$180 Cheap American Airlines flights Knoxville (TYS) to Seattle (SEA)

Scoring cheap one-way American Airlines flights from TYS to SEA from $180 on Expedia is a cinch — just filter by "Price (lowest to highest)." Or check out our budget-friendly round-trip fares from $316 for your next exciting getaway.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

For cheap American Airlines fares from McGhee Tyson Airport (TYS) to Seattle - Tacoma Intl. Airport (SEA), start searching one to three months before your intended departure. Securing domestic flights 34 to 86 days in advance could save you 25% compared to booking just 6 to 12 days ahead. The day you book can also affect what you pay. Sunday is generally the cheapest, while Monday is often the most expensive for domestic flights. You can save 6% on average by choosing to book on a Sunday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

Browse American Airlines's earliest flights from TYS to SEA by checking the "Early Morning" and "Morning" filters. Not only will you arrive sooner, early departures also experience 20% fewer cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.