Southwest Illinois Vacations from $315
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Photo by Southernmost Illinois Tourism Bureau
Your Southwest Illinois Vacation
When it's time for your next epic adventure, our Southwest Illinois vacation packages are the answer. Culture and history are among the many things that make this destination such a special place. Begin your trip to Southwest Illinois with some time exploring O'Fallon visiting popular sights like O'Fallon Family Sports Park and FanDuel Sportsbook and Horse Racing. Marion is another city that lures travelers from all over. Lake of Egypt and Crab Orchard National Wildlife Refuge are two of the top places to see in this destination. From the moment you book your Southwest Illinois vacation to the second you come back home, Expedia will be with you each step of the way.
The Latest Southwest Illinois vacation packages
Price found within the past 48 hours. Click for updated prices.
The Wildwood Hotel
Save 100% on your flight
Price was $647, price is now $351 per person
$351
per person
Aug 21 - Aug 24
found 13 hours ago
Roundtrip flight included
Dallas (DFW) to St. Louis (STL)
9.2/10 Wonderful! (1,657 reviews)
Everything was good, except the air conditioning was so loud,we couldn't sleep at all.
Reviewed on Jun 11, 2026
Angad Arts Hotel St. Louis, Tapestry Collection by Hilton
Grand Center
Price was $498, price is now $372 per person
$372
per person
Aug 21 - Aug 24
found 13 hours ago
Roundtrip flight included
Dallas (DFW) to St. Louis (STL)
8.8/10 Excellent! (1,063 reviews)
Really unique place and wondefull rooftop
Reviewed on Jun 7, 2026
DoubleTree by Hilton Hotel St. Louis - Chesterfield
Price was $506, price is now $381 per person
$381
per person
Aug 21 - Aug 24
found 13 hours ago
Roundtrip flight included
Dallas (DFW) to St. Louis (STL)
8.8/10 Excellent! (1,001 reviews)
Stayed at this hotel for the weekend. Very nice hotel. Check in was easy. Stayed in king size bed room, with couch sofa. It was nice, didn’t use the sofa, but the room size was good for 2 ppl. Maybe it would be alittle crowded with more. Their beds are really comfortable. And showers have great pressure. The toilet acted up on our second day, but smone came out and took care of it right away.
The only con I’d give is for their buffet breakfast they offer 3 different kinds of bacon products. It would be nice to have smthing kosher. The only protein available were eggs and the rest sm type of pork protein. So the buffet breakfast was limited for us.
Other then that great hotel to stay in!
Reviewed on May 23, 2026
Ameristar Casino Resort and Spa
Price was $637, price is now $493 per person
$493
per person
Aug 21 - Aug 24
found 10 hours ago
Roundtrip flight included
Dallas (DFW) to St. Louis (STL)
8.6/10 Excellent! (1,000 reviews)
Very special treat to get to stay at this property while in St. Charles.
Reviewed on Jun 10, 2026
Don't see what you're looking for?
See all available trips from Columbus to Southwest Illinois
View all tripsWhere to stay in Southwest Illinois
Find the best Southwest Illinois areas and neighborhoods for the activities you enjoy most. Learn more about Southwest Illinois
Eastport
If you're spending some time in Eastport, Gateway Conference Center and Splash City Family Waterpark are top sights worth seeing.
Discover the most popular places to visit in Southwest Illinois
Southern Illinois University
4.5/5(175 reviews)
Take a campus tour or just explore the area of Southern Illinois University, during your trip to Carbondale. Check out the shops and top-notch restaurants in this family-friendly area.
Giant City State Park
4.5/5(80 reviews)
Walk amid mystical woodland, admire geological wonders, go horseback riding and camp in the wilderness in the spectacular countryside of Southwest Illinois.
Tunnel Hill State Trail
4/5(2 reviews)
You can take time to visit Tunnel Hill State Trail during your travels to Vienna. Amble around the area's parks or experience its museums.
Southwest Illinois Hotel Deals
Drury Plaza Hotel Mt. Vernon
145 North 44th Street Mount Vernon IL
Fully refundableReserve now, pay when you stay
$111 nightly
The price is $125 total per night from Jul 12 to Jul 13
$125 total
Jul 12 - Jul 13
Total with taxes and fees
9.6/10 Exceptional! (1,727 reviews)
"Staff was very pleasant, our room was very nice and entire hotel was clean, shiny and classy!"
Reviewed on Jun 11, 2026
Drury Inn & Suites St. Louis Fairview Heights
12 Ludwig Dr Fairview Heights IL
Fully refundableReserve now, pay when you stay
$97 nightly
The price is $110 total per night from Jun 21 to Jun 22
$110 total
Jun 21 - Jun 22
Total with taxes and fees
9.2/10 Wonderful! (1,018 reviews)
"It was a simple stay, I didn’t spend much time at the hotel but they were quick with no issues. I might have left my white button up in the closet. But overall everything was fine."
Reviewed on Jun 9, 2026
Super 8 by Wyndham O'Fallon
1100 Eastgate Dr O'Fallon IL
Fully refundableReserve now, pay when you stay
$57 nightly
The price is $65 total per night from Jun 21 to Jun 22
$65 total
Jun 21 - Jun 22
Total with taxes and fees
6.8/10 (1,008 reviews)
"they have roaches in every room, i was switch 5 times to different rooms even different floors. they have bed bugs my daughters were bit up all over even on their faces, i complained to the staff with no help they can hardly understand you, housekeeping is extremely rude even when they’re at fault, ..."
Reviewed on Jun 10, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find the Best Southwest Illinois Vacation Packages
Southwest Illinois Essential Information
Language | English |
|---|---|
Currency | U.S dollars |
Closest Airport | Lambert-St. Louis Intl. Airport (STL) |
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.