$191 Cheap Flights from Medellín (MDE) to Santo Domingo (SDQ)

View $191 flight on Wed, Oct 29, 2025Opens in a new window

Popular airlines from Jose Maria Cordova Intl. Airport (MDE) to Las Americas Intl. Airport (SDQ)

    notification illustration

    Be in the know

    Get alerts if flight prices drop or rise*
    deals illustration

    Book smarter

    Save up to 30% on select hotels after you book a flight*
    trophy illustration

    Earn twice

    Earn your airline miles on top of our OneKeyCash
    Learn about One Key

Cheap Flights from Medellín to Santo Domingo (MDE-SDQ)

Prices were available within the past 7 days and start at $191 for one-way flights and $257 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Arajet
Tue, Jan 20 - Wed, Jan 21
MDE
Medellin
SDQ
Santo Domingo
$257 Roundtrip, found 5 days ago
$257
Roundtrip
found 5 days ago
Select Arajet flight, departing Tue, Jan 20 from Medellin to Santo Domingo, returning Wed, Jan 21, priced at $257 found 5 days ago
Arajet
Wed, Nov 5 - Fri, Nov 7
MDE
Medellin
SDQ
Santo Domingo
$270 Roundtrip, found 6 days ago
$270
Roundtrip
found 6 days ago
Select Arajet flight, departing Wed, Nov 5 from Medellin to Santo Domingo, returning Fri, Nov 7, priced at $270 found 6 days ago
Copa
Wed, Oct 29 - Sun, Nov 2
MDE
Medellin
SDQ
Santo Domingo
$278 Roundtrip, found 3 days ago
$278
Roundtrip
found 3 days ago
Select Copa flight, departing Wed, Oct 29 from Medellin to Santo Domingo, returning Sun, Nov 2, priced at $278 found 3 days ago
Copa
Thu, Nov 6 - Mon, Nov 10
MDE
Medellin
SDQ
Santo Domingo
$279 Roundtrip, found 1 hour ago
$279
Roundtrip
found 1 hour ago
Select Copa flight, departing Thu, Nov 6 from Medellin to Santo Domingo, returning Mon, Nov 10, priced at $279 found 1 hour ago
Copa
Wed, Oct 29 - Sun, Nov 2
MDE
Medellin
SDQ
Santo Domingo
$289 Roundtrip, found 3 days ago
$289
Roundtrip
found 3 days ago
Select Copa flight, departing Wed, Oct 29 from Medellin to Santo Domingo, returning Sun, Nov 2, priced at $289 found 3 days ago
Copa
Fri, Oct 24 - Fri, Nov 14
MDE
Medellin
SDQ
Santo Domingo
$289 Roundtrip, found 2 days ago
$289
Roundtrip
found 2 days ago
Select Copa flight, departing Fri, Oct 24 from Medellin to Santo Domingo, returning Fri, Nov 14, priced at $289 found 2 days ago
Copa
Thu, Nov 6 - Mon, Nov 10
MDE
Medellin
SDQ
Santo Domingo
$290 Roundtrip, found 1 hour ago
$290
Roundtrip
found 1 hour ago
Select Copa flight, departing Thu, Nov 6 from Medellin to Santo Domingo, returning Mon, Nov 10, priced at $290 found 1 hour ago
World Ticket Ltd
Thu, Oct 30 - Fri, Oct 31
MDE
Medellin
SDQ
Santo Domingo
$334 Roundtrip, found 3 days ago
$334
Roundtrip
found 3 days ago
Select World Ticket Ltd flight, departing Thu, Oct 30 from Medellin to Santo Domingo, returning Fri, Oct 31, priced at $334 found 3 days ago
Hahn Air Technologies
Wed, Nov 19 - Thu, Nov 27
MDE
Medellin
SDQ
Santo Domingo
$351 Roundtrip, found 2 days ago
$351
Roundtrip
found 2 days ago
Select Hahn Air Technologies flight, departing Wed, Nov 19 from Medellin to Santo Domingo, returning Thu, Nov 27, priced at $351 found 2 days ago
avianca
Wed, Oct 22 - Thu, Oct 23
MDE
Medellin
SDQ
Santo Domingo
$464 Roundtrip, found 1 hour ago
$464
Roundtrip
found 1 hour ago
Select avianca flight, departing Wed, Oct 22 from Medellin to Santo Domingo, returning Thu, Oct 23, priced at $464 found 1 hour ago

Find the cheapest month to fly from Medellín (MDE) to Santo Domingo (SDQ)

February is typically the cheapest month to fly

From $225 - $398 per traveler.

