$44 Cheap Flights from Denver (DEN) to Knoxville (TYS)

View $44 flight on Wed, Jun 24, 2026Opens in a new window

Popular airlines from Denver Intl. Airport (DEN) to McGhee Tyson Airport (TYS)

Cheap Flights from Denver to Knoxville (DEN-TYS)

Prices were available within the past 7 days and start at $44 for one-way flights and $116 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Frontier Airlines
Wed, Jun 24 - Wed, Jul 1
DEN
Denver
TYS
Knoxville
$116 Roundtrip, found 2 days ago
$116
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Wed, Jun 24 from Denver to Knoxville, returning Wed, Jul 1, priced at $116 found 2 days ago
Frontier Airlines
Mon, Aug 10 - Fri, Aug 14
DEN
Denver
TYS
Knoxville
$121 Roundtrip, found 5 days ago
$121
Roundtrip
found 5 days ago
Select Frontier Airlines flight, departing Mon, Aug 10 from Denver to Knoxville, returning Fri, Aug 14, priced at $121 found 5 days ago
Frontier Airlines
Wed, Jun 24 - Mon, Jun 29
DEN
Denver
TYS
Knoxville
$122 Roundtrip, found 1 day ago
$122
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Wed, Jun 24 from Denver to Knoxville, returning Mon, Jun 29, priced at $122 found 1 day ago
Frontier Airlines
Wed, Jun 10 - Wed, Jun 24
DEN
Denver
TYS
Knoxville
$126 Roundtrip, found 2 days ago
$126
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Wed, Jun 10 from Denver to Knoxville, returning Wed, Jun 24, priced at $126 found 2 days ago
Frontier Airlines
Wed, Jun 24 - Mon, Jul 13
DEN
Denver
TYS
Knoxville
$132 Roundtrip, found 1 day ago
$132
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Wed, Jun 24 from Denver to Knoxville, returning Mon, Jul 13, priced at $132 found 1 day ago
Frontier Airlines
Wed, Jun 10 - Wed, Jun 24
DEN
Denver
TYS
Knoxville
$146 Roundtrip, found 3 days ago
$146
Roundtrip
found 3 days ago
Select Frontier Airlines flight, departing Wed, Jun 10 from Denver to Knoxville, returning Wed, Jun 24, priced at $146 found 3 days ago
Southwest Airlines
Thu, Aug 13 - Wed, Aug 19
DEN
Denver
TYS
Knoxville
$203 Roundtrip, found 6 days ago
$203
Roundtrip
found 6 days ago
Select Southwest Airlines flight, departing Thu, Aug 13 from Denver to Knoxville, returning Wed, Aug 19, priced at $203 found 6 days ago
United
Wed, Aug 12 - Tue, Aug 18
DEN
Denver
TYS
Knoxville
$283 Roundtrip, found 3 days ago
$283
Roundtrip
found 3 days ago
Select United flight, departing Wed, Aug 12 from Denver to Knoxville, returning Tue, Aug 18, priced at $283 found 3 days ago
American Airlines
Wed, Jun 24 - Tue, Jun 30
DEN
Denver
TYS
Knoxville
$303 Roundtrip, found 14 hours ago
$303
Roundtrip
found 14 hours ago
Select American Airlines flight, departing Wed, Jun 24 from Denver to Knoxville, returning Tue, Jun 30, priced at $303 found 14 hours ago
Delta
Wed, Jun 24 - Tue, Jun 30
DEN
Denver
TYS
Knoxville
$303 Roundtrip, found 14 hours ago
$303
Roundtrip
found 14 hours ago
Select Delta flight, departing Wed, Jun 24 from Denver to Knoxville, returning Tue, Jun 30, priced at $303 found 14 hours ago

Alternative airports near Knoxville

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to McGhee Tyson TYS. Cheapest and Closest option available. Average driving time to city center is 22 minutes. Flights from $442
TYS
McGhee Tyson
CheapestClosest
Average driving time to city center22 min
Flights from $442

Frequently asked questions

How much does a flight from Denver, CO (DEN-Denver Intl.) to Knoxville, TN (TYS-McGhee Tyson) cost?
You can find cheap one-way flights and cheap return flights from $116 Denver, CO (DEN-Denver Intl.) to Knoxville, TN (TYS-McGhee Tyson) with Expedia. One-way flights generally range between $192 and $845, and roundtrip flights usually range from $352 to $1221. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Denver, CO (DEN-Denver Intl.) to Knoxville, TN (TYS-McGhee Tyson) ticket fares go up or down.*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.
What is the cheapest month to fly from Denver, CO (DEN-Denver Intl.) to Knoxville, TN (TYS-McGhee Tyson)?
The cheapest month to fly from DEN to TYS is June when demand is low. Traveling in off-peak or shoulder months is usually a good way to secure cheap tickets, just remember to avoid flying during holidays if you're able to. Use the calendar view in your search to see which months have low fares on this route.
Which airlines fly direct from Denver, CO (DEN-Denver Intl.) to Knoxville, TN (TYS-McGhee Tyson)?
There are 2 airlines offering direct flights from DEN to TYS:

  • United operates around 22 direct flights from DEN to TYS every week
  • Frontier Airlines operates around 7 direct flights from DEN to TYS every week

