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$178 Cheap Flights from Chicago (ORD) to Greenville (GSP)

View $178 flight on Thu, Dec 31, 2026Opens in a new window

Popular airlines from Chicago O'Hare Intl. Airport (ORD) to Greenville-Spartanburg Intl. Airport (GSP)

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Cheap Flights from Chicago to Greenville (ORD-GSP)

Prices were available within the past 7 days and start at $178 for one-way flights and $299 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Wed, Oct 14 - Sat, Oct 24
ORD
Chicago
GSP
Greenville
$299 Roundtrip, found 1 hour ago
$299
Roundtrip
found 1 hour ago
Select American Airlines flight, departing Wed, Oct 14 from Chicago to Greenville, returning Sat, Oct 24, priced at $299 found 1 hour ago
American Airlines
Tue, Dec 22 - Tue, Dec 29
ORD
Chicago
GSP
Greenville
$302 Roundtrip, found 14 hours ago
$302
Roundtrip
found 14 hours ago
Select American Airlines flight, departing Tue, Dec 22 from Chicago to Greenville, returning Tue, Dec 29, priced at $302 found 14 hours ago
American Airlines
Wed, Oct 14 - Sat, Oct 24
ORD
Chicago
GSP
Greenville
$309 Roundtrip, found 1 hour ago
$309
Roundtrip
found 1 hour ago
Select American Airlines flight, departing Wed, Oct 14 from Chicago to Greenville, returning Sat, Oct 24, priced at $309 found 1 hour ago
Delta
Sat, Oct 24 - Tue, Oct 27
ORD
Chicago
GSP
Greenville
$311 Roundtrip, found 1 day ago
$311
Roundtrip
found 1 day ago
Select Delta flight, departing Sat, Oct 24 from Chicago to Greenville, returning Tue, Oct 27, priced at $311 found 1 day ago
American Airlines
Tue, Oct 6 - Tue, Oct 13
ORD
Chicago
GSP
Greenville
$312 Roundtrip, found 4 hours ago
$312
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Tue, Oct 6 from Chicago to Greenville, returning Tue, Oct 13, priced at $312 found 4 hours ago
United
Fri, Oct 16 - Mon, Oct 19
ORD
Chicago
GSP
Greenville
$313 Roundtrip, found 20 hours ago
$313
Roundtrip
found 20 hours ago
Select United flight, departing Fri, Oct 16 from Chicago to Greenville, returning Mon, Oct 19, priced at $313 found 20 hours ago
United
Fri, Oct 9 - Sat, Oct 10
ORD
Chicago
GSP
Greenville
$318 Roundtrip, found 14 hours ago
$318
Roundtrip
found 14 hours ago
Select United flight, departing Fri, Oct 9 from Chicago to Greenville, returning Sat, Oct 10, priced at $318 found 14 hours ago
United
Fri, Sep 25 - Sat, Sep 26
ORD
Chicago
GSP
Greenville
$319 Roundtrip, found 19 hours ago
$319
Roundtrip
found 19 hours ago
Select United flight, departing Fri, Sep 25 from Chicago to Greenville, returning Sat, Sep 26, priced at $319 found 19 hours ago
United
Wed, Oct 14 - Sat, Oct 24
ORD
Chicago
GSP
Greenville
$319 Roundtrip, found 1 hour ago
$319
Roundtrip
found 1 hour ago
Select United flight, departing Wed, Oct 14 from Chicago to Greenville, returning Sat, Oct 24, priced at $319 found 1 hour ago
Delta
Sat, Oct 24 - Mon, Oct 26
ORD
Chicago
GSP
Greenville
$321 Roundtrip, found 1 day ago
$321
Roundtrip
found 1 day ago
Select Delta flight, departing Sat, Oct 24 from Chicago to Greenville, returning Mon, Oct 26, priced at $321 found 1 day ago

Find the cheapest month to fly from Chicago (ORD) to Greenville (GSP)

February is typically the cheapest month to fly

From $195 - $275 per traveler.

What you need to know for your flight from O'Hare Intl. to Greenville-Spartanburg Intl.

