
Isolotto Vacations from $914
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Your Isolotto Vacation
Reserving a tailor-made Isolotto vacation package is a good way to know the ins and outs of this unique neighborhood. From its must-see spots to its lesser-known delights, there's a lot to delve into. When it's time to head out and explore, you'll find plenty of popular attractions nearby including Cathedral of Santa Maria del Fiore, Ponte Vecchio and Uffizi Gallery. Visit one, two or more during your trip to Isolotto. Stop dreaming and start doing. When it's time to book your next vacation to Isolotto, Expedia is here to help.
The Latest Isolotto Vacation Packages

Hotel La Scaletta Al Ponte Vecchio
Reviewed on Jan 13, 2026

Eurostars Florence Boutique
Reviewed on Dec 13, 2025

The Moon Boutique Hotel & Spa
Reviewed on Jan 2, 2026

Allegroitalia San Gallo Firenze
Reviewed on Dec 16, 2025

Relais Uffizi, Tailor made Hotel
Reviewed on Oct 18, 2025
Where to stay in Isolotto

Historic Centre of Florence
Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.
Isolotto Hotel Deals

c-hotels Ambasciatori
Great location, short walk to the Duomo, museums and shopping. A clean quiet room awaited me.
Reviewed on Jan 21, 2026

IQ Hotel Firenze
Fantastic service, exceptionallly clean room, free drink and minibar was a nice addition. Highly recommend. Lovely coming home after a day sightseeing.
Reviewed on Feb 1, 2026

Bernini Palace
Staff very helpful Rooms very clean Good breakfast options
Reviewed on Jan 30, 2026
Discover the most popular places to visit in Isolotto

Piazza di Santa Maria Novella
Relax before or after a long trip in this renovated piazza just a few minutes from Florence’s main train station.

Ponte Vecchio
Take a trip over Florence’s iconic bridge, spared by the Nazis for its beauty and home to jewelers for more than four centuries.

Cathedral of Santa Maria del Fiore
The “Saint Mary of the Flower” cathedral and its towering dome have come to symbolize Florence.
Things to do

Tuscany Experience In Pisa, Siena, San Gimignano & Chianti

Skip the Line: Florence's Accademia Gallery Priority Entrance Ticket























