$169 Cheap American Airlines flights Jacksonville (JAX) to San Diego (SAN)

You can discover affordable round-trip American Airlines flights from $337 from JAX to SAN by organizing your results from "Price (lowest to highest)" on Expedia. Or look for bargains from $169 for a one-way journey.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Search for affordable American Airlines flights from Jacksonville Intl. Airport (JAX) to San Diego Intl. Airport (SAN) one to three months ahead of your departure day. Travelers who book domestic flights 34 to 86 days in advance can save 25% compared to those who book just 6 to 12 days ahead. Regardless of fare class and journey, the best day to book a domestic flight is generally Sunday and the most expensive day is typically Monday. Passengers who book on a Sunday can save 6% on average compared to those who book their travel on a Monday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

Sort your results by "Morning" and "Early Morning" to see the earliest flights from JAX to SAN. Taking off early means you're 20% less likely to experience cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.