Chicago (ORD) to Greenville (GSP) at a glance

Travel from Chicago (ORD) to Greenville (GSP) with a range of airlines on this domestic short-haul route. Explore flights from Chicago and compare various options from both full-service and low-cost carriers to discover the best itinerary that suits your budget and schedule. As you plan your adventure in Greenville, don’t miss the chance to check out the latest deals on flights and make the most of your trip to this charming destination.

  • Fastest flight duration: around 2 hours non-stop
  • Route distance: roughly 600 miles (970 km)
  • Flights per week: around 20+ flights with multiple daily departures on average
  • Typical fares (one-way): economy tickets often range from $100–$370, depending on seasonality and how far ahead you book

Flights from O'Hare International Airport (ORD) to Greenville-Spartanburg International Airport (GSP)

Based on recent traveler bookings, here are the top airlines favored for flights from Chicago to Greenville, especially for non-stop and one-stop options. Popular layover points include Hartsfield-Jackson Atlanta International Airport (ATL) with a layover of about 1 hour and 30 minutes, Charlotte-Douglas International Airport (CLT) at approximately 1 hour and 15 minutes, and Baltimore Washington International Thurgood Marshall Airport (BWI) with a 2-hour layover. This variety allows you to balance price, total travel time, and cabin class to create your ideal itinerary.

  • United: This full-service airline provides both non-stop and one-stop options, with one-way ticket prices generally falling between $105 and $390. It holds about 48% of the departures on this route and typically offers a non-stop travel time of around 2 hours.
  • American Airlines: Another full-service carrier, American Airlines features non-stop and one-stop services. One-way fares usually range from $100 to $365, and the airline is responsible for roughly 47% of departures on this route, with a standard non-stop flight duration of 2 hours.
  • Delta: As a full-service option that mainly provides one-stop flights, Delta's one-way fares typically vary from $105 to $580. This airline accounts for approximately 3% of the departures, with an in-flight duration of 3 hours and 15 minutes and a total travel time of around 4 hours and 45 minutes, including layover.
  • Southwest Airlines: This low-cost carrier offers one-stop service, with one-way fares generally priced between $125 and $265. Southwest Airlines represents about 3% of departures on this route, featuring an in-flight time of 3 hours and 15 minutes, totaling around 4 hours and 45 minutes when factoring in layover time.

Travelers can enhance their journey from Chicago to Greenville by upgrading to first class, available through both United and American Airlines for this route.

Best time to fly from Chicago (ORD) to Greenville (GSP)

The most popular months for travelers flying from Chicago to Greenville are February, March, and April, when peak temperatures in Greenville reach up to 59.9°F in April. If you prefer quieter travel, consider August, the least busy and relatively cheaper time to visit with fewer crowds and temperatures around 77.5°F. For better deals, April and June usually offer the lowest average one-way fares around $196. Flight availability peaks in October, with approximately 28 flights per week, making it easier to find convenient departure times. January has the fewest flights, with approximately 15 flights per week.

  • Cheapest time to fly: April and June usually offer good deals with average one-way fares around $196, roughly 5% cheaper than the yearly average.
  • More budget-friendly months to fly: February and May typically offer average one-way fares of around $198.
  • Most flight options: October has the highest number of flights from Chicago to Greenville, with approximately 28 flights per week, giving you more flexibility in scheduling your trip.
calendar iconMonthtemperature iconTemperaturecrowd level iconDemandflights iconWeekly Flightsprice iconAverage one-way Fare
January41.4°F (5.2°C)Average15$218
February45.3°F (7.4°C)High18$197
March51.8°F (11.0°C)High23$201
April59.9°F (15.5°C)High21$196
May68.4°F (20.2°C)Average23$200
June76.1°F (24.5°C)Average23$196
July79.5°F (26.4°C)Low22$233
August77.5°F (25.3°C)Low19$208
September72.3°F (22.4°C)Low20$216
October61.9°F (16.6°C)Average28$203
November51.1°F (10.6°C)Average25$202
December45.3°F (7.4°C)Average22$220

*Average one-way fare is based on Expedia flight booking data from January 2025 to April 2026 for the specified route and travel class and may change depending on availability, dates, and demand.

