Title: Isolotto Vacation Packages 2026 from $956 | Expedia.com

[Isolotto Travel Guide](https://expedia.com/Florence-Isolotto.dx6141943)[Hotels in Isolotto](https://expedia.com/Isolotto-Florence-Hotels.0-n6141943-0.Travel-Guide-Filter-Hotels)[Flights to Florence](https://expedia.com/Cheap-Flights-To-Florence.d1222.Travel-Guide-Flights)[Things to do in Florence](https://expedia.com/Things-To-Do-In-Florence.d1222.Travel-Guide-Activities)[Car Rentals in Isolotto](https://expedia.com/Car-Rentals-In-Isolotto.d6141943.Car-Rental-Guide)

![](https://images.trvl-media.com/place/6141943/836e5c0b-5439-4b83-86da-dc1553121395.jpg?impolicy=fcrop&w=1200&h=300&q=medium)

# Isolotto Vacations from $956

## Book a Hotel + Flight or Car together to unlock savings

- ##  
Plan, book, travel with confidence
- ###  
Better together  
Save up to $1,045 when you book a flight and hotel together\*
- ###  
Find the right fit  
With over 300,000 hotels worldwide, it's easy to create a perfect package
- ###  
Rest easy  
Plan, book, and manage your trip all in one place

## Your Isolotto Vacation

Reserving a tailor-made Isolotto vacation package is a good way to know the ins and outs of this unique neighborhood. From its must-see spots to its lesser-known delights, there's a lot to delve into. When it's time to head out and explore, you'll find plenty of popular attractions nearby including [Cathedral of Santa Maria del Fiore](https://www.expedia.com/Cathedral-Of-Santa-Maria-Del-Fiore-Duomo.d501046.Vacation-Attraction), [Ponte Vecchio](https://www.expedia.com/Ponte-Vecchio-Oltrarno.d6075434.Vacation-Attraction) and [Uffizi Gallery](https://www.expedia.com/Uffizi-Gallery-Duomo.d6075462.Vacation-Attraction). Visit one, two or more during your trip to Isolotto. Stop dreaming and start doing. When it's time to book your next vacation to Isolotto, Expedia is here to help.

## The Latest Isolotto Vacation Packages

Price found within the past 48 hours. Click for updated prices.

![Aurum Firenze](https://images.trvl-media.com/lodging/29000000/28970000/28962000/28961941/3c6602ae_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Aurum Firenze

Historic Centre of Florence

Save 100% on your flight

$956

per person

Apr 25 - Apr 28

found 1 day ago

Roundtrip non-stop flight included

Boston (BOS) to Florence (FLR)

7.6/10 Good! (1,002 reviews)

It was near the train and next to awesome places. The view if you get a balcony is so cute and peaceful

Reviewed on Feb 28, 2026

![Aurum Uffizi](https://images.trvl-media.com/lodging/3000000/2550000/2541700/2541615/4fb74083_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Aurum Uffizi

Historic Centre of Florence

Save 100% on your flight

$1,220

per person

May 13 - May 18

found 1 day ago

Roundtrip non-stop flight included

Newark Liberty Intl. Airport (EWR) to Florence (FLR)

7.6/10 Good! (1,000 reviews)

Smaller room then expected and shower did flood the floor so not the best of showers. Bed very comfortable Nice friendly & helpful staff and perfect location to explore the city.

Reviewed on Feb 22, 2026

![Eurostars Florence Boutique](https://images.trvl-media.com/lodging/2000000/1170000/1167000/1166901/88283612_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Eurostars Florence Boutique

Historic Centre of Florence

Save 100% on your flight

$1,166

per person

May 13 - May 18

found 1 day ago

Roundtrip non-stop flight included

Newark Liberty Intl. Airport (EWR) to Florence (FLR)

8.6/10 Excellent! (483 reviews)

The room was clean and the staff very accommodating. The breakfast was quite sufficient and had a good variety. The location is great. It's a short walk from the square, shopping and from restaurants.

