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$318 Cheap Flights from Medford (MFR) to Buffalo (BUF)

View $318 flight on Sat, Sep 26, 2026Opens in a new window

Popular airlines from Rogue Valley Intl. Airport (MFR) to Buffalo Niagara Intl. Airport (BUF)

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Cheap Flights from Medford to Buffalo (MFR-BUF)

Prices were available within the past 7 days and start at $318 for one-way flights and $386 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Wed, Oct 14 - Wed, Oct 21
MFR
Medford
BUF
Buffalo
$386 Roundtrip, found 2 days ago
$386
Roundtrip
found 2 days ago
Select Delta flight, departing Wed, Oct 14 from Medford to Buffalo, returning Wed, Oct 21, priced at $386 found 2 days ago
Delta
Wed, Oct 14 - Wed, Oct 21
MFR
Medford
BUF
Buffalo
$418 Roundtrip, found 2 days ago
$418
Roundtrip
found 2 days ago
Select Delta flight, departing Wed, Oct 14 from Medford to Buffalo, returning Wed, Oct 21, priced at $418 found 2 days ago
Delta
Thu, Oct 22 - Sat, Oct 24
MFR
Medford
BUF
Buffalo
$420 Roundtrip, found 1 day ago
$420
Roundtrip
found 1 day ago
Select Delta flight, departing Thu, Oct 22 from Medford to Buffalo, returning Sat, Oct 24, priced at $420 found 1 day ago
United
Fri, Sep 18 - Sat, Sep 19
MFR
Medford
BUF
Buffalo
$432 Roundtrip, found 2 days ago
$432
Roundtrip
found 2 days ago
Select United flight, departing Fri, Sep 18 from Medford to Buffalo, returning Sat, Sep 19, priced at $432 found 2 days ago
United
Fri, Sep 18 - Sat, Sep 19
MFR
Medford
BUF
Buffalo
$434 Roundtrip, found 2 days ago
$434
Roundtrip
found 2 days ago
Select United flight, departing Fri, Sep 18 from Medford to Buffalo, returning Sat, Sep 19, priced at $434 found 2 days ago
Delta
Wed, Oct 14 - Wed, Oct 21
MFR
Medford
BUF
Buffalo
$437 Roundtrip, found 2 days ago
$437
Roundtrip
found 2 days ago
Select Delta flight, departing Wed, Oct 14 from Medford to Buffalo, returning Wed, Oct 21, priced at $437 found 2 days ago
American Airlines
Wed, Oct 14 - Wed, Oct 21
MFR
Medford
BUF
Buffalo
$440 Roundtrip, found 2 days ago
$440
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Oct 14 from Medford to Buffalo, returning Wed, Oct 21, priced at $440 found 2 days ago
Delta
Wed, May 5 - Wed, May 12
MFR
Medford
BUF
Buffalo
$449 Roundtrip, found 6 days ago
$449
Roundtrip
found 6 days ago
Select Delta flight, departing Wed, May 5 from Medford to Buffalo, returning Wed, May 12, priced at $449 found 6 days ago
United
Wed, Oct 14 - Wed, Oct 21
MFR
Medford
BUF
Buffalo
$456 Roundtrip, found 2 days ago
$456
Roundtrip
found 2 days ago
Select United flight, departing Wed, Oct 14 from Medford to Buffalo, returning Wed, Oct 21, priced at $456 found 2 days ago
Alaska Airlines
Wed, Oct 14 - Wed, Oct 21
MFR
Medford
BUF
Buffalo
$644 Roundtrip, found 2 days ago
$644
Roundtrip
found 2 days ago
Select Alaska Airlines flight, departing Wed, Oct 14 from Medford to Buffalo, returning Wed, Oct 21, priced at $644 found 2 days ago

Find the cheapest month to fly from Medford (MFR) to Buffalo (BUF)

January is typically the cheapest month to fly

From $313 - $1,113 per traveler.

What you need to know for your flight from Rogue Valley Intl. to Buffalo Niagara Intl.

Medford (MFR) to Buffalo (BUF) at a glance

Travel through a range of airlines offering flights from Medford (MFR) to Buffalo (BUF) on this domestic long-haul route. Compare choices from full-service carriers to discover the itinerary that best aligns with your budget, schedule, and travel plans while you uncover Buffalo's renowned attractions and neighborhoods. Get all the essential details for flights departing from Rogue Valley International Airport (MFR) to Buffalo Niagara International Airport (BUF).

