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$284 Cheap Flights from Harrisburg (MDT) to Panama City (ECP)

View $284 flight on Tue, Jan 26, 2027Opens in a new window

Popular airlines from Harrisburg Intl. Airport (MDT) to Northwest Florida Beaches Intl. Airport (ECP)

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Cheap Flights from Harrisburg to Panama City (MDT-ECP)

Prices were available within the past 7 days and start at $284 for one-way flights and $291 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Wed, Jan 27 - Wed, Feb 10
MDT
Harrisburg
ECP
Panama City
$291 Roundtrip, found 15 hours ago
$291
Roundtrip
found 15 hours ago
Select American Airlines flight, departing Wed, Jan 27 from Harrisburg to Panama City, returning Wed, Feb 10, priced at $291 found 15 hours ago
Delta
Wed, Jan 27 - Wed, Feb 10
MDT
Harrisburg
ECP
Panama City
$291 Roundtrip, found 15 hours ago
$291
Roundtrip
found 15 hours ago
Select Delta flight, departing Wed, Jan 27 from Harrisburg to Panama City, returning Wed, Feb 10, priced at $291 found 15 hours ago
United
Wed, Jan 27 - Wed, Feb 10
MDT
Harrisburg
ECP
Panama City
$291 Roundtrip, found 15 hours ago
$291
Roundtrip
found 15 hours ago
Select United flight, departing Wed, Jan 27 from Harrisburg to Panama City, returning Wed, Feb 10, priced at $291 found 15 hours ago
United
Wed, Jan 27 - Wed, Feb 10
MDT
Harrisburg
ECP
Panama City
$296 Roundtrip, found 15 hours ago
$296
Roundtrip
found 15 hours ago
Select United flight, departing Wed, Jan 27 from Harrisburg to Panama City, returning Wed, Feb 10, priced at $296 found 15 hours ago
United
Tue, Jan 26 - Sat, Feb 13
MDT
Harrisburg
ECP
Panama City
$315 Roundtrip, found 8 hours ago
$315
Roundtrip
found 8 hours ago
Select United flight, departing Tue, Jan 26 from Harrisburg to Panama City, returning Sat, Feb 13, priced at $315 found 8 hours ago
Delta
Wed, Dec 9 - Mon, Dec 14
MDT
Harrisburg
ECP
Panama City
$316 Roundtrip, found 7 hours ago
$316
Roundtrip
found 7 hours ago
Select Delta flight, departing Wed, Dec 9 from Harrisburg to Panama City, returning Mon, Dec 14, priced at $316 found 7 hours ago
United
Tue, Jan 26 - Sat, Feb 13
MDT
Harrisburg
ECP
Panama City
$320 Roundtrip, found 8 hours ago
$320
Roundtrip
found 8 hours ago
Select United flight, departing Tue, Jan 26 from Harrisburg to Panama City, returning Sat, Feb 13, priced at $320 found 8 hours ago
United
Sat, Nov 14 - Wed, Nov 18
MDT
Harrisburg
ECP
Panama City
$324 Roundtrip, found 3 days ago
$324
Roundtrip
found 3 days ago
Select United flight, departing Sat, Nov 14 from Harrisburg to Panama City, returning Wed, Nov 18, priced at $324 found 3 days ago
United
Tue, Jan 26 - Sat, Feb 13
MDT
Harrisburg
ECP
Panama City
$325 Roundtrip, found 8 hours ago
$325
Roundtrip
found 8 hours ago
Select United flight, departing Tue, Jan 26 from Harrisburg to Panama City, returning Sat, Feb 13, priced at $325 found 8 hours ago
United
Sat, Nov 14 - Wed, Nov 18
MDT
Harrisburg
ECP
Panama City
$329 Roundtrip, found 3 days ago
$329
Roundtrip
found 3 days ago
Select United flight, departing Sat, Nov 14 from Harrisburg to Panama City, returning Wed, Nov 18, priced at $329 found 3 days ago

What you need to know for your flight from Harrisburg Intl. to Northwest Florida Beaches Intl.

