Photo by Meredith Breckner

Defiance Vacation Rentals

Vacation Rentals in Defiance

Pool
☆BackYard BBQ Hidden Gem☆Perfect Location~Groups /Pets Welcome
9.0 out of 10, Wonderful, (40)
"Dirty, animal hair everywhere, stunk of animals, mouse traps everywhere, mouse poop all over, clothes in the dryer, shower faucet was half broken, bed sheets and animals hair, not a 4 bedroom as advertised, air mattresses all had holes. Not at all acceptable for a "vacation rental", 2 nights we stayed and it was not cheap, I expected way more."
☆BackYard BBQ Hidden Gem☆Perfect Location~Groups /Pets Welcome
Fridge, microwave, oven, stovetop
🌟 Adorable Historic 🏠 in the ❤️ of St. Charles 🌟
10.0 out of 10, Exceptional, (38)
"We enjoyed our stay and loved the close proximity to Main Street. The downstairs shower could use an upgrade but other than that the house was warm and cozy."
🌟 Adorable Historic 🏠 in the ❤️ of St. Charles 🌟
Exterior
Authentic Log cabin with something for everyone!
9.6 out of 10, Exceptional, (313)
"Rustic, spacious, good outdoor areas, peaceful private lake, well equipped. Nearby neighbors but not intrusive. Had weather cooperated better it would have been an ideal setting for our retreat."
Authentic Log cabin with something for everyone!
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free
Bar (on property)
1830's Luxury Brick Cottage, Cozy Fireplace, right off the Cobblestone Streets!
10.0 out of 10, Exceptional, (184)
"The cottage is immaculately furnished inside, and the bed is very comfortable. Just a very short walk to Main Street. Would recommend to anyone who is visiting St. Charles."
1830's Luxury Brick Cottage, Cozy Fireplace, right off the Cobblestone Streets!
Dining
The Lofts of North Main Street
9.6 out of 10, Exceptional, (90)
"Photos don't do it justice. This was the perfect place to stay for me and my family during my college graduation weekend. The accommodations are a perfect balance between chic, cozy, and modern. There was plenty of space for all 5 of us to spread out and relax. We never felt like we were crowded or had too little privacy. The upstairs loft is a neat spot to chill or to sleep, and in the living room/dining room/kitchen area we could visit while watching TV, eating, and cooking/cleaning in the...
The price is $119
$253 total
includes taxes & fees
May 29 - May 30
The Lofts of North Main Street
Exterior
1790's Renovated Barn, Main Street St. Charles, Hot Tub in private backyard!
10.0 out of 10, Exceptional, (185)
"We had a great time! The Red Barn was just what we needed for some quiet time to relax and take our time in St. Charles. The location is the perfect distance from the main street so you don't have to walk far to find something to do, but it's also not right on the "main drag" where you'd have people walking by all the time. Thanks for the hospitality!"
1790's Renovated Barn, Main Street St. Charles, Hot Tub in private backyard!
TV, fireplace, DVD player, stereo
Escape the city to quiet and picturesque Golden Eagle, IL..
10.0 out of 10, Exceptional, (310)
"This was the perfect place for my husband and me to get away for the weekend! Everything was perfect & we hated to leave!"
Escape the city to quiet and picturesque Golden Eagle, IL..
View from property
Gorgeous Lakefront Getaway - Innsbrook Chalet with Outdoor Spa!
10.0 out of 10, Exceptional, (68)
"The house was in a remote quiet location on a pretty lake. Very very clean and well appointed. Wonderful firepit and firewood provided. But the second bedroom is actually a loft open to below! Very surprised as the listing called it a 2 bedroom! Overall a great house at Innsbrook!"
Gorgeous Lakefront Getaway - Innsbrook Chalet with Outdoor Spa!
Bar (on property)
The St. Charles Guest House, lovely historic home, fun for families and groups
10.0 out of 10, Exceptional, (107)
"This house was perfect for our family to hang out and hit Main Street in St. Charles. The house itself has an updated kitchen and bathrooms and has enough space for a big family chill and watch movies or play video games. It is within walking distance of all the attractions on Main Street and if you are up to it, the Ameristar casino."
The St. Charles Guest House, lovely historic home, fun for families and groups
Property grounds
Cozy 2 bedroom waterfront chalet with private beach, hot tub at Innsbrook Resort
10.0 out of 10, Exceptional, (51)
"So much outdoor lake fun. Hot tub, paddle boards, kayaks, fire pit, beach and multiple decks and seating areas. Lake life!"
The price is $450
$755 total
includes taxes & fees
Jun 24 - Jun 25
Cozy 2 bedroom waterfront chalet with private beach, hot tub at Innsbrook Resort
Fridge, microwave, oven, stovetop
The Lewis & Clark Hangout
