Title: Isolotto Vacation Packages 2026 from $1,480 | Expedia.com

[Isolotto Travel Guide](https://expedia.com/Florence-Isolotto.dx6141943)[Hotels in Isolotto](https://expedia.com/Isolotto-Florence-Hotels.0-n6141943-0.Travel-Guide-Filter-Hotels)[Flights to Florence](https://expedia.com/Cheap-Flights-To-Florence.d1222.Travel-Guide-Flights)[Things to do in Florence](https://expedia.com/Things-To-Do-In-Florence.d1222.Travel-Guide-Activities)[Car Rentals in Isolotto](https://expedia.com/Car-Rentals-In-Isolotto.d6141943.Car-Rental-Guide)

![](https://images.trvl-media.com/place/6141943/836e5c0b-5439-4b83-86da-dc1553121395.jpg?impolicy=fcrop&w=1200&h=300&q=medium)

# Isolotto Vacations from $1,480

## Book a Hotel + Flight or Car together to unlock savings

- ##  
Plan, book, travel with confidence
- ###  
Better together  
Save up to $1,045 when you book a flight and hotel together\*
- ###  
Find the right fit  
With over 300,000 hotels worldwide, it's easy to create a perfect package
- ###  
Rest easy  
Plan, book, and manage your trip all in one place

## Your Isolotto Vacation

Reserving a tailor-made Isolotto vacation package is a good way to know the ins and outs of this unique neighborhood. From its must-see spots to its lesser-known delights, there's a lot to delve into. When it's time to head out and explore, you'll find plenty of popular attractions nearby including [Cathedral of Santa Maria del Fiore](https://www.expedia.com/Cathedral-Of-Santa-Maria-Del-Fiore-Duomo.d501046.Vacation-Attraction), [Ponte Vecchio](https://www.expedia.com/Ponte-Vecchio-Oltrarno.d6075434.Vacation-Attraction) and [Uffizi Gallery](https://www.expedia.com/Uffizi-Gallery-Duomo.d6075462.Vacation-Attraction). Visit one, two or more during your trip to Isolotto. Stop dreaming and start doing. When it's time to book your next vacation to Isolotto, Expedia is here to help.

## The Latest Isolotto Vacation Packages

Price found within the past 48 hours. Click for updated prices.

![Aurum Firenze](https://images.trvl-media.com/lodging/29000000/28970000/28962000/28961941/3c6602ae_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Aurum Firenze

Historic Centre of Florence

Save 100% on your flight

$1,480

per person

May 18 - May 24

found 1 day ago

Roundtrip non-stop flight included

Boston (BOS) to Florence (FLR)

7.6/10 Good! (1,008 reviews)

Windows head blinds that would not open so we never got to see outside. Shower was very small. You could barely move in the shower stall. There were only two large towels, no washcloths no hand towels and they did not change them the next day we had to ask for fresh ones received two bottles of water in the refrigerator the first day and never anymore the following days air conditioning unit worked well plenty of outlets clean facility. Breakfast buffet was OK, front desk young lady was very helpful and nice hotel was down the block from the train station so it was quite crowded but manageable.

Reviewed on Apr 5, 2026

![Aurum Uffizi](https://images.trvl-media.com/lodging/3000000/2550000/2541700/2541615/4fb74083_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Aurum Uffizi

Historic Centre of Florence

Save 100% on your flight

$1,552

per person

May 18 - May 24

found 1 day ago

Roundtrip non-stop flight included

Boston (BOS) to Florence (FLR)

7.6/10 Good! (1,002 reviews)

Great location, but on a noisy alley.

Reviewed on Mar 20, 2026

![Eurostars Florence Boutique](https://images.trvl-media.com/lodging/2000000/1170000/1167000/1166901/88283612_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Eurostars Florence Boutique

Historic Centre of Florence

Save 100% on your flight

$1,717

per person

May 18 - May 24

found 1 day ago

Roundtrip non-stop flight included

Boston (BOS) to Florence (FLR)

8.6/10 Excellent! (483 reviews)

The room was clean and the staff very accommodating. The breakfast was quite sufficient and had a good variety. The location is great. It's a short walk from the square, shopping and from restaurants.

