$216 Cheap Flights from Des Moines (DSM) to Mobile (MOB)

View $216 flight on Sat, Feb 21, 2026Opens in a new window

Popular airlines from Des Moines International Airport (DSM) to Mobile Regional Airport (MOB)

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Cheap Flights from Des Moines to Mobile (DSM-MOB)

Prices were available within the past 7 days and start at $216 for one-way flights and $269 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Tue, Mar 31 - Sat, Apr 4
DSM
Des Moines
MOB
Mobile
$269 Roundtrip, found 2 hours ago
$269
Roundtrip
found 2 hours ago
Select Delta flight, departing Tue, Mar 31 from Des Moines to Mobile, returning Sat, Apr 4, priced at $269 found 2 hours ago
Delta
Wed, Apr 8 - Sat, Apr 25
DSM
Des Moines
MOB
Mobile
$276 Roundtrip, found 2 days ago
$276
Roundtrip
found 2 days ago
Select Delta flight, departing Wed, Apr 8 from Des Moines to Mobile, returning Sat, Apr 25, priced at $276 found 2 days ago
United
Wed, May 27 - Wed, Jun 3
DSM
Des Moines
MOB
Mobile
$309 Roundtrip, found 3 days ago
$309
Roundtrip
found 3 days ago
Select United flight, departing Wed, May 27 from Des Moines to Mobile, returning Wed, Jun 3, priced at $309 found 3 days ago
American Airlines
Sat, Apr 4 - Tue, Apr 7
DSM
Des Moines
MOB
Mobile
$313 Roundtrip, found 1 day ago
$313
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Apr 4 from Des Moines to Mobile, returning Tue, Apr 7, priced at $313 found 1 day ago
Delta
Sat, Jul 18 - Sat, Jul 25
DSM
Des Moines
MOB
Mobile
$326 Roundtrip, found 4 days ago
$326
Roundtrip
found 4 days ago
Select Delta flight, departing Sat, Jul 18 from Des Moines to Mobile, returning Sat, Jul 25, priced at $326 found 4 days ago
American Airlines
Sat, Apr 4 - Tue, Apr 7
DSM
Des Moines
MOB
Mobile
$331 Roundtrip, found 1 day ago
$331
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Apr 4 from Des Moines to Mobile, returning Tue, Apr 7, priced at $331 found 1 day ago
Delta
Sat, May 30 - Tue, Jun 2
DSM
Des Moines
MOB
Mobile
$332 Roundtrip, found 3 days ago
$332
Roundtrip
found 3 days ago
Select Delta flight, departing Sat, May 30 from Des Moines to Mobile, returning Tue, Jun 2, priced at $332 found 3 days ago
United
Wed, May 27 - Wed, Jun 3
DSM
Des Moines
MOB
Mobile
$336 Roundtrip, found 3 days ago
$336
Roundtrip
found 3 days ago
Select United flight, departing Wed, May 27 from Des Moines to Mobile, returning Wed, Jun 3, priced at $336 found 3 days ago
Delta
Tue, Mar 31 - Sat, Apr 4
DSM
Des Moines
MOB
Mobile
$339 Roundtrip, found 2 hours ago
$339
Roundtrip
found 2 hours ago
Select Delta flight, departing Tue, Mar 31 from Des Moines to Mobile, returning Sat, Apr 4, priced at $339 found 2 hours ago
American Airlines
Tue, Apr 21 - Wed, Apr 29
DSM
Des Moines
MOB
Mobile
$340 Roundtrip, found 21 hours ago
$340
Roundtrip
found 21 hours ago
Select American Airlines flight, departing Tue, Apr 21 from Des Moines to Mobile, returning Wed, Apr 29, priced at $340 found 21 hours ago

Alternative airports near Mobile

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Mobile Regional MOB. Cheapest option available. Average driving time to city center is 22 minutes. Flights from $428
MOB
Mobile Regional
Cheapest
Average driving time to city center22 min
Flights from $428

Find the cheapest month to fly from Des Moines (DSM) to Mobile (MOB)

February is typically the cheapest month to fly

From $224 - $559 per traveler.
Flights from Des Moines (DSM) to Mobile (MOB)
Origin airport
Des Moines Intl.
Destination airport
Mobile Regional
Airlines serving
American Airlines, Delta, United
Roundtrip price
$268
Distance
807 mi

Des Moines to Mobile Flights

The cheapest times to fly from Des Moines to Mobile

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Des Moines to Mobile are during the month of March. You can find some of the cheapest flights from Des Moines to Mobile with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Des Moines to Mobile

Sunday is one of the best days to book for cheap flights from Des Moines to Mobile: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Des Moines to Mobile