Alternative route from Chicago (ORD) to Greenville (GSP)

  • Chicago to Greenville (MDW-GSP): Midway International Airport (MDW) is located approximately 16 miles from O'Hare International Airport (ORD). One-way economy ticket prices for this route generally fall between $115 and $335, varying by season and how far in advance you book. Typically, flights on this route feature one-stop options, with common layover locations being Nashville International Airport (BNA) and Hartsfield-Jackson Atlanta International Airport (ATL). Major airlines servicing this route include low-cost carrier Southwest Airlines and Delta. First-class service is also available on this route.

How to find the best prices for flights from Chicago (ORD) to Greenville (GSP)

Getting some of the best deals on flights from Chicago to Greenville is all about timing and flexibility. Here are some key tips to help you save:

  1. Best times to book and fly: cheaper fares are usually found when booking 2 to 8 weeks in advance, which coincides with when most travelers make their reservations. Morning departures, between 5 AM and 12 PM, tend to offer lower prices and are also the most popular flight times. Additionally, flying on Wednesday generally provides cheaper prices, while Friday remains the busiest travel day.
  2. Set up price alerts: stay updated on price changes by using Expedia's Price Tracker. Receive alerts when fares drop for your selected route.
  3. Bundle and save: bundle your flight and hotel to save on Expedia, or unlock a hotel deal after booking your flight.* Find Greenville hotel and flight deals.
  4. Compare flight options: use Expedia's search tool to compare airlines, routes, direct vs. non-direct flights, and flight times. You can also sort by price to find the most affordable options.
  5. Stay flexible with dates: being open to different travel days can sometimes help you find better prices on flights and hotels.
  6. Think about luggage: nowadays, it's important to check the airline's baggage policies to find the best value. That may be paying for an additional carry-on bag or booking a ticket with checked luggage included. Either way, double-check your allowance before confirming your booking to avoid excess baggage fees at the airport.

*Members only. Savings vary and are not available on all bundles. Select hotels.

Arriving at Greenville-Spartanburg International Airport from O'Hare International Airport

Greenville welcomes travelers from Chicago with a range of transport options based on price, convenience, and proximity. Greenville city center is approximately a 20-minute drive (covering about 16 miles) from Greenville-Spartanburg International Airport, depending on traffic. Here's how to reach Greenville efficiently:

  • Hotel transfer: Transfers offer a convenient way to reach your hotel in Greenville, with options including free hotel shuttles and private rides, which can be arranged in advance with your hotel.
  • Car rental: Renting a car from Greenville-Spartanburg International Airport is a great option if you plan to explore and sightsee beyond the city. Browse cheap car rentals at Greenville-Spartanburg International Airport on Expedia.
  • Taxi/ride-hailing: Taxis and ride-hailing services may be available from designated pickup areas outside the terminal, check locally on arrival.

Frequently asked questions

How much does a flight from Chicago, IL (ORD-O'Hare Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) cost?
You can find cheap one-way flights from $178 and cheap return flights from $299 Chicago, IL (ORD-O'Hare Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) with Expedia. One-way flights generally range between $173 and $569, and roundtrip flights usually range from $285 to $1133. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Chicago, IL (ORD-O'Hare Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) ticket fares go up or down.*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.
What is the cheapest month to fly from Chicago, IL (ORD-O'Hare Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)?
January is the cheapest month to fly from Chicago to Greenville, SC, with average return fares around $283. This is about 13% lower than the average price throughout the year, as travel demand is typically lower after the holiday season. Other cheap months to fly from Chicago to Greenville include February and September.*Averages based on flights available on Expedia in the last year.
Which airlines fly direct from Chicago, IL (ORD-O'Hare Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)?
Choose from 2 airlines operating direct flights from ORD to GSP:

  • United operates around 39 direct flights from ORD to GSP every week
  • American Airlines operates around 27 direct flights from ORD to GSP every week

