Title: Isolotto Vacation Packages 2026 from $1,388 | Expedia.com

[Isolotto Travel Guide](https://expedia.com/Florence-Isolotto.dx6141943)[Hotels in Isolotto](https://expedia.com/Isolotto-Florence-Hotels.0-n6141943-0.Travel-Guide-Filter-Hotels)[Flights to Florence](https://expedia.com/Cheap-Flights-To-Florence.d1222.Travel-Guide-Flights)[Things to do in Florence](https://expedia.com/Things-To-Do-In-Florence.d1222.Travel-Guide-Activities)[Car Rentals in Isolotto](https://expedia.com/Car-Rentals-In-Isolotto.d6141943.Car-Rental-Guide)

![](https://images.trvl-media.com/place/6141943/836e5c0b-5439-4b83-86da-dc1553121395.jpg?impolicy=fcrop&w=1200&h=300&q=medium)

# Isolotto Vacations from $1,388

## Book a Hotel + Flight or Car together to unlock savings

- ##  
Plan, book, travel with confidence
- ###  
Better together  
Save up to $1,045 when you book a flight and hotel together\*
- ###  
Find the right fit  
With over 300,000 hotels worldwide, it's easy to create a perfect package
- ###  
Rest easy  
Plan, book, and manage your trip all in one place

## Your Isolotto Vacation

Reserving a tailor-made Isolotto vacation package is a good way to know the ins and outs of this unique neighborhood. From its must-see spots to its lesser-known delights, there's a lot to delve into. When it's time to head out and explore, you'll find plenty of popular attractions nearby including [Cathedral of Santa Maria del Fiore](https://www.expedia.com/Cathedral-Of-Santa-Maria-Del-Fiore-Duomo.d501046.Vacation-Attraction), [Ponte Vecchio](https://www.expedia.com/Ponte-Vecchio-Oltrarno.d6075434.Vacation-Attraction) and [Uffizi Gallery](https://www.expedia.com/Uffizi-Gallery-Duomo.d6075462.Vacation-Attraction). Visit one, two or more during your trip to Isolotto. Stop dreaming and start doing. When it's time to book your next vacation to Isolotto, Expedia is here to help.

## The Latest Isolotto Vacation Packages

Price found within the past 48 hours. Click for updated prices.

![Aurum Firenze](https://images.trvl-media.com/lodging/29000000/28970000/28962000/28961941/3c6602ae_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Aurum Firenze

Historic Centre of Florence

$1,388

per person

May 21 - May 26

found 5 hours ago

Roundtrip non-stop flight included

Boston (BOS) to Florence (FLR)

7.6/10 Good! (1,006 reviews)

It was near the train and next to awesome places. The view if you get a balcony is so cute and peaceful

Reviewed on Feb 28, 2026

![Aurum Uffizi](https://images.trvl-media.com/lodging/3000000/2550000/2541700/2541615/4fb74083_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Aurum Uffizi

Historic Centre of Florence

Save 100% on your flight

$1,486

per person

May 12 - May 18

found 1 day ago

Roundtrip non-stop flight included

Boston (BOS) to Florence (FLR)

7.6/10 Good! (1,000 reviews)

Smaller room then expected and shower did flood the floor so not the best of showers. Bed very comfortable Nice friendly & helpful staff and perfect location to explore the city.

Reviewed on Feb 22, 2026

![Eurostars Florence Boutique](https://images.trvl-media.com/lodging/2000000/1170000/1167000/1166901/88283612_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Eurostars Florence Boutique

Historic Centre of Florence

Save 100% on your flight

$1,418

per person

May 12 - May 18

found 1 day ago

Roundtrip non-stop flight included

Boston (BOS) to Florence (FLR)

8.6/10 Excellent! (483 reviews)

The room was clean and the staff very accommodating. The breakfast was quite sufficient and had a good variety. The location is great. It's a short walk from the square, shopping and from restaurants.