Alternative airports near Santo Domingo

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Las Americas Intl. SDQ. Cheapest option available. Average driving time to city center is 22 minutes. Flights from $435
SDQ
Las Americas Intl.
Cheapest
Average driving time to city center22 min
Flights from $435

Frequently asked questions

How much does a flight from Jose Maria Cordova Intl. Airport (MDE) to Las Americas Intl. Airport (SDQ) cost?
Grab a cheap one-way flight from $191 or cheap return flight from $257 from Jose Maria Cordova Intl. Airport (MDE) to Las Americas Intl. Airport (SDQ) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Jose Maria Cordova Intl. Airport (MDE) to Las Americas Intl. Airport (SDQ)?
January is the cheapest month to fly from MDE to SDQ. Traveling during an off-peak travel window is often the key to finding better deals on flights.
Which airlines fly direct from Jose Maria Cordova Intl. Airport (MDE) to Las Americas Intl. Airport (SDQ)?
You can fly straight from Jose Maria Cordova Intl. Airport (MDE) to Las Americas Intl. Airport (SDQ) on an Arajet flight.
What is the cheapest airline that flies from Jose Maria Cordova Intl. Airport (MDE) to Las Americas Intl. Airport (SDQ)?
While prices can change depending on your travel dates, Wingo and Arajet are often frequently picked for flights between Jose Maria Cordova Intl. Airport (MDE) and Las Americas Intl. Airport (SDQ). You can also compare airlines on Expedia and use the "Sort by" filter to find the lowest-priced ticket for your MDE to SDQ flight.
How many flights per day from Jose Maria Cordova Intl. Airport (MDE) to Las Americas Intl. Airport (SDQ)?
On average, only 1 nonstop flight departs each day from Jose Maria Cordova Intl. Airport (MDE) to Las Americas Intl. Airport (SDQ). Looking for more options? Use Expedia's filter tool to find flights with layovers and squeeze another destination into your itinerary.
What are the most popular departure times for flights from Jose Maria Cordova Intl. Airport (MDE) to Las Americas Intl. Airport (SDQ)?
The 8 PM departures from MDE to SDQ are the busiest. They can also be more expensive. If you want to save on your trip, choose a less crowded time to fly.
What day of the week has the most flights from MDE to SDQ?
Saturday has the most flights from Jose Maria Cordova Intl. Airport (MDE) to Las Americas Intl. Airport (SDQ). Consider leaving on this day and you'll have a greater chance of finding a departure that fits your plans.
What is the earliest flight from Jose Maria Cordova Intl. Airport (MDE) to Las Americas Intl. Airport (SDQ)?
Take the earliest flight at around 5:50AM UTC-5, departing from Jose Maria Cordova Intl. Airport (MDE). You'll be traveling for roughly 2h 34m, arriving at Las Americas Intl. Airport (SDQ) at approximately 9:24AM UTC-4.
How long does it take to fly from Jose Maria Cordova Intl. Airport (MDE) to Las Americas Intl. Airport (SDQ)?
Flights from MDE to SDQ have an average travel time of 2 hours and 32 minutes. The distance between these two airports is 930 mi.
What is the best time to fly from Jose Maria Cordova Intl. Airport (MDE) to Las Americas Intl. Airport (SDQ)?
To reach Las Americas Intl. Airport (SDQ) without delays, choose a flight that takes off from Jose Maria Cordova Intl. Airport (MDE) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
What airports do you fly into for Santo Domingo from Jose Maria Cordova Intl. Airport (MDE)?
Check out your flight options from Jose Maria Cordova Intl. Airport (MDE) to Las Americas Intl. Airport (SDQ). This is the only Santo Domingo airport you can touch down at if you're taking a direct flight.
Is it cheaper to buy a plane ticket from Jose Maria Cordova Intl. Airport (MDE) to Las Americas Intl. Airport (SDQ) last-minute?
Holding off until right before your break to book a flight from MDE to SDQ generally means paying more. While you may find some last-minute discounts, they aren't always guaranteed. Keep your travel plans flexible to maximize your chances of getting a bargain.
Is it cheaper to book a MDE to SDQ flight and hotel package?
Booking a MDE to SDQ flight and hotel package tends to be cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your travels all in one place. Pick from our extensive range of hotels and then add flights, car rentals and activities to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Jose Maria Cordova Intl. Airport (MDE) to Las Americas Intl. Airport (SDQ)?
In most cases, you can modify or cancel your MDE to SDQ flight. However, there may be additional charges, especially if your booking was made more than 24 hours ago. Check your itinerary for the airline's rules and fees on flight changes, or if you'd like further information, visit our Customer Service portal.

Travel information

Origin airport
José María Córdova Intl.
Destination airport
Las Americas Intl.
Airlines serving
American Airlines, Copa, Hahn Air Technologies, United, World Ticket Ltd, avianca
Roundtrip price
$257
Distance
931 mi
Average flight time
3 hours 32 mins

Book with confidence

Medellín to Santo Domingo Flights

The cheapest times to fly from Medellín to Santo Domingo

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Medellín to Santo Domingo are during the month of January. You can find some of the cheapest flights from Medellín to Santo Domingo with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Medellín to Santo Domingo

Sunday is one of the best days to book for cheap flights from Medellín to Santo Domingo: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Medellín to Santo Domingo

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Medellín to Santo Domingo in 2025. You can also book with separate airlines for your outbound and return journeys, from $191 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Medellín to Santo Domingo flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Medellín to Santo Domingo airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Medellín to Santo Domingo Flights

Explore a world of travel with Expedia

*Available to One Key members.