$149 Cheap American Airlines flights Knoxville (TYS) to Houston (IAH)

Landing cheap one-way American Airlines flights from TYS to IAH from $149 on Expedia couldn't be simpler — just filter by "Price (lowest to highest)." Or check out our budget-friendly round-trip fares from $229 for your next break.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Start searching one to three months before your departure to score cheap fares on American Airlines flights from McGhee Tyson Airport (TYS) to George Bush Intercontinental Airport (IAH). You can save 25% by booking your domestic flight 34 to 86 days in advance compared to last-minute reservations made 6 to 12 days out. You could also reduce costs by buying your fare on a Sunday, as it's 6% cheaper on average than a Monday, the most expensive day to book.* Get your timing right, and you can enjoy significant savings on domestic trips.*Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

Filter your results by "Morning" and "Early Morning" to see the earliest departures from TYS to IAH. Heading off early means you're less likely to experience cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.