Find 5 Star Hotels in Mission District, CA from $148

Start date: Check-in selected.
To Date
End date: Check-out

Check availability on Mission District 5 Star Hotels

Tonight
Nov 29 - Nov 30
Tomorrow
Nov 30 - Dec 1
Next weekend
Dec 5 - Dec 7
In two weeks
Dec 12 - Dec 14

Compare Mission District 5 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Terrace/patio
Fairmont San Francisco

Fairmont San Francisco

5.0 star property
Downtown San Francisco
9.0 out of 10, Wonderful, (1440)
"Always a great place to stay! "
United States
Everett
$210 nightly
The price is $247
Nov 30 - Dec 1
Total with taxes and fees
Fairmont San Francisco
3 outdoor pools, open 6:00 AM to 9:00 PM, pool umbrellas, sun loungers
Claremont Resort & Club

Claremont Resort & Club

5.0 star property
Claremont Hills
8.8 out of 10, Excellent, (1026)
"Clean room, great staff, wonderful property"
United States
John
$251 nightly
The price is $282
Dec 21 - Dec 22
Total with taxes and fees
Claremont Resort & Club
View from property
Palace Hotel, a Luxury Collection Hotel, San Francisco

Palace Hotel, a Luxury Collection Hotel, San Francisco

5.0 star property
Downtown San Francisco
9.2 out of 10, Wonderful, (1007)
"Everything was fantastic including the breakfast!"
United States
David
$271 nightly
The price is $319
Dec 23 - Dec 24
Total with taxes and fees
Palace Hotel, a Luxury Collection Hotel, San Francisco
City view
Taj Campton Place

Taj Campton Place

5.0 star property
Union Square
9.2 out of 10, Wonderful, (1013)
"Very friendly and attentive staff"
United States
Azmir
$208 nightly
The price is $244
Dec 1 - Dec 2
Total with taxes and fees
Taj Campton Place
Terrace/patio
Four Seasons Hotel San Francisco

Four Seasons Hotel San Francisco

5.0 star property
Downtown San Francisco
9.4 out of 10, Exceptional, (1006)
"great room and staff. "
United States
chunguang
$395 nightly
The price is $465
Dec 18 - Dec 19
Total with taxes and fees
Four Seasons Hotel San Francisco
2 restaurants, breakfast, lunch, dinner served; Californian cuisine
The Ritz-Carlton, San Francisco

The Ritz-Carlton, San Francisco

5.0 star property
Downtown San Francisco
9.4 out of 10, Exceptional, (1003)
"I mean what else can I say, it’s the Ritz, amazing everything. Food at restaurant was great. Again it’s the Ritz. "
United States
Cesar
$348 nightly
The price is $409
Dec 18 - Dec 19
Total with taxes and fees
The Ritz-Carlton, San Francisco
Breakfast, lunch, dinner served; alfresco dining
1 Hotel San Francisco

1 Hotel San Francisco

5.0 star property
Downtown San Francisco
9.2 out of 10, Wonderful, (475)
"Beautiful hotel. Great staff. "
United States
Elizabeth L.
$377 nightly
The price is $444
Dec 22 - Dec 23
Total with taxes and fees
1 Hotel San Francisco
Rooftop terrace
Four Seasons Hotel San Francisco at Embarcadero

Four Seasons Hotel San Francisco at Embarcadero

5.0 star property
Downtown San Francisco
9.6 out of 10, Exceptional, (1007)
"Rooms great location, friendly and hospitable staff. Great experience overall!"
United States
mac santa
$421 nightly
The price is $495
Dec 21 - Dec 22
Total with taxes and fees
Four Seasons Hotel San Francisco at Embarcadero
Suite, 1 Bedroom, Corner | Frette Italian sheets, premium bedding, down comforters, pillowtop beds
The St. Regis San Francisco

The St. Regis San Francisco

5.0 star property
Downtown San Francisco
9.4 out of 10, Exceptional, (691)
"Had a great stay "
United Kingdom
Thomas
$399 nightly
The price is $470
Dec 12 - Dec 13
Total with taxes and fees
The St. Regis San Francisco
Property entrance
Hotel Drisco

Hotel Drisco

5.0 star property
Pacific Heights
9.8 out of 10, Exceptional, (452)
"The breakfast was amazing, lots of variety including hot items cooked freshly"
United Kingdom
Julie Ann
$566 nightly
The price is $658
Dec 18 - Dec 19
Total with taxes and fees
Hotel Drisco
Exterior
Fairmont Heritage Place, Ghirardelli Square

Fairmont Heritage Place, Ghirardelli Square

5.0 star property
Fisherman's Wharf
9.4 out of 10, Exceptional, (385)
"Great staff, clean, excellent location, spacious rooms"
United States
Christopher
$564 nightly
The price is $662
Dec 29 - Dec 30
Total with taxes and fees
Fairmont Heritage Place, Ghirardelli Square
Front of property - evening/night
Neighbourgood Sutter Mansion

