Title: Isolotto Vacation Packages 2026 from $1,385 | Expedia.com

[Isolotto Travel Guide](https://expedia.com/Florence-Isolotto.dx6141943)[Hotels in Isolotto](https://expedia.com/Isolotto-Florence-Hotels.0-n6141943-0.Travel-Guide-Filter-Hotels)[Flights to Florence](https://expedia.com/Cheap-Flights-To-Florence.d1222.Travel-Guide-Flights)[Things to do in Florence](https://expedia.com/Things-To-Do-In-Florence.d1222.Travel-Guide-Activities)[Car Rentals in Isolotto](https://expedia.com/Car-Rentals-In-Isolotto.d6141943.Car-Rental-Guide)

![](https://images.trvl-media.com/place/6141943/836e5c0b-5439-4b83-86da-dc1553121395.jpg?impolicy=fcrop&w=1200&h=300&q=medium)

# Isolotto Vacations from $1,385

## Book a Hotel + Flight or Car together to unlock savings

## Your Isolotto Vacation

Reserving a tailor-made Isolotto vacation package is a good way to know the ins and outs of this unique neighborhood. From its must-see spots to its lesser-known delights, there's a lot to delve into. When it's time to head out and explore, you'll find plenty of popular attractions nearby including [Cathedral of Santa Maria del Fiore](https://www.expedia.com/Cathedral-Of-Santa-Maria-Del-Fiore-Duomo.d501046.Vacation-Attraction), [Ponte Vecchio](https://www.expedia.com/Ponte-Vecchio-Oltrarno.d6075434.Vacation-Attraction) and [Uffizi Gallery](https://www.expedia.com/Uffizi-Gallery-Duomo.d6075462.Vacation-Attraction). Visit one, two or more during your trip to Isolotto. Stop dreaming and start doing. When it's time to book your next vacation to Isolotto, Expedia is here to help.

## The Latest Isolotto Vacation Packages

Price found within the past 48 hours. Click for updated prices.

![Aurum Firenze](https://images.trvl-media.com/lodging/29000000/28970000/28962000/28961941/3c6602ae_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Aurum Firenze

Historic Centre of Florence

$1,385

per person

Jun 19 - Jun 25

found 1 day ago

Roundtrip non-stop flight included

New York (NYC) to Florence (FLR)

7.6/10 Good! (1,008 reviews)

The maid or the cleaning lady she is really nice and she cleaned my room very well, I am thankful for her!! I enjoyed my room I hope to get the same room again :)

Reviewed on Apr 4, 2026

![Eurostars Florence Boutique](https://images.trvl-media.com/lodging/2000000/1170000/1167000/1166901/88283612_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Eurostars Florence Boutique

Historic Centre of Florence

$1,694

per person

May 12 - May 17

found 1 day ago

Roundtrip non-stop flight included

Boston (BOS) to Florence (FLR)

8.6/10 Excellent! (483 reviews)

The room was clean and the staff very accommodating. The breakfast was quite sufficient and had a good variety. The location is great. It's a short walk from the square, shopping and from restaurants.

Reviewed on Dec 13, 2025

![Park Hotel Villa Ariston](https://images.trvl-media.com/lodging/2000000/1170000/1160500/1160411/5fdfdcc7_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Park Hotel Villa Ariston

$1,841

per person

Jun 19 - Jun 25

found 1 day ago

Roundtrip non-stop flight included

New York (NYC) to Florence (FLR)

8.8/10 Excellent! (128 reviews)

Amazing property with good facilities. Easy access to the beach and local restaurants. Simming pool is excellent and the staff very friendly. You can have a nice and peaceful stay there

Reviewed on Sep 8, 2024

![Hotel Santa Maria Novella](https://images.trvl-media.com/lodging/1000000/930000/920500/920451/7b96b723_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Hotel Santa Maria Novella

Historic Centre of Florence

$2,563

per person

May 12 - May 17

found 1 day ago

Roundtrip non-stop flight included

Boston (BOS) to Florence (FLR)

