$515 Cheap Flights from Mexicali (MXL) to Santo Domingo (SDQ)

View $515 flight on Tue, Nov 11, 2025Opens in a new window

Popular airlines from Mexicali, Baja California Norte (MXL-General Rodolfo Sanchez Taboada Intl.) to Las Americas Intl. Airport (SDQ)

Cheap Flights from Mexicali to Santo Domingo (MXL-SDQ)

Prices were available within the past 7 days and start at $515 for one-way flights and $612 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Aeromexico
Sun, Feb 1 - Sun, Feb 8
MXL
Mexicali
SDQ
Santo Domingo
$612 Roundtrip, found 4 days ago
$612
Roundtrip
found 4 days ago
Select Aeromexico flight, departing Sun, Feb 1 from Mexicali to Santo Domingo, returning Sun, Feb 8, priced at $612 found 4 days ago
Aeromexico
Sun, Feb 1 - Sun, Feb 8
MXL
Mexicali
SDQ
Santo Domingo
$636 Roundtrip, found 4 days ago
$636
Roundtrip
found 4 days ago
Select Aeromexico flight, departing Sun, Feb 1 from Mexicali to Santo Domingo, returning Sun, Feb 8, priced at $636 found 4 days ago
Aeromexico
Tue, Feb 3 - Sat, Feb 7
MXL
Mexicali
SDQ
Santo Domingo
$654 Roundtrip, found 4 days ago
$654
Roundtrip
found 4 days ago
Select Aeromexico flight, departing Tue, Feb 3 from Mexicali to Santo Domingo, returning Sat, Feb 7, priced at $654 found 4 days ago
Aeromexico
Wed, Feb 4 - Tue, Feb 10
MXL
Mexicali
SDQ
Santo Domingo
$675 Roundtrip, found 4 days ago
$675
Roundtrip
found 4 days ago
Select Aeromexico flight, departing Wed, Feb 4 from Mexicali to Santo Domingo, returning Tue, Feb 10, priced at $675 found 4 days ago
Aeromexico
Mon, Jan 19 - Mon, Jan 26
MXL
Mexicali
SDQ
Santo Domingo
$678 Roundtrip, found 6 days ago
$678
Roundtrip
found 6 days ago
Select Aeromexico flight, departing Mon, Jan 19 from Mexicali to Santo Domingo, returning Mon, Jan 26, priced at $678 found 6 days ago
Aeromexico
Thu, Jan 22 - Tue, Jan 27
MXL
Mexicali
SDQ
Santo Domingo
$689 Roundtrip, found 6 days ago
$689
Roundtrip
found 6 days ago
Select Aeromexico flight, departing Thu, Jan 22 from Mexicali to Santo Domingo, returning Tue, Jan 27, priced at $689 found 6 days ago
Aeromexico
Thu, Jan 22 - Tue, Jan 27
MXL
Mexicali
SDQ
Santo Domingo
$696 Roundtrip, found 6 days ago
$696
Roundtrip
found 6 days ago
Select Aeromexico flight, departing Thu, Jan 22 from Mexicali to Santo Domingo, returning Tue, Jan 27, priced at $696 found 6 days ago
Aeromexico
Mon, Feb 2 - Sun, Feb 8
MXL
Mexicali
SDQ
Santo Domingo
$699 Roundtrip, found 4 days ago
$699
Roundtrip
found 4 days ago
Select Aeromexico flight, departing Mon, Feb 2 from Mexicali to Santo Domingo, returning Sun, Feb 8, priced at $699 found 4 days ago
Aeromexico
Tue, Feb 3 - Sun, Feb 8
MXL
Mexicali
SDQ
Santo Domingo
$708 Roundtrip, found 4 days ago
$708
Roundtrip
found 4 days ago
Select Aeromexico flight, departing Tue, Feb 3 from Mexicali to Santo Domingo, returning Sun, Feb 8, priced at $708 found 4 days ago
Aeromexico
Fri, Jan 30 - Sun, Feb 8
MXL
Mexicali
SDQ
Santo Domingo
$714 Roundtrip, found 4 days ago
$714
Roundtrip
found 4 days ago
Select Aeromexico flight, departing Fri, Jan 30 from Mexicali to Santo Domingo, returning Sun, Feb 8, priced at $714 found 4 days ago
Flights from Mexicali (MXL) to Santo Domingo (SDQ)
Origin airport
General Rodolfo Sanchez Taboada Intl.
Destination airport
Las Americas Intl.
Roundtrip price
$612
Distance
2980 mi

