Matthews Vacation Rentals from $99: Search Short-Term Rentals

Check prices for these dates

In two weeks

In two months

In three months

In four months

Our top choices for Matthews vacation rentals

1. Spacious 3-bedroom 2 story house in New Madrid near boat ramp with a toy room!

New Madrid

Jessica S.

$343 nightly

Aug 17 - Aug 18

Total with taxes and fees

2. Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy

Dexter

Susan R.

$202 nightly

Aug 17 - Aug 18

Total with taxes and fees

3. Tiny house on the lake with tv free internet walk shower

Tiptonville

Katherine P.

$207 nightly

Aug 17 - Aug 18

Total with taxes and fees

4. 2 Queen Beds|Non-Smoking

Malden MO

Anonymous traveler

$100 nightly

Sep 15 - Sep 16

Total with taxes and fees

5. Vacation rental attached to our house out in the country.

Union City

Sherrie S.

$145 nightly

Aug 17 - Aug 18

Total with taxes and fees

6. King Bed|Non-Smoking

Malden MO

Anonymous traveler

$90 nightly

Sep 9 - Sep 10

Total with taxes and fees

Coffee/tea maker, fridge, microwave, oven

7. The Cutie Patootie on Helen- Cute, Cozy, Comfortable - 3 BR Home in Dexter, MO

Dexter

$150 nightly

Aug 17 - Aug 18

Total with taxes and fees

View all properties

Find vacation rentals that suit your style

Apartments

Private vacation homes

Save an average of 15% on thousands of hotels when you're signed in

Sign in

Sign up, it's free

Top Matthews Hotel Reviews

Econo Lodge Dexter

10/10 Excellent

"Pretty much just slept, but it all was peaceful!"

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

10/10 Excellent

"I was there on a business trip during the Boot Heel Rodeo. Sikeston was packed. Staff helped me with my printing and got down on their hand and knees to find my phone which turned up in my car. Great customer service and WiFi and everything worked perfectly!"

Super 8 by Wyndham Sikeston/Miner Area

8/10 Good

"the room was a time warp to the 1970's, the clerk was as helpful as flo from monsters inc and i find it shady they have a request to pay the room deposit in cash for quicker reimbursement. its next to a mcdonalds and the free way so quick eat and jet possibility but it was clean the water was hot and it didnt smell of old dogs so for what it was it was ok"

The Riverstone Hotel Charleston-Sikeston

8/10 Good

"The ad and picture for the hotel is a little deceiving. It shows a large fountain in front of the front lobby. There was none. This is the former Quality Inn Hotel was not good at all. The hotel has been cleaned up and rebranded. The room was nice. My only concern was all the bugs that were outside the room door and flew into the room when you opened your door at night. The other thing that I did not like was the surprise $100 fee that I had to pay up front for potential damage to the room. This fee was returned during check out."

Hampton Inn Sikeston

8/10 Good

"Hotel was nice but unfortunately someone decided to smoke in the elevator one night which made it shut down. So, until the repair was completed, everyone one the upper floors had to take the stairs down multiple floors. Usually not that big of an issue, but we were there for a bike ride and had to carry our bikes down three floors in the morning. Thankfully the elevator was fixed by the time we got back. Not really anything the hotel or staff caused, but just repercussions from the act of one person doing something stupid! We will definitely stay here again"

Find out more about Matthews

Everything you need to know about Matthews vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Matthews vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Matthews vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Matthews vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Matthews. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Matthews in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $99 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Matthews rentals

At Expedia, we put the best Matthews vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Matthews rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Matthews vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Matthews. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Frequently asked questions

Are there vacation rentals in Matthews?

Yes, we offer vacation rentals near the most popular local attractions in Matthews, or you can choose a secluded option if you're looking for a relaxing stay.

What are some of the best vacation rentals that Matthews has to offer?

Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy: This vacation home rental near Matthews offers a fireplace, a balcony, and a barbecue grill to help you feel perfectly comfortable in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. You can relax into your vacation with a garden and a selection of games.

What’s there to see and do in Matthews?

While you're exploring the area, Big Oak Tree State Park and Central Park are a couple of picturesque spots to get outside and enjoy nature. Sikeston Depot Museum and New Madrid Historical Museum are a couple of places you'll find in the larger area.

What’s a vacation rental in Matthews like?

Vacation rentals are privately owned properties you can book for a few weeks or just a few days in Matthews. Vacation rentals feature amenities such as laundry facilities and kitchens so you'll have all the conveniences of home. If you're concerned about a clean environment, vacation rentals can offer a sense of security away from shared hotel elevators and lobbies packed with people while still allowing you to travel. You'll also find more space in a vacation rental than in a standard hotel, which makes a vacation rental an attractive choice for families.

Room 1

Bundle & Save

OneKeyCash

Upfront pricing

Check prices for these dates

Our top choices for Matthews vacation rentals

1. Spacious 3-bedroom 2 story house in New Madrid near boat ramp with a toy room!

2. Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy

3. Tiny house on the lake with tv free internet walk shower

4. 2 Queen Beds|Non-Smoking

5. Vacation rental attached to our house out in the country.

6. King Bed|Non-Smoking

7. The Cutie Patootie on Helen- Cute, Cozy, Comfortable - 3 BR Home in Dexter, MO

Find vacation rentals that suit your style

Top Matthews Hotel Reviews

Econo Lodge Dexter

Hampton Inn By Hilton Dexter

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Super 8 by Wyndham Sikeston/Miner Area

Fairfield Inn & Suites by Marriott Sikeston

The Riverstone Hotel Charleston-Sikeston

Hampton Inn Sikeston

Super 8 by Wyndham Charleston/Sikeston East MO

Dexter Inn

Find out more about Matthews

Frequently asked questions

Go further with the Expedia app