$100 Cheap American Airlines flights Buffalo (BUF) to Myrtle Beach (MYR)

Scoring cheap one-way American Airlines flights from BUF to MYR from $100 on Expedia is a cinch — just filter by “Price (lowest to highest).” Alternatively, check out our budget-friendly round-trip fares from $208 for your next exciting vacation.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Look for one-way or round-trip flights to Myrtle Beach in January or November. You could find lower fares with American Airlines during these off-peak times.

Start searching one to three months before your departure to score cheap fares on American Airlines flights from Buffalo Niagara Intl. Airport (BUF) to Myrtle Beach Intl. Airport (MYR). You can save 25% by booking your domestic flight 34 to 86 days in advance compared to last-minute reservations made 6 to 12 days out. You could also cut costs by buying your fare on a Sunday, as it’s 6% cheaper on average than a Monday, the most expensive day to book.* Get the timing right, and you can enjoy significant savings on domestic trips.*Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC’s global airline sales database.

Simply enter your dates, click search and check the “Nonstop” filter on Expedia to find any direct flights from BUF to MYR with American Airlines or other airlines.

To find the earliest departure from BUF to MYR with American Airlines, filter your results by “Early Morning” and “Morning.” Booking an early flight generally means cancellations are less likely.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.

Myrtle Beach Intl. Airport (MYR) is the main Myrtle Beach gateway for American Airlines flights from Buffalo Niagara Intl. Airport (BUF).

Depending on your fare type, a fee will generally apply if you cancel or change your booking more than 24 hours after it has been confirmed. To find flexible plane tickets, select our “No cancel fee” or “Changes included” filter when looking for flights. To learn more about canceling or modifying your reservation, head to “Trips,” select your flight and click on “Manage Booking.”