A large bridge spanning a body of water with a city skyline in the background.

$124 Cheap Flights from Medford (MFR) to San Diego (SAN)

View $124 flight on Tue, Feb 9, 2027Opens in a new window

Popular airlines from Rogue Valley Intl. Airport (MFR) to San Diego Intl. Airport (SAN)

  • Be in the know

    Get alerts if flight prices drop or rise*

  • Book smarter

    Save up to 30% on select hotels after you book a flight*

  • Earn twice

    Earn your airline miles on top of our OneKeyCash
    Learn about One Key

Cheap Flights from Medford to San Diego (MFR-SAN)

Prices were available within the past 7 days and start at $124 for one-way flights and $203 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Fri, Nov 6 - Mon, Nov 9
MFR
Medford
SAN
San Diego
$203 Roundtrip, found 3 hours ago
$203
Roundtrip
found 3 hours ago
Select Delta flight, departing Fri, Nov 6 from Medford to San Diego, returning Mon, Nov 9, priced at $203 found 3 hours ago
Alaska Airlines
Wed, Nov 4 - Sat, Nov 7
MFR
Medford
SAN
San Diego
$237 Roundtrip, found 22 hours ago
$237
Roundtrip
found 22 hours ago
Select Alaska Airlines flight, departing Wed, Nov 4 from Medford to San Diego, returning Sat, Nov 7, priced at $237 found 22 hours ago
Alaska Airlines
Fri, Oct 9 - Sat, Oct 10
MFR
Medford
SAN
San Diego
$240 Roundtrip, found 1 hour ago
$240
Roundtrip
found 1 hour ago
Select Alaska Airlines flight, departing Fri, Oct 9 from Medford to San Diego, returning Sat, Oct 10, priced at $240 found 1 hour ago
United
Tue, Nov 3 - Sat, Nov 7
MFR
Medford
SAN
San Diego
$242 Roundtrip, found 1 day ago
$242
Roundtrip
found 1 day ago
Select United flight, departing Tue, Nov 3 from Medford to San Diego, returning Sat, Nov 7, priced at $242 found 1 day ago
Alaska Airlines
Wed, Nov 11 - Sat, Nov 14
MFR
Medford
SAN
San Diego
$244 Roundtrip, found 22 hours ago
$244
Roundtrip
found 22 hours ago
Select Alaska Airlines flight, departing Wed, Nov 11 from Medford to San Diego, returning Sat, Nov 14, priced at $244 found 22 hours ago
Alaska Airlines
Sat, Oct 17 - Tue, Oct 20
MFR
Medford
SAN
San Diego
$246 Roundtrip, found 3 days ago
$246
Roundtrip
found 3 days ago
Select Alaska Airlines flight, departing Sat, Oct 17 from Medford to San Diego, returning Tue, Oct 20, priced at $246 found 3 days ago
United
Sat, Oct 10 - Tue, Oct 13
MFR
Medford
SAN
San Diego
$247 Roundtrip, found 8 hours ago
$247
Roundtrip
found 8 hours ago
Select United flight, departing Sat, Oct 10 from Medford to San Diego, returning Tue, Oct 13, priced at $247 found 8 hours ago
Alaska Airlines
Tue, Nov 3 - Tue, Nov 17
MFR
Medford
SAN
San Diego
$247 Roundtrip, found 1 day ago
$247
Roundtrip
found 1 day ago
Select Alaska Airlines flight, departing Tue, Nov 3 from Medford to San Diego, returning Tue, Nov 17, priced at $247 found 1 day ago
Alaska Airlines
Thu, Nov 12 - Wed, Nov 18
MFR
Medford
SAN
San Diego
$250 Roundtrip, found 3 hours ago
$250
Roundtrip
found 3 hours ago
Select Alaska Airlines flight, departing Thu, Nov 12 from Medford to San Diego, returning Wed, Nov 18, priced at $250 found 3 hours ago
American Airlines
Thu, Nov 12 - Wed, Nov 18
MFR
Medford
SAN
San Diego
$262 Roundtrip, found 3 hours ago
$262
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Thu, Nov 12 from Medford to San Diego, returning Wed, Nov 18, priced at $262 found 3 hours ago

Alternative airports near San Diego

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to McClellan-Palomar CLD. Average driving time to city center is 38 minutes. Flights from $334
CLD
McClellan-Palomar
Average driving time to city center38 min
Flights from $334

Find the cheapest month to fly from Medford (MFR) to San Diego (SAN)

October is typically the cheapest month to fly

From $197 - $281 per traveler.

What you need to know for your flight from Rogue Valley Intl. to San Diego Intl.