Reviewed on Dec 13, 2025

![Grand Hotel Cavour](https://images.trvl-media.com/lodging/1000000/20000/11000/10993/50470bbc_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Grand Hotel Cavour

Historic Centre of Florence

Save 100% on your flight

$3,162

per person

Apr 30 - May 4

found 1 day ago

Roundtrip non-stop flight included

Boston (BOS) to Florence (FLR)

9.2/10 Wonderful! (1,002 reviews)

Great hotel near the center. Walking distance to everything. I enjoyed the quality of the hotel and the roof top bar was amazing. Good service. Rooms were a little small but not sure if that was because of my budget or whether the hotel rooms were just smaller due to the type/age of the building. All in all I would recommend and most of your time is spent outdoors anyway.

Reviewed on Mar 3, 2026

![Hotel Donatello](https://images.trvl-media.com/lodging/2000000/1200000/1192400/1192329/b82709a8_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Hotel Donatello

Historic Centre of Florence

$1,322

per person

Apr 27 - May 1

found 1 day ago

Roundtrip non-stop flight included

San Francisco (SFO) to Florence (FLR)

7.4/10 Good! (465 reviews)

Beautiful breakfast buffet. Great location to walking to all the beautiful sights. Would stay again!!

Reviewed on Oct 2, 2025

## Where to stay in Isolotto

Find the best Isolotto areas and neighborhoods for the activities you enjoy most. [Learn more about Isolotto](https://expedia.com/Florence-Isolotto.dx6141943)

![Arcetri showing a bridge and a river or creek](https://images.trvl-media.com/place/6075434/96ba5e7b-ca43-4d9f-9921-bde07164fcbc.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### Historic Centre of Florence

10 out of top 10 points of interest in this area

 Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias. 

[Find hotel + flight trips in Historic Centre of Florence](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Historic%20Centre%20of%20Florence&DestID=6141938&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

![Duomo featuring heritage architecture and street scenes as well as a small group of people](https://images.trvl-media.com/place/6141938/4816fa4b-dceb-4db3-bc3d-7fd0a5eb8789.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### Duomo

5/5(2,214 area reviews)

 Framed by a magnificent cathedral and charming streets lined with churches and restaurants, this neighborhood rests at the very heart of Florence. 

[Find hotel + flight trips in Duomo](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Duomo&DestID=6084346&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

![Ponte Vecchio showing a bridge and a river or creek](https://images.trvl-media.com/place/6075434/7c194037-41c2-40fb-a601-3da01105de7b.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### San Giovanni

 If you're spending some time in San Giovanni, Cathedral of Santa Maria del Fiore and Piazza della Repubblica are top sights worth seeing. 

[Find hotel + flight trips in San Giovanni](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=San%20Giovanni&DestID=553248635976383065&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

![Santa Maria Novella which includes heritage architecture, a church or cathedral and street scenes](https://images.trvl-media.com/place/6084343/def994ac-70f7-40cd-89a8-ec519f783ac9.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### Santa Maria Novella

4.5/5(1,057 area reviews)

 Spend some time in an attractive neighborhood close to the city center that encompasses ancient buildings and churches and a large park of outstanding beauty. 

[Find hotel + flight trips in Santa Maria Novella](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Santa%20Maria%20Novella&DestID=6084343&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

![Piazza Santa Croce showing a city and street scenes](https://images.trvl-media.com/place/6248194/236c34a1-6c95-481e-b9b8-957b594360cd.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### Santa Croce

4.5/5(211 area reviews)

 One of the historic districts of Florence has a network of medieval streets lined with opulent churches, leather stores, markets and atmospheric restaurants. 

[Find hotel + flight trips in Santa Croce](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Santa%20Croce&DestID=6084344&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

## Isolotto Hotel Deals

![IQ Hotel Firenze](https://images.trvl-media.com/lodging/90000000/89040000/89035100/89035039/72f32f77_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

IQ Hotel Firenze

Via Camillo Cavour, 88 Florence FI

Fully refundableReserve now, pay when you stay

$94 nightly

$120 total

Mar 5 - Mar 6

Total with taxes and fees

9.6/10 Exceptional! (1,181 reviews)

We had a really lovely stay here, the staff were very welcoming and attentive and did everything possible to make our stay enjoyable. The spa facilities were lovely and the free food and drink in the room was an unexpected bonus. Would highly recommend.

