Title: Visit Santa Cruz Acatepec: 2026 Travel Guide for Santa Cruz Acatepec, Oaxaca | Expedia.com [Hotels in Santa Cruz Acatepec](https://expedia.com/Santa-Cruz-Acatepec-Hotels.d553248635640632325.Travel-Guide-Hotels)[Vacation Rentals in Santa Cruz Acatepec](https://expedia.com/Santa-Cruz-Acatepec-Vacation-Rentals.d553248635640632325.Travel-Guide-VacationRentals)[Flights to Santa Cruz Acatepec](https://expedia.com/Cheap-Flights-To-Santa-Cruz-Acatepec.d553248635640632325.Travel-Guide-Flights)[Car Rentals in Santa Cruz Acatepec](https://expedia.com/Car-Rentals-In-Santa-Cruz-Acatepec.d553248635640632325.Car-Rental-Guide)[Santa Cruz Acatepec Vacation Packages](https://expedia.com/Santa-Cruz-Acatepec.d553248635640632325.Destination-Travel-Guides) # Santa Cruz Acatepec ## Travel Guide ## Visit Santa Cruz Acatepec ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.com/deals?rfrr=DX_SPRING_PROMO_553248635640632325) - Santa Cruz Acatepec Hotel Deals - Vacation Rentals in Santa Cruz Acatepec ![Rustic House in the Tehuacan-Cuicatlan Biosphere Reserve](https://images.trvl-media.com/lodging/113000000/112230000/112220600/112220550/488ae3ea_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Rustic House in the Tehuacan-Cuicatlan Biosphere Reserve Santa María Tecomavaca OAX $110 nightly $129 total Feb 13 - Feb 14 Total with taxes and fees Stay at this cottage in Santa María Tecomavaca. Enjoy laundry facilities. I booked this house in November and paid the full price then. When I contacted the host the day before we arrived she told me her family was staying there and didn't remember my reservation. Then she said we could share the house with her family. We had no other option for accommodation and had a ... Reviewed on Jan 18, 2026 [](https://expedia.com/Hotel-Search?startDate=2%2F13%2F2026&endDate=2%2F14%2F2026&selected=112220550&PinnedHotelID=112220550&HadPinnedHotel=true®ionId=553248635640632325) ![Casa Rustica Reserva Biosfera Tehuacan Cuicatlan](https://images.trvl-media.com/lodging/92000000/91630000/91626200/91626110/ab9c8444_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Casa Rustica Reserva Biosfera Tehuacan Cuicatlan Santa María Tecomavaca OAX Stay at this residence in Santa María Tecomavaca. Enjoy free WiFi, free parking, and a garden. [Get rates](https://expedia.com/Hotel-Search?startDate=2%2F26%2F2026&endDate=2%2F27%2F2026&selected=91626110&PinnedHotelID=91626110&HadPinnedHotel=true®ionId=553248635640632325) [](https://expedia.com/Hotel-Search?startDate=2%2F26%2F2026&endDate=2%2F27%2F2026&selected=91626110&PinnedHotelID=91626110&HadPinnedHotel=true®ionId=553248635640632325) ![Mazatec Corner](https://images.trvl-media.com/lodging/123000000/122400000/122390200/122390141/abd0f143_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Mazatec Corner Huautla de Jiménez Oax. Stay at this cabin in Huautla de Jiménez. Popular attractions María Sabina Museum and Velo de Novia Waterfall are located nearby. [Get rates](https://expedia.com/Hotel-Search?startDate=2%2F26%2F2026&endDate=2%2F27%2F2026&selected=122390141&PinnedHotelID=122390141&HadPinnedHotel=true®ionId=553248635640632325) [](https://expedia.com/Hotel-Search?startDate=2%2F26%2F2026&endDate=2%2F27%2F2026&selected=122390141&PinnedHotelID=122390141&HadPinnedHotel=true®ionId=553248635640632325) [See all 5 properties in Santa Cruz Acatepec](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=2%2F13%2F2026&endDate=2%2F14%2F2026®ionId=553248635640632325) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![Rustic House in the Tehuacan-Cuicatlan Biosphere Reserve](https://images.trvl-media.com/lodging/113000000/112230000/112220600/112220550/488ae3ea_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Rustic House in the Tehuacan-Cuicatlan Biosphere Reserve Santa María Tecomavaca OAX Stay at this cottage in Santa María Tecomavaca. Enjoy laundry facilities. I booked this house in November and paid the full price then. When I contacted the host the day before we arrived she told me her family was staying there and didn't remember my reservation. Then she said we could share the house with her family. We had no other option for accommodation and had a ... Reviewed on Jan 18, 2026 [](https://expedia.com/Santa-Maria-Tecomavaca-Hotels-Vrbo-Property.h112220550.Hotel-Information) ![Casa Rustica Reserva Biosfera Tehuacan Cuicatlan](https://images.trvl-media.com/lodging/92000000/91630000/91626200/91626110/ab9c8444_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Casa Rustica Reserva Biosfera Tehuacan Cuicatlan Santa María Tecomavaca OAX Stay at this residence in Santa María Tecomavaca. Enjoy free WiFi, free parking, and a garden. [](https://expedia.com/Santa-Maria-Tecomavaca-Hotels-Casa-Rustica-Reserva-Biosfera-Tehuacan-Cuicatlan.h91626110.Hotel-Information) ![Mazatec Corner](https://images.trvl-media.com/lodging/123000000/122400000/122390200/122390141/abd0f143_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Mazatec Corner Huautla de Jiménez Oax. Stay at this cabin in Huautla de Jiménez. Popular attractions María Sabina Museum and Velo de Novia Waterfall are located nearby. [](https://expedia.com/Huautla-De-Jimenez-Hotels-Vrbo-Property.h122390141.Hotel-Information) [See all properties in Santa Cruz Acatepec](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience®ionId=553248635640632325&sort=VACATION_RENTAL) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Check Santa Cruz Acatepec hotel availability [Tonight ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635640632325&startDate=2026-02-12&endDate=2026-02-13)[Feb 12 - Feb 13](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635640632325&startDate=2026-02-12&endDate=2026-02-13) [Tomorrow night ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635640632325&startDate=2026-02-13&endDate=2026-02-14)[Feb 13 - Feb 14](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635640632325&startDate=2026-02-13&endDate=2026-02-14) [This weekend ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635640632325&startDate=2%2F13%2F2026&endDate=2%2F15%2F2026)[Feb 13 - Feb 15](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635640632325&startDate=2%2F13%2F2026&endDate=2%2F15%2F2026) [Next weekend ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635640632325&startDate=2%2F20%2F2026&endDate=2%2F22%2F2026)[Feb 20 - Feb 22](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635640632325&startDate=2%2F20%2F2026&endDate=2%2F22%2F2026) - Cities near Santa Cruz Acatepec - Places of interest - [Tehuacán-Cuicatlán Biosphere Reserve ](https://expedia.com/Tehuacan-Cuicatlan-Biosphere-Reserve-Mexico.d553248635954091586.Vacation-Attraction) - [María Sabina Museum ](https://expedia.com/Maria-Sabina-Museum-Huautla-de-Jimenez.d553248635998073766.Vacation-Attraction) - [Velo de Novia Waterfall ](https://expedia.com/Velo-De-Novia-Waterfall-Huautla-de-Jimenez.d553248635998074148.Vacation-Attraction) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save even more - get up to 20% on select hotels when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. 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