Reviewed on Dec 13, 2025

![The Moon Boutique Hotel & Spa](https://images.trvl-media.com/lodging/23000000/22260000/22255000/22254976/a69619e4_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### The Moon Boutique Hotel & Spa

Historic Centre of Florence

Save 100% on your flight

$1,810

per person

May 27 - Jun 1

found 1 day ago

Roundtrip non-stop flight included

New York (NYC) to Florence (FLR)

9.6/10 Exceptional! (511 reviews)

Outstanding Boutique Hotel. Friendly Multilingual Staff, Great Breakfast, beautiful and spacious room. Absolutely amazing Wellness Spa! Centrally located for easy access to all of Firenze via public transportation. 30 mins from airport. I highly recommend The Moon Hotel And Spa!

Reviewed on Feb 23, 2026

![Hotel La Scaletta Al Ponte Vecchio](https://images.trvl-media.com/lodging/2000000/1610000/1604300/1604285/d1c916cb_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Hotel La Scaletta Al Ponte Vecchio

Historic Centre of Florence

Save 100% on your flight

$2,213

per person

May 21 - May 26

found 5 hours ago

Roundtrip non-stop flight included

Boston (BOS) to Florence (FLR)

8.8/10 Excellent! (965 reviews)

Close to everything!! That is a plus, however, room was warm and no screams on the windows. Several mosquito bites

Reviewed on Mar 6, 2026

## Where to stay in Isolotto

Find the best Isolotto areas and neighborhoods for the activities you enjoy most. [Learn more about Isolotto](https://expedia.com/Florence-Isolotto.dx6141943)

![Arcetri showing a bridge and a river or creek](https://images.trvl-media.com/place/6075434/96ba5e7b-ca43-4d9f-9921-bde07164fcbc.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### Historic Centre of Florence

10 out of top 10 points of interest in this area

 Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias. 

[Find hotel + flight trips in Historic Centre of Florence](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Historic%20Centre%20of%20Florence&DestID=6141938&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

![Duomo featuring heritage architecture and street scenes as well as a small group of people](https://images.trvl-media.com/place/6141938/4816fa4b-dceb-4db3-bc3d-7fd0a5eb8789.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### Duomo

5/5(2,214 area reviews)

 Framed by a magnificent cathedral and charming streets lined with churches and restaurants, this neighborhood rests at the very heart of Florence. 

[Find hotel + flight trips in Duomo](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Duomo&DestID=6084346&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

![Ponte Vecchio showing a bridge and a river or creek](https://images.trvl-media.com/place/6075434/7c194037-41c2-40fb-a601-3da01105de7b.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### San Giovanni

 If you're spending some time in San Giovanni, Cathedral of Santa Maria del Fiore and Piazza della Repubblica are top sights worth seeing. 

[Find hotel + flight trips in San Giovanni](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=San%20Giovanni&DestID=553248635976383065&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

![Santa Maria Novella which includes heritage architecture, a church or cathedral and street scenes](https://images.trvl-media.com/place/6084343/def994ac-70f7-40cd-89a8-ec519f783ac9.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### Santa Maria Novella

4.5/5(1,057 area reviews)

 Spend some time in an attractive neighborhood close to the city center that encompasses ancient buildings and churches and a large park of outstanding beauty. 

[Find hotel + flight trips in Santa Maria Novella](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Santa%20Maria%20Novella&DestID=6084343&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

![Piazza Santa Croce showing a city and street scenes](https://images.trvl-media.com/place/6248194/236c34a1-6c95-481e-b9b8-957b594360cd.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### Santa Croce

4.5/5(211 area reviews)

 One of the historic districts of Florence has a network of medieval streets lined with opulent churches, leather stores, markets and atmospheric restaurants. 

[Find hotel + flight trips in Santa Croce](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Santa%20Croce&DestID=6084344&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

## Isolotto Hotel Deals

![IQ Hotel Firenze](https://images.trvl-media.com/lodging/90000000/89040000/89035100/89035039/72f32f77_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

IQ Hotel Firenze

Via Camillo Cavour, 88 Florence FI

Fully refundableReserve now, pay when you stay

$94 nightly

$120 total

Mar 8 - Mar 9

Total with taxes and fees

9.6/10 Exceptional! (1,184 reviews)

Great place. Excellent staff. If you’re doing laundry understand that the dryer is meant for small loads only. Prepare to run it at least twice. I would definitely stay here again.