What is the cheapest airline that flies from Chicago, IL (ORD-O'Hare Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)?
United is one of the cheapest airlines offering nonstop flights from Chicago (ORD) to Greenville (GSP) starting from around $186. Use Expedia's search tool to compare the prices and schedules of airlines that fly this route to find the best option for your plans and budget.*Prices based on flights available on Expedia in the last year.
How do I find cheap flights from Chicago, IL (ORD-O'Hare Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)?
To find a cheap flight from Chicago, IL (ORD-O'Hare Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best airline to fly with from Chicago, IL (ORD-O'Hare Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)?
The best airline to fly with from Chicago, IL (ORD) to Greenville, SC (GSP) will differ from traveler to traveler. If you like to fly early, American Airlines offers early morning flights. If price is the most important factor, United typically offers the lowest fares. American Airlines also offers the most daily flights from Chicago to Greenville, which is great if flexibility is what you value most. The best carrier for this journey could also be the one you have a loyalty membership with, as flying with that airline or another airline within the same alliance could help you collect points or enjoy lounge access.
What is the best time to fly from Chicago, IL (ORD-O'Hare Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)?
For flights from Chicago, IL (ORD) to Greenville, SC (GSP), January and September are the best months to consider. Return flights during these months average around $283, making them quite affordable. January is ideal for avoiding the summer crowds, while September offers pleasant weather for exploring Greenville.*Prices based on flights available on Expedia in the last year.
How many flights per day from Chicago, IL (ORD-O'Hare Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)?
On average, there are around 9 nonstop flights per day from O'Hare Intl. (ORD) to Greenville-Spartanburg Intl. (GSP). For more options, look at flights that include layovers.
What is the earliest flight from Chicago, IL (ORD-O'Hare Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)?
The earliest flight from O'Hare International (ORD) to Greenville-Spartanburg International (GSP) typically departs at 12:00 AM, operated by United. This is a seasonal service, so check for availability during the active months. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What are the most popular departure times for flights from Chicago, IL (ORD-O'Hare Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)?
The most popular departure times for flights from Chicago, IL (ORD) to Greenville, SC (GSP) are in the early morning, from 6am to 9am. About 27% of passengers prefer this time window. Many major carriers, including American Airlines and Delta Airlines, offer flights during this window. This timing is favored because it allows you to arrive in Greenville with plenty of time to enjoy your day.
How long does it take to fly from Chicago, IL (ORD-O'Hare Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)?
Flying nonstop from ORD to GSP takes around 2 hours, with the route covering approximately 578 miles. Flights with a layover typically take 4 hours 20 minutes longer than direct options. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Chicago, IL (ORD-O'Hare Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)?
You can fly first class between ORD and GSP. First class cabins are available on:

  • Delta Air Lines
  • American Airlines
  • United Airlines

How much is a business class flight from Chicago, IL (ORD-O'Hare Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)?
A direct, return business class ticket from Chicago (ORD) to Greenville (GSP) typically costs between $827 - $1,085. A non-stop, one-way business class flight is usually around $357 - $507. Prices often fluctuate based on seasonality and how early you book. You may also be able to find a cheaper business class journey between Chicago, IL (ORD-O'Hare Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) if you opt for a connecting flight.*Prices based on flights available on Expedia in the last year.
How do I earn miles on a Chicago, IL (ORD-O'Hare Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) flight with Expedia?
It's easy to earn miles on a Chicago, IL (ORD-O'Hare Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Greenville from O'Hare Intl. (ORD)?
From O'Hare Intl. (ORD), you can fly into Mid Delta Regional (GLH), Pitt-Greenville (PGV) and Greenville-Spartanburg Intl. (GSP) in Greenville. Some flights may connect through major hubs like George Bush Intercontinental (IAH), Waynesville Regional (TBN) before reaching Greenville. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Chicago, IL (ORD-O'Hare Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) at the last minute?
Typically, booking a last minute flight from Chicago, IL (ORD-O'Hare Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Chicago, IL (ORD-O'Hare Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) flight and hotel package?
Securing a Chicago, IL (ORD-O'Hare Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Chicago, IL (ORD-O'Hare Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)?
If you booked your Chicago, IL (ORD-O'Hare Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
O'Hare Intl.
Destination airport
Greenville-Spartanburg Intl.
Airlines serving
American Airlines, Delta, United
Roundtrip price
$299
Distance
577 mi
Average flight time
2 hours 52 mins

Book with confidence

Chicago to Greenville Flights

The cheapest times to fly from Chicago to Greenville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Chicago to Greenville are during the month of October. You can find some of the cheapest flights from Chicago to Greenville with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Chicago to Greenville

Sunday is one of the best days to book for cheap flights from Chicago to Greenville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Chicago to Greenville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Chicago to Greenville in 2026. You can also book with separate airlines for your outbound and return journeys, from $178 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Chicago to Greenville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Chicago to Greenville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Chicago to Greenville Flights

*Flight schedules are subject to change.

*Available to One Key members.

 

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