A lakeside resort with boats docked, a golf course, and a large building surrounded by trees.

$175 Cheap Flights from Islip (ISP) to Greenville (GSP)

View $175 flight on Fri, Dec 4, 2026Opens in a new window

Popular airlines from MacArthur Airport (ISP) to Greenville-Spartanburg Intl. Airport (GSP)

  • Be in the know

    Get alerts if flight prices drop or rise*

  • Book smarter

    Save up to 30% on select hotels after you book a flight*

  • Earn twice

    Earn your airline miles on top of our OneKeyCash
    Learn about One Key

Cheap Flights from Islip to Greenville (ISP-GSP)

Prices were available within the past 7 days and start at $175 for one-way flights and $309 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Southwest Airlines
Wed, Nov 4 - Thu, Nov 5
ISP
Islip
GSP
Greenville
$309 Roundtrip, found 3 days ago
$309
Roundtrip
found 3 days ago
Select Southwest Airlines flight, departing Wed, Nov 4 from Islip to Greenville, returning Thu, Nov 5, priced at $309 found 3 days ago
Southwest Airlines
Fri, Nov 13 - Sat, Nov 14
ISP
Islip
GSP
Greenville
$339 Roundtrip, found 3 days ago
$339
Roundtrip
found 3 days ago
Select Southwest Airlines flight, departing Fri, Nov 13 from Islip to Greenville, returning Sat, Nov 14, priced at $339 found 3 days ago
Southwest Airlines
Tue, Nov 3 - Wed, Nov 4
ISP
Islip
GSP
Greenville
$341 Roundtrip, found 3 days ago
$341
Roundtrip
found 3 days ago
Select Southwest Airlines flight, departing Tue, Nov 3 from Islip to Greenville, returning Wed, Nov 4, priced at $341 found 3 days ago
Southwest Airlines
Mon, Oct 5 - Wed, Oct 7
ISP
Islip
GSP
Greenville
$349 Roundtrip, found 3 days ago
$349
Roundtrip
found 3 days ago
Select Southwest Airlines flight, departing Mon, Oct 5 from Islip to Greenville, returning Wed, Oct 7, priced at $349 found 3 days ago
Southwest Airlines
Fri, Nov 13 - Mon, Nov 16
ISP
Islip
GSP
Greenville
$350 Roundtrip, found 3 days ago
$350
Roundtrip
found 3 days ago
Select Southwest Airlines flight, departing Fri, Nov 13 from Islip to Greenville, returning Mon, Nov 16, priced at $350 found 3 days ago
Southwest Airlines
Thu, Nov 12 - Sat, Nov 14
ISP
Islip
GSP
Greenville
$351 Roundtrip, found 4 days ago
$351
Roundtrip
found 4 days ago
Select Southwest Airlines flight, departing Thu, Nov 12 from Islip to Greenville, returning Sat, Nov 14, priced at $351 found 4 days ago
Southwest Airlines
Fri, Nov 13 - Sat, Nov 14
ISP
Islip
GSP
Greenville
$353 Roundtrip, found 3 days ago
$353
Roundtrip
found 3 days ago
Select Southwest Airlines flight, departing Fri, Nov 13 from Islip to Greenville, returning Sat, Nov 14, priced at $353 found 3 days ago
Southwest Airlines
Thu, Jan 21 - Sat, Jan 23
ISP
Islip
GSP
Greenville
$354 Roundtrip, found 6 days ago
$354
Roundtrip
found 6 days ago
Select Southwest Airlines flight, departing Thu, Jan 21 from Islip to Greenville, returning Sat, Jan 23, priced at $354 found 6 days ago
Southwest Airlines
Fri, Nov 13 - Mon, Nov 16
ISP
Islip
GSP
Greenville
$356 Roundtrip, found 3 days ago
$356
Roundtrip
found 3 days ago
Select Southwest Airlines flight, departing Fri, Nov 13 from Islip to Greenville, returning Mon, Nov 16, priced at $356 found 3 days ago
Breeze Airways
Sun, Oct 25 - Mon, Nov 9
ISP
Islip
GSP
Greenville
$619 Roundtrip, found 4 days ago
$619
Roundtrip
found 4 days ago
Select Breeze Airways flight, departing Sun, Oct 25 from Islip to Greenville, returning Mon, Nov 9, priced at $619 found 4 days ago

