia.com/Anderson-Hotels-Horizon-Inn-Suites.h6496.Hotel-Information)