Reviewed on Dec 13, 2025

![Bernini Palace](https://images.trvl-media.com/lodging/1000000/20000/14000/13999/c71352fb_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Bernini Palace

Historic Centre of Florence

Save 100% on your flight

$3,386

per person

May 11 - May 17

found 1 day ago

Roundtrip non-stop flight included

Boston (BOS) to Florence (FLR)

9.8/10 Exceptional! (1,010 reviews)

Exelente ubicación cerca de todo. Propiedad en muy buen estado y habitaciones muy cómodas

Reviewed on Apr 4, 2026

![The Place Firenze](https://images.trvl-media.com/lodging/1000000/920000/915900/915828/eb0fe8c9_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### The Place Firenze

Historic Centre of Florence

Save 100% on your flight

$5,504

per person

May 18 - May 23

found 1 day ago

Roundtrip flight included

Dallas (DFW) to Florence (FLR)

9.8/10 Exceptional! (193 reviews)

Fantastic location, hotel, and staff. We very much loved our stay and would highly recommend this hotel.

Reviewed on Apr 3, 2026

## Where to stay in Isolotto

Find the best Isolotto areas and neighborhoods for the activities you enjoy most. [Learn more about Isolotto](https://expedia.com/Florence-Isolotto.dx6141943)

![Historic Centre of Florence](https://images.trvl-media.com/place/6075434/96ba5e7b-ca43-4d9f-9921-bde07164fcbc.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### Historic Centre of Florence

10 out of top 10 points of interest in this area

 Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias. 

[Find hotel + flight trips in Historic Centre of Florence](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Historic%20Centre%20of%20Florence&DestID=6141938&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

![Duomo](https://images.trvl-media.com/place/6141938/4816fa4b-dceb-4db3-bc3d-7fd0a5eb8789.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### Duomo

5/5(2,242 area reviews)

 Framed by a magnificent cathedral and charming streets lined with churches and restaurants, this neighborhood rests at the very heart of Florence. 

[Find hotel + flight trips in Duomo](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Duomo&DestID=6084346&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

![San Giovanni](https://images.trvl-media.com/place/6075434/7c194037-41c2-40fb-a601-3da01105de7b.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### San Giovanni

 If you're spending some time in San Giovanni, Cathedral of Santa Maria del Fiore and Piazza della Repubblica are top sights worth seeing. 

[Find hotel + flight trips in San Giovanni](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=San%20Giovanni&DestID=553248635976383065&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

![Santa Maria Novella](https://images.trvl-media.com/place/6084343/def994ac-70f7-40cd-89a8-ec519f783ac9.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### Santa Maria Novella

4.5/5(1,073 area reviews)

 Spend some time in an attractive neighborhood close to the city center that encompasses ancient buildings and churches and a large park of outstanding beauty. 

[Find hotel + flight trips in Santa Maria Novella](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Santa%20Maria%20Novella&DestID=6084343&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

![Santa Croce](https://images.trvl-media.com/place/6248194/236c34a1-6c95-481e-b9b8-957b594360cd.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### Santa Croce

4.5/5(213 area reviews)

 One of the historic districts of Florence has a network of medieval streets lined with opulent churches, leather stores, markets and atmospheric restaurants. 

[Find hotel + flight trips in Santa Croce](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Santa%20Croce&DestID=6084344&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

## Isolotto Hotel Deals

![The Social Hub Florence Lavagnini](https://images.trvl-media.com/lodging/24000000/23200000/23198300/23198289/fdc60d68_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

The Social Hub Florence Lavagnini

Viale Spartaco Lavagnini 70 72 Florence FI

Fully refundableReserve now, pay when you stay

$130 nightly

$159 total

Apr 12 - Apr 13

Total with taxes and fees

9/10 Wonderful! (1,322 reviews)

Room very basic/no upgrade/first floor very noisy/breakfast OK Location Ok near train station/20 min by walk to center

