Title: Main Street Hyannis Tours - Book Now | Expedia.com [Main Street Hyannis Hotels](https://expedia.com/Main-Street-Hyannis-Hotels.0-l6287458-0.Travel-Guide-Filter-Hotels)[Flights to Hyannis](https://expedia.com/Cheap-Flights-To-Hyannis.d1544.Travel-Guide-Flights)[Things to do in Hyannis](https://expedia.com/Things-To-Do-In-Hyannis.d1544.Travel-Guide-Activities)[Car Rentals in Main Street Hyannis](https://expedia.com/Car-Rentals-In-Main-Street-Hyannis.d6287458.Car-Rental-Guide)[Hyannis Vacation Packages](https://expedia.com/Hyannis.d1544.Destination-Travel-Guides) # Main Street Hyannis Tours ![Main Street Hyannis which includes street scenes as well as a couple](https://images.trvl-media.com/place/6287458/3dc1167b-95a0-4295-b537-9961081522cb.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Main Street Hyannis which includes street scenes as well as a couple](https://images.trvl-media.com/place/6287458/3dc1167b-95a0-4295-b537-9961081522cb.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Main Street Hyannis showing signage](https://images.trvl-media.com/place/6287458/6cbd6bcb-75e5-4848-be65-87e11f5c8e91.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Main Street Hyannis featuring street scenes as well as a couple](https://images.trvl-media.com/place/6287458/f083813a-eac6-4b18-a763-a901fa1ed4e5.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Main Street Hyannis](https://images.trvl-media.com/place/6287458/41cb7c4b-31e0-402f-ba25-cc551d995f6c.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ## Visit Main Street Hyannis Activities [Hyannis Travel Guide](https://expedia.com/Hyannis.dx1544) --- --- ## Plan a trip to see Main Street Hyannis Price found within the past 48 hours. Click for updated prices. ![Margaritaville Resort Cape Cod](https://images.trvl-media.com/lodging/1000000/20000/12900/12897/b57e0b1f_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Margaritaville Resort Cape Cod $728 per person May 24 - May 28 found 6 hours ago Roundtrip non-stop flight included Dallas (DFW) to Hyannis (HYA) 8.8/10 Excellent! (401 reviews) I love this resort. Close enough to home and just enough to make it feel like your in paradise for a little while. Reviewed on Mar 1, 2026 ![Chapter House](https://images.trvl-media.com/lodging/2000000/1200000/1196200/1196169/d1cecd38_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Chapter House Save 100% on your flight $756 per person May 24 - May 30 found 1 day ago Roundtrip flight included New York (JFK) to Hyannis (HYA) 9.2/10 Wonderful! (162 reviews) This property was clean and well maintained. There was ample parking and the staff was very friendly. Reviewed on Sep 26, 2025 ### Popular places to visit ![John F. Kennedy Hyannis Museum showing a statue or sculpture](https://images.trvl-media.com/place/6070185/7e9e6a58-eb55-48ff-bc35-a3283de6db0c.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### John F. Kennedy Hyannis Museum Learn about the 35th president of the United States at this revealing museum, which is just a short distance from the Kennedy Compound. [](https://expedia.com/John-F-Kennedy-Hyannis-Museum-Hyannis.d6070185.Vacation-Attraction) ![Hyannis](https://images.trvl-media.com/place/553248635146342095/f4f9f2be-5681-4d82-8f2a-a01d46fc93fc.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Cape Cod Maritime Museum Learn about boats, boatbuilding and more at this beloved Hyannis museum dedicated to inspiring and educating visitors about maritime topics. [](https://expedia.com/Cape-Cod-Maritime-Museum-Hyannis.d553248635146342095.Vacation-Attraction) ![Hyannis](https://images.trvl-media.com/place/6286986/68f1113f-193c-4991-a964-5912a97a8e48.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### St. Francis Xavier Church After visiting St. Francis Xavier Church, make a plan to see the other sights and activities in Hyannis. Wander the beautiful beaches and waterfront in this family-friendly area. [](https://expedia.com/St-Francis-Xavier-Church-Hyannis.d6286986.Vacation-Attraction) ![Hyannis Harbor which includes a sunset and a bay or harbor as well as a small group of people](https://images.trvl-media.com/place/6127091/1a09cb90-8904-47ba-add1-64a005b0f780.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Hyannis Harbor See the Cape Cod peninsula from a different perspective by riding a boat out of this picturesque harbor or wandering along its docks and jetties. [](https://expedia.com/Hyannis-Harbor-Hyannis.d6127091.Vacation-Attraction) ![John F. Kennedy Memorial](https://images.trvl-media.com/place/6286978/c00333f7-44ea-4627-8dea-9172edb188af.