Title: Islip to Greenville cheap flights from $136 (ISP to GSP) - Expedia.com ![](https://images.trvl-media.com/place/1388/2f1c4846-4013-4641-a8dd-db2da5ca5774.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Visit Greenville, South Carolina ![](https://images.trvl-media.com/place/1388/2f1c4846-4013-4641-a8dd-db2da5ca5774.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # $136 Cheap Flights from Islip (ISP) to Greenville (GSP) [View $136 flight on Wed, Apr 22, 2026](https://expedia.com/Flights-Search?trip=oneway&leg1=from:ISP,to:GSP,departure:4/22/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:135.97&airProductToken=AQpgCi4I15wBEgQxMDc2GMh8IMFFKMyDiwMwnISLAzhHQABYAWoDV0dBcgdHTEFWUDJGCi4I15wBEgQxMzUwGMFFIMZ8KOyEiwMwxoWLAzhHQAFYAWoDV0dBcgdHTEFWUDJGEgoIAhABGAIqAldOGAEiBAgBEAEoAigDKAQwAQ) ## Popular airlines from MacArthur Airport (ISP) to Greenville-Spartanburg Intl. Airport (GSP) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_WN.svg) Southwest Airlines [](https://www.expedia.com/Flights-Search?leg1=from:ISP,to:GSP,departure:4/15/2026TANYT&leg2=from:GSP,to:ISP,departure:4/22/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"WN"}}]) ## Cheap Flights from Islip to Greenville (ISP-GSP) Prices were available within the past 7 days and start at $136 for one-way flights and $303 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply. All deals One way Roundtrip ![Southwest Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/wn.gif) Mon, Jun 1 - Sat, Jun 6 ISP Islip GSP Greenville $303 Roundtrip found 5 days ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:ISP,to:GSP,departure:6/1/2026TANYT&leg2=from:GSP,to:ISP,departure:6/6/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:302.40&airProductToken=AQpgCi4I15wBEgQxMjU3GMh8IMFFKI7JjgMw3smOAzhFQABYAWoDV0dBcgdFTEFXVjJGCi4I15wBEgQxMTQzGMFFIMZ8KLjKjgMwl8uOAzhFQAFYAWoDV0dBcgdFTEFXVjJGCmAKLgjXnAESBDE4OTkYxnwgwUUov_2OAzCU_o4DOEVAAFgBagNXR0FyB0VMQVdWMkYKLgjXnAESBDQ2OTEYwUUgyHwowf6OAzCH_44DOEVAAVgBagNXR0FyB0VMQVdWMkYSCggCEAEYAioCV04YASIECAEQASgCKAMoBDAB) ![Southwest Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/wn.gif) Tue, Apr 28 - Wed, Apr 29 ISP Islip GSP Greenville $319 Roundtrip found 11 hours ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:ISP,to:GSP,departure:4/28/2026TANYT&leg2=from:GSP,to:ISP,departure:4/29/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:318.40&airProductToken=AQpfCi0I15wBEgM5OTMYyHwgwUUousqLAzCKy4sDOEFAAFgBagNXR0FyB0FCQVZOMkYKLgjXnAESBDExNDMYwUUgxnwowcuLAzCgzIsDOEFAAVgBagNXR0FyB0FCQVZOMkYKYAouCNecARIEMjI0NBjGfCDBRSjT1IsDMK3ViwM4QUAAWAFqA1dHQXIHQUJBVk4yRgouCNecARIEMzE2MRjBRSDIfCj814sDMMLYiwM4QUABWAFqA1dHQXIHQUJBVk4yRhIKCAEQARgBKgJXThgBIgQIARABKAIoAygEMAE) ![Southwest Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/wn.gif) Tue, Apr 21 - Sat, Apr 25 ISP Islip GSP Greenville $329 Roundtrip found 14 hours ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:ISP,to:GSP,departure:4/21/2026TANYT&leg2=from:GSP,to:ISP,departure:4/25/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:328.40&airProductToken=AQpgCi4I15wBEgQxMDc2GMh8IMFFKKz4igMw_PiKAzhBQABYAWoDV0dBcgdBQkFWTjJGCi4I15wBEgQxMzUwGMFFIMZ8KMz5igMwpvqKAzhBQAFYAWoDV0dBcgdBQkFWTjJGCmAKLgjXnAESBDIyNDMYxnwgwUUo8KSLAzDKpYsDOEZAAFgBagNXR0FyB0ZaQVZOMkYKLgjXnAESBDExNTYYwUUgyHwogaaLAzDHposDOEZAAVgBagNXR0FyB0ZaQVZOMkYSCggBEAEYASoCV04YASIECAEQASgCKAMoBDAB) ![Southwest Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/wn.gif) Tue, Apr 21 - Sat, Apr 25 ISP Islip GSP Greenville $334 Roundtrip found 14 hours ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:ISP,to:GSP,departure:4/21/2026TANYT&leg2=from:GSP,to:ISP,departure:4/25/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:333.70&airProductToken=AQqQAQouCNecARIEMjQ5OBjIfCDMcCiv94oDMM_4igM4QUAAWAFqA1dHQXIHQUJBVk4yRgouCNecARIEMzA4NRjMcCChAyj3-IoDMPT5igM4QUABWAFqA1dHQXIHQUJBVk4yRgouCNecARIEMTY3MRihAyDGfCie-4oDMOT7igM4QUABWAFqA1dHQXIHQUJBVk4yRhIKCAEQARgBKgJXThgBIgQIARABKAIoAygEMAE) ![Southwest Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/wn.gif) Wed, May 13 - Sat, May 16 ISP Islip GSP Greenville $339 Roundtrip found 1 day ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:ISP,to:GSP,departure:5/13/2026TANYT&leg2=from:GSP,to:ISP,departure:5/16/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:338.39&airProductToken=AQpgCi4I15wBEgQxMDc2GMh8IMFFKOzvjAMwvPCMAzhGQABYAWoDV0dBcgdGWkFWTjJGCi4I15wBEgQxMzUwGMFFIMZ8KIzxjAMw5vGMAzhGQAFYAWoDV0dBcgdGWkFWTjJGCmAKLgjXnAESBDIyNDMYxnwgwUUokJGNAzDqkY0DOEZAAFgBagNXR0FyB0ZaQVZOMkYKLgjXnAESBDIzNTcYwUUgyHwoqpSNAzDwlI0DOEZAAVgBagNXR0FyB0ZaQVZOMkYSCggBEAEYASoCV04YASIECAEQASgCKAMoBDAB) ![Southwest Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/wn.gif) Tue, Apr 21 - Sat, Apr 25 ISP Islip GSP Greenville $339 Roundtrip found 14 hours ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:ISP,to:GSP,departure:4/21/2026TANYT&leg2=from:GSP,to:ISP,departure:4/25/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:339.00&airProductToken=AQqQAQouCNecARIEMjQ5OBjIfCDMcCiv94oDMM_4igM4QUAAWAFqA1dHQXIHQUJBVk4yRgouCNecARIEMjcxOBjMcCChAyit-4oDMP_8igM4QUABWAFqA1dHQXIHQUJBVk4yRgouCNecARIENDY2ORihAyDGfCje_YoDMKT-igM4QUABWAFqA1dHQXIHQUJBVk4yRgpgCi4I15wBEgQyMjQzGMZ8IMFFKPCkiwMwyqWLAzhGQABYAWoDV0dBcgdGWkFWTjJGCi4I15wBEgQxMTU2GMFFIMh8KIGmiwMwx6aLAzhGQAFYAWoDV0dBcgdGWkFWTjJGEgoIARABGAEqAldOGAEiBAgBEAEoAigDKAQwAQ) ![Southwest Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/wn.gif) Mon, Jun 1 - Sat, Jun 6 ISP Islip GSP Greenville $345 Roundtrip found 5 days ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:ISP,to:GSP,departure:6/1/2026TANYT&leg2=from:GSP,to:ISP,departure:6/6/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:344.40&airProductToken=AQpgCi4I15wBEgQyMTYwGMh8IMFFKJjEjgMw6MSOAzhFQABYAWoDV0dBcgdFTEFXVjJGCi4I15wBEgQxMzUwGMFFIMZ8KPHGjgMwy8eOAzhFQAFYAWoDV0dBcgdFTEFXVjJGCmAKLgjXnAESBDEwMzkYxnwgwUUok4CPAzDtgI8DOEVAAFgBagNXR0FyB0VMQVdWMkYKLgjXnAESBDQzMjEYwUUgyHwo-IOPAzC-hI8DOEVAAVgBagNXR0FyB0VMQVdWMkYSCggCEAEYAioCV04YASIECAEQASgCKAMoBDAB) ![Southwest Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/wn.gif) Tue, Apr 21 - Sat, Apr 25 ISP Islip GSP Greenville $345 Roundtrip found 14 hours ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:ISP,to:GSP,departure:4/21/2026TANYT&leg2=from:GSP,to:ISP,departure:4/25/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:344.60&airProductToken=AQqQAQouCNecARIEMjQ5OBjIfCDMcCiv94oDMM_4igM4QUAAWAFqA1dHQXIHQUJBVk4yRgouCNecARIEMjcxOBjMcCChAyit-4oDMP_8igM4QUABWAFqA1dHQXIHQUJBVk4yRgouCNecARIENDY2ORihAyDGfCje_YoDMKT-igM4QUABWAFqA1dHQXIHQUJBVk4yRhIKCAEQARgBKgJXThgBIgQIARABKAIoAygEMAE) ![Southwest Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/wn.gif) Wed, Jul 1 - Tue, Jul 7 ISP Islip GSP Greenville $353 Roundtrip found 1 day ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:ISP,to:GSP,departure:7/1/2026TANYT&leg2=from:GSP,to:ISP,departure:7/7/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:352.40&airProductToken=AQpgCi4I15wBEgQyMTQ1GMh8IMFFKNiakQMwo5uRAzhBQABYAWoDV0dBcgdBQkFWTjJGCi4I15wBEgQzODM5GMFFIMZ8KNWbkQMwr5yRAzhBQAFYAWoDV0dBcgdBQkFWTjJGCmAKLgjXnAESBDE4OTkYxnwgwUUoqdqRAzD-2pEDOEVAAFgBagNXR0FyB0VMQVdWMkYKLgjXnAESBDQ2OTEYwUUgyHwosNuRAzD225EDOEVAAVgBagNXR0FyB0VMQVdWMkYSCggBEAEYASoCV04YASIECAEQASgCKAMoBDAB) ![Breeze Airways](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/MX.gif) Wed, Apr 15 - Fri, Apr 24 ISP Islip GSP Greenville $704 Roundtrip found 5 days ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:ISP,to:GSP,departure:4/15/2026TANYT&leg2=from:GSP,to:ISP,departure:4/24/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:703.19&airProductToken=AQpECiAIzbABEgM3ODcYyHwg0bQBKOe5igMwqruKAzhOQABYAQogCM2wARIDMTU2GNG0ASDGfCj4xIoDMOPFigM4VkABWAEKQgofCM2wARIDNTYyGMZ8IPMDKLediwMwm56LAzhWQABYAQofCM2wARIDMTM0GPMDIMh8KLSkiwMwrqaLAzhUQAFYARIKCAEQARgBKgJNWBgBIgQIARABKAQwAQ) ## Frequently asked questions ### How much does a flight from Islip, NY (ISP-MacArthur) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) cost? ### What is the cheapest month to fly from Islip, NY (ISP-MacArthur) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)? ### Which airlines fly direct from Islip, NY (ISP-MacArthur) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)? ### How do I find cheap flights from Islip, NY (ISP-MacArthur) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)? ### What is the best time to fly from Islip, NY (ISP-MacArthur) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)? ### What is the earliest flight from Islip, NY (ISP-MacArthur) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)? ### What are the most popular departure times for flights from Islip, NY (ISP-MacArthur) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)? ### How long does it take to fly from Islip, NY (ISP-MacArthur) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)? ### Can you fly business or first class from Islip, NY (ISP-MacArthur) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)? ### How do I earn miles on a Islip, NY (ISP-MacArthur) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) flight with Expedia? ### What airports do you fly into for Greenville from MacArthur (ISP)? ### Is it cheaper to buy a plane ticket from Islip, NY (ISP-MacArthur) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) at the last minute? ### Is it cheaper to book a Islip, NY (ISP-MacArthur) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) flight and hotel package? ### Can I cancel or change the date of my flight from Islip, NY (ISP-MacArthur) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)? ## Travel information | Origin airport | MacArthur | | ------------------- | ---------------------------- | | Destination airport | Greenville-Spartanburg Intl. | | Airlines serving | Southwest Airlines | | Roundtrip price | $302 | | Distance | 642 mi | ## Book with confidence # Islip to Greenville Flights The cheapest times to fly from Islip to Greenville On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Islip to Greenville are during the month of June. You can find some of the cheapest flights from Islip to Greenville with Expedia's search tool and vast selection of airlines. The best time to book a flight from Islip to Greenville Sunday is one of the best days to book for cheap flights from Islip to Greenville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance. How to find cheap round-trip tickets from Islip to Greenville Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Islip to Greenville in 2026\. You can also book with separate airlines for your outbound and return journeys, from $136 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference\*. This is available for a small fee, and is free to One Key Gold and Platinum tier members. Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Islip to Greenville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps. You could also save big by booking one of Expedia's [vacation packages](https://www.expedia.com/package-deals). Bundling together your Islip to Greenville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures. \*Terms apply. Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023\. 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