Frequently asked questions

How much does a flight from Islip, NY (ISP-MacArthur) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) cost?
You can find cheap one-way flights from $175 and cheap return flights from $309 Islip, NY (ISP-MacArthur) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) with Expedia. One-way flights typically cost between $254 and $1018, and return flights often range between $484 and $1882. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Islip, NY (ISP-MacArthur) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) ticket fares go up or down.*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.
What is the cheapest month to fly from Islip, NY (ISP-MacArthur) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)?
The cheapest month to fly from ISP to GSP is November when demand is low. Traveling in off-peak or shoulder months is usually a good way to secure cheap tickets, just remember to avoid flying during holidays if you're able to. Use the calendar view in your search to see which months have low fares on this route.
Which airlines fly direct from Islip, NY (ISP-MacArthur) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)?
Enter ISP to GSP and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
How do I find cheap flights from Islip, NY (ISP-MacArthur) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)?
To find a cheap flight from Islip, NY (ISP-MacArthur) to Greenville, SC (GSP-Greenville-Spartanburg Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Islip, NY (ISP-MacArthur) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
What is the earliest flight from Islip, NY (ISP-MacArthur) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)?
The earliest flight from MacArthur Airport (ISP) to Greenville-Spartanburg International (GSP) typically departs at around 5:05 AM, operated by Southwest Airlines. This seasonal service is active in July, allowing you to kick off your day early in Greenville. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What are the most popular departure times for flights from Islip, NY (ISP-MacArthur) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)?
The most popular departure times for flights from Islip, NY (ISP-MacArthur) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) are in the late morning, from 9am to noon. About 37% of passengers prefer this time window. Many major carriers, including Southwest Airlines, United Airlines, and American Airlines, offer flights during this window. This timing works well because it allows you to start your day early and arrive in Greenville with plenty of time to explore.
How long does it take to fly from Islip, NY (ISP-MacArthur) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)?
A flight from ISP to GSP with a layover takes around 4 hours, with the route covering approximately 643 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Islip, NY (ISP-MacArthur) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)?
Select the "Business class" and "First class" filters when looking for ISP to GSP flights on Expedia. This is the easiest way to compare prices, routes and flight times for your trip.
How do I earn miles on a Islip, NY (ISP-MacArthur) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) flight with Expedia?
It's easy to earn miles on a Islip, NY (ISP-MacArthur) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Greenville from MacArthur (ISP)?
If you're planning to travel to Greenville from MacArthur (ISP), you can fly into Greenville-Spartanburg Intl. (GSP) Some flights may connect through major hubs like Logan Intl. (BOS), Orlando Intl. (MCO), Baltimore Washington Intl. Thurgood Marshall (BWI) before reaching Greenville. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Islip, NY (ISP-MacArthur) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) at the last minute?
Typically, booking a last minute flight from Islip, NY (ISP-MacArthur) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Islip, NY (ISP-MacArthur) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) flight and hotel package?
Securing a Islip, NY (ISP-MacArthur) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Islip, NY (ISP-MacArthur) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)?
If you booked your Islip, NY (ISP-MacArthur) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
MacArthur
Destination airport
Greenville-Spartanburg Intl.
Airlines serving
Southwest Airlines
Roundtrip price
$308
Distance
642 mi

Book with confidence

Islip to Greenville Flights

The cheapest times to fly from Islip to Greenville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Islip to Greenville are during the month of November. You can find some of the cheapest flights from Islip to Greenville with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Islip to Greenville

Sunday is one of the best days to book for cheap flights from Islip to Greenville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Islip to Greenville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Islip to Greenville in 2026. You can also book with separate airlines for your outbound and return journeys, from $175 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Islip to Greenville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Islip to Greenville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Islip to Greenville Flights

*Flight schedules are subject to change.

*Available to One Key members.

 

Explore a world of travel with Expedia