  • Fastest flight duration: around 5h 45m in-flight, plus roughly 1 hour layover with one stop
  • Route distance: roughly 2,200 miles (3,540 km)
  • Flights per week: around 8 departures on average
  • Typical fares (one-way): economy tickets often range from $130–$600, depending on seasonality and how far ahead you book

Flights from Rogue Valley International Airport (MFR) to Buffalo Niagara International Airport (BUF)

Based on the latest traveler bookings, here are the most popular airlines for flights from Medford to Buffalo, focusing on both one-stop and multi-stop options. Many travelers choose itineraries that connect through major hubs like O'Hare International Airport (ORD) with approximately a 1-hour layover, Denver International Airport (DEN) with about a 1 hour and 15 minutes layover, and Seattle-Tacoma International Airport (SEA) offering around a 3-hour layover. This variety allows you to mix and match pricing, total travel time, and cabin class to find the ideal itinerary.

  • United: As a comprehensive carrier, United provides both one-stop and multi-stop options on this route. One-way ticket prices generally fall between $140 and $525, making up around 63% of all departures. Expect about 5 hours and 45 minutes of flight time, with a total travel duration of approximately 7 hours.
  • Delta: Delta, another full-service airline, specializes in multi-stop routes, offering one-way fares that typically range from $145 to $415. This carrier constitutes around 24% of the departures on this route. Passengers can anticipate an in-flight duration of 7 hours and 30 minutes, with the overall journey lasting about 11 hours, including layovers.
  • American Airlines: American Airlines operates as a full-service carrier with multi-stop services, featuring one-way fares that usually range from $140 to $775. This airline accounts for roughly 13% of the departures on this route. Travelers can expect a flight time of 7 hours and 30 minutes, with a total journey time of around 11 hours, factoring in layovers.

Alternative route from Medford (MFR) to Buffalo (BUF)

  • Medford to Rochester (MFR-ROC): Located approximately 56 miles from Buffalo Niagara International Airport (BUF), Greater Rochester International Airport (ROC) offers a range of one-way economy fares typically between $160 and $495, influenced by the time of year and how early you book. Flights on this route usually involve multiple stops, with common layover points at O'Hare International Airport (ORD) and Seattle - Tacoma International Airport (SEA). Leading airlines servicing this route include United and Delta.

How to find the best prices for flights from Medford (MFR) to Buffalo (BUF)

Getting some of the best deals on flights from Medford to Buffalo is all about timing and flexibility. Here are some key tips to help you save:

  1. Best times to book and fly: cheaper fares are usually available when booking at least two months in advance, although most travelers book their flights two to eight weeks ahead. Morning departures (5 a.m. to 12 p.m.) tend to be less expensive, while afternoon flights (12 p.m. to 6 p.m.) are more popular. Additionally, flying on Tuesday often offers lower prices, while Saturday remains the most popular travel day.
  2. Set up price alerts: stay updated on price changes by using Expedia's Price Tracker. Receive alerts when fares drop for your selected route.
  3. Bundle and save: bundle your flight and hotel to save on Expedia, or unlock a hotel deal after booking your flight.*
  4. Compare flight options: use Expedia's search tool to compare airlines, routes, direct vs. non-direct flights, and flight times. You can also sort by price to find the most affordable options.
  5. Stay flexible with dates: being open to different travel days can sometimes help you find better prices on flights and hotels.
  6. Think about luggage: nowadays, it's important to check the airline's baggage policies to find the best value. That may be paying for an additional carry-on bag or booking a ticket with checked luggage included. Either way, double-check your allowance before confirming your booking to avoid excess baggage fees at the airport.

*Members only. Savings vary and are not available on all bundles. Select hotels.

Arriving at Buffalo Niagara International Airport from Rogue Valley International Airport

Buffalo welcomes travelers from Medford with a range of transport options based on price, convenience, and proximity. Here's how to reach Buffalo efficiently:

  • Hotel transfer: Transfers offer a convenient way to reach your hotel in Buffalo, with private rides that can be arranged in advance.
  • Car rental: Renting a car from Buffalo Niagara International Airport is a great option if you plan to explore and sightsee beyond the city. Browse cheap car rentals at Buffalo Niagara International Airport on Expedia.
  • Taxi/ride-hailing: Taxis and ride-hailing services may be available from designated pickup areas outside the terminal, check locally on arrival.
  • Public transportation: From Buffalo Niagara International Airport, Buffalo-Depew Station, a train station, is located about 2.6 miles away by car, while University Station, a metro station, is situated approximately 6.5 miles away by car, providing convenient access to public transportation options.