9.6/10 Exceptional! (1,006 reviews)

The breakfast room is so pretty, and the breakfast is truly excellent. The staff were friendly and professional and welcomed our little dogs. It was quiet even though it is right in the center of everything. The bed was very comfortable and all the linens were of excellent quality, i would definitely stay here again,

Reviewed on Mar 29, 2026

![Hotel L'Orologio Firenze](https://images.trvl-media.com/lodging/3000000/2980000/2970900/2970892/117818f0_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Hotel L'Orologio Firenze

Historic Centre of Florence

$2,312

per person

May 12 - May 17

found 1 day ago

Roundtrip non-stop flight included

Boston (BOS) to Florence (FLR)

9.6/10 Exceptional! (1,008 reviews)

Excellent location and staff

Reviewed on Mar 13, 2026

## Where to stay in Isolotto

Find the best Isolotto areas and neighborhoods for the activities you enjoy most. [Learn more about Isolotto](https://expedia.com/Florence-Isolotto.dx6141943)

![Historic Centre of Florence](https://images.trvl-media.com/place/6075434/96ba5e7b-ca43-4d9f-9921-bde07164fcbc.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### Historic Centre of Florence

10 out of top 10 points of interest in this area

 Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias. 

[Find hotel + flight trips in Historic Centre of Florence](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Historic%20Centre%20of%20Florence&DestID=6141938&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

![Duomo](https://images.trvl-media.com/place/6141938/4816fa4b-dceb-4db3-bc3d-7fd0a5eb8789.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### Duomo

5/5(2,242 area reviews)

 Framed by a magnificent cathedral and charming streets lined with churches and restaurants, this neighborhood rests at the very heart of Florence. 

[Find hotel + flight trips in Duomo](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Duomo&DestID=6084346&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

![San Giovanni](https://images.trvl-media.com/place/6075434/7c194037-41c2-40fb-a601-3da01105de7b.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### San Giovanni

 If you're spending some time in San Giovanni, Uffizi Gallery and Cathedral of Santa Maria del Fiore are top sights worth seeing. 

[Find hotel + flight trips in San Giovanni](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=San%20Giovanni&DestID=553248635976383065&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

![Santa Maria Novella](https://images.trvl-media.com/place/6084343/def994ac-70f7-40cd-89a8-ec519f783ac9.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### Santa Maria Novella

4.5/5(1,073 area reviews)

 Spend some time in an attractive neighborhood close to the city center that encompasses ancient buildings and churches and a large park of outstanding beauty. 

[Find hotel + flight trips in Santa Maria Novella](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Santa%20Maria%20Novella&DestID=6084343&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

![Santa Croce](https://images.trvl-media.com/place/6248194/236c34a1-6c95-481e-b9b8-957b594360cd.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### Santa Croce

4.5/5(213 area reviews)

 One of the historic districts of Florence has a network of medieval streets lined with opulent churches, leather stores, markets and atmospheric restaurants. 

[Find hotel + flight trips in Santa Croce](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Santa%20Croce&DestID=6084344&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

## Isolotto Hotel Deals

![The Social Hub Florence Lavagnini](https://images.trvl-media.com/lodging/24000000/23200000/23198300/23198289/fdc60d68_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

The Social Hub Florence Lavagnini

Viale Spartaco Lavagnini 70 72 Florence FI

Fully refundableReserve now, pay when you stay

$154 nightly

$186 total

Apr 6 - Apr 7

Total with taxes and fees

9/10 Wonderful! (1,320 reviews)

Very good location rooms are okay but small little bit confusing lifts for exploring hotels for older travelers but you get after little while beautiful swings on entry View from top floor is beautiful

Reviewed on Apr 3, 2026

[](https://expedia.com/Hotel-Search?startDate=4%2F6%2F2026&endDate=4%2F7%2F2026&selected=23198289&PinnedHotelID=23198289&HadPinnedHotel=true&regionId=6141943)

