Southeast Ohio Vacations from $539

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • payments icon

    Better together

    Save up to $1,045 when you book a flight and hotel together*
    lob hotels icon

    Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
    lob packages icon

    Rest easy

    Plan, book, and manage your trip all in one place

Your Southeast Ohio Vacation

Choose a vacation package to Southeast Ohio and make planning your getaway quick and easy. With the logistics arranged before you depart, you can focus on enjoying every second in this destination. Begin your trip to Southeast Ohio with some time in Clarksville visiting popular sights like KFC Yum Center and Kentucky Kingdom. Athens is another city that lures crowds from far and wide. Fun Barn and Strouds Run State Park are two of the top places to see in this destination. Expedia is a one-stop shop for planning your Southeast Ohio vacation. From accommodations and flights, to car rentals and activities, we know how to create a travel experience like no other.

The Latest Southeast Ohio vacation packages

Price found within the past 48 hours. Click for updated prices.
The Jungle Oasis
Prescott Master House
Jungle Casa Uno
Don't see what you're looking for?
See all available trips from Columbus to Southeast Ohio
View all trips

Discover the most popular places to visit in Southeast Ohio

Southeast Ohio Hotel Deals

Days Inn by Wyndham Columbus East Airport

Days Inn by Wyndham Columbus East Airport

2.5 out of 5
2100 Brice Road, Reynoldsburg, OH
$70 nightly
The price is $83 total per night from Aug 21 to Aug 22
$83 total
Aug 21 - Aug 22
Total includes taxes and fees
7/10 Good! (1,007 reviews)
"The pool area stay clean , staff shows respect also house keeping good"

Reviewed on Aug 14, 2025

Days Inn by Wyndham Columbus East Airport
Cherry Valley Hotel

Cherry Valley Hotel

3 out of 5
2299 Cherry Valley Rd Se, Newark, OH
Fully refundableReserve now, pay when you stay
$114 nightly
The price is $130 total per night from Aug 24 to Aug 25
$130 total
Aug 24 - Aug 25
Total includes taxes and fees
8.6/10 Excellent! (949 reviews)
"Great hotel"

Reviewed on Aug 17, 2025

Cherry Valley Hotel
Ohio University Inn & Conference Center

Ohio University Inn & Conference Center

3.5 out of 5
331 Richland Ave, Athens, OH
Fully refundableReserve now, pay when you stay
$113 nightly
The price is $128 total per night from Sep 14 to Sep 15
$128 total
Sep 14 - Sep 15
Total includes taxes and fees
9/10 Wonderful! (1,004 reviews)
"Extremely welcoming staff and beautiful rooms. Great amenities and service"

Reviewed on Aug 16, 2025

Ohio University Inn & Conference Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

More vacations you might like

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.