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### John F. Kennedy Memorial Take a moment to reflect on John F. Kennedy’s defining role in American politics, as well as his untimely death, at this poignant memorial. [](https://expedia.com/John-F-Kennedy-Memorial-Hyannis.d6286978.Vacation-Attraction) #### Hyannis Armory Learn about the local history of Hyannis when you take a trip to Hyannis Armory. Wander the waterfront and beautiful beaches in the area. [](https://expedia.com/Hyannis-Armory-Hyannis.d950930054190297088.Vacation-Attraction) --- ## Best Lodging Options Near Main Street Hyannis ## Check availability on hotels close to Main Street Hyannis [Tonight ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=6287458&startDate=2026-03-04&endDate=2026-03-05)[Mar 4 - Mar 5](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=6287458&startDate=2026-03-04&endDate=2026-03-05) [Tomorrow night ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=6287458&startDate=2026-03-05&endDate=2026-03-06)[Mar 5 - Mar 6](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=6287458&startDate=2026-03-05&endDate=2026-03-06) [This weekend ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=6287458&startDate=3%2F6%2F2026&endDate=3%2F8%2F2026)[Mar 6 - Mar 8](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=6287458&startDate=3%2F6%2F2026&endDate=3%2F8%2F2026) [Next weekend ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=6287458&startDate=3%2F13%2F2026&endDate=3%2F15%2F2026)[Mar 13 - Mar 15](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=6287458&startDate=3%2F13%2F2026&endDate=3%2F15%2F2026) ![Courtyard Resort](https://images.trvl-media.com/lodging/116000000/115250000/115243800/115243739/5d7ebe6e_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Courtyard Resort 125 North St Hyannis MA [](https://expedia.com/Hyannis-Hotels-Courtyard-Resort.h115243739.Hotel-Information) ![Margaritaville Resort Cape Cod](https://images.trvl-media.com/lodging/1000000/20000/12900/12897/b57e0b1f_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Margaritaville Resort Cape Cod 1225 Iyannough Rd Hyannis MA [](https://expedia.com/Hyannis-Hotels-Cape-Codder-Resort-And-Spa.h12897.Hotel-Information) ![Hyannis Travel Inn](https://images.trvl-media.com/lodging/2000000/1380000/1379200/1379109/5a8499c3_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hyannis Travel Inn 18 North St Hyannis MA [](https://expedia.com/Hyannis-Hotels-Hyannis-Travel-Inn.h1379109.Hotel-Information) ![Comfort Inn Hyannis - Cape Cod](https://images.trvl-media.com/lodging/2000000/1250000/1240500/1240460/b37d6e5b_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Comfort Inn Hyannis - Cape Cod 259 Main Street Hyannis MA [](https://expedia.com/Hyannis-Hotels-Comfort-Inn.h1240460.Hotel-Information) ![Hyannis Plaza Hotel](https://images.trvl-media.com/lodging/2000000/1120000/1119300/1119277/f7fc1d07_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hyannis Plaza Hotel 662 Main Street Hyannis MA [](https://expedia.com/Hyannis-Hotels-Hyannis-Plaza-Hotel.h1119277.Hotel-Information) ![Hyannis Harbor Hotel](https://images.trvl-media.com/lodging/1000000/60000/55000/54945/0271fbcb_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hyannis Harbor Hotel 213 Ocean St Hyannis MA [](https://expedia.com/Hyannis-Hotels-Hyannis-Harbor-Hotel.h54945.Hotel-Information) ![SeaCoast Inn](https://images.trvl-media.com/lodging/10000000/9410000/9400300/9400206/90-92aafafd_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### SeaCoast Inn 33 Ocean Street Hyannis MA [](https://expedia.com/Hyannis-Hotels-SeaCoast-Inn.h9400206.Hotel-Information) ![Heritage House Inn on Cape Cod, an Ascend Collection Hotel](https://images.trvl-media.com/lodging/65000000/64650000/64648900/64648858/42f74739_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Heritage House Inn on Cape Cod, an Ascend Collection Hotel 540 Old Colony Rd Hyannis MA [](https://expedia.com/Hyannis-Hotels-Heritage-House-Inn.h64648858.Hotel-Information) ![Americas Best Value Inn & Suites Hyannis Cape Cod](https://images.trvl-media.com/lodging/1000000/920000/913800/913772/b88f545c_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Americas Best Value Inn & Suites Hyannis Cape Cod 206 Main St Hyannis MA [](https://expedia.com/Hyannis-Hotels-Americas-Best-Value-Inn-Suites-Hyannis-Cape-Cod.h913772.Hotel-Information) [See all 3,522 properties in Main Street Hyannis](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package®ionId=6287458) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. 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