10.0 out of 10, Exceptional, (3)
"Great place for our group. The place is really cool. Exactly as described. Great for families and friends groups."
The price is $169
$403 total
includes taxes & fees
May 26 - May 27
The Lewis & Clark Hangout
Smart TV, video games
Spacious, Beautiful St. Charles Home - Remodeled - Sleeps 10!
10.0 out of 10, Exceptional, (31)
"House was beautiful! Plenty of room for eight people to stay and plenty of living space to eat/hang out together. Would recommend staying on this property. Thank you!"
Spacious, Beautiful St. Charles Home - Remodeled - Sleeps 10!
Exterior
Beautifully Renovated home in the heart of Historic Saint Charles
9.6 out of 10, Exceptional, (39)
"Home was in perfect location. Close to the Historic District. Very pet friendly home and location; great places to walk our dog. Host provided clear instructions on how to locate the home and checkin process. House was clean and even though our stay was over a weekend, it was quiet. Plenty of towels - we didn't cook but kitchen seemed stocked with the necessities. We would definitely stay here again and highly recommend."
Beautifully Renovated home in the heart of Historic Saint Charles
Smart TV
Residence on the Roundabout
9.6 out of 10, Exceptional, (105)
"This was the perfect place for us to stay for the Paint the Town weekend in St. Charles. We were close enough to Frenchtown, that we were able to walk back and forth. The home was clean and the traffic noise was not noticeable."
Residence on the Roundabout
Fridge, microwave, oven, stovetop
Beautiful house - safe & quiet - 4 BR 2.5 B - 6 Queen Beds
10.0 out of 10, Exceptional, (12)
"We enjoyed our stay! The house is well equipped, especially the kitchen. One note for others- it is a split-level house, so there are a few (steep) stairs to navigate. A very quiet neighborhood, just the birds chirping in the surrounding trees."
The price is $135
$312 total
includes taxes & fees
May 27 - May 28
Beautiful house - safe & quiet - 4 BR 2.5 B - 6 Queen Beds
Fridge, microwave, oven, stovetop
Cheerful 2-Bed Townhome Near Park w Garage Parking
9.8 out of 10, Exceptional, (20)
"Location is close to the interstate making it accessible to the airport and an easy drive to downtown St. Louis. Just a short drive to the quaint downtown St. Charles which we took advantage for a quick meal at Lewis and Clark. Owners are responsive and check in/out was easy. Accommodations were clean and kitchen has updated appliances. Great fenced backyard was perfect for our pup."
Cheerful 2-Bed Townhome Near Park w Garage Parking
Desk, laptop workspace, blackout drapes, WiFi
Craigshire Suites
3.0 star property
7.0 out of 10, Good, (1108)
"Great customer service "
The price is $98
$114 total
includes taxes & fees
May 26 - May 27
Craigshire Suites
Exterior
Cozy Cottage, we're told it's heavenly!
10.0 out of 10, Exceptional, (149)
"It was indeed a nice place to stay. During our stay, it was rainy and cool, which we really loved (much better than scorching hot). As a down side, we could not use the grill due to the rain. The cabin is really where you can cool off and get away. The pictures are accurate. The host was also very responsive, so we never felt left on our own. I wish the dogs (likely the host's dogs) would let our cat enjoy the deck a little more though. The poor guy didn't get a chance to relax! All in all,...
Cozy Cottage, we're told it's heavenly!
Exterior
Remodeled Kirkwood Guest house
10.0 out of 10, Exceptional, (54)
"My husband and I stayed here while visiting some friends in St. Louis. The apartment is located above the garage but do not let that deter you. Ryan was super friendly we ran into him a few times but there was NO awkwardness or inconvenience getting to or from the apartment. The apartment was super clean and comfy and larger than expected. Kirkwood is a beautiful area, safe and very close to downtown St. Louis. Would Definitely Stay here again."
Remodeled Kirkwood Guest house
Outdoor dining
Quiet Lakefront Cottage with Dock & Resort Access!
9.6 out of 10, Exceptional, (116)
"Quick birthday getaway to our favorite hidden gem in Missouri. Can’t say enough about Innsbrook. Chalet had everything we needed - large master bath on first floor. Big plus versus most of the other chalets in area. Larry was very accessible leading up to and during our stay. First time staying on Aspen lake so it was nice to sit down on the large dock and take in all of Mother Nature. Highly recommend staying at this property."
Quiet Lakefront Cottage with Dock & Resort Access!
Don't see what you're looking for?
See all available properties in Defiance
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Defiance Vacation Rental Travel Info