Reviewed on Apr 5, 2026

[](https://expedia.com/Hotel-Search?startDate=4%2F12%2F2026&endDate=4%2F13%2F2026&selected=23198289&PinnedHotelID=23198289&HadPinnedHotel=true&regionId=6141943)

![IQ Hotel Firenze](https://images.trvl-media.com/lodging/90000000/89040000/89035100/89035039/72f32f77_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

IQ Hotel Firenze

Via Camillo Cavour, 88 Florence FI

Fully refundableReserve now, pay when you stay

$153 nightly

$184 total

Apr 12 - Apr 13

Total with taxes and fees

9.6/10 Exceptional! (1,207 reviews)

No issues. It was a nice property.

Reviewed on Apr 5, 2026

[](https://expedia.com/Hotel-Search?startDate=4%2F12%2F2026&endDate=4%2F13%2F2026&selected=89035039&PinnedHotelID=89035039&HadPinnedHotel=true&regionId=6141943)

![Hotel Machiavelli Palace](https://images.trvl-media.com/lodging/1000000/530000/521300/521248/ab2b96dc_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Hotel Machiavelli Palace

Via Nazionale 10 Florence FI

Fully refundableReserve now, pay when you stay

$123 nightly

$149 total

Apr 12 - Apr 13

Total with taxes and fees

8.4/10 Very Good! (172 reviews)

Breakfast very fresh and large buffet Very nice staff .only problem i had was mattress was too hard and pilllow was too soft .

Reviewed on Apr 2, 2026

[](https://expedia.com/Hotel-Search?startDate=4%2F12%2F2026&endDate=4%2F13%2F2026&selected=521248&PinnedHotelID=521248&HadPinnedHotel=true&regionId=6141943)

[See all 11,402 properties in Isolotto](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=4%2F7%2F2026&endDate=4%2F8%2F2026&regionId=6141943)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

All Inclusive Vacations

[](https://expedia.com/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Beach Vacations

[](https://expedia.com/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Kid Friendly Vacations

[](https://expedia.com/lp/theme-vacations/kid-friendly-vacations?rfrr=editorial.Kid_Friendly%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Golf Vacations

[](https://expedia.com/lp/theme-vacations/golf-vacations?rfrr=editorial.Golf_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/07/15/US_Luxury_VR_Miami.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Luxury Vacations

[](https://expedia.com/lp/theme-vacations/luxury-vacations?rfrr=editorial.Luxury_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/29/romantic.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Romantic Vacations

[](https://expedia.com/lp/theme-vacations/romantic-vacations?rfrr=editorial.Romantic_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/31952_v1_atfraraski22_insta_4.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Ski Vacations

[](https://expedia.com/lp/theme-vacations/ski-vacations?rfrr=editorial.Ski_Vacations.click)

![Gay Friendly Vacations](https://forever.travel-assets.com/flex/flexmanager/images/2023/06/15/LGBTQIA_Holiday_Package.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

LGBTQ Friendly Vacations

[](https://expedia.com/lp/theme-holidays/gay-friendly-holidays?rfrr=editorial.LGBTQ_Friendly%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2017/07/05/170615_Adventure_1320_2.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Adventure Vacations

[](https://expedia.com/lp/theme-vacations/adventure-vacations?rfrr=editorial.Adventure_Vacations.click)

![Vacations in Month](https://forever.travel-assets.com/flex/flexmanager/images/2023/05/10/mesog-34434-card-venice.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Where to go when

[](https://expedia.com/lp/b/where-to-go-when?rfrr=editorial.Where_to%20go%20when.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/21/honeymoon_hawaii.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Honeymoon Vacations

[](https://expedia.com/lp/theme-vacations/honeymoon-vacations?rfrr=editorial.Honeymoon_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/Mountain-vacations.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Mountain Vacations

[](https://expedia.com/lp/theme-vacations/mountain-vacations?rfrr=editorial.Mountain_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/fishing-vacations-2.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Fishing Vacations

[](https://expedia.com/lp/theme-vacations/fishing-vacations?rfrr=editorial.Fishing_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2019/05/16/Hyatt%20Zilara%20Cancun%20-%20All%20Inclusive%20-%20Adults%20Only.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Adults Only Vacations