Frequently asked questions

How much does a flight from Medford, OR (MFR-Rogue Valley Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.) cost?
You can find cheap one-way flights from $318 and cheap return flights from $386 Medford, OR (MFR-Rogue Valley Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.) with Expedia. Roundtrip flights usually range from $534 to $2078. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Medford, OR (MFR-Rogue Valley Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.) ticket fares go up or down.*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.
What is the cheapest month to fly from Medford, OR (MFR-Rogue Valley Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.)?
The cheapest month to fly from MFR to BUF is October when demand is low. Traveling in off-peak or shoulder months is usually a good way to secure cheap tickets, just remember to avoid flying during holidays if you're able to. Use the calendar view in your search to see which months have low fares on this route.
Which airlines fly direct from Medford, OR (MFR-Rogue Valley Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.)?
Enter MFR to BUF and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
What is the cheapest airline that flies from Medford, OR (MFR-Rogue Valley Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.)?
United is one of the cheapest airlines offering connecting flights from Medford (MFR) to Buffalo (BUF) with a layover in San Francisco Intl. (SFO), starting from around $1,254. Use Expedia's search tool to compare the prices and schedules of airlines that fly this route to find the best option for your plans and budget.*Prices based on flights available on Expedia in the last year.
How do I find cheap flights from Medford, OR (MFR-Rogue Valley Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.)?
To find a cheap flight from Medford, OR (MFR-Rogue Valley Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Medford, OR (MFR-Rogue Valley Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
What is the earliest flight from Medford, OR (MFR-Rogue Valley Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.)?
The earliest flight from Rogue Valley International (MFR) to Buffalo Niagara International (BUF) typically leaves at around 5:00 AM. This seasonal service is operated by Delta, providing an early start to your travels. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What are the most popular departure times for flights from Medford, OR (MFR-Rogue Valley Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.)?
The most popular departure times for flights from Medford (MFR) to Buffalo (BUF) are in the early morning, from 3am to 6am. About 26% of passengers prefer this time window. Many major carriers, including United Airlines, offer flights during this window. This timing works well because it allows you to start your day early and arrive in Buffalo with time to spare.
How long does it take to fly from Medford, OR (MFR-Rogue Valley Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.)?
Flying from MFR to BUF with a connection usually takes about 7 hours, traveling roughly 2,217 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Medford, OR (MFR-Rogue Valley Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.)?
Select the "Business class" and "First class" filters when looking for MFR to BUF flights on Expedia. This is the easiest way to compare prices, routes and flight times for your trip.
How do I earn miles on a Medford, OR (MFR-Rogue Valley Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.) flight with Expedia?
It's easy to earn miles on a Medford, OR (MFR-Rogue Valley Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Buffalo from Rogue Valley Intl. (MFR)?
From Rogue Valley Intl. (MFR), you can fly into Buffalo Niagara Intl. (BUF) to reach Buffalo. Some flights may connect through major hubs like San Francisco Intl. (SFO), Sky Harbor Intl. (PHX), Denver Intl. (DEN) before reaching Buffalo. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Medford, OR (MFR-Rogue Valley Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.) at the last minute?
Typically, booking a last minute flight from Medford, OR (MFR-Rogue Valley Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Medford, OR (MFR-Rogue Valley Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.) flight and hotel package?
Securing a Medford, OR (MFR-Rogue Valley Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.) Buffalo Vacation Packages is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Medford, OR (MFR-Rogue Valley Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.)?
If you booked your Medford, OR (MFR-Rogue Valley Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Rogue Valley Intl.
Destination airport
Buffalo Niagara Intl.
Airlines serving
Alaska Airlines, American Airlines, Delta, United
Roundtrip price
$385
Distance
2217 mi

Book with confidence

Medford to Buffalo Flights

The cheapest times to fly from Medford to Buffalo

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Medford to Buffalo are during the month of October. You can find some of the cheapest flights from Medford to Buffalo with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Medford to Buffalo

Sunday is one of the best days to book for cheap flights from Medford to Buffalo: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Medford to Buffalo

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Medford to Buffalo in 2026. You can also book with separate airlines for your outbound and return journeys, from $318 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Medford to Buffalo flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Medford to Buffalo airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Medford to Buffalo Flights

*Flight schedules are subject to change.

*Available to One Key members.

 

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