Reviewed on Mar 6, 2026

[](https://expedia.com/Hotel-Search?startDate=3%2F8%2F2026&endDate=3%2F9%2F2026&selected=89035039&PinnedHotelID=89035039&HadPinnedHotel=true&regionId=6141943)

![c-hotels Ambasciatori](https://images.trvl-media.com/lodging/1000000/10000/1900/1829/ac4739c5_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

c-hotels Ambasciatori

Via Luigi Alamanni 3 Florence FI

Fully refundableReserve now, pay when you stay

$96 nightly

$122 total

Mar 8 - Mar 9

Total with taxes and fees

8.2/10 Very Good! (1,001 reviews)

It was amazing and clean and really really perfect

Reviewed on Feb 17, 2026

[](https://expedia.com/Hotel-Search?startDate=3%2F8%2F2026&endDate=3%2F9%2F2026&selected=1829&PinnedHotelID=1829&HadPinnedHotel=true&regionId=6141943)

![Hotel Machiavelli Palace](https://images.trvl-media.com/lodging/1000000/530000/521300/521248/ab2b96dc_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Hotel Machiavelli Palace

Via Nazionale 10 Florence FI

Fully refundableReserve now, pay when you stay

$93 nightly

$116 total

Mar 15 - Mar 16

Total with taxes and fees

8.4/10 Very Good! (168 reviews)

The location was perfect, close to train station and local restaurants. The rooms were large and lovely, very clean. Staff was friendly and helpful.

Reviewed on Mar 3, 2026

[](https://expedia.com/Hotel-Search?startDate=3%2F15%2F2026&endDate=3%2F16%2F2026&selected=521248&PinnedHotelID=521248&HadPinnedHotel=true&regionId=6141943)

[See all 11,453 properties in Isolotto](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=3%2F7%2F2026&endDate=3%2F8%2F2026&regionId=6141943)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

All Inclusive Vacations

[](https://expedia.com/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Beach Vacations

[](https://expedia.com/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Kid Friendly Vacations

[](https://expedia.com/lp/theme-vacations/kid-friendly-vacations?rfrr=editorial.Kid_Friendly%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Golf Vacations

[](https://expedia.com/lp/theme-vacations/golf-vacations?rfrr=editorial.Golf_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/07/15/US_Luxury_VR_Miami.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Luxury Vacations

[](https://expedia.com/lp/theme-vacations/luxury-vacations?rfrr=editorial.Luxury_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/29/romantic.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Romantic Vacations

[](https://expedia.com/lp/theme-vacations/romantic-vacations?rfrr=editorial.Romantic_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/31952_v1_atfraraski22_insta_4.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Ski Vacations

[](https://expedia.com/lp/theme-vacations/ski-vacations?rfrr=editorial.Ski_Vacations.click)

![Gay Friendly Vacations](https://forever.travel-assets.com/flex/flexmanager/images/2023/06/15/LGBTQIA_Holiday_Package.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

LGBTQ Friendly Vacations

[](https://expedia.com/lp/theme-holidays/gay-friendly-holidays?rfrr=editorial.LGBTQ_Friendly%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2017/07/05/170615_Adventure_1320_2.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Adventure Vacations

[](https://expedia.com/lp/theme-vacations/adventure-vacations?rfrr=editorial.Adventure_Vacations.click)

![Vacations in Month](https://forever.travel-assets.com/flex/flexmanager/images/2023/05/10/mesog-34434-card-venice.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Where to go when

[](https://expedia.com/lp/b/where-to-go-when?rfrr=editorial.Where_to%20go%20when.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/21/honeymoon_hawaii.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Honeymoon Vacations

[](https://expedia.com/lp/theme-vacations/honeymoon-vacations?rfrr=editorial.Honeymoon_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/Mountain-vacations.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Mountain Vacations

[](https://expedia.com/lp/theme-vacations/mountain-vacations?rfrr=editorial.Mountain_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/fishing-vacations-2.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Fishing Vacations

[](https://expedia.com/lp/theme-vacations/fishing-vacations?rfrr=editorial.Fishing_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2019/05/16/Hyatt%20Zilara%20Cancun%20-%20All%20Inclusive%20-%20Adults%20Only.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Adults Only Vacations