[](https://expedia.com/lp/theme-vacations/adults-only-vacations?rfrr=editorial.Adults_Only%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/waterpark-vacations.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Waterpark Vacations

[](https://expedia.com/lp/theme-vacations/waterpark-vacations?rfrr=editorial.Waterpark_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/08/Caribean_scuba_diving.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Scuba Diving Vacations

[](https://expedia.com/lp/theme-vacations/scuba-diving-vacations?rfrr=editorial.Scuba_Diving%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/08/aruba_yoga.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Yoga Vacations

[](https://expedia.com/lp/theme-vacations/yoga-vacations?rfrr=editorial.Yoga_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2023/04/04/EPS-RBC-SummerBeachVacations-AdobeStock_206356322.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Cheap Vacations

[](https://expedia.com/lp/theme-vacations/cheap-vacations?rfrr=editorial.Cheap_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/06/26/1175883311.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Solo Vacations

[](https://expedia.com/lp/b/vacations/solo-vacations?rfrr=editorial.Solo_Vacations.click)

### Discover the most popular places to visit in Isolotto

![Piazza di Santa Maria Novella](https://images.trvl-media.com/place/6167447/7f4e9e58-353d-4a42-8920-7d465f5e16de.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Piazza di Santa Maria Novella

4.5/5(22 reviews)

Relax before or after a long trip in this renovated piazza just a few minutes from Florence’s main train station.

[](https://expedia.com/Piazza-Di-Santa-Maria-Novella-Historic-Centre-of-Florence.d6167447.Vacation-Attraction)

![Cathedral of Santa Maria del Fiore](https://images.trvl-media.com/place/501046/58cc313e-b63c-4e3e-825f-1235037a9d48.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Cathedral of Santa Maria del Fiore

4.5/5(1,319 reviews)

The “Saint Mary of the Flower” cathedral and its towering dome have come to symbolize Florence.

[](https://expedia.com/Cathedral-Of-Santa-Maria-Del-Fiore-Historic-Centre-of-Florence.d501046.Vacation-Attraction)

![Ponte Vecchio](https://images.trvl-media.com/place/6075434/67189072-9377-4114-81b7-8ffaa6705976.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Ponte Vecchio

4.5/5(2,096 reviews)

Take a trip over Florence’s iconic bridge, spared by the Nazis for its beauty and home to jewelers for more than four centuries.

[](https://expedia.com/Ponte-Vecchio-Historic-Centre-of-Florence.d6075434.Vacation-Attraction)

### Things to do

![Small-Group Wine Tasting Experience in the Tuscan Countryside](https://mediaim.expedia.com/localexpert/1137622/a19a4ec1-65bf-4731-8e59-f83e639bcf44.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Small-Group Wine Tasting Experience in the Tuscan Countryside

$102

per adult

**98%** of travellers recommend

[](https://expedia.com/things-to-do/small-group-wine-tasting-experience-in-the-tuscan-countryside.a1137622.activity-details)

![Skip-the-Line Duomo: Priority-Access 30-Minute Guided Tour](https://mediaim.expedia.com/localexpert/507532/cbdef260-9919-420e-a482-1d2f9b3d6ccc.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Skip-the-Line Florence Duomo: Priority-Access Express Guided Tour

$26

per adult

**80%** of travellers recommend

[](https://expedia.com/things-to-do/skip-the-line-florence-duomo-priority-access-express-guided-tour.a507532.activity-details)

![Florence half day combo tour with David, Uffizi & Duomo](https://mediaim.expedia.com/localexpert/177530/67736287-bdb2-4b4e-a2f9-65e0ac592e0e.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Florence Half Day Tour with Michelangelo’s David, Accademia & Uffizi Option

$33

per adult

**92%** of travellers recommend

[](https://expedia.com/things-to-do/florence-half-day-tour-with-michelangelos-david.a177530.activity-details)

[See all activities in Florence](https://expedia.com/things-to-do/search?rid=6141943)

\* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.