$214 Cheap American Airlines flights Philadelphia (PHL) to Knoxville (TYS)

Set the "Price (lowest to highest)" filter on Expedia to find cheap American Airlines return flights from $355 from PHL to TYS. Affordable one-way tickets from $214 are available as well.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Search for cheap American Airlines flights from Philadelphia Intl. Airport (PHL) to McGhee Tyson Airport (TYS) one to three months before your departure date. Travelers who book domestic flights 34 to 86 days in advance can save 25% compared to those who book just 6 to 12 days ahead. Regardless of fare type and itinerary, the ideal day to book a domestic flight is usually Sunday and the most expensive is typically Monday. Passengers who book on a Sunday can save 6% on average compared to those who book their travel on a Monday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

Taking off from PHL at 8:20AM UTC-5, the earliest American Airlines flight to TYS arrives at 10:37AM UTC-5. Traveling early means you're less likely to encounter delays or cancellations.* Not an early riser? The last American Airlines flight from PHL to TYS departs at 6:42PM UTC-5 and touches down at 8:49PM UTC-5.*Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.