Mexicali to Santo Domingo Flights

The cheapest times to fly from Mexicali to Santo Domingo

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Mexicali to Santo Domingo are during the month of February. You can find some of the cheapest flights from Mexicali to Santo Domingo with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Mexicali to Santo Domingo

Sunday is one of the best days to book for cheap flights from Mexicali to Santo Domingo: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Mexicali to Santo Domingo

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Mexicali to Santo Domingo in 2025. You can also book with separate airlines for your outbound and return journeys, from $515 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Mexicali to Santo Domingo flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Mexicali to Santo Domingo airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from General Rodolfo Sanchez Taboada Intl. Airport (MXL) to Las Americas Intl. Airport (SDQ) cost?
Lock in a cheap one-way flight from $515 or cheap return flight from $612 from General Rodolfo Sanchez Taboada Intl. Airport (MXL) to Las Americas Intl. Airport (SDQ) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from General Rodolfo Sanchez Taboada Intl. Airport (MXL) to Las Americas Intl. Airport (SDQ)?
The cheapest month to fly from MXL to SDQ is February, when demand is low. Off-peak season is often when you'll find lower airfares between these airports.
What is the cheapest airline that flies from General Rodolfo Sanchez Taboada Intl. Airport (MXL) to Las Americas Intl. Airport (SDQ)?
To find the cheapest airline flying from MXL to SDQ, use Expedia's filter tool. Customize your search based on your travel style, such as preferred carriers and seat class. You can then sort your results by "Price (lowest to highest)" to see the most affordable options first.
How many flights per day from General Rodolfo Sanchez Taboada Intl. Airport (MXL) to Las Americas Intl. Airport (SDQ)?
Direct flights from General Rodolfo Sanchez Taboada Intl. Airport (MXL) to Las Americas Intl. Airport (SDQ) aren't available daily, so you'll have to take a flight with a layover. Explore your options with our filter tool. Enter your travel details and pick either "1 Stop" or "2+ Stops."
What day of the week has the most flights from MXL to SDQ?
Generally you'll find the largest variety of flight choices on a Friday. Tuesdays are often the quietest.* But this can vary depending on the time of year, airline and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from General Rodolfo Sanchez Taboada Intl. Airport (MXL) to Las Americas Intl. Airport (SDQ)?
To touch down at Las Americas Intl. Airport (SDQ) on time, book a flight that takes off from General Rodolfo Sanchez Taboada Intl. Airport (MXL) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from General Rodolfo Sanchez Taboada Intl. Airport (MXL) to Las Americas Intl. Airport (SDQ) last-minute?
Last-minute fares from MXL to SDQ are usually more expensive. To secure the cheapest rates, start looking for flights early. That said, if you're flexible with your travel plans, you may find a cheap fare right before you leave.
Is it cheaper to book a MXL to SDQ flight and hotel package?
You'll generally save money by securing a MXL to SDQ flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's simple to manage everything in one convenient place. After selecting your preferred accommodations and flights, consider adding extras like activities, tours and car rentals.
Can I cancel or change the date of my flight from General Rodolfo Sanchez Taboada Intl. Airport (MXL) to Las Americas Intl. Airport (SDQ)?
Typically, you're able to reschedule or cancel your MXL to SDQ flight. However, additional charges may apply, especially if your booking was made over 24 hours ago. Double-check your itinerary for the airline's fees and policies on flight changes, or if you need further details, head to our Customer Service portal.

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*Available to One Key members.