$427 Cheap Flights from Madison (MSN) to Florence (FLO)

View $427 flight on Tue, Apr 21, 2026Opens in a new window

Popular airlines from Dane County Regional Airport (MSN) to Florence, SC (FLO-Florence Regional)

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Cheap Flights from Madison to Florence (MSN-FLO)

Prices were available within the past 7 days and start at $427 for one-way flights and $599 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Thu, Mar 19 - Mon, Mar 23
MSN
Madison
FLO
Florence
$599 Roundtrip, found 5 days ago
$599
Roundtrip
found 5 days ago
Select American Airlines flight, departing Thu, Mar 19 from Madison to Florence, returning Mon, Mar 23, priced at $599 found 5 days ago
American Airlines
Thu, Mar 19 - Mon, Mar 23
MSN
Madison
FLO
Florence
$699 Roundtrip, found 5 days ago
$699
Roundtrip
found 5 days ago
Select American Airlines flight, departing Thu, Mar 19 from Madison to Florence, returning Mon, Mar 23, priced at $699 found 5 days ago
American Airlines
Thu, Mar 19 - Mon, Mar 23
MSN
Madison
FLO
Florence
$727 Roundtrip, found 5 days ago
$727
Roundtrip
found 5 days ago
Select American Airlines flight, departing Thu, Mar 19 from Madison to Florence, returning Mon, Mar 23, priced at $727 found 5 days ago
American Airlines
Thu, Mar 19 - Mon, Mar 23
MSN
Madison
FLO
Florence
$741 Roundtrip, found 5 days ago
$741
Roundtrip
found 5 days ago
Select American Airlines flight, departing Thu, Mar 19 from Madison to Florence, returning Mon, Mar 23, priced at $741 found 5 days ago
American Airlines
Thu, Mar 19 - Mon, Mar 23
MSN
Madison
FLO
Florence
$965 Roundtrip, found 5 days ago
$965
Roundtrip
found 5 days ago
Select American Airlines flight, departing Thu, Mar 19 from Madison to Florence, returning Mon, Mar 23, priced at $965 found 5 days ago
American Airlines
Thu, Mar 19 - Mon, Mar 23
MSN
Madison
FLO
Florence
$979 Roundtrip, found 5 days ago
$979
Roundtrip
found 5 days ago
Select American Airlines flight, departing Thu, Mar 19 from Madison to Florence, returning Mon, Mar 23, priced at $979 found 5 days ago

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Frequently asked questions

How much does a flight from Dane County Regional Airport (MSN) to Florence Regional Airport (FLO) cost?
Get a cheap one-way flight from $427 or cheap return flight from $599 from Dane County Regional Airport (MSN) to Florence Regional Airport (FLO) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Dane County Regional Airport (MSN) to Florence Regional Airport (FLO)?
March is the cheapest month to fly from MSN to FLO. Traveling outside of peak seasons is often the key to finding a great deal.
What is the cheapest airline that flies from Dane County Regional Airport (MSN) to Florence Regional Airport (FLO)?
Expedia's filter tool lets you easily compare different airlines, departure times and fares all in one place. Customize the search to your preferences, then sort by "Price (lowest to highest)" to see which carrier offers the cheapest MSN to FLO flight.
How many flights per day from Dane County Regional Airport (MSN) to Florence Regional Airport (FLO)?
There aren't any daily direct flights departing from Dane County Regional Airport (MSN) to Florence Regional Airport (FLO). But you can opt for flights with layovers. Filter your search results on Expedia to include one or two stops, and you'll be soaring above the clouds in no time at all.
What day of the week has the most flights from MSN to FLO?
Friday is usually the busiest day for flights, while Tuesday is often the quietest.* Just remember that flight schedules can vary based on a number of factors, including the time of year and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Dane County Regional Airport (MSN) to Florence Regional Airport (FLO)?
Select a flight from Dane County Regional Airport (MSN) to Florence Regional Airport (FLO) that takes off before 3 PM to reduce the risk of delays and cancellations. Departures after this time have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Dane County Regional Airport (MSN) to Florence Regional Airport (FLO) last-minute?
Holding off until just before your trip to book a flight from MSN to FLO generally means paying more. Although you may find some last-minute discounts, they're not always guaranteed. Keep your travel plans flexible for the best chance of snagging a bargain.
Is it cheaper to book a MSN to FLO flight and hotel package?
You'll typically save money by booking a MSN to FLO flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's easy to manage everything in one place. Once you've chosen your preferred accommodations and flights, you can add extras such as activities, tours and car rentals.
Can I cancel or change the date of my flight from Dane County Regional Airport (MSN) to Florence Regional Airport (FLO)?
If you reserved your MSN to FLO flight in the last 24 hours, you may be able to modify or cancel it at no cost. Depending on the airline and the type of ticket you purchased, additional charges may apply for changes beyond that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, visit our Customer Service portal for further details.

Travel information

Origin airport
Dane County Regional
Destination airport
Florence Regional
Roundtrip price
$598
Distance
805 mi

Book with confidence

Madison to Florence Flights

The cheapest times to fly from Madison to Florence

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Madison to Florence are during the month of March. You can find some of the cheapest flights from Madison to Florence with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Madison to Florence

Sunday is one of the best days to book for cheap flights from Madison to Florence: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Madison to Florence

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Madison to Florence in 2026. You can also book with separate airlines for your outbound and return journeys, from $427 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Madison to Florence flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Madison to Florence airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Madison to Florence Flights

*Flight schedules are subject to change.

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*Available to One Key members.