Title: The Best 4 Star Hotels in Florence, SC  | Expedia.com

[Florence Travel Guide](https://expedia.com/Florence.dx1221)[Hotels in Florence](https://expedia.com/Florence-Hotels.d1221.Travel-Guide-Hotels)[Vacation Rentals in Florence](https://expedia.com/Florence-Vacation-Rentals.d1221.Travel-Guide-VacationRentals)[Flights to Florence](https://expedia.com/Cheap-Flights-To-Florence.d1221.Travel-Guide-Flights)[Things to do in Florence](https://expedia.com/Things-To-Do-In-Florence.d1221.Travel-Guide-Activities)[Car Rentals in Florence](https://expedia.com/Car-Rentals-In-Florence.d1221.Car-Rental-Guide)[Florence Vacation Packages](https://expedia.com/Florence.d1221.Destination-Travel-Guides)

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## Check availability on Florence 4 Star Hotels

Tonight

[Feb 5 - Feb 6](https://www.expedia.com/Hotel-Search?regionId=1221&startDate=2026-02-05&endDate=2026-02-06&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Feb 6 - Feb 7](https://www.expedia.com/Hotel-Search?regionId=1221&startDate=2026-02-06&endDate=2026-02-07&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Feb 6 - Feb 8](https://www.expedia.com/Hotel-Search?regionId=1221&startDate=2026-02-06&endDate=2026-02-08&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Feb 13 - Feb 15](https://www.expedia.com/Hotel-Search?regionId=1221&startDate=2026-02-13&endDate=2026-02-15&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Florence 4-star hotels

![Front of property - evening/night](https://images.trvl-media.com/lodging/12000000/11970000/11962200/11962122/252819ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior detail](https://images.trvl-media.com/lodging/12000000/11970000/11962200/11962122/70ec241d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily full breakfast](https://images.trvl-media.com/lodging/12000000/11970000/11962200/11962122/e8d69b6e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior entrance](https://images.trvl-media.com/lodging/12000000/11970000/11962200/11962122/680270b4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Rosewood Manor House B&B

[](https://www.expedia.com/Florence-Hotels-Rosewood-Manor-House-Bed-And-Breakfast.h11962122.Hotel-Information)

Marion

10/10

Exceptional

(29 reviews)

"This place is as close as you will ever get to perfection. A perfect match between southern hospitality and beauty! Breakfast was all freshly cooked and delicious. An extra ordinary place of beauty. A must ! Should be on your bucket list."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

rita

[](https://www.expedia.com/Florence-Hotels-Rosewood-Manor-House-Bed-And-Breakfast.h11962122.Hotel-Information)

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## Florence and related destinations

- Florence
- Mahwah - Nanuet
- Katy
- Texarkana
- Rolla

Stroll through the West Broad Street Historic District to soak up local history before exploring the Florence Museum's diverse exhibits. Catch a show at the Florence Civic Center or hunt for bargains at Magnolia Mall for a taste of modern entertainment.

[See all hotels in Florence](https://www.expedia.com/Hotel-Search?startDate=2026-02-19&endDate=2026-02-20&adults=2&regionId=1221)

![Wyche Pavilion Greenville South Carolina ](https://images.trvl-media.com/place/1221/22638cec-95e4-4f53-af15-3963f8a47f19.jpg?impolicy=fcrop&w=900&h=600&p=1&q=high)

## Top Florence Hotel Reviews

## Find out more about Florence

The preparation of any well-deserved holiday starts with picking a spot. Florence is a popular choice with tourists because it offers so much to keep you entertained. Location is everything, but that accounts for more than the city you are flying into. When you want a vacation that is amazing from start to finish, you need the perfect accommodation.

### Accommodations as Scenic as the City

Florence saw its fair share of visitors last year. Expedia's review section features comments which can help you select the accommodation that is optimal for your vacation. When you reserve a 4-star hotel you can rest easy knowing that these properties are designed to fulfill your wishes. These hotels work hard to make their facilities and grounds hospitable during your stay. You won't need to go far for to keep up with your exercise routine, an invigorating dip, or gourmet meal. Florence has dozens of fabulous accommodations that offer the perfect getaway.

Rooms have been furnished to keep your utmost comfort in mind, with amenities like specially designed bathroom products, ultra-comfortable bedding, and in-room coffee or tea. So, sit back and relax. Moreover, if you find that you are need of something else, you can be confident the staff will try their hardest to ensure you stay pleased during your time. These hotels are so nice that you'll regret the day you have to return home.

### Reserve a 4-Star Hotel in Florence Today!

A vacation to Florence should be one where you don't have to concern yourself about the little things. Reserve a 4-star hotel in Florence soon, because everybody else is as well.

## Frequently asked questions

### How much does it cost to stay in a 4-star hotel in Florence?

> - Search for the lowest price

### What's the difference between 5-star and 4-star hotels in Florence?

### Does Florence have any 4-star all-inclusive resorts?

## Explore a world of travel with Expedia

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- [Mcleod Regional Medical Center ](https://www.expedia.com/Mcleod-Regional-Medical-Center-Florence.d6162127.Vacation-Attraction)
- [Florence Museum ](https://www.expedia.com/Florence-Museum-Florence.d6162137.Vacation-Attraction)

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