Medford (MFR) to San Diego (SAN) at a glance

Travel from Medford (MFR) to San Diego (SAN) with a selection of airlines operating this domestic short-haul route. Explore various options, from full-service carriers to budget-friendly choices, to find the flights from Medford that align with your travel plans, budget, and schedule. Whether you're eager to experience San Diego's iconic attractions or its vibrant neighborhoods, you'll find all the essential details for your journey from Rogue Valley International Airport to San Diego International Airport right here.

  • Fastest flight duration: around 2h 15m non-stop
  • Route distance: roughly 700 miles (1,130 km)
  • Flights per week: around 13 departures on average
  • Typical fares (one-way): economy tickets often range from $80–$360, depending on seasonality and how far ahead you book

Flights from Rogue Valley International Airport (MFR) to San Diego International Airport (SAN)

Based on the latest traveler bookings, here are the top airlines favored for flights from Medford to San Diego, particularly for non-stop and one-stop options. Popular layover points include San Francisco International Airport (SFO) with a 1 hour 15 minute layover, Seattle-Tacoma International Airport (SEA) at about 1 hour 30 minutes, and Portland International Airport (PDX) with a 1 hour layover. These choices allow you to mix and match factors like price, total travel time, and cabin class to discover the ideal itinerary for your trip.

  • Alaska Airlines: This full-service airline provides non-stop, one-stop, and multi-stop flight options. With one-way ticket prices typically between $80 and $365, it operates around 53% of departures on this route, offering a standard non-stop flight duration of 2 hours and 15 minutes.
  • United: A full-service airline that offers one-stop routes, United's one-way fares generally fall between $100 and $365. It accounts for about 28% of departures on this route, featuring an in-flight duration of 3 hours and 30 minutes, and a total travel time of approximately 4 hours and 30 minutes, including layover.
  • Delta: This full-service carrier provides one-stop services, with one-way fares usually ranging from $85 to $365. Delta represents roughly 14% of the departures for this route, with an in-flight time of 3 hours and 30 minutes and a total journey time of around 4 hours and 30 minutes, including layover.
  • American Airlines: Another full-service option, American Airlines offers one-stop services with one-way fares typically between $110 and $365. It makes up about 3% of the departures on this route, featuring an in-flight duration of 3 hours and 30 minutes and a total travel time of roughly 4 hours and 30 minutes, including layover.
  • Hawaiian Airlines: Known for its non-stop service, Hawaiian Airlines provides one-way fares that generally range from $160 to $220. This airline accounts for approximately 1% of departures on this route, with a total travel time of 2 hours and 15 minutes.

Travelers flying from Medford to San Diego have the option to upgrade their experience with Alaska Airlines, which offers both first class and business class service on this route.

Best time to fly from Medford (MFR) to San Diego (SAN)

The most popular months for travelers flying from Medford to San Diego are January, March, and April, when peak temperatures in San Diego reach up to 60.6°F in April. If you prefer quieter travel, consider December, the least busy and relatively cheaper time to visit with fewer crowds and temperatures around 57.4°F. For better deals, September usually offers the lowest average one-way fare around $158. Flight availability peaks in May and August, with approximately 15 flights per week, making it easier to find convenient departure times.

  • Cheapest time to fly: September usually offers good deals with average one-way fare around $158, roughly 16% cheaper than the yearly average.
  • Another budget-friendly time to fly: August typically offers an average one-way fare of around $165.
  • Most flight options: May and August have the highest number of flights from Medford to San Diego, with approximately 15 flights per week, giving you more flexibility in scheduling your trip.
calendar iconMonthtemperature iconTemperaturecrowd level iconDemandflights iconWeekly Flightsprice iconAverage one-way Fare
January57.4°F (14.1°C)Slightly High12$182
February56.8°F (13.8°C)Average11$213
March58.1°F (14.5°C)Slightly High13$225
April60.6°F (15.9°C)Slightly High14$197
May62.6°F (17.0°C)Slightly Low15$197
June66.4°F (19.1°C)Slightly Low11$196
July70.5°F (21.4°C)Average13$187
August72.3°F (22.4°C)Average15$165
September72.0°F (22.2°C)Average14$158
October68.2°F (20.1°C)Average14$183
November62.6°F (17.0°C)Average12$183
December57.4°F (14.1°C)Slightly Low11$194

*Average one-way fare is based on Expedia flight booking data from January 2025 to April 2026 for the specified route and travel class and may change depending on availability, dates, and demand.

Alternative routes from Medford (MFR) to San Diego (SAN)

  • Medford to San Diego (MFR-SEE): Gillespie Field Airport (SEE) is located approximately 14 miles from San Diego International Airport (SAN).
  • Medford to Carlsbad (MFR-CLD): McClellan-Palomar Airport (CLD) lies roughly 28 miles from San Diego International Airport (SAN).
  • Klamath Falls to San Diego (LMT-SAN): Klamath Falls International Airport (LMT) is situated about 60 miles from Rogue Valley International Airport (MFR).