Harrisburg (MDT) to Panama City (ECP) at a glance

Travel from Harrisburg (MDT) to Panama City (ECP) with a range of airlines catering to this domestic short-haul route. Discover options for cheap flights from Harrisburg and compare various itineraries from full-service carriers to find the best fit for your budget and schedule. As you prepare to explore the vibrant sights and neighborhoods of Panama City, gather all the essential details for flights from Harrisburg International Airport to Northwest Florida Beaches International Airport.

  • Fastest flight duration: around 3h 30m in-flight, plus roughly 2 hours layover with one stop
  • Route distance: roughly 800 miles (1,290 km)
  • Flights per week: around 8 departures on average
  • Typical fares (one-way): economy tickets often range from $125–$445, depending on seasonality and how far ahead you book

Flights from Harrisburg International Airport (MDT) to Northwest Florida Beaches International Airport (ECP)

Recent traveler bookings reveal the top airlines flying from Harrisburg to Panama City, with many opting for one-stop services. Popular layover locations include Hartsfield-Jackson Atlanta International Airport (ATL) with approximately a 2-hour stop, Charlotte-Douglas International Airport (CLT) at around 1 hour and 30 minutes, and O'Hare International Airport (ORD) featuring about a 3-hour layover. This gives you the opportunity to compare prices, total travel times, and cabin classes to craft the ideal itinerary.

  • Delta: This full-service airline is known for its one-stop flights, holding around 47% of departures on this route. One-way fares usually fall between $125 and $465, with an in-flight duration of approximately 3 hours and 30 minutes, leading to a total travel time of about 5 hours and 15 minutes, including layovers.
  • American Airlines: Another key player in the market, American Airlines also offers one-stop service and comprises about 47% of the departures. Its one-way fares generally range from $125 to $405. Passengers can expect an in-flight time of 3 hours and 30 minutes, with the overall journey taking around 5 hours and 15 minutes, including layover time.
  • United: Representing about 7% of the departures on this route, United Airlines provides one-stop service with one-way fares ranging from $140 to $695. Travelers will spend approximately 3 hours and 30 minutes in the air, while the total journey time, including layovers, is estimated to be about 5 hours and 15 minutes.

Best time to fly from Harrisburg (MDT) to Panama City (ECP)

The most popular months for travelers flying from Harrisburg to Panama City are April, July, and October, when peak temperatures in Panama City reach up to 82.6°F in July. If you prefer quieter travel, consider August, the least busy and relatively cheaper time to visit with fewer crowds and temperatures around 82.8°F. For better deals, January usually offers the lowest average one-way fare around $203. Flight availability peaks in June, with approximately 11 flights per week, making it easier to find convenient departure times.

  • Cheapest time to fly: January usually offers good deals with average one-way fare around $203, roughly 15% cheaper than the yearly average.
  • More budget-friendly months to fly: May, August, and July typically offer average one-way fares of around $214.
  • Most flight options: June has the highest number of flights from Harrisburg to Panama City, with approximately 11 flights per week, giving you more flexibility in scheduling your trip.
calendar iconMonthtemperature iconTemperaturecrowd level iconDemandflights iconWeekly Flightsprice iconAverage one-way Fare
January54.1°F (12.3°C)Average7$203
February57.9°F (14.4°C)Average8$245
March62.8°F (17.1°C)Average8$252
April68.4°F (20.2°C)High8$278
May75.0°F (23.9°C)Average8$210
June81.1°F (27.3°C)Average11$223
July82.6°F (28.1°C)High8$219
August82.8°F (28.2°C)Low7$214
September79.5°F (26.4°C)Low7$278
October72.0°F (22.2°C)High8$239
November62.4°F (16.9°C)Low7$289
December58.1°F (14.5°C)Average8$241

*Average one-way fare is based on Expedia flight booking data from January 2025 to April 2026 for the specified route and travel class and may change depending on availability, dates, and demand.