![IQ Hotel Firenze](https://images.trvl-media.com/lodging/90000000/89040000/89035100/89035039/72f32f77_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

IQ Hotel Firenze

Via Camillo Cavour, 88 Florence FI

Fully refundableReserve now, pay when you stay

$192 nightly

$228 total

Apr 12 - Apr 13

Total with taxes and fees

9.6/10 Exceptional! (1,202 reviews)

Amazing! Only negatives were the pool hours were short and that they charge for pool towels. Everything else was absolutely amazing. The breakfast was fresh, delicious, and had a good variety. The room was beautiful and clean. The staff was helpful and kind. Absolutely recommend to anyone but especially ...

Reviewed on Mar 31, 2026

[](https://expedia.com/Hotel-Search?startDate=4%2F12%2F2026&endDate=4%2F13%2F2026&selected=89035039&PinnedHotelID=89035039&HadPinnedHotel=true&regionId=6141943)

![Hotel Machiavelli Palace](https://images.trvl-media.com/lodging/1000000/530000/521300/521248/ab2b96dc_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Hotel Machiavelli Palace

Via Nazionale 10 Florence FI

Fully refundableReserve now, pay when you stay

$123 nightly

$149 total

Apr 6 - Apr 7

Total with taxes and fees

8.4/10 Very Good! (171 reviews)

Breakfast very fresh and large buffet Very nice staff .only problem i had was mattress was too hard and pilllow was too soft .

Reviewed on Apr 2, 2026

[](https://expedia.com/Hotel-Search?startDate=4%2F6%2F2026&endDate=4%2F7%2F2026&selected=521248&PinnedHotelID=521248&HadPinnedHotel=true&regionId=6141943)

[See all 11,515 properties in Isolotto](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=4%2F5%2F2026&endDate=4%2F6%2F2026&regionId=6141943)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

All Inclusive Vacations

[](https://expedia.com/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Beach Vacations

[](https://expedia.com/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Kid Friendly Vacations

[](https://expedia.com/lp/theme-vacations/kid-friendly-vacations?rfrr=editorial.Kid_Friendly%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Golf Vacations

[](https://expedia.com/lp/theme-vacations/golf-vacations?rfrr=editorial.Golf_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/07/15/US_Luxury_VR_Miami.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Luxury Vacations

[](https://expedia.com/lp/theme-vacations/luxury-vacations?rfrr=editorial.Luxury_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/29/romantic.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Romantic Vacations

[](https://expedia.com/lp/theme-vacations/romantic-vacations?rfrr=editorial.Romantic_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/31952_v1_atfraraski22_insta_4.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Ski Vacations

[](https://expedia.com/lp/theme-vacations/ski-vacations?rfrr=editorial.Ski_Vacations.click)

![Gay Friendly Vacations](https://forever.travel-assets.com/flex/flexmanager/images/2023/06/15/LGBTQIA_Holiday_Package.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

LGBTQ Friendly Vacations

[](https://expedia.com/lp/theme-holidays/gay-friendly-holidays?rfrr=editorial.LGBTQ_Friendly%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2017/07/05/170615_Adventure_1320_2.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Adventure Vacations

[](https://expedia.com/lp/theme-vacations/adventure-vacations?rfrr=editorial.Adventure_Vacations.click)

![Vacations in Month](https://forever.travel-assets.com/flex/flexmanager/images/2023/05/10/mesog-34434-card-venice.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Where to go when

[](https://expedia.com/lp/b/where-to-go-when?rfrr=editorial.Where_to%20go%20when.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/21/honeymoon_hawaii.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Honeymoon Vacations

[](https://expedia.com/lp/theme-vacations/honeymoon-vacations?rfrr=editorial.Honeymoon_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/Mountain-vacations.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Mountain Vacations

[](https://expedia.com/lp/theme-vacations/mountain-vacations?rfrr=editorial.Mountain_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/fishing-vacations-2.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Fishing Vacations

