$481 Cheap Flights from Medellín (MDE) to Key West (EYW)

View $481 flight on Fri, Aug 22, 2025Opens in a new window

Popular airlines from Jose Maria Cordova Intl. Airport (MDE) to Key West Intl. Airport (EYW)

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Cheap Flights from Medellín to Key West (MDE-EYW)

Prices were available within the past 7 days and start at $481 for one-way flights and $756 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Fri, Aug 22 - Wed, Aug 27
MDE
Medellin
EYW
Key West
$756 Roundtrip, found 4 days ago
$756
Roundtrip
found 4 days ago
Select American Airlines flight, departing Fri, Aug 22 from Medellin to Key West, returning Wed, Aug 27, priced at $756 found 4 days ago
American Airlines
Fri, Aug 22 - Wed, Aug 27
MDE
Medellin
EYW
Key West
$762 Roundtrip, found 4 days ago
$762
Roundtrip
found 4 days ago
Select American Airlines flight, departing Fri, Aug 22 from Medellin to Key West, returning Wed, Aug 27, priced at $762 found 4 days ago
American Airlines
Fri, Aug 22 - Wed, Aug 27
MDE
Medellin
EYW
Key West
$769 Roundtrip, found 4 days ago
$769
Roundtrip
found 4 days ago
Select American Airlines flight, departing Fri, Aug 22 from Medellin to Key West, returning Wed, Aug 27, priced at $769 found 4 days ago
American Airlines
Fri, Aug 22 - Wed, Aug 27
MDE
Medellin
EYW
Key West
$798 Roundtrip, found 4 days ago
$798
Roundtrip
found 4 days ago
Select American Airlines flight, departing Fri, Aug 22 from Medellin to Key West, returning Wed, Aug 27, priced at $798 found 4 days ago
American Airlines
Fri, Aug 22 - Wed, Aug 27
MDE
Medellin
EYW
Key West
$805 Roundtrip, found 4 days ago
$805
Roundtrip
found 4 days ago
Select American Airlines flight, departing Fri, Aug 22 from Medellin to Key West, returning Wed, Aug 27, priced at $805 found 4 days ago
American Airlines
Fri, Aug 22 - Wed, Aug 27
MDE
Medellin
EYW
Key West
$909 Roundtrip, found 4 days ago
$909
Roundtrip
found 4 days ago
Select American Airlines flight, departing Fri, Aug 22 from Medellin to Key West, returning Wed, Aug 27, priced at $909 found 4 days ago
American Airlines
Fri, Aug 22 - Wed, Aug 27
MDE
Medellin
EYW
Key West
$916 Roundtrip, found 4 days ago
$916
Roundtrip
found 4 days ago
Select American Airlines flight, departing Fri, Aug 22 from Medellin to Key West, returning Wed, Aug 27, priced at $916 found 4 days ago
American Airlines
Fri, Aug 22 - Wed, Aug 27
MDE
Medellin
EYW
Key West
$916 Roundtrip, found 4 days ago
$916
Roundtrip
found 4 days ago
Select American Airlines flight, departing Fri, Aug 22 from Medellin to Key West, returning Wed, Aug 27, priced at $916 found 4 days ago
American Airlines
Fri, Aug 22 - Wed, Aug 27
MDE
Medellin
EYW
Key West
$923 Roundtrip, found 4 days ago
$923
Roundtrip
found 4 days ago
Select American Airlines flight, departing Fri, Aug 22 from Medellin to Key West, returning Wed, Aug 27, priced at $923 found 4 days ago
Delta
Fri, Aug 22 - Wed, Aug 27
MDE
Medellin
EYW
Key West
$1,295 Roundtrip, found 4 days ago
$1,295
Roundtrip
found 4 days ago
Select Delta flight, departing Fri, Aug 22 from Medellin to Key West, returning Wed, Aug 27, priced at $1,295 found 4 days ago
Flights from Medellín (MDE) to Key West (EYW)
Origin airport
José María Córdova Intl.
Destination airport
Key West Intl.
Roundtrip price
$755
Distance
1337 mi

Medellín to Key West Flights

The cheapest times to fly from Medellín to Key West

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Medellín to Key West are during the month of August. You can find some of the cheapest flights from Medellín to Key West with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Medellín to Key West

Sunday is one of the best days to book for cheap flights from Medellín to Key West: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Medellín to Key West

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Medellín to Key West in 2025. You can also book with separate airlines for your outbound and return journeys, from $481 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Medellín to Key West flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Medellín to Key West airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Jose Maria Cordova Intl. Airport (MDE) to Key West Intl. Airport (EYW) cost?
Snag a cheap one-way flight from $481 or cheap return flight from $756 from Jose Maria Cordova Intl. Airport (MDE) to Key West Intl. Airport (EYW) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Jose Maria Cordova Intl. Airport (MDE) to Key West Intl. Airport (EYW)?
The cheapest month to fly from MDE to EYW is August, when there's less demand. Off-peak months are generally when airlines offer better prices between these airports.
What is the cheapest airline that flies from Jose Maria Cordova Intl. Airport (MDE) to Key West Intl. Airport (EYW)?
Expedia's filter tool lets you easily compare airlines, flight times and fares all in one place. Tailor the search to your trip, then sort by "Price (lowest to highest)" to find out which carrier offers the cheapest MDE to EYW flight.
How many flights per day from Jose Maria Cordova Intl. Airport (MDE) to Key West Intl. Airport (EYW)?
You'll have to hop on a flight with a layover when traveling from Jose Maria Cordova Intl. Airport (MDE) to Key West Intl. Airport (EYW). There are no daily direct flights on this route. However, just filter your search to include one or more stops to find the best option for your trip.
What day of the week has the most flights from MDE to EYW?
Usually you'll find the widest variety of flight choices on a Friday. Tuesdays tend to be the quietest.* However, this can vary depending on the time of year, carrier and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Jose Maria Cordova Intl. Airport (MDE) to Key West Intl. Airport (EYW)?
To arrive at Key West Intl. Airport (EYW) without delays, book a flight that leaves from Jose Maria Cordova Intl. Airport (MDE) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this time.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Jose Maria Cordova Intl. Airport (MDE) to Key West Intl. Airport (EYW) last-minute?
Waiting until right before your break to book a ticket from MDE to EYW often results in higher prices. While you may find some last-minute deals, they're not always guaranteed. Be flexible with your itinerary for a better chance of getting a bargain.
Is it cheaper to book a MDE to EYW flight and hotel package?
Compared with arranging hotels and flights separately, booking a MDE to EYW flight and hotel package with Expedia could result in significant savings. Better still, managing everything in one place will take the stress out of planning your trip. Just secure your flights and choose from our extensive range of stays, then customize your trip with other add-ons like activities, tours and car rentals.
Can I cancel or change the date of my flight from Jose Maria Cordova Intl. Airport (MDE) to Key West Intl. Airport (EYW)?
Typically, it's possible to cancel or reschedule your MDE to EYW flight. However, for bookings made more than 24 hours ago, additional charges may apply. Refer to your airline's policies in your itinerary to see what changes are possible and if any costs are involved. You'll also find further details on our Customer Service portal.

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*Available to One Key members.