How to find the best prices for flights from Medford (MFR) to San Diego (SAN)

Getting some of the best deals on flights from Medford to San Diego is all about timing and flexibility. Here are some key tips to help you save:

  1. Best times to book and fly: cheaper fares are usually available when booking 2-8 weeks in advance, which coincides with when most travelers make their reservations. Departures in the afternoon (12pm-6pm) often provide lower prices and are also the most popular flight times. Additionally, flying on Wednesday typically yields cheaper rates, while Thursday is the most preferred travel day.
  2. Set up price alerts: stay updated on price changes by using Expedia's Price Tracker. Receive alerts when fares drop for your selected route.
  3. Bundle and save: bundle your flight and hotel to save on Expedia, or unlock a hotel deal after booking your flight.* Find San Diego hotel and flight deals.
  4. Compare flight options: use Expedia's search tool to compare airlines, routes, direct vs. non-direct flights, and flight times. You can also sort by price to find the most affordable options.
  5. Stay flexible with dates: being open to different travel days can sometimes help you find better prices on flights and hotels.
  6. Think about luggage: nowadays, it's important to check the airline's baggage policies to find the best value. That may be paying for an additional carry-on bag or booking a ticket with checked luggage included. Either way, double-check your allowance before confirming your booking to avoid excess baggage fees at the airport.

*Members only. Savings vary and are not available on all bundles. Select hotels.

Arriving at San Diego International Airport from Rogue Valley International Airport

San Diego welcomes travelers from Medford with a range of transport options based on price, convenience, and proximity. Here's how to reach San Diego efficiently:

  • Hotel transfer: Transfers offer a convenient way to reach your hotel in San Diego, with options including free hotel shuttles and private rides, which can be arranged in advance with your hotel.
  • Car rental: Renting a car from San Diego International Airport is a great option if you plan to explore and sightsee beyond the city. Browse cheap car rentals at San Diego International Airport on Expedia.
  • Taxi/ride-hailing: Taxis and ride-hailing services may be available from designated pickup areas outside the terminal, check locally on arrival.
  • Public transportation: From San Diego International Airport, the Seaport (a seaport) is located just about 0.1 miles away on foot, while Middletown Station (a metro station) is approximately 2.3 miles from the airport by car. For those looking to embark on a cruise, B Street Cruise Ship Terminal (a cruise terminal) is situated around 3 miles away by car.

Frequently asked questions

How much does a flight from Medford, OR (MFR-Rogue Valley Intl.) to San Diego, CA (SAN-San Diego Intl.) cost?
You can find cheap one-way flights from $124 and cheap return flights from $203 Medford, OR (MFR-Rogue Valley Intl.) to San Diego, CA (SAN-San Diego Intl.) with Expedia. One-way flights typically cost between $115 and $632, and return flights often range between $249 and $997. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Medford, OR (MFR-Rogue Valley Intl.) to San Diego, CA (SAN-San Diego Intl.) ticket fares go up or down.*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.
What is the cheapest month to fly from Medford, OR (MFR-Rogue Valley Intl.) to San Diego, CA (SAN-San Diego Intl.)?
The cheapest month to fly from MFR to SAN is November when demand is low. Traveling in off-peak or shoulder months is usually a good way to secure cheap tickets, just remember to avoid flying during holidays if you're able to. Use the calendar view in your search to see which months have low fares on this route.
Which airlines fly direct from Medford, OR (MFR-Rogue Valley Intl.) to San Diego, CA (SAN-San Diego Intl.)?
Hawaiian Airlines operates around 7 direct flights from MFR to SAN every week.
What is the cheapest airline that flies from Medford, OR (MFR-Rogue Valley Intl.) to San Diego, CA (SAN-San Diego Intl.)?
Alaska Airlines is one of the cheapest airlines offering nonstop flights from Medford, OR (MFR) to San Diego, CA (SAN), with round-trip tickets starting from around $107. Use Expedia's search tool to compare the prices and schedules of airlines that fly this route to find the best option for your plans and budget.*Prices based on flights available on Expedia in the last year.
How do I find cheap flights from Medford, OR (MFR-Rogue Valley Intl.) to San Diego, CA (SAN-San Diego Intl.)?
To find a cheap flight from Medford, OR (MFR-Rogue Valley Intl.) to San Diego, CA (SAN-San Diego Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best airline to fly with from Medford, OR (MFR-Rogue Valley Intl.) to San Diego, CA (SAN-San Diego Intl.)?
The best airline to fly with from Medford, OR (MFR) to San Diego, CA (SAN) will differ from traveler to traveler. If you like to fly early, Alaska Airlines offers early morning flights. If price is the most important factor, Alaska Airlines typically offers the lowest fares. Alaska Airlines offers the most daily flights from MFR to SAN, which is great if flexibility is what you value most. The best carrier for this journey could also be the one you have a loyalty membership with, as flying with that airline or another airline within the same alliance could help you collect points or enjoy lounge access.
What is the best time to fly from Medford, OR (MFR-Rogue Valley Intl.) to San Diego, CA (SAN-San Diego Intl.)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
How many flights per day from Medford, OR (MFR-Rogue Valley Intl.) to San Diego, CA (SAN-San Diego Intl.)?
There are approximately 1 nonstop flights per day from Rogue Valley Intl. (MFR) to San Diego Intl. (SAN). For more options, look at flights that include layovers.
What is the earliest flight from Medford, OR (MFR-Rogue Valley Intl.) to San Diego, CA (SAN-San Diego Intl.)?
The earliest flight from Medford (MFR) to San Diego (SAN) usually leaves at around 5:00 AM, operated by American Airlines. This seasonal service is active in November and December, giving you an early start to your California getaway. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What are the most popular departure times for flights from Medford, OR (MFR-Rogue Valley Intl.) to San Diego, CA (SAN-San Diego Intl.)?
The most popular departure times for flights from Medford, OR (MFR) to San Diego, CA (SAN) are in the early afternoon, from 12pm to 3pm. About 43% of passengers prefer this time window. Many major carriers, including Alaska Airlines and United Airlines, offer flights during this window. This timing is favored as it allows you to arrive in San Diego with ample time to enjoy the city.
How long does it take to fly from Medford, OR (MFR-Rogue Valley Intl.) to San Diego, CA (SAN-San Diego Intl.)?
A nonstop flight from MFR to SAN typically takes around 2 hours, covering approximately 734 miles. Connecting flights on this route usually add 4 hours 50 minutes to your travel time. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Medford, OR (MFR-Rogue Valley Intl.) to San Diego, CA (SAN-San Diego Intl.)?
First class is available on flights from MFR to SAN. First class cabins are available on:

  • Delta Air Lines
  • United Airlines
  • American Airlines

How much is a business class flight from Medford, OR (MFR-Rogue Valley Intl.) to San Diego, CA (SAN-San Diego Intl.)?
A direct, return business class ticket from Medford, OR (MFR) to San Diego, CA (SAN) typically costs between $803 - $1,378. Prices often fluctuate based on seasonality and how early you book. You may also be able to find a cheaper business class journey between Medford, OR (MFR-Rogue Valley Intl.) to San Diego, CA (SAN-San Diego Intl.) if you opt for a connecting flight.*Prices based on flights available on Expedia in the last year.
How do I earn miles on a Medford, OR (MFR-Rogue Valley Intl.) to San Diego, CA (SAN-San Diego Intl.) flight with Expedia?
It's easy to earn miles on a Medford, OR (MFR-Rogue Valley Intl.) to San Diego, CA (SAN-San Diego Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for San Diego from Rogue Valley Intl. (MFR)?
From Rogue Valley Intl. (MFR), you can fly into San Diego Intl. (SAN) to reach San Diego. Some flights may connect through major hubs like San Francisco Intl. (SFO), Denver Intl. (DEN), Portland Intl. (PDX) before reaching San Diego. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Medford, OR (MFR-Rogue Valley Intl.) to San Diego, CA (SAN-San Diego Intl.) at the last minute?
Typically, booking a last minute flight from Medford, OR (MFR-Rogue Valley Intl.) to San Diego, CA (SAN-San Diego Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Medford, OR (MFR-Rogue Valley Intl.) to San Diego, CA (SAN-San Diego Intl.) flight and hotel package?
Securing a Medford, OR (MFR-Rogue Valley Intl.) to San Diego, CA (SAN-San Diego Intl.) San Diego Vacation Packages is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Medford, OR (MFR-Rogue Valley Intl.) to San Diego, CA (SAN-San Diego Intl.)?
If you booked your Medford, OR (MFR-Rogue Valley Intl.) to San Diego, CA (SAN-San Diego Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Rogue Valley Intl.
Destination airport
San Diego Intl.
Airlines serving
Alaska Airlines, American Airlines, Delta, United
Roundtrip price
$202
Distance
734 mi
Average flight time
2 hours 19 mins

Book with confidence

Medford to San Diego Flights

The cheapest times to fly from Medford to San Diego

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Medford to San Diego are during the month of November. You can find some of the cheapest flights from Medford to San Diego with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Medford to San Diego

Sunday is one of the best days to book for cheap flights from Medford to San Diego: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Medford to San Diego

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Medford to San Diego in 2026. You can also book with separate airlines for your outbound and return journeys, from $124 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Medford to San Diego flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Medford to San Diego airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Medford to San Diego Flights

*Flight schedules are subject to change.

*Available to One Key members.

 

Explore a world of travel with Expedia