[](https://expedia.com/lp/theme-vacations/adults-only-vacations?rfrr=editorial.Adults_Only%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/waterpark-vacations.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Waterpark Vacations

[](https://expedia.com/lp/theme-vacations/waterpark-vacations?rfrr=editorial.Waterpark_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/08/Caribean_scuba_diving.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Scuba Diving Vacations

[](https://expedia.com/lp/theme-vacations/scuba-diving-vacations?rfrr=editorial.Scuba_Diving%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/08/aruba_yoga.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Yoga Vacations

[](https://expedia.com/lp/theme-vacations/yoga-vacations?rfrr=editorial.Yoga_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2023/04/04/EPS-RBC-SummerBeachVacations-AdobeStock_206356322.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Cheap Vacations

[](https://expedia.com/lp/theme-vacations/cheap-vacations?rfrr=editorial.Cheap_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/06/26/1175883311.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Solo Vacations

[](https://expedia.com/lp/b/vacations/solo-vacations?rfrr=editorial.Solo_Vacations.click)

### Discover the most popular places to visit in Isolotto

![Piazza di Santa Maria Novella which includes a garden, heritage architecture and a church or cathedral](https://images.trvl-media.com/place/6167447/7f4e9e58-353d-4a42-8920-7d465f5e16de.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Piazza di Santa Maria Novella

4.5/5(22 reviews)

Relax before or after a long trip in this renovated piazza just a few minutes from Florence’s main train station.

[](https://expedia.com/Piazza-Di-Santa-Maria-Novella-Historic-Centre-of-Florence.d6167447.Vacation-Attraction)

![Cathedral of Santa Maria del Fiore featuring a city, heritage architecture and a church or cathedral](https://images.trvl-media.com/place/501046/58cc313e-b63c-4e3e-825f-1235037a9d48.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Cathedral of Santa Maria del Fiore

4.5/5(1,301 reviews)

The “Saint Mary of the Flower” cathedral and its towering dome have come to symbolize Florence.

[](https://expedia.com/Cathedral-Of-Santa-Maria-Del-Fiore-Historic-Centre-of-Florence.d501046.Vacation-Attraction)

![Uffizi Gallery in Florence in Italy](https://images.trvl-media.com/place/6075462/638682df-5d23-4089-83af-be7850616ae1.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Uffizi Gallery

4.5/5(1,486 reviews)

Art lovers will be in their element in this famous museum, home to the most extensive and important collection of masterpieces in the world.

[](https://expedia.com/Uffizi-Gallery-Historic-Centre-of-Florence.d6075462.Vacation-Attraction)

### Things to do

![Skip-the-Line Duomo: Priority-Access 30-Minute Guided Tour](https://mediaim.expedia.com/localexpert/507532/cbdef260-9919-420e-a482-1d2f9b3d6ccc.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Skip-the-Line Florence Duomo: Priority-Access Express Guided Tour

$26

per adult

**80%** of travellers recommend

[](https://expedia.com/things-to-do/skip-the-line-florence-duomo-priority-access-express-guided-tour.a507532.activity-details)

![Micheal Angelo's David](https://mediaim.expedia.com/localexpert/2479829/2bebb71d-abeb-452a-9a00-2b6fddf3b233.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Skip the Line: Florence's Accademia Gallery Priority Entrance Ticket

$37

per adult

**86%** of travellers recommend

[](https://expedia.com/things-to-do/skip-the-line-florences-accademia-gallery-priority-entrance-ticket.a2479829.activity-details)

![Uffizi Gallery Small-Group Guided Tour with Skip-the-Line ](https://mediaim.expedia.com/localexpert/177545/64032470-3160-4cb3-af48-28fcc0e58d64.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Uffizi Gallery: Small Group Guided Tour or Reserved Entry Ticket

$50

per adult

**86%** of travellers recommend

[](https://expedia.com/things-to-do/uffizi-gallery-small-group-guided-tour-or-reserved-entry-ticket.a177545.activity-details)

[See all activities in Florence](https://expedia.com/things-to-do/search?rid=6141943)

\* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.