Southwest Illinois Vacations from $530
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Your Southwest Illinois Vacation
When it's time for your next epic adventure, our Southwest Illinois vacation packages are the answer. Culture and history are among the many things that make this destination such a special place. Begin your trip to Southwest Illinois with some time exploring O'Fallon visiting popular sights like O'Fallon Family Sports Park and FanDuel Sportsbook and Horse Racing. Marion is another city that lures travelers from all over. Lake of Egypt and Crab Orchard National Wildlife Refuge are two of the top places to see in this destination. From the moment you book your Southwest Illinois vacation to the second you come back home, Expedia will be with you each step of the way.
The Latest Southwest Illinois vacation packages
Price found within the past 48 hours. Click for updated prices.
Crowne Plaza St. Louis Airport by IHG
Price was $676, price is now $530 per person
$530
per person
Mar 19 - Mar 23
found 1 day ago
Roundtrip flight included
Denver (DEN) to St. Louis (STL)
8/10 Very Good! (1,002 reviews)
I was there for the fantail show. Everything was fantastic! Thank you so much!
Reviewed on Jan 14, 2026
21C Museum Hotel St Louis
Downtown West
Price was $902, price is now $700 per person
$700
per person
Mar 19 - Mar 23
found 1 day ago
Roundtrip flight included
Denver (DEN) to St. Louis (STL)
9/10 Wonderful! (1,458 reviews)
Great staff, cool amenities, amazing environment. We had a lot of fun with the penguins! ;)
Reviewed on Jan 19, 2026
Angad Arts Hotel St. Louis, Tapestry Collection by Hilton
Grand Center
Price was $783, price is now $612 per person
$612
per person
Mar 19 - Mar 23
found 11 hours ago
Roundtrip flight included
Denver (DEN) to St. Louis (STL)
8.8/10 Excellent! (1,022 reviews)
The hotel was amazing. The room was clean, and the location was perfectly centralized. The young lady in reception who checked md in had a horrible attitude each time i encountered her. I was also due a parking pass at the time of check in which she intentionally left off. I had to get one from someone else and I intentionally waited until she wasn’t at the front desk to get it. Dealing with her alone soured the experience.
Reviewed on Jan 24, 2026
Don't see what you're looking for?
See all available trips from Columbus to Southwest Illinois
View all tripsWhere to stay in Southwest Illinois
Find the best Southwest Illinois areas and neighborhoods for the activities you enjoy most. Learn more about Southwest Illinois
Eastport
If you're spending some time in Eastport, Gateway Conference Center and Splash City Family Waterpark are top sights worth seeing.
Discover the most popular places to visit in Southwest Illinois
Southern Illinois University
Take a campus tour or just explore the area of Southern Illinois University, during your trip to Carbondale. Check out the shops and top-notch restaurants in this family-friendly area.
Giant City State Park
Walk amid mystical woodland, admire geological wonders, go horseback riding and camp in the wilderness in the spectacular countryside of Southwest Illinois.
Ferne Clyffe State Park
You can take time to visit Ferne Clyffe State Park during your travels to Goreville. While you're in the area, wander around the parks.
Southwest Illinois Hotel Deals
Drury Inn & Suites Marion
2706 W DeYoung St Marion IL
$94 nightly
The price is $113 total per night from Feb 18 to Feb 19
$113 total
Feb 18 - Feb 19
Total with taxes and fees
9.2/10 Wonderful! (1,012 reviews)
Bed was extremely comfortable, pool and hot tub were nice, staff was great, offered free dinner and breakfast- good food, good value
Reviewed on Jan 24, 2026
Drury Plaza Hotel Mt. Vernon
145 North 44th Street Mount Vernon IL
Fully refundableReserve now, pay when you stay
$111 nightly
The price is $125 total per night from Jan 31 to Feb 1
$125 total
Jan 31 - Feb 1
Total with taxes and fees
9.6/10 Exceptional! (1,639 reviews)
Courteous staff. Great onsite meals
Reviewed on Jan 22, 2026
Drury Inn & Suites St. Louis Fairview Heights
12 Ludwig Dr Fairview Heights IL
$94 nightly
The price is $106 total per night from Feb 16 to Feb 17
$106 total
Feb 16 - Feb 17
Total with taxes and fees
9/10 Wonderful! (1,014 reviews)
All was good. Breakfast especially at 100%.
Reviewed on Jan 22, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find the Best Southwest Illinois Vacation Packages
Southwest Illinois Essential Information
Language | English |
|---|---|
Currency | U.S dollars |
Closest Airport | Lambert-St. Louis Intl. Airport (STL) |
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
