Main Street Hyannis Tours

Main Street Hyannis which includes street scenes as well as a couple
Main Street Hyannis showing signage
Main Street Hyannis featuring street scenes as well as a couple
Main Street Hyannis
Main Street Hyannis showing signage

Plan a trip to see Main Street Hyannis

Price found within the past 48 hours. Click for updated prices.
Chapter House

Chapter House

3.5 out of 5
Save 100% on your flight
per person
Sep 18 - Sep 21
found 2 hours ago
Roundtrip flight included
Detroit (DTW) to Hyannis (HYA)
9.4/10 Exceptional! (149 reviews)
The property was absolutely stunning. We also had a problem with the shower and having hot water and they immediately accommodated us by putting us in the main house. Wonderful stay!

Reviewed on Jul 13, 2025

Inn on Main

Inn on Main

3.5 out of 5
Save 100% on your flight
per person
Sep 18 - Sep 21
found 2 hours ago
Roundtrip flight included
Detroit (DTW) to Hyannis (HYA)
10/10 Exceptional! (68 reviews)
Terrific B&B on Cape Cod - super dog friendly and very hospitable! Excellent breakfasts, charming space, and wonderful hosts. It’s a very convenient mid-Cape location, you will not regret booking with them.

Reviewed on May 10, 2025

Anchor In Distinctive Waterfront Lodging

Anchor In Distinctive Waterfront Lodging

3 out of 5
Save 100% on your flight
per person
Sep 18 - Sep 21
found 2 hours ago
Roundtrip flight included
Detroit (DTW) to Hyannis (HYA)
9.4/10 Exceptional! (1,001 reviews)
Definitely a must stay! Will be back!

Reviewed on Jul 10, 2025

Popular places to visit

John F. Kennedy Hyannis Museum showing a statue or sculpture

John F. Kennedy Hyannis Museum

4.5/5(137 reviews)

Learn about the 35th president of the United States at this revealing museum, which is just a short distance from the Kennedy Compound.

John F. Kennedy Hyannis Museum
Hyannis

Cape Cod Maritime Museum

Learn about boats, boatbuilding and more at this beloved Hyannis museum dedicated to inspiring and educating visitors about maritime topics.

Cape Cod Maritime Museum
Hyannis

St. Francis Xavier Church

4.5/5(8 reviews)

Learn about the local history of Hyannis with a stop at St. Francis Xavier Church. Amble around this family-friendly area's beautiful beaches and enjoy its seafood restaurants.

St. Francis Xavier Church
Hyannis Harbor which includes a sunset and a bay or harbor as well as a small group of people

Hyannis Harbor

4.5/5(591 reviews)

See the Cape Cod peninsula from a different perspective by riding a boat out of this picturesque harbor or wandering along its docks and jetties.

Hyannis Harbor
John F. Kennedy Memorial

John F. Kennedy Memorial

4.5/5(24 reviews)

Take a moment to reflect on John F. Kennedy’s defining role in American politics, as well as his untimely death, at this poignant memorial.

John F. Kennedy Memorial

Hyannis Armory

Learn about the local history of Hyannis when you take a trip to Hyannis Armory. Wander the waterfront and beautiful beaches in the area.

Hyannis Armory

Best Lodging Options Near Main Street Hyannis

Hyannis Harbor Hotel
Hyannis Harbor Hotel
3.5 out of 5
213 Ocean St, Hyannis, MA
Hyannis Harbor Hotel
Hyannis Inn
Hyannis Inn
2 out of 5
473 MAIN ST, Hyannis, MA
Hyannis Inn
Americas Best Value Inn & Suites Hyannis Cape Cod
Americas Best Value Inn & Suites Hyannis Cape Cod
2 out of 5
206 Main St, Hyannis, MA
Americas Best Value Inn & Suites Hyannis Cape Cod
Hyannis Travel Inn
Hyannis Travel Inn
2.5 out of 5
18 North St, Hyannis, MA
Hyannis Travel Inn
Hyannis Plaza Hotel
Hyannis Plaza Hotel
2.5 out of 5
662 Main Street, Hyannis, MA
Hyannis Plaza Hotel
Cape Sands Inn
Cape Sands Inn
2.5 out of 5
149 Main St - RT 28, West Yarmouth, MA
Cape Sands Inn
Comfort Inn Hyannis - Cape Cod
Comfort Inn Hyannis - Cape Cod
2.5 out of 5
259 Main Street, Hyannis, MA
Comfort Inn Hyannis - Cape Cod
Bayside Resort Hotel
Bayside Resort Hotel
3 out of 5
225 Route 28, West Yarmouth, MA
Bayside Resort Hotel
Heritage House Inn on Cape Cod
Heritage House Inn on Cape Cod
2.5 out of 5
540 Old Colony Rd, Hyannis, MA
Heritage House Inn on Cape Cod
See all 3,705 properties in Main Street Hyannis
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.