Number of vacation rentals
3
Popular accommodation
Defiance cabins
Known landmarks
Augusta Winery, Chandler Hill Vineyards and Montelle Winery
International airport
St. Louis, MO (STL-Lambert-St. Louis Intl.)

Other types of properties in Defiance you may be interested in

Front of property - evening/night
Hollywood Casino & Hotel St. Louis
3.5 star property
8.2 out of 10, Very Good, (1194)
"Love coming for concerts with the shuttle service and staff is always friendly and helpful. "
The price is $130
$161 total
includes taxes & fees
Jun 9 - Jun 10
Hollywood Casino & Hotel St. Louis
Studio Suite, 1 King Bed | Blackout drapes, soundproofing, iron/ironing board
Sonesta ES Suites St. Louis - Chesterfield
3.0 star property
8.2 out of 10, Very Good, (1004)
"Love it!! "
The price is $103
$119 total
includes taxes & fees
Jun 18 - Jun 19
Sonesta ES Suites St. Louis - Chesterfield
Lobby sitting area
The Wildwood Hotel
3.5 star property
8.8 out of 10, Excellent, (1284)
"Great location "
The price is $94
$114 total
includes taxes & fees
May 27 - May 28
The Wildwood Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Everything you need to know about Defiance vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Defiance vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Defiance vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Defiance vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Defiance. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Defiance in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $98 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Defiance rentals

At Expedia, we put the best Defiance vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Defiance rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Defiance vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Defiance. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Frequently asked questions

Can I find vacation rentals in Defiance?

Yes, there are vacation rentals where you'll be just 9.8 mi (15.8 km) from Six Flags St. Louis, providing a secluded option if you'd like a quiet spot to stay. Defiance is known for its wineries and parks.

What are some of the best vacation home rentals that Defiance has to offer?

The St. Charles Guest House, lovely historic home, fun for families and groups: This vacation home rental outside of Defiance is located on a river and offers a fireplace, air-conditioning, and laundry facilities to help you feel perfectly comfortable in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family.

What’s there to see and do in Defiance?

Missouri River and August A. Busch Memorial Conservation Area are a couple of scenic spots to enjoy the outdoors, whereas Historic Daniel Boone Home and Heritage Center is one of the cultural attractions. Other places in town to visit include Chandler Hill Vineyards and Sugar Creek Winery.

What’s a vacation rental in Defiance like?

A vacation rental is a private property where you can stay for a few weeks or just a few days in Defiance. Vacation rentals feature amenities like laundry facilities and kitchens so your stay will be comfortable. If you're concerned about cleanliness, vacation rentals can offer a sense of security away from shared hotel elevators and busy front desks while still allowing you a great travel experience. You'll also get more space in a vacation rental than in a traditional hotel, which makes a vacation rental a great option for families.

Recent reviews of Defiance properties
Expedia verified reviews

Country Inn & Suites by Radisson, St. Charles, MO

Country Inn & Suites by Radisson, St. Charles, MO

5/5 Excellent
"Great staff, walking distance to downtown St Charles."
A verified traveler stayed at Country Inn & Suites by Radisson, St. Charles, MO
Posted 2 days ago
Country Inn & Suites by Radisson, St. Charles, MO