
Isolotto Vacations from $1,003
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Your Isolotto Vacation
Reserving a tailor-made Isolotto vacation package is a good way to know the ins and outs of this unique neighborhood. From its must-see spots to its lesser-known delights, there's a lot to delve into. When it's time to head out and explore, you'll find plenty of popular attractions nearby including Cathedral of Santa Maria del Fiore, Ponte Vecchio and Uffizi Gallery. Visit one, two or more during your trip to Isolotto. Stop dreaming and start doing. When it's time to book your next vacation to Isolotto, Expedia is here to help.
The Latest Isolotto Vacation Packages

Aurum Uffizi
Reviewed on Feb 22, 2026

Borgo Scopeto Wine & Country Relais
Reviewed on Sep 2, 2025

Eurostars Florence Boutique
Reviewed on Dec 13, 2025

Glimpse Hotel
Reviewed on Jan 9, 2026

The Moon Boutique Hotel & Spa
Reviewed on Feb 23, 2026
Where to stay in Isolotto

Historic Centre of Florence
Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.
Isolotto Hotel Deals

IQ Hotel Firenze
Yes to all
Reviewed on Feb 25, 2026

c-hotels Ambasciatori
It was amazing and clean and really really perfect
Reviewed on Feb 17, 2026

Hotel Delle Nazioni
The staff was extremely helpful. Much appreciated. The location was great, right across from the Central Station, so convenient. I would, for sure, recommend this hotel for visiting Florence
Reviewed on Feb 18, 2026
Discover the most popular places to visit in Isolotto

Piazza di Santa Maria Novella
Relax before or after a long trip in this renovated piazza just a few minutes from Florence’s main train station.

Cathedral of Santa Maria del Fiore
The “Saint Mary of the Flower” cathedral and its towering dome have come to symbolize Florence.

Ponte Vecchio
Take a trip over Florence’s iconic bridge, spared by the Nazis for its beauty and home to jewelers for more than four centuries.
Things to do

Skip-the-Line Florence Duomo: Priority-Access Express Guided Tour

Skip the Line: Florence's Accademia Gallery Priority Entrance Ticket























