Title: Top America's Best Inns in Central, SC - Expedia.com [Central Travel Guide](https://expedia.com/Central.dx10503)[Hotels in Central](https://expedia.com/Central-Hotels.d10503.Travel-Guide-Hotels)[Vacation Rentals in Central](https://expedia.com/Central-Vacation-Rentals.d10503.Travel-Guide-VacationRentals)[Flights to Central](https://expedia.com/Cheap-Flights-To-Central.d10503.Travel-Guide-Flights)[Car Rentals in Central](https://expedia.com/Car-Rentals-In-Central.d10503.Car-Rental-Guide)[Central Vacation Packages](https://expedia.com/Central.d10503.Destination-Travel-Guides) ![Todd Creek Falls](https://images.trvl-media.com/place/10503/baefe116-5881-466e-b320-6ded2828ee1d.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/10503/baefe116-5881-466e-b320-6ded2828ee1d.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ## Check prices for these dates Tonight [Apr 4 - Apr 5](https://www.expedia.com/Hotel-Search?regionId=10503&startDate=2026-04-04&endDate=2026-04-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Apr 5 - Apr 6](https://www.expedia.com/Hotel-Search?regionId=10503&startDate=2026-04-05&endDate=2026-04-06&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Apr 10 - Apr 12](https://www.expedia.com/Hotel-Search?regionId=10503&startDate=2026-04-10&endDate=2026-04-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Apr 17 - Apr 19](https://www.expedia.com/Hotel-Search?regionId=10503&startDate=2026-04-17&endDate=2026-04-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FCentral-Hotels-Americas-Best-Inns.0-0-d10503--bAmericasBestInns.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FCentral-Hotels-Americas-Best-Inns.0-0-d10503--bAmericasBestInns.Travel-Guide-Filter-Hotels) ## Top Central Hotel Reviews ![Lakeside Lodge Clemson](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/db449d90_y.jpg) ### Lakeside Lodge Clemson 10/10 Excellent "Room was spacious and clean. Great pool. Close to campus." [](https://expedia.com/Anderson-Hotels-Lakeside-Lodge-Clemson.h40217319.Hotel-Information) ![Best Western Plus Clemson Hotel & Conference Center](https://images.trvl-media.com/lodging/1000000/10000/1400/1370/w3837h2558x3y3-4efd29d6_y.jpg) ### Best Western Plus Clemson Hotel & Conference Center 10/10 Excellent "Clean rooms, nice staff, free breakfast" [](https://expedia.com/Anderson-Hotels-Best-Western-Plus-University-Inn-Conference-Center.h1370.Hotel-Information) ![Inn @ Clemson](https://images.trvl-media.com/lodging/1000000/90000/84700/84636/d257793d_y.jpg) ### Inn @ Clemson 10/10 Excellent "Breakfast was not so good. Have had better breakfast and breakfast choices! " [](https://expedia.com/Anderson-Hotels-Inn-Clemson.h84636.Hotel-Information) ![Quality Inn Seneca Clemson Area US-123](https://images.trvl-media.com/lodging/1000000/80000/76800/76800/375f69b2_y.jpg) ### Quality Inn Seneca Clemson Area US-123 8/10 Good "Stayed for a hiking weekend base camp. It was basic, but exactly what we needed for an inexpensive place to sleep between long days on the trail. The property is older, but clean and well-kept. Staff were friendly, and the hotel was quiet both nights. We slept well, which is really what matters on a trip like this. Breakfast was simple: waffles, cereal, toast, muffins, apples, coffee, and juice. No real protein options, but it was enough to get us started before heading out. If you’re looking for a no-frills, affordable place to stay for hiking around Walhalla/Seneca, this is a solid option." [](https://expedia.com/Anderson-Hotels-Quality-Inn-Seneca-US-123.h76800.Hotel-Information) ![The Abernathy of Clemson](https://images.trvl-media.com/lodging/18000000/17230000/17229400/17229377/ead974b7_y.jpg) ### The Abernathy of Clemson 10/10 Excellent "Amazing hotel, amazing location. Highly recommended. " [](https://expedia.com/Anderson-Hotels-The-Abernathy-Of-Clemson.h17229377.Hotel-Information) ![Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy](https://images.trvl-media.com/lodging/111000000/110490000/110487400/110487306/d7c06df6_y.jpg) ### Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy 10/10 Excellent "Great spot for couples wanting to connect or a solo trip. " [](https://expedia.com/Postcard-Cabins-Lake-Hartwell.h110487306.Hotel-Information) ![Tru by Hilton Seneca Clemson](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323330/83732283_y.jpg) ### Tru by Hilton Seneca Clemson 10/10 Excellent "The breakfast menu was fresh and the parking felt safe and easy. Staff were extremely helpful. " [](https://expedia.com/Anderson-Hotels-Tru-By-Hilton-Seneca-Clemson.h34323330.Hotel-Information) ![Days Inn by Wyndham Anderson](https://images.trvl-media.com/lodging/1000000/10000/6400/6344/bea0c9d1_y.jpg) ### Days Inn by Wyndham Anderson 10/10 Excellent "I had the business suite and it was worth the price " [](https://expedia.com/Anderson-Hotels-Days-Inn-By-Wyndham-Anderson.h6344.Hotel-Information) ![The Inn at Patrick Square](https://images.trvl-media.com/lodging/20000000/19520000/19511400/19511329/4d00561c_y.jpg) ### The Inn at Patrick Square 10/10 Excellent "Clean room and lobby, friendly staff." [](https://expedia.com/Anderson-Hotels-The-Inn-At-Patrick-Square.h19511329.Hotel-Information)