Neighbourgood Sutter Mansion

5.0 star property
Western Addition
9.4 out of 10, Exceptional, (224)
"Beautifully restored property with very tasteful furnishings. Staff very helpful and polite. A real pleasure to stay in. Top quality stay."
United Kingdom
Jonathan
$281 nightly
The price is $328
Nov 30 - Dec 1
Total with taxes and fees
Neighbourgood Sutter Mansion
Terrace/patio
Dimond Abode Vacation Rental 3428

Dimond Abode Vacation Rental 3428

5.0 star property
Dimond
9.4 out of 10, Exceptional, (6)
"Great place, great customer service!"
United States
Anonymous traveler
Dimond Abode Vacation Rental 3428
Deluxe House | Balcony
Dimond Abode Vacation Rental

Dimond Abode Vacation Rental

5.0 star property
Dimond
10.0 out of 10, Exceptional, (1)
"The unit was extremely clean and having access to a garage was definitely a plus for our stay! Nice touches, especially coffee / tea , snacks, and a well equipped kitchen made us feel welcomed the minute we stepped through the door. A+"
United States
Camille
Dimond Abode Vacation Rental
Studio (4 Bedrooms) | Private kitchen | Microwave, oven, dishwasher, coffee/tea maker
KBM Resorts Long Term Lease 4 Bed/3 Bath Luxury Home Pool, Bbq, Fitness Center Orinda Retreat Ldd-32

KBM Resorts Long Term Lease 4 Bed/3 Bath Luxury Home Pool, Bbq, Fitness Center Orinda Retreat Ldd-32

5.0 star property
Orinda
KBM Resorts Long Term Lease 4 Bed/3 Bath Luxury Home Pool, Bbq, Fitness Center Orinda Retreat Ldd-32
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Mission District.
Hyatt Regency San Francisco

Hyatt Regency San Francisco

5 Embarcadero Center San Francisco CA
$183 nightly
The price is $215 total per night from Dec 14 to Dec 15
$215 total
Dec 14 - Dec 15
Total with taxes and fees
9.2/10 Wonderful! (1,985 reviews)
Still don't see what you're looking for?
See all properties in Mission District.
You can also use these popular filters to refine your search.
PoolSpaHot tubBreakfast includedWaterpark
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Mission District

Visit this San Francisco neighborhood brimming with culture, history, a lively art scene, buzzing nightlife and some of the city’s best burritos.

See all hotels in Mission District
Mission District which includes outdoor art

Top Mission District Hotel Reviews

Fairmont San Francisco

Fairmont San Francisco

10/10 Excellent
"No body wash in the shower "
Dushyant 1-night trip
Posted 20 hours ago
Fairmont San Francisco

Find out more about Mission District

There's nothing wrong with enjoying the finer things in life. Add an extra layer of pleasure on your next trip to Mission District by treating yourself to the best of the best when it comes to accommodation. It's an ideal combination. There's no reason to delay a getaway to Mission District any longer. You'll join the multitudes of vacationers who have made Mission District so fashionable in the last few seasons. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. You deserve the great vacation you're dreaming about. Book one of Expedia's luxurious 5-star hotels in Mission District and get ready to be pampered like never before.

5-Star Hotels in Mission District

You'll have a fantastic time at one of these 5-star hotels. Top-notch service, delicious meals, and one-on-one attention are all ready for you. You're sure to find exactly the accommodation you need. You'll also enjoy a high standard of care and meticulous guest relations, so get ready for a wonderful adventure. What kind of amenities will make your stay a wonderful one? A rejuvenating facial treatment to help your cares fall away? A concierge to help you pick out your next adventure? Plush carpeting, delectable chocolate desserts, and even a hot tub in the bathroom...these hotels will leave you amazed. Want to see for yourself? Explore our listings and pick the perfect accommodation for your needs.

Can't wait to get outside? We've got you covered. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what you end up doing, the 5-star hotels in Mission District are the perfect place to relax after a busy day.

Make Your Escape

The results are in, and Mission District 5-star hotels are the place to be when you book your next vacation. If you've been dreaming about a vacation set here, then go ahead and book it. Expedia can help you land a great deal on accommodation. Don't put off your dream vacation any longer. Choose one of Expedia's Mission District 5-star hotels today and decompress in the lap of luxury tomorrow.

Frequently asked questions

What are the best 5-star hotels in Mission District?
Based on reviews by our travelers, Mansion on Sutter is one of the leading retreats for an indulgent getaway in the San Francisco neighborhood of Mission District. Looking for more 5-star hotels around the area? Four Seasons Hotel San Francisco and The St. Regis San Francisco will meet your high-end desires.
How much does it cost to stay in a 5-star hotel in Mission District?
How much you pay for a 5-star hotel in Mission District can vary depending on when you decide to travel and how long you plan to stay, among other factors. Take advantage of our price per night filter and other search tools to score the best deal on a high-end getaway.

  • Search for the lowest price per night from $148

What makes a hotel 5 stars in Mission District?
Outstanding guest service characterizes every 5-star hotel in Mission District. From the minute you arrive, staff cater to your every need, whether recommending activities and tours or providing in-room massages. Additionally, hotels have to offer top-rate amenities to be eligible for a 5-star rating. These can include luxury bath products, spas or saunas, swimming pools, fine dining kitchens and knowledgeable concierge.

Explore a world of travel with Expedia