Alternative route from Harrisburg (MDT) to Panama City (ECP)

  • Harrisburg to Fort Walton Beach (MDT-VPS): Northwest Florida Regional Airport (VPS) is located approximately 46 miles from Northwest Florida Beaches International Airport (ECP). The typical range for one-way economy fares on this route is between $165 and $430, influenced by the season and how early you book. Flights usually involve one stop, with common layover points being Charlotte-Douglas International Airport (CLT) and Hartsfield-Jackson Atlanta International Airport (ATL). Leading airlines for this journey include American Airlines and Delta, and first-class service is also an option on this route.

How to find the best prices for flights from Harrisburg (MDT) to Panama City (ECP)

Getting some of the best deals on flights from Harrisburg to Panama City is all about timing and flexibility. Here are some key tips to help you save:

  1. Best times to book and fly: cheaper fares are usually found when booking 2-8 weeks in advance, which coincides with when most travelers make their reservations. Departures in the afternoon (12pm-6pm) often offer lower prices, while morning flights (5am-12pm) are more popular. Additionally, flying on Saturday tends to be cheaper, although Thursday remains the most favored travel day.
  2. Set up price alerts: stay updated on price changes by using Expedia's Price Tracker. Receive alerts when fares drop for your selected route.
  3. Bundle and save: bundle your flight and hotel to save on Expedia, or unlock a hotel deal after booking your flight.*
  4. Compare flight options: use Expedia's search tool to compare airlines, routes, direct vs. non-direct flights, and flight times. You can also sort by price to find the most affordable options.
  5. Stay flexible with dates: being open to different travel days can sometimes help you find better prices on flights and hotels.
  6. Think about luggage: nowadays, it's important to check the airline's baggage policies to find the best value. That may be paying for an additional carry-on bag or booking a ticket with checked luggage included. Either way, double-check your allowance before confirming your booking to avoid excess baggage fees at the airport.

*Members only. Savings vary and are not available on all bundles. Select hotels.

Arriving at Northwest Florida Beaches International Airport from Harrisburg International Airport

Panama City welcomes travelers from Harrisburg with a range of transport options based on price, convenience, and proximity. For departures, Harrisburg International Airport is roughly a 15-minute drive (covering about 12 miles) from central Harrisburg. Here's how to reach Panama City efficiently:

  • Hotel transfer: Transfers offer a convenient way to reach your hotel in Panama City, with options including free hotel shuttles and private rides, which can be arranged in advance with your hotel.
  • Car rental: Renting a car from Northwest Florida Beaches International Airport is a great option if you plan to explore and sightsee beyond the city. Browse cheap car rentals at Northwest Florida Beaches International Airport on Expedia.
  • Taxi/ride-hailing: Taxis and ride-hailing services may be available from designated pickup areas outside the terminal, check locally on arrival.