How do I find cheap flights from Denver, CO (DEN-Denver Intl.) to Knoxville, TN (TYS-McGhee Tyson)?
To find a cheap flight from Denver, CO (DEN-Denver Intl.) to Knoxville, TN (TYS-McGhee Tyson), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best airline to fly with from Denver, CO (DEN-Denver Intl.) to Knoxville, TN (TYS-McGhee Tyson)?
The best airline to fly with from Denver, CO (DEN) to Knoxville, TN (TYS) will differ from traveler to traveler. If you like to fly early, United offers early morning flights. If price is the most important factor, Frontier Airlines typically offers the lowest fares. United offers the most daily flights from Denver to Knoxville, which is great if flexibility is what you value most. The best carrier for this journey could also be the one you have a loyalty membership with, as flying with that airline or another airline within the same alliance could help you collect points or enjoy lounge access.
What is the best time to fly from Denver, CO (DEN-Denver Intl.) to Knoxville, TN (TYS-McGhee Tyson)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
How many flights per day from Denver, CO (DEN-Denver Intl.) to Knoxville, TN (TYS-McGhee Tyson)?
There are approximately 4 nonstop flights per day from Denver Intl. (DEN) to McGhee Tyson (TYS). For more options, look at flights that include layovers.
What is the earliest flight from Denver, CO (DEN-Denver Intl.) to Knoxville, TN (TYS-McGhee Tyson)?
The earliest flight from Denver, CO (DEN-Denver Intl.) to Knoxville, TN (TYS-McGhee Tyson) typically departs at around 12:20 AM, operated by American Airlines. This is a seasonal service active in March, allowing you to maximize your time in Tennessee. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What are the most popular departure times for flights from Denver, CO (DEN-Denver Intl.) to Knoxville, TN (TYS-McGhee Tyson)?
The most popular departure times for flights from Denver, CO (DEN) to Knoxville, TN (TYS) are in the late morning, from 9am to 12pm. This time window accounts for around 29% of total traffic. Many major carriers, including American Airlines and United, offer flights during this window. This timing is popular because it allows you to travel after the morning rush, making for a smoother airport experience.
How long does it take to fly from Denver, CO (DEN-Denver Intl.) to Knoxville, TN (TYS-McGhee Tyson)?
Flying nonstop from DEN to TYS takes around 3 hours, with the route covering approximately 1,160 miles. Flights with a layover typically take 2 hours 20 minutes longer than direct options. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Denver, CO (DEN-Denver Intl.) to Knoxville, TN (TYS-McGhee Tyson)?
First class seats are offered on the DEN to TYS route. First class cabins are available on:

  • Delta Air Lines
  • American Airlines
  • United Airlines

How much is a business class flight from Denver, CO (DEN-Denver Intl.) to Knoxville, TN (TYS-McGhee Tyson)?
A direct, return business class ticket from Denver, CO (DEN) to Knoxville, TN (TYS) typically costs between $1,246 - $1,715. A non-stop, one-way business class flight is usually around $838 - $1,108. Prices often fluctuate based on seasonality and how early you book. You may also be able to find a cheaper business class journey between Denver, CO (DEN-Denver Intl.) to Knoxville, TN (TYS-McGhee Tyson) if you opt for a connecting flight.*Prices based on flights available on Expedia in the last year.
How do I earn miles on a Denver, CO (DEN-Denver Intl.) to Knoxville, TN (TYS-McGhee Tyson) flight with Expedia?
It's easy to earn miles on a Denver, CO (DEN-Denver Intl.) to Knoxville, TN (TYS-McGhee Tyson) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Knoxville from Denver Intl. (DEN)?
From Denver Intl. (DEN), you can fly into McGhee Tyson (TYS) to reach Knoxville. Some flights may connect through major hubs like O'Hare Intl. (ORD), Sky Harbor Intl. (PHX), Charlotte-Douglas Intl. (CLT) before reaching Knoxville. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Denver, CO (DEN-Denver Intl.) to Knoxville, TN (TYS-McGhee Tyson) at the last minute?
Typically, booking a last minute flight from Denver, CO (DEN-Denver Intl.) to Knoxville, TN (TYS-McGhee Tyson) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Denver, CO (DEN-Denver Intl.) to Knoxville, TN (TYS-McGhee Tyson) flight and hotel package?
Securing a Denver, CO (DEN-Denver Intl.) to Knoxville, TN (TYS-McGhee Tyson) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Denver, CO (DEN-Denver Intl.) to Knoxville, TN (TYS-McGhee Tyson)?
If you booked your Denver, CO (DEN-Denver Intl.) to Knoxville, TN (TYS-McGhee Tyson) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Denver Intl.
Destination airport
McGhee Tyson
Airlines serving
American Airlines, Delta, Frontier Airlines, Southwest Airlines, United
Roundtrip price
$116
Distance
1159 mi
Average flight time
4 hours 52 mins

Book with confidence

Denver to Knoxville Flights

The cheapest times to fly from Denver to Knoxville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Denver to Knoxville are during the month of June. You can find some of the cheapest flights from Denver to Knoxville with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Denver to Knoxville

Sunday is one of the best days to book for cheap flights from Denver to Knoxville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Denver to Knoxville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Denver to Knoxville in 2026. You can also book with separate airlines for your outbound and return journeys, from $44 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Denver to Knoxville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Denver to Knoxville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Denver to Knoxville Flights

*Flight schedules are subject to change.

*Available to One Key members.

 

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