$720 Cheap Flights from Myrtle Beach (MYR) to Johannesburg (JNB)

View $720 flight on Thu, Feb 5, 2026Opens in a new window

Popular airlines from Myrtle Beach Intl. Airport (MYR) to O.R. Tambo Intl. Airport (JNB)

Cheap Flights from Myrtle Beach to Johannesburg (MYR-JNB)

Prices were available within the past 7 days and start at $720 for one-way flights and $1,222 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Wed, Apr 29 - Wed, May 6
MYR
Myrtle Beach
JNB
Johannesburg
$1,222 Roundtrip, found 5 days ago
$1,222
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Apr 29 from Myrtle Beach to Johannesburg, returning Wed, May 6, priced at $1,222 found 5 days ago
American Airlines
Fri, Jan 23 - Thu, Feb 5
MYR
Myrtle Beach
JNB
Johannesburg
$1,236 Roundtrip, found 1 hour ago
$1,236
Roundtrip
found 1 hour ago
Select American Airlines flight, departing Fri, Jan 23 from Myrtle Beach to Johannesburg, returning Thu, Feb 5, priced at $1,236 found 1 hour ago
American Airlines
Tue, Apr 28 - Wed, May 6
MYR
Myrtle Beach
JNB
Johannesburg
$1,242 Roundtrip, found 1 day ago
$1,242
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Apr 28 from Myrtle Beach to Johannesburg, returning Wed, May 6, priced at $1