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Des Moines to Mobile in 2026. You can also book with separate airlines for your outbound and return journeys, from $216 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Des Moines to Mobile flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Des Moines to Mobile airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Des Moines, IA (DSM-Des Moines Intl.) to Mobile, AL (MOB-Mobile Regional) cost?
You can find cheap one-way flights from $216 and cheap return flights from $269 Des Moines, IA (DSM-Des Moines Intl.) to Mobile, AL (MOB-Mobile Regional) with Expedia. One-way flights usually range from $336 to $645, and return flights typically cost between $311 and $1025. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Des Moines, IA (DSM-Des Moines Intl.) to Mobile, AL (MOB-Mobile Regional) ticket fares go up or down.*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.
What is the cheapest month to fly from Des Moines, IA (DSM-Des Moines Intl.) to Mobile, AL (MOB-Mobile Regional)?
April is the cheapest month to fly from Des Moines (DSM) to Mobile (MOB), with average round-trip fares around $279. This is about 26% lower than the average price for the year, as demand tends to drop in spring. Other affordable months include October and December.*Averages based on flights available on Expedia in the last year.
Which airlines fly direct from Des Moines, IA (DSM-Des Moines Intl.) to Mobile, AL (MOB-Mobile Regional)?
Enter DSM to MOB and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
What is the cheapest airline that flies from Des Moines, IA (DSM-Des Moines Intl.) to Mobile, AL (MOB-Mobile Regional)?
American Airlines is one of the cheapest airlines offering connecting flights from Des Moines International Airport (DSM) to Mobile, AL (MOB), with return tickets starting from around $248 with a layover in O'Hare International (ORD). Use Expedia's search tool to compare the prices and schedules of airlines that fly this route to find the best option for your plans and budget.*Prices based on flights available on Expedia in the last year.
How do I find cheap flights from Des Moines, IA (DSM-Des Moines Intl.) to Mobile, AL (MOB-Mobile Regional)?
To find a cheap flight from Des Moines, IA (DSM-Des Moines Intl.) to Mobile, AL (MOB-Mobile Regional), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Des Moines, IA (DSM-Des Moines Intl.) to Mobile, AL (MOB-Mobile Regional)?
When flying from Des Moines to Mobile, April and December are the best months. You can find return flights for about $279, making it a cost-effective choice. April is popular for spring travel, while December offers a festive atmosphere during the holidays.*Prices based on flights available on Expedia in the last year.
What is the earliest flight from Des Moines, IA (DSM-Des Moines Intl.) to Mobile, AL (MOB-Mobile Regional)?
The earliest flight from Des Moines International Airport (DSM) to Mobile Regional Airport (MOB) typically departs at 5:00 AM, operated by American Airlines. This seasonal service is available in November and December, allowing you to start your day early in Mobile. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What are the most popular departure times for flights from Des Moines, IA (DSM-Des Moines Intl.) to Mobile, AL (MOB-Mobile Regional)?
The most popular departure times for flights from Des Moines, IA (DSM) to Mobile, AL (MOB) are in the early morning, from 6am to 9am. About 28% of passengers prefer this time window. United Airlines and American Airlines both offer flights during this window. Many travelers choose this time to ensure they have a full day ahead upon arrival in Mobile.
How long does it take to fly from Des Moines, IA (DSM-Des Moines Intl.) to Mobile, AL (MOB-Mobile Regional)?
A flight from DSM to MOB with a layover takes around 7 hours, with the route covering approximately 808 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Des Moines, IA (DSM-Des Moines Intl.) to Mobile, AL (MOB-Mobile Regional)?
First class seats are offered on the DSM to MOB route. First class cabins are available on:

  • Delta Air Lines
  • American Airlines
  • United Airlines

How do I earn miles on a Des Moines, IA (DSM-Des Moines Intl.) to Mobile, AL (MOB-Mobile Regional) flight with Expedia?
It's easy to earn miles on a Des Moines, IA (DSM-Des Moines Intl.) to Mobile, AL (MOB-Mobile Regional) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Mobile from Des Moines Intl. (DSM)?
If you're planning to travel to Mobile from Des Moines Intl. (DSM), you can fly into Mobile Regional (MOB) Some flights may connect through major hubs like O'Hare Intl. (ORD), Denver Intl. (DEN), LaGuardia (LGA) before reaching Mobile. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Des Moines, IA (DSM-Des Moines Intl.) to Mobile, AL (MOB-Mobile Regional) at the last minute?
Typically, booking a last minute flight from Des Moines, IA (DSM-Des Moines Intl.) to Mobile, AL (MOB-Mobile Regional) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Des Moines, IA (DSM-Des Moines Intl.) to Mobile, AL (MOB-Mobile Regional) flight and hotel package?
Securing a Des Moines, IA (DSM-Des Moines Intl.) to Mobile, AL (MOB-Mobile Regional) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Des Moines, IA (DSM-Des Moines Intl.) to Mobile, AL (MOB-Mobile Regional)?
If you booked your Des Moines, IA (DSM-Des Moines Intl.) to Mobile, AL (MOB-Mobile Regional) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

*Flight schedules are subject to change.

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*Available to One Key members.