Southeast Ohio Vacations from $394
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Your Southeast Ohio Vacation
Choose a vacation package to Southeast Ohio and make planning your getaway quick and easy. With the logistics arranged before you depart, you can focus on enjoying every second in this destination. Begin your trip to Southeast Ohio with some time in Clarksville visiting popular sights like KFC Yum Center and Kentucky Kingdom. Athens is another city that lures crowds from far and wide. Fun Barn and Strouds Run State Park are two of the top places to see in this destination. Expedia is a one-stop shop for planning your Southeast Ohio vacation. From accommodations and flights, to car rentals and activities, we know how to create a travel experience like no other.
The Latest Southeast Ohio vacation packages
Price found within the past 48 hours. Click for updated prices.
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See all available trips from Columbus to Southeast Ohio
View all tripsDiscover the most popular places to visit in Southeast Ohio
Ohio University
5/5(205 reviews)
Explore the campus of Ohio University, during your travels in Athens. Discover the bars and its entertainment venues while you're in the area.
Denison University
4.5/5(73 reviews)
Enjoy the collegiate vibe when you visit Denison University, during your trip to Granville. Take in the entertainment venues in this romantic area.
The Wilds
4.5/5(51 reviews)
See the exotic and native animals who live at The Wilds during your travels in Chandlersville. Discover the area's museums and monuments.
Southeast Ohio Hotel Deals
Days Inn by Wyndham Columbus East Airport
2100 Brice Road, Reynoldsburg, OH
$68 nightly
The price is $80 total per night from Aug 31 to Sep 1
$80 total
Aug 31 - Sep 1
Total with taxes and fees
7/10 Good! (1,006 reviews)
"It was a quiet place to stay."
Reviewed on Aug 23, 2025
Cherry Valley Hotel
2299 Cherry Valley Rd Se, Newark, OH
Fully refundableReserve now, pay when you stay
$116 nightly
The price is $131 total per night from Aug 27 to Aug 28
$131 total
Aug 27 - Aug 28
Total with taxes and fees
8.6/10 Excellent! (959 reviews)
"Always enjoy staying here"
Reviewed on Aug 22, 2025
Ohio University Inn & Conference Center
331 Richland Ave, Athens, OH
Fully refundableReserve now, pay when you stay
$113 nightly
The price is $128 total per night from Aug 31 to Sep 1
$128 total
Aug 31 - Sep 1
Total with taxes and fees
9/10 Wonderful! (1,007 reviews)
"Stayed here a few times and it’s been great each time. The place is bigger than it looks. The Tavern is great for drinks. The food is also good. It’s convenient to have a bar and restaurant in the hotel. Wish they had a free breakfast, but not a show stopper with how close they are to the OHIO ..."
Reviewed on Aug 22, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.