Isolotto Vacations from $1,378

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Your Isolotto Vacation

Reserving a tailor-made Isolotto vacation package is a good way to know the ins and outs of this unique neighborhood. From its must-see spots to its lesser-known delights, there's a lot to delve into. When it's time to head out and explore, you'll find plenty of popular attractions nearby including Cathedral of Santa Maria del Fiore, Ponte Vecchio and Uffizi Gallery. Visit one, two or more during your trip to Isolotto. Stop dreaming and start doing. When it's time to book your next vacation to Isolotto, Expedia is here to help.

The Latest Isolotto Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Aurum Firenze
Aurum Uffizi
Precise Tale Poggio Alla Sala
Portrait Firenze - Lungarno Collection
Hotel Balestri

Where to stay in Isolotto

Find the best Isolotto areas and neighborhoods for the activities you enjoy most. Learn more about Isolotto

Isolotto Hotel Deals

The Social Hub Florence Lavagnini

The Social Hub Florence Lavagnini

4 out of 5
Viale Spartaco Lavagnini 70 72 Florence FI
Fully refundableReserve now, pay when you stay
$157 nightly
The price is $189 total per night from Apr 24 to Apr 25
$189 total
Apr 24 - Apr 25
Total with taxes and fees
9/10 Wonderful! (1,330 reviews)
Great experience

Reviewed on Apr 12, 2026

The Social Hub Florence Lavagnini
IQ Hotel Firenze

IQ Hotel Firenze

4 out of 5
Via Camillo Cavour, 88 Florence FI
Fully refundableReserve now, pay when you stay
$201 nightly
The price is $238 total per night from Apr 14 to Apr 15
$238 total
Apr 14 - Apr 15
Total with taxes and fees
9.6/10 Exceptional! (1,216 reviews)
Great hotel & awesome staff were so accommodating. Highly recommend this hotel. It is about 10 min walk from Duomo. They also supply water and snacks at no cost to the guests. The room is very clean everyday. The breakfast were also excellent for the price. We enjoyed staying for 10 days.

Reviewed on Apr 12, 2026

IQ Hotel Firenze
Hotel Machiavelli Palace

Hotel Machiavelli Palace

3 out of 5
Via Nazionale 10 Florence FI
Fully refundableReserve now, pay when you stay
$141 nightly
The price is $170 total per night from Apr 15 to Apr 16
$170 total
Apr 15 - Apr 16
Total with taxes and fees
8.4/10 Very Good! (174 reviews)
Breakfast very fresh and large buffet Very nice staff .only problem i had was mattress was too hard and pilllow was too soft .

Reviewed on Apr 2, 2026

Hotel Machiavelli Palace
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in Isolotto

Things to do

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.