Find 5 Star Hotels in Mission District, CA from $148
Check availability on Mission District 5 Star Hotels
Compare Mission District 5 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Fairmont San Francisco

Claremont Resort & Club

Palace Hotel, a Luxury Collection Hotel, San Francisco

Taj Campton Place

Four Seasons Hotel San Francisco

The Ritz-Carlton, San Francisco

1 Hotel San Francisco

Four Seasons Hotel San Francisco at Embarcadero
Explore similar 4-star hotels

Hyatt Regency San Francisco
Learn more about Mission District
Visit this San Francisco neighborhood brimming with culture, history, a lively art scene, buzzing nightlife and some of the city’s best burritos.

Top Mission District Hotel Reviews

Fairmont San Francisco
Find out more about Mission District
There's nothing wrong with enjoying the finer things in life. Add an extra layer of pleasure on your next trip to Mission District by treating yourself to the best of the best when it comes to accommodation. It's an ideal combination. There's no reason to delay a getaway to Mission District any longer. You'll join the multitudes of vacationers who have made Mission District so fashionable in the last few seasons. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. You deserve the great vacation you're dreaming about. Book one of Expedia's luxurious 5-star hotels in Mission District and get ready to be pampered like never before.
5-Star Hotels in Mission District
You'll have a fantastic time at one of these 5-star hotels. Top-notch service, delicious meals, and one-on-one attention are all ready for you. You're sure to find exactly the accommodation you need. You'll also enjoy a high standard of care and meticulous guest relations, so get ready for a wonderful adventure. What kind of amenities will make your stay a wonderful one? A rejuvenating facial treatment to help your cares fall away? A concierge to help you pick out your next adventure? Plush carpeting, delectable chocolate desserts, and even a hot tub in the bathroom...these hotels will leave you amazed. Want to see for yourself? Explore our listings and pick the perfect accommodation for your needs.
Can't wait to get outside? We've got you covered. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what you end up doing, the 5-star hotels in Mission District are the perfect place to relax after a busy day.
Make Your Escape
The results are in, and Mission District 5-star hotels are the place to be when you book your next vacation. If you've been dreaming about a vacation set here, then go ahead and book it. Expedia can help you land a great deal on accommodation. Don't put off your dream vacation any longer. Choose one of Expedia's Mission District 5-star hotels today and decompress in the lap of luxury tomorrow.
Frequently asked questions
Explore a world of travel with Expedia
- San Francisco Hotels
- Cheap Hotels in San Francisco
- Hotels with Free Airport Shuttle in San Francisco
- Hotels near Downtown San Francisco
- Hotels near Hua Zang Si
- Hotels near Southern Exposure
- Hotels near Clarion Alley
- Hotels near Women's Building
- Hotels near Victoria Theatre
- Hotels near Marsh Theater
- Hotels near 16th Street Mission Station
- Motels in 16th Street Mission Station
- Hotels near San Francisco Public Library
- Hotels near 24th Street Mission Station
- Hotels near Ratio 3
- Hotels near Mission Dolores Park
- Hotels near Balmy Alley
- 4 Star Hotels in Castro District
- 3 Star Hotels in Castro District
- 5 Star Hotels in Castro District
- Hotels near SF Armory
- Hotels near Mission High School
- Hotels near Mission Dolores
- Hotels near Right Of Way/Liberty St Stop
- Hotels near Mission San Francisco de Asís
- Hotels near Hosfelt Gallery
- Hotels near Galería de la Raza
- 5 Star Hotels in Noe Valley
- 5 Star Hotels in San Francisco
- 4 Star Hotels in Noe Valley
- 4 Star Hotels in Bernal Heights
- Hotels near 22nd St Hill
- 4 Star Hotels in Hayes Valley
- Hotels near Oracle Park
- Hotels near Union Square
- Vacation Homes in Church St & 24th St Stop
- Hotels near Market St & Dolores St Stop
- Hotels near Anchor Brewing Company
- Hotels near Castro District
- Hotels near Church Street Station
- Hotels near Market St & Buchanan St Stop
- Hotels near Market St & Guerrero St Stop
- Hotels near Market St & Laguna St Stop
- B&B in Church St & 14th St Stop
- Hotels near Market St & Sanchez St Stop
- 4 Star Hotels in Civic Center
- 5 Star Hotels in Civic Center
- 3 Star Hotels in Civic Center
- Hotels near SOMArts
- Hotels near Church St & Clipper St Stop
- Hotels near U.S. Mint
- Hotels near Duboce Ave & Church St Stop
- 5 Star Hotels in South of Market
- 4 Star Hotels in South of Market
- 3 Star Hotels in South of Market
- Hotels near Emergence Healing Arts Studio
- Hotels near Bill Graham Civic Auditorium
- Gay friendly Hotels in Castro District
- Hotels near Castro Street
- Luxury Hotels in Castro District
- Hotels with Free Parking in Castro District
- Family Hotels in Castro District
- Motel 6 Hotels in Castro District
- Hotels with Balconies in Castro District
- Extended Stay Hotels in Castro District
- Green Hotels in Castro District
- Resorts & Hotels with Spas in Castro District
- Romantic Hotels in Castro District
- Beach Hotels in Castro District
- Adults Only Resorts & in Castro District
- Hotels near California College of the Arts
- Hotels near Castro Theatre
- Hotels near Dolores Heights
- Hotels near Duboce Triangle
- Hotels near UCSF/Chase Center Stop






















