Frequently asked questions

How much does a flight from Harrisburg, PA (MDT-Harrisburg Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.) cost?
You can find cheap one-way flights from $284 and cheap return flights from $291 Harrisburg, PA (MDT-Harrisburg Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.) with Expedia. One-way flights usually range from $238 to $543, and return flights typically cost between $460 and $1586. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Harrisburg, PA (MDT-Harrisburg Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.) ticket fares go up or down.*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.
What is the cheapest month to fly from Harrisburg, PA (MDT-Harrisburg Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.)?
June is the cheapest month to fly from Harrisburg, PA (MDT) to Panama City, FL (ECP), with average round-trip fares around $386. This price is about 18% lower than the average throughout the year, as June typically sees a drop in travel demand after the spring season. Other cheap months to fly from Harrisburg to Panama City include January and May.*Averages based on flights available on Expedia in the last year.
Which airlines fly direct from Harrisburg, PA (MDT-Harrisburg Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.)?
Enter MDT to ECP and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
What is the cheapest airline that flies from Harrisburg, PA (MDT-Harrisburg Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.)?
American Airlines is one of the cheapest airlines offering connecting flights from Harrisburg (MDT) to Panama City (ECP), with round-trip tickets starting from around $826 with a layover in Philadelphia Intl. (PHL). Use Expedia's search tool to compare the prices and schedules of airlines that fly this route to find the best option for your plans and budget.*Prices based on flights available on Expedia in the last year.
How do I find cheap flights from Harrisburg, PA (MDT-Harrisburg Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.)?
To find a cheap flight from Harrisburg, PA (MDT-Harrisburg Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Harrisburg, PA (MDT-Harrisburg Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.)?
The best time to fly from Harrisburg, PA (MDT) to Panama City, FL (ECP) is typically in May or June. During these months, you can expect average prices around $386 for a return flight, making it a budget-friendly option. May offers pleasant weather, while June sees a rise in travel, ensuring plenty of flight options for your trip.*Prices based on flights available on Expedia in the last year.
What is the earliest flight from Harrisburg, PA (MDT-Harrisburg Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.)?
The earliest flight from Harrisburg International Airport (MDT) to Northwest Florida Beaches International Airport (ECP) typically departs at around 5:00 AM, operated by American Airlines. This is a seasonal service active in December, allowing you to start your day early and make the most of your time in Florida. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What are the most popular departure times for flights from Harrisburg, PA (MDT-Harrisburg Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.)?
For flights from Harrisburg, PA (MDT-Harrisburg Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.), the most popular departure times are in the early morning, from 6am to 9am. This time window accounts for around 57% of total traffic, indicating a strong preference among travelers. Airlines like United Airlines and Delta Airlines operate flights during this time, making it a great option for your travel plans.
How long does it take to fly from Harrisburg, PA (MDT-Harrisburg Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.)?
Flying from MDT to ECP with a connection usually takes about 6 hours, traveling roughly 849 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Harrisburg, PA (MDT-Harrisburg Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.)?
First class seats are offered on the MDT to ECP route. First class cabins are available on:

  • Delta Air Lines
  • American Airlines
  • United Airlines

How do I earn miles on a Harrisburg, PA (MDT-Harrisburg Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.) flight with Expedia?
It's easy to earn miles on a Harrisburg, PA (MDT-Harrisburg Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Panama City from Harrisburg Intl. (MDT)?
When traveling from Harrisburg Intl. (MDT) to Panama City, you can fly into Tocumen Intl. (PTY) and Northwest Florida Beaches Intl. (ECP). Some flights may connect through major hubs like Charlotte-Douglas Intl. (CLT), O'Hare Intl. (ORD), Washington Dulles Intl. (IAD) before reaching Panama City. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Harrisburg, PA (MDT-Harrisburg Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.) at the last minute?
Typically, booking a last minute flight from Harrisburg, PA (MDT-Harrisburg Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Harrisburg, PA (MDT-Harrisburg Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.) flight and hotel package?
Securing a Harrisburg, PA (MDT-Harrisburg Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Harrisburg, PA (MDT-Harrisburg Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.)?
If you booked your Harrisburg, PA (MDT-Harrisburg Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Harrisburg Intl.
Destination airport
Northwest Florida Beaches Intl.
Airlines serving
American Airlines, Delta, United
Roundtrip price
$290
Distance
848 mi

Book with confidence

Harrisburg to Panama City Flights

The cheapest times to fly from Harrisburg to Panama City

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Harrisburg to Panama City are during the month of January. You can find some of the cheapest flights from Harrisburg to Panama City with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Harrisburg to Panama City

Sunday is one of the best days to book for cheap flights from Harrisburg to Panama City: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Harrisburg to Panama City

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Harrisburg to Panama City in 2026. You can also book with separate airlines for your outbound and return journeys, from $284 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Harrisburg to Panama City flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Harrisburg to Panama City airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Harrisburg to Panama City Flights

*Flight schedules are subject to change.

*Available to One Key members.

 

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