$456 Cheap Flights from Brussels (BRU) to Greenville (GSP)

View $456 flight on Tue, Apr 7, 2026Opens in a new window

Popular airlines from Brussels Airport (BRU) to Greenville-Spartanburg Intl. Airport (GSP)

Cheap Flights from Brussels to Greenville (BRU-GSP)

Prices were available within the past 7 days and start at $456 for one-way flights and $731 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

British Airways
Wed, Apr 22 - Thu, Apr 30
BRU
Brussels
GSP
Greenville
$731 Roundtrip, found 6 days ago
$731
Roundtrip
found 6 days ago
Select British Airways flight, departing Wed, Apr 22 from Brussels to Greenville, returning Thu, Apr 30, priced at $731 found 6 days ago
British Airways
Wed, Apr 22 - Thu, Apr 30
BRU
Brussels
GSP
Greenville
$731 Roundtrip, found 6 days ago
$731
Roundtrip
found 6 days ago
Select British Airways flight, departing Wed, Apr 22 from Brussels to Greenville, returning Thu, Apr 30, priced at $731 found 6 days ago
Lufthansa
Wed, Apr 22 - Thu, Apr 30
BRU
Brussels
GSP
Greenville
$732 Roundtrip, found 6 days ago
$732
Roundtrip
found 6 days ago
Select Lufthansa flight, departing Wed, Apr 22 from Brussels to Greenville, returning Thu, Apr 30, priced at $732 found 6 days ago
Lufthansa
Wed, Apr 22 - Thu, Apr 30
BRU
Brussels
GSP
Greenville
$736 Roundtrip, found 6 days ago
$736
Roundtrip
found 6 days ago
Select Lufthansa flight, departing Wed, Apr 22 from Brussels to Greenville, returning Thu, Apr 30, priced at $736 found 6 days ago
Lufthansa
Wed, Apr 22 - Thu, Apr 30
BRU
Brussels
GSP
Greenville
$737 Roundtrip, found 6 days ago
$737
Roundtrip
found 6 days ago
Select Lufthansa flight, departing Wed, Apr 22 from Brussels to Greenville, returning Thu, Apr 30, priced at $737 found 6 days ago
United
Wed, Apr 22 - Thu, Apr 30
BRU
Brussels
GSP
Greenville
$746 Roundtrip, found 6 days ago
$746
Roundtrip
found 6 days ago
Select United flight, departing Wed, Apr 22 from Brussels to Greenville, returning Thu, Apr 30, priced at $746 found 6 days ago
United
Wed, Apr 22 - Thu, Apr 30
BRU
Brussels
GSP
Greenville
$746 Roundtrip, found 6 days ago
$746
Roundtrip
found 6 days ago
Select United flight, departing Wed, Apr 22 from Brussels to Greenville, returning Thu, Apr 30, priced at $746 found 6 days ago
United
Wed, Apr 22 - Thu, Apr 30
BRU
Brussels
GSP
Greenville
$751 Roundtrip, found 6 days ago
$751
Roundtrip
found 6 days ago
Select United flight, departing Wed, Apr 22 from Brussels to Greenville, returning Thu, Apr 30, priced at $751 found 6 days ago
Scandinavian Airlines
Wed, Apr 22 - Thu, Apr 30
BRU
Brussels
GSP
Greenville
$755 Roundtrip, found 6 days ago
$755
Roundtrip
found 6 days ago
Select Scandinavian Airlines flight, departing Wed, Apr 22 from Brussels to Greenville, returning Thu, Apr 30, priced at $755 found 6 days ago
Brussels Airlines
Wed, Apr 22 - Thu, Apr 30
BRU
Brussels
GSP
Greenville
$755 Roundtrip, found 6 days ago
$755
Roundtrip
found 6 days ago
Select Brussels Airlines flight, departing Wed, Apr 22 from Brussels to Greenville, returning Thu, Apr 30, priced at $755 found 6 days ago

Frequently asked questions

How much does a flight from Brussels - National Airport (BRU) to Greenville-Spartanburg Intl. Airport (GSP) cost?
Snag a cheap one-way flight from $456 or cheap return flight from $731 from Brussels - National Airport (BRU) to Greenville-Spartanburg Intl. Airport (GSP) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Brussels - National Airport (BRU) to Greenville-Spartanburg Intl. Airport (GSP)?
Flying in April is a great way to save, as it's the cheapest month for flights between BRU and GSP. You'll often find the lowest fares during off-peak months.
What is the cheapest airline that flies from Brussels - National Airport (BRU) to Greenville-Spartanburg Intl. Airport (GSP)?
Use the filters on Expedia to compare different airlines and find the cheapest carrier that'll fly you from BRU to GSP. Then, sort your results by "Price (lowest to highest)" to pick up the best deal available.
How many flights per day from Brussels - National Airport (BRU) to Greenville-Spartanburg Intl. Airport (GSP)?
You'll have to catch a flight with a layover when traveling from Brussels - National Airport (BRU) to Greenville-Spartanburg Intl. Airport (GSP). Direct flights don't operate daily on this route. However, just filter your search to include one or two stops to discover an option that works for you.
What day of the week has the most flights from BRU to GSP?
Friday is usually the busiest day for flights, while Tuesday tends to be the quietest.* Keep in mind that flight schedules can change based on a number of factors, including the carrier and season.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Brussels - National Airport (BRU) to Greenville-Spartanburg Intl. Airport (GSP)?
Select a flight from Brussels - National Airport (BRU) to Greenville-Spartanburg Intl. Airport (GSP) that leaves before 3 PM to reduce the likelihood of delays and cancellations. Departures later than this have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Brussels - National Airport (BRU) to Greenville-Spartanburg Intl. Airport (GSP) last-minute?
Booking your plane ticket from BRU to GSP right before your trip is generally more expensive. However, if you're flexible with your travel dates and times, you could grab a cheap last-minute fare.
Is it cheaper to book a BRU to GSP flight and hotel package?
Compared with arranging hotels and flights separately, booking a BRU to GSP flight and hotel package with Expedia could lead to significant savings. Better yet, managing everything in one place will take the stress out of travel planning. Just secure your flights and choose from our wide range of hotels, then customize your trip with other add-ons like tours, car rentals and activities.
Can I cancel or change the date of my flight from Brussels - National Airport (BRU) to Greenville-Spartanburg Intl. Airport (GSP)?
In most instances, you're able to cancel or reschedule your BRU to GSP flight. However, there may be additional charges, especially if your booking was made over 24 hours ago. Check your itinerary for the airline's fees and policies on flight changes, or if you want more information, visit our Customer Service portal.

Travel information

Origin airport
Brussels - National
Destination airport
Greenville-Spartanburg Intl.
Roundtrip price
$731
Distance
4264 mi

Book with confidence

Brussels to Greenville Flights

The cheapest times to fly from Brussels to Greenville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Brussels to Greenville are during the month of April. You can find some of the cheapest flights from Brussels to Greenville with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Brussels to Greenville

Sunday is one of the best days to book for cheap flights from Brussels to Greenville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Brussels to Greenville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Brussels to Greenville in 2025. You can also book with separate airlines for your outbound and return journeys, from $456 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Brussels to Greenville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Brussels to Greenville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Brussels to Greenville Flights

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*Available to One Key members.