[](https://expedia.com/lp/theme-vacations/fishing-vacations?rfrr=editorial.Fishing_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2019/05/16/Hyatt%20Zilara%20Cancun%20-%20All%20Inclusive%20-%20Adults%20Only.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Adults Only Vacations

[](https://expedia.com/lp/theme-vacations/adults-only-vacations?rfrr=editorial.Adults_Only%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/waterpark-vacations.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Waterpark Vacations

[](https://expedia.com/lp/theme-vacations/waterpark-vacations?rfrr=editorial.Waterpark_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/08/Caribean_scuba_diving.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Scuba Diving Vacations

[](https://expedia.com/lp/theme-vacations/scuba-diving-vacations?rfrr=editorial.Scuba_Diving%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/08/aruba_yoga.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Yoga Vacations

[](https://expedia.com/lp/theme-vacations/yoga-vacations?rfrr=editorial.Yoga_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2023/04/04/EPS-RBC-SummerBeachVacations-AdobeStock_206356322.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Cheap Vacations

[](https://expedia.com/lp/theme-vacations/cheap-vacations?rfrr=editorial.Cheap_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/06/26/1175883311.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Solo Vacations

[](https://expedia.com/lp/b/vacations/solo-vacations?rfrr=editorial.Solo_Vacations.click)

### Discover the most popular places to visit in Isolotto

![Piazza di Santa Maria Novella](https://images.trvl-media.com/place/6167447/7f4e9e58-353d-4a42-8920-7d465f5e16de.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Piazza di Santa Maria Novella

Relax before or after a long trip in this renovated piazza just a few minutes from Florence’s main train station.

[](https://expedia.com/Piazza-Di-Santa-Maria-Novella-Historic-Centre-of-Florence.d6167447.Vacation-Attraction)

![Cathedral of Santa Maria del Fiore](https://images.trvl-media.com/place/501046/58cc313e-b63c-4e3e-825f-1235037a9d48.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Cathedral of Santa Maria del Fiore

The “Saint Mary of the Flower” cathedral and its towering dome have come to symbolize Florence.

[](https://expedia.com/Cathedral-Of-Santa-Maria-Del-Fiore-Historic-Centre-of-Florence.d501046.Vacation-Attraction)

![Ponte Vecchio](https://images.trvl-media.com/place/6075434/67189072-9377-4114-81b7-8ffaa6705976.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Ponte Vecchio

Take a trip over Florence’s iconic bridge, spared by the Nazis for its beauty and home to jewelers for more than four centuries.

[](https://expedia.com/Ponte-Vecchio-Historic-Centre-of-Florence.d6075434.Vacation-Attraction)

### Things to do

![City Sightseeing Florence Hop-on Hop-off](https://mediaim.expedia.com/localexpert/507279/4825cc48-9826-48b2-bfa5-8b03f7177e99.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### City Sightseeing Florence Hop-on Hop-off Bus Tour

$35

per adult

**76%** of travellers recommend

[](https://expedia.com/things-to-do/city-sightseeing-florence-hop-on-hop-off-bus-tour.a507279.activity-details)

![Small-Group Wine Tasting Experience in the Tuscan Countryside](https://mediaim.expedia.com/localexpert/1137622/a19a4ec1-65bf-4731-8e59-f83e639bcf44.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Small-Group Wine Tasting Experience in the Tuscan Countryside

$102

per adult

**98%** of travellers recommend

[](https://expedia.com/things-to-do/small-group-wine-tasting-experience-in-the-tuscan-countryside.a1137622.activity-details)

![Skip-the-Line Duomo: Priority-Access 30-Minute Guided Tour](https://mediaim.expedia.com/localexpert/507532/cbdef260-9919-420e-a482-1d2f9b3d6ccc.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Skip-the-Line Florence Duomo: Priority-Access Express Guided Tour

$26

per adult

**80%** of travellers recommend

[](https://expedia.com/things-to-do/skip-the-line-florence-duomo-priority-access-express-guided-tour.a507532.activity-details)

[See all activities in Florence](https://expedia.com/things-to-do/search?rid=6141943)

\* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.