$178 Cheap Delta flights Detroit (DTW) to Knoxville (TYS)

View $178 flight on Fri, Sep 19, 2025Opens in a new window

  • Plan, book, fly with confidence

  • trending down icon

    Be in the know

    Get alerts if flight prices drop or rise*
  • bex rewards loyalty icon

    Book smarter

    Save up to 30% on select hotels after you book a flight*
  • one key icon

    Earn twice

    Earn your airline miles on top of our OneKeyCash
    Learn about One Key

$178 Cheap Delta flights Detroit (DTW) to Knoxville (TYS)

Prices were available within the past 7 days and start at $178 for one-way flights and $303 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Fri, Sep 5 - Sun, Sep 7
DTW
Detroit
TYS
Knoxville
$303 Roundtrip, found 3 days ago
$303
Roundtrip
found 3 days ago
Select Delta flight, departing Fri, Sep 5 from Detroit to Knoxville, returning Sun, Sep 7, priced at $303 found 3 days ago
Delta
Fri, Sep 12 - Sun, Sep 14
DTW
Detroit
TYS
Knoxville
$332 Roundtrip, found 12 hours ago
$332
Roundtrip
found 12 hours ago
Select Delta flight, departing Fri, Sep 12 from Detroit to Knoxville, returning Sun, Sep 14, priced at $332 found 12 hours ago
Delta
Fri, Oct 3 - Sun, Oct 5
DTW
Detroit
TYS
Knoxville
$333 Roundtrip, found 15 hours ago
$333
Roundtrip
found 15 hours ago
Select Delta flight, departing Fri, Oct 3 from Detroit to Knoxville, returning Sun, Oct 5, priced at $333 found 15 hours ago
Delta
Fri, Sep 26 - Sun, Sep 28
DTW
Detroit
TYS
Knoxville
$337 Roundtrip, found 2 days ago
$337
Roundtrip
found 2 days ago
Select Delta flight, departing Fri, Sep 26 from Detroit to Knoxville, returning Sun, Sep 28, priced at $337 found 2 days ago
Delta
Fri, Oct 31 - Mon, Nov 3
DTW
Detroit
TYS
Knoxville
$359 Roundtrip, just found
$359
Roundtrip
just found
Select Delta flight, departing Fri, Oct 31 from Detroit to Knoxville, returning Mon, Nov 3, priced at $359 just found
Delta
Wed, Sep 24 - Tue, Sep 30
DTW
Detroit
TYS
Knoxville
$366 Roundtrip, found 2 days ago
$366
Roundtrip
found 2 days ago
Select Delta flight, departing Wed, Sep 24 from Detroit to Knoxville, returning Tue, Sep 30, priced at $366 found 2 days ago
Flights from Detroit (DTW) to Knoxville (TYS)
Origin airport
Detroit Metropolitan Wayne County
Destination airport
McGhee Tyson
Airlines serving
American Airlines, Delta, Frontier Airlines, United
Popular airline
Delta
Distance
444 mi
Average flight time
2 hours 15 mins

Frequently asked questions

How much is a Delta Air Lines flight from Detroit Metropolitan Wayne County Airport (DTW) to McGhee Tyson Airport (TYS)?
Grab cheap return Delta Air Lines flights from $303 from DTW to TYS by sorting your results from "Price (lowest to highest)" on Expedia. Or look for deals from $178 for a one-way trip.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.
What is the cheapest month to fly from DTW to TYS with Delta Air Lines?
January is one of the cheapest months to jet away to Knoxville with Delta Air Lines. You could also find fantastic deals on return and one-way tickets in December.
What is the cheapest time to book flights from Detroit Metropolitan Wayne County Airport (DTW) to McGhee Tyson Airport (TYS) with Delta Air Lines?
To find cheap Delta Air Lines fares from Detroit Metropolitan Wayne County Airport (DTW) to McGhee Tyson Airport (TYS), start searching one to three months before your intended departure. Reserving domestic flights 34 to 86 days in advance could save you 25% compared to booking just 6 to 12 days ahead. The day you book can also influence the price you pay. Sunday is typically the cheapest, while Monday is often the most expensive for domestic flights. You can save 6% on average by booking your trip on a Sunday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.
Does Delta Air Lines fly nonstop from Detroit Metropolitan Wayne County Airport (DTW) to McGhee Tyson Airport (TYS)?
You can easily fly from Detroit Metropolitan Wayne County Airport (DTW) to McGhee Tyson Airport (TYS) on any of Delta Air Lines's 13 weekly direct flights. Use our "Nonstop" and "Airline" filters to find the Delta Air Lines flight that'll get you to TYS at a time that suits you.
How long does it take to fly from DTW to TYS with Delta Air Lines?
It takes around 1h 41m to travel nonstop from Detroit Metropolitan Wayne County Airport (DTW) to McGhee Tyson Airport (TYS) with Delta Air Lines.
Which day of the week has the most Delta Air Lines flights from Detroit Metropolitan Wayne County Airport (DTW) to McGhee Tyson Airport (TYS)?
Saturday has the most Delta Air Lines flights from Detroit Metropolitan Wayne County Airport (DTW) to McGhee Tyson Airport (TYS). With 2 daily departures, this is the best day of the week to book something that will suit your schedule.
What is the earliest Delta Air Lines flight from DTW to TYS?
The first flight from DTW to TYS with Delta Air Lines leaves at 10:30AM UTC-5. You'll land at 12:14PM UTC-5. The last Delta Air Lines flight of the day takes off at 8:40PM UTC-5 and arrives at 10:26PM UTC-5. With approximately 20% fewer cancellations for morning departures, starting your travel day early is generally the best option.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
What airports does Delta Air Lines fly into in Knoxville?
Take a Delta Air Lines flight from Detroit Metropolitan Wayne County Airport (DTW) to Knoxville, and you'll probably land at McGhee Tyson Airport (TYS). This is the airline's main hub in this destination.
Why fly with Delta Air Lines from DTW to TYS?
Jetting off from DTW to TYS with Delta Air Lines comes with a host of benefits, such as an excellent in-flight experience and a rewarding loyalty program. Plus, when you book through Expedia, One Key™ members can collect OneKeyCash™* to use on select future travel purchases. That's in addition to the Delta SkyMiles points you can earn with Delta Air Lines.*OneKeyCash™ disclaimer - OneKeyCash™ is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.
What type of plane does Delta Air Lines fly from Detroit Metropolitan Wayne County Airport (DTW) to McGhee Tyson Airport (TYS)?
You'll probably be flying on a Bombardier CRJ900 for your Delta Air Lines flight from Detroit Metropolitan Wayne County Airport (DTW) to McGhee Tyson Airport (TYS). However, you may end up on another aircraft if there are operational changes.
Can I change or cancel my Delta Air Lines flight from Detroit Metropolitan Wayne County Airport (DTW) to McGhee Tyson Airport (TYS)?
Typically, you can cancel or change your flight, although additional fees may apply if your booking was made more than 24 hours ago. Need flexible options? Use Expedia's "Changes included" and "No cancel fee" filters to find flights that won't charge extra if you have to adjust your plans. To make modifications, go to "Trips," select your flight and click on "Manage Booking" for further information.

Explore a world of travel with Expedia

*Available to One Key members.