
Isolotto Vacations from $1,433
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Your Isolotto Vacation
Reserving a tailor-made Isolotto vacation package is a good way to know the ins and outs of this unique neighborhood. From its must-see spots to its lesser-known delights, there's a lot to delve into. When it's time to head out and explore, you'll find plenty of popular attractions nearby including Cathedral of Santa Maria del Fiore, Ponte Vecchio and Uffizi Gallery. Visit one, two or more during your trip to Isolotto. Stop dreaming and start doing. When it's time to book your next vacation to Isolotto, Expedia is here to help.
The Latest Isolotto Vacation Packages




The Place Firenze
Reviewed on Apr 3, 2026

Residenza Florentia
Reviewed on Apr 6, 2026
Where to stay in Isolotto

Historic Centre of Florence
Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.
Isolotto Hotel Deals

The Social Hub Florence Lavagnini
Comfy hotel, spacious, loved the roof top gym.
Reviewed on Apr 8, 2026

IQ Hotel Firenze
We really enjoyed our stay at iQ Hotel Firenze. The hotel is modern, very clean, and in a great location close to the city center, which made it easy to explore Florence. The breakfast was excellent, with a wide variety of food and many healthy options. The staff was also very helpful and welcoming. ...
Reviewed on Apr 8, 2026

Hotel Machiavelli Palace
Breakfast very fresh and large buffet Very nice staff .only problem i had was mattress was too hard and pilllow was too soft .
Reviewed on Apr 2, 2026
Discover the most popular places to visit in Isolotto

Piazza di Santa Maria Novella
Relax before or after a long trip in this renovated piazza just a few minutes from Florence’s main train station.

Cathedral of Santa Maria del Fiore
The “Saint Mary of the Flower” cathedral and its towering dome have come to symbolize Florence.

Ponte Vecchio
Take a trip over Florence’s iconic bridge, spared by the Nazis for its beauty and home to jewelers for more than four centuries.
Things to do

Small-Group Wine Tasting Experience in the Tuscan Countryside

Skip-the-Line Florence Duomo: Priority-Access Express Guided Tour























