
Popular airlines from Des Moines International Airport (DSM) to Jacksonville International Airport (JAX)
- United
United
- American Airlines
American Airlines
- Delta
Delta
- Southwest Airlines
Southwest Airlines
- Plan, book, fly with confidence
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Cheap Flights from Des Moines to Jacksonville (DSM-JAX)
Prices were available within the past 7 days and start at $143 for one-way flights and $285 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.










Find the cheapest month to fly from Des Moines (DSM) to Jacksonville (JAX)
August is typically the cheapest month to fly
Graph displaying average flight prices per month
Alternative airports near Jacksonville
Prices were available within the past 7 days. Prices and availability are subject to change.
Origin airport | Des Moines Intl. |
Destination airport | Jacksonville Intl. |
Airlines serving | American Airlines, Delta, Southwest Airlines, United |
Roundtrip price | $284 |
Distance | 1012 mi |
Average flight time | 2 hours 37 mins |
Des Moines to Jacksonville Flights
The cheapest times to fly from Des Moines to Jacksonville
On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Des Moines to Jacksonville are during the month of January. You can find some of the cheapest flights from Des Moines to Jacksonville with Expedia's search tool and vast selection of airlines.
The best time to book a flight from Des Moines to Jacksonville
Sunday is one of the best days to book for cheap flights from Des Moines to Jacksonville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.
How to find cheap round-trip tickets from Des Moines to Jacksonville
Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Des Moines to Jacksonville in 2025. You can also book with separate airlines for your outbound and return journeys, from $143 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.
Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Des Moines to Jacksonville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.
You could also save big by booking one of Expedia's vacation packages. Bundling together your Des Moines to Jacksonville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.
*Terms apply.
Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.
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Top Routes from Des Moines
- Des Moines to Chicago (DSM - ORD)
- Des Moines to Phoenix (DSM - PHX)
- Des Moines to San Diego (DSM - SAN)
- Des Moines to Newark Liberty Intl. Airport (DSM - EWR)
- Des Moines to Los Angeles (DSM - LAX)
- Des Moines to Miami (DSM - MIA)
- Des Moines to New York (DSM - LGA)
- Des Moines to Honolulu (DSM - HNL)
- Des Moines to Fort Lauderdale (DSM - FLL)
- Des Moines to Denver (DSM - DEN)
- Des Moines to Seattle (DSM - SEA)
- Des Moines to New York (DSM - JFK)
Top Routes to Jacksonville
- Chicago to Jacksonville (ORD - JAX)
- Newark Liberty Intl. Airport to Jacksonville (EWR - JAX)
- Los Angeles to Jacksonville (LAX - JAX)
- Norfolk to Jacksonville (ORF - JAX)
- Washington to Jacksonville (DCA - JAX)
- Miami to Jacksonville (MIA - JAX)
- Detroit to Jacksonville (DTW - JAX)
- New York to Jacksonville (LGA - JAX)
- Boston to Jacksonville (BOS - JAX)
- Minneapolis to Jacksonville (MSP - JAX)
- Denver to Jacksonville (DEN - JAX)
- Washington to Jacksonville (IAD - JAX)
Top Routes from Des Moines
- Delta Des Moines to Chicago
- United Des Moines to Phoenix
- American Airlines Des Moines to San Diego
- Delta Des Moines to Newark Liberty Intl. Airport
- United Des Moines to Los Angeles
- American Airlines Des Moines to Miami
- Delta Des Moines to New York
- United Des Moines to Honolulu
- Delta Des Moines to Fort Lauderdale
- United Des Moines to Denver
Top Routes to Jacksonville
- American Airlines Chicago to Jacksonville
- United Newark Liberty Intl. Airport to Jacksonville
- JetBlue Airways Los Angeles to Jacksonville
- American Airlines Miami to Jacksonville
- Delta Detroit to Jacksonville
- American Airlines New York to Jacksonville
- JetBlue Airways Boston to Jacksonville
- Delta Minneapolis to Jacksonville
- American Airlines Denver to Jacksonville
- United Washington to Jacksonville
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Nearby Airports
- Fort Dodge Regional Airport (FOD)
- Waterloo Regional Airport (ALO)
- Eastern Iowa Airport (CID)
- Mason City Municipal Airport (MCW)
- Kirksville Municipal Airport (IRK)
- Eppley Field Airport (OMA)
- Millard Airport (MIQ)
- Southeast Iowa Regional Airport (BRL)
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