Reviewed on Mar 3, 2026

[](https://expedia.com/Hotel-Search?startDate=3%2F5%2F2026&endDate=3%2F6%2F2026&selected=89035039&PinnedHotelID=89035039&HadPinnedHotel=true&regionId=6141943)

![c-hotels Ambasciatori](https://images.trvl-media.com/lodging/1000000/10000/1900/1829/ac4739c5_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

c-hotels Ambasciatori

Via Luigi Alamanni 3 Florence FI

Fully refundableReserve now, pay when you stay

$119 nightly

$147 total

Mar 6 - Mar 7

Total with taxes and fees

8.2/10 Very Good! (1,000 reviews)

It was amazing and clean and really really perfect

Reviewed on Feb 17, 2026

[](https://expedia.com/Hotel-Search?startDate=3%2F6%2F2026&endDate=3%2F7%2F2026&selected=1829&PinnedHotelID=1829&HadPinnedHotel=true&regionId=6141943)

![Hotel Delle Nazioni](https://images.trvl-media.com/lodging/1000000/930000/920200/920176/dd1e8db6_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Hotel Delle Nazioni

Via Luigi Alamanni, 15 Florence FI

$93 nightly

$117 total

Mar 5 - Mar 6

Total with taxes and fees

8.4/10 Very Good! (1,005 reviews)

Old tired and noisy

Reviewed on Mar 3, 2026

[](https://expedia.com/Hotel-Search?startDate=3%2F5%2F2026&endDate=3%2F6%2F2026&selected=920176&PinnedHotelID=920176&HadPinnedHotel=true&regionId=6141943)

[See all 11,378 properties in Isolotto](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=3%2F5%2F2026&endDate=3%2F6%2F2026&regionId=6141943)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

All Inclusive Vacations

[](https://expedia.com/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Beach Vacations

[](https://expedia.com/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Kid Friendly Vacations

[](https://expedia.com/lp/theme-vacations/kid-friendly-vacations?rfrr=editorial.Kid_Friendly%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Golf Vacations

[](https://expedia.com/lp/theme-vacations/golf-vacations?rfrr=editorial.Golf_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/07/15/US_Luxury_VR_Miami.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Luxury Vacations

[](https://expedia.com/lp/theme-vacations/luxury-vacations?rfrr=editorial.Luxury_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/29/romantic.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Romantic Vacations

[](https://expedia.com/lp/theme-vacations/romantic-vacations?rfrr=editorial.Romantic_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/31952_v1_atfraraski22_insta_4.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Ski Vacations

[](https://expedia.com/lp/theme-vacations/ski-vacations?rfrr=editorial.Ski_Vacations.click)

![Gay Friendly Vacations](https://forever.travel-assets.com/flex/flexmanager/images/2023/06/15/LGBTQIA_Holiday_Package.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

LGBTQ Friendly Vacations

[](https://expedia.com/lp/theme-holidays/gay-friendly-holidays?rfrr=editorial.LGBTQ_Friendly%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2017/07/05/170615_Adventure_1320_2.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Adventure Vacations

[](https://expedia.com/lp/theme-vacations/adventure-vacations?rfrr=editorial.Adventure_Vacations.click)

![Vacations in Month](https://forever.travel-assets.com/flex/flexmanager/images/2023/05/10/mesog-34434-card-venice.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Where to go when

[](https://expedia.com/lp/b/where-to-go-when?rfrr=editorial.Where_to%20go%20when.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/21/honeymoon_hawaii.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Honeymoon Vacations

[](https://expedia.com/lp/theme-vacations/honeymoon-vacations?rfrr=editorial.Honeymoon_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/Mountain-vacations.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Mountain Vacations

[](https://expedia.com/lp/theme-vacations/mountain-vacations?rfrr=editorial.Mountain_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/fishing-vacations-2.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Fishing Vacations

[](https://expedia.com/lp/theme-vacations/fishing-vacations?rfrr=editorial.Fishing_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2019/05/16/Hyatt%20Zilara%20Cancun%20-%20All%20Inclusive%20-%20Adults%20Only.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Adults Only Vacations

