$446 Cheap Flights from Des Moines (DSM) to Brussels (BRU)

View $446 flight on Wed, Dec 3, 2025Opens in a new window

Popular airlines from Des Moines International Airport (DSM) to Brussels Airport (BRU)

Cheap Flights from Des Moines to Brussels (DSM-BRU)

Prices were available within the past 7 days and start at $446 for one-way flights and $638 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

British Airways
Sun, Nov 23 - Thu, Dec 4
DSM
Des Moines
BRU
Brussels
$638 Roundtrip, found 3 days ago
$638
Roundtrip
found 3 days ago
Select British Airways flight, departing Sun, Nov 23 from Des Moines to Brussels, returning Thu, Dec 4, priced at $638 found 3 days ago
British Airways
Wed, Oct 29 - Tue, Nov 4
DSM
Des Moines
BRU
Brussels
$665 Roundtrip, found 5 days ago
$665
Roundtrip
found 5 days ago
Select British Airways flight, departing Wed, Oct 29 from Des Moines to Brussels, returning Tue, Nov 4, priced at $665 found 5 days ago
British Airways
Sun, Nov 30 - Mon, Dec 8
DSM
Des Moines
BRU
Brussels
$671 Roundtrip, found 5 days ago
$671
Roundtrip
found 5 days ago
Select British Airways flight, departing Sun, Nov 30 from Des Moines to Brussels, returning Mon, Dec 8, priced at $671 found 5 days ago
Scandinavian Airlines
Mon, Dec 1 - Fri, Dec 5
DSM
Des Moines
BRU
Brussels
$693 Roundtrip, found 5 days ago
$693
Roundtrip
found 5 days ago
Select Scandinavian Airlines flight, departing Mon, Dec 1 from Des Moines to Brussels, returning Fri, Dec 5, priced at $693 found 5 days ago
British Airways
Sun, Nov 23 - Thu, Dec 4
DSM
Des Moines
BRU
Brussels
$708 Roundtrip, found 3 days ago
$708
Roundtrip
found 3 days ago
Select British Airways flight, departing Sun, Nov 23 from Des Moines to Brussels, returning Thu, Dec 4, priced at $708 found 3 days ago
British Airways
Fri, Oct 31 - Tue, Nov 4
DSM
Des Moines
BRU
Brussels
$715 Roundtrip, found 5 days ago
$715
Roundtrip
found 5 days ago
Select British Airways flight, departing Fri, Oct 31 from Des Moines to Brussels, returning Tue, Nov 4, priced at $715 found 5 days ago
Air Canada
Fri, Sep 12 - Tue, Sep 23
DSM
Des Moines
BRU
Brussels
$715 Roundtrip, found 21 hours ago
$715
Roundtrip
found 21 hours ago
Select Air Canada flight, departing Fri, Sep 12 from Des Moines to Brussels, returning Tue, Sep 23, priced at $715 found 21 hours ago
Iberia
Sun, Nov 23 - Thu, Dec 4
DSM
Des Moines
BRU
Brussels
$717 Roundtrip, found 3 days ago
$717
Roundtrip
found 3 days ago
Select Iberia flight, departing Sun, Nov 23 from Des Moines to Brussels, returning Thu, Dec 4, priced at $717 found 3 days ago
British Airways
Sun, Nov 23 - Thu, Dec 4
DSM
Des Moines
BRU
Brussels
$718 Roundtrip, found 3 days ago
$718
Roundtrip
found 3 days ago
Select British Airways flight, departing Sun, Nov 23 from Des Moines to Brussels, returning Thu, Dec 4, priced at $718 found 3 days ago
United
Wed, Aug 27 - Wed, Sep 3
DSM
Des Moines
BRU
Brussels
$726 Roundtrip, found 22 hours ago
$726
Roundtrip
found 22 hours ago
Select United flight, departing Wed, Aug 27 from Des Moines to Brussels, returning Wed, Sep 3, priced at $726 found 22 hours ago
Flights from Des Moines (DSM) to Brussels (BRU)
Origin airport
Des Moines Intl.
Destination airport
Brussels - National
Airlines serving
Aer Lingus, Air Canada, American Airlines, British Airways, Delta, Finnair, Iberia, KLM, Lufthansa, Scandinavian Airlines, United, Virgin Atlantic
Roundtrip price
$638
Distance
4380 mi

Des Moines to Brussels Flights

The cheapest times to fly from Des Moines to Brussels

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Des Moines to Brussels are during the month of November. You can find some of the cheapest flights from Des Moines to Brussels with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Des Moines to Brussels

Sunday is one of the best days to book for cheap flights from Des Moines to Brussels: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Des Moines to Brussels

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Des Moines to Brussels in 2025. You can also book with separate airlines for your outbound and return journeys, from $446 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Des Moines to Brussels flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Des Moines to Brussels airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Des Moines Intl. Airport (DSM) to Brussels - National Airport (BRU) cost?
Get a cheap one-way flight from $446 or cheap return flight from $638 from Des Moines Intl. Airport (DSM) to Brussels - National Airport (BRU) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Des Moines Intl. Airport (DSM) to Brussels - National Airport (BRU)?
The cheapest month to fly from DSM to BRU is November, when there's less demand. Off-peak season is typically when airlines offer better prices between these airports.
What is the cheapest airline that flies from Des Moines Intl. Airport (DSM) to Brussels - National Airport (BRU)?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that'll fly you from DSM to BRU. Then, sort your results by "Price (lowest to highest)" to score the best deal available.
How many flights per day from Des Moines Intl. Airport (DSM) to Brussels - National Airport (BRU)?
There are no daily direct flights available from Des Moines Intl. Airport (DSM) to Brussels - National Airport (BRU). But you can choose flights with layovers. Filter your search on Expedia to include one or more stops, and you'll be soaring above the clouds in no time.
What day of the week has the most flights from DSM to BRU?
Friday is usually the busiest day for flights, while Tuesday tends to be the quietest.* Remember that flight schedules can change based on a number of factors, such as the time of year and carrier.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Des Moines Intl. Airport (DSM) to Brussels - National Airport (BRU)?
To avoid potential delays on the Des Moines Intl. Airport (DSM) to Brussels - National Airport (BRU) route, travel before 3 PM. Later departures are 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Des Moines Intl. Airport (DSM) to Brussels - National Airport (BRU) last-minute?
Booking your ticket from DSM to BRU shortly before your journey is typically more expensive. However, if there's some wiggle room with your travel dates and times, you could land a cheap last-minute fare.
Is it cheaper to book a DSM to BRU flight and hotel package?
You can save money by securing a DSM to BRU flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's easy to manage everything in one place. After choosing your preferred flights and accommodations, you can add extras like tours, car rentals and activities.
Can I cancel or change the date of my flight from Des Moines Intl. Airport (DSM) to Brussels - National Airport (BRU)?
If you reserved your DSM to BRU flight within the last 24 hours, you may be able to modify or cancel it without fees. Depending on the airline and the fare type you purchased, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal for more information.

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*Available to One Key members.