$191 Cheap American Airlines flights Medford (MFR) to Detroit (DTW)

Finding cheap one-way American Airlines flights from MFR to DTW from $191 on Expedia is easy — just filter by "Price (lowest to highest)." Or check out our budget-friendly return fares from $371 for your next break.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Start searching one to three months ahead of your travel date to get cheaper fares on American Airlines flights from Rogue Valley Intl. Airport (MFR) to Detroit Metropolitan Wayne County Airport (DTW). You can save 25% by booking your domestic flight 34 to 86 days in advance compared to last-minute reservations made 6 to 12 days out. You could also reduce costs by buying your fare on a Sunday, as it's 6% cheaper on average than a Monday, the most expensive day to book.* Get your timing right, and you can enjoy significant savings on domestic journeys.*Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

Sort your results by "Morning" and "Early Morning" to browse the earliest departures from MFR to DTW. Jetting off early means flight cancellations are less likely.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.