[](https://expedia.com/lp/theme-vacations/adults-only-vacations?rfrr=editorial.Adults_Only%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/waterpark-vacations.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Waterpark Vacations

[](https://expedia.com/lp/theme-vacations/waterpark-vacations?rfrr=editorial.Waterpark_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/08/Caribean_scuba_diving.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Scuba Diving Vacations

[](https://expedia.com/lp/theme-vacations/scuba-diving-vacations?rfrr=editorial.Scuba_Diving%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/08/aruba_yoga.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Yoga Vacations

[](https://expedia.com/lp/theme-vacations/yoga-vacations?rfrr=editorial.Yoga_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2023/04/04/EPS-RBC-SummerBeachVacations-AdobeStock_206356322.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Cheap Vacations

[](https://expedia.com/lp/theme-vacations/cheap-vacations?rfrr=editorial.Cheap_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/06/26/1175883311.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Solo Vacations

[](https://expedia.com/lp/b/vacations/solo-vacations?rfrr=editorial.Solo_Vacations.click)

### Discover the most popular places to visit in Isolotto

![Piazza di Santa Maria Novella which includes a garden, heritage architecture and a church or cathedral](https://images.trvl-media.com/place/6167447/7f4e9e58-353d-4a42-8920-7d465f5e16de.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Piazza di Santa Maria Novella

4.5/5(22 reviews)

Relax before or after a long trip in this renovated piazza just a few minutes from Florence’s main train station.

[](https://expedia.com/Piazza-Di-Santa-Maria-Novella-Historic-Centre-of-Florence.d6167447.Vacation-Attraction)

![Cathedral of Santa Maria del Fiore featuring a city, heritage architecture and a church or cathedral](https://images.trvl-media.com/place/501046/58cc313e-b63c-4e3e-825f-1235037a9d48.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Cathedral of Santa Maria del Fiore

4.5/5(1,301 reviews)

The “Saint Mary of the Flower” cathedral and its towering dome have come to symbolize Florence.

[](https://expedia.com/Cathedral-Of-Santa-Maria-Del-Fiore-Historic-Centre-of-Florence.d501046.Vacation-Attraction)

![Uffizi Gallery in Florence in Italy](https://images.trvl-media.com/place/6075462/638682df-5d23-4089-83af-be7850616ae1.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Uffizi Gallery

4.5/5(1,486 reviews)

Art lovers will be in their element in this famous museum, home to the most extensive and important collection of masterpieces in the world.

[](https://expedia.com/Uffizi-Gallery-Historic-Centre-of-Florence.d6075462.Vacation-Attraction)

### Things to do

![Skip-the-Line Duomo: Priority-Access 30-Minute Guided Tour](https://mediaim.expedia.com/localexpert/507532/cbdef260-9919-420e-a482-1d2f9b3d6ccc.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Skip-the-Line Florence Duomo: Priority-Access Express Guided Tour

$26

per adult

**80%** of travellers recommend

[](https://expedia.com/things-to-do/skip-the-line-florence-duomo-priority-access-express-guided-tour.a507532.activity-details)

![Micheal Angelo's David](https://mediaim.expedia.com/localexpert/2479829/2bebb71d-abeb-452a-9a00-2b6fddf3b233.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Skip the Line: Florence's Accademia Gallery Priority Entrance Ticket

$37

per adult

**86%** of travellers recommend

[](https://expedia.com/things-to-do/skip-the-line-florences-accademia-gallery-priority-entrance-ticket.a2479829.activity-details)

![Tuscany Experience In Pisa, Siena, San Gimignano & Chianti](https://mediaim.expedia.com/localexpert/880286/269c0081-b51e-4e1d-ac21-b19cf125da10.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Tuscany Experience In Pisa, Siena, San Gimignano & Chianti

$101

per adult

**92%** of travellers recommend

[](https://expedia.com/things-to-do/tuscany-experience-in-pisa.a880286.activity-details)

[See all activities in Florence](https://expedia.com/things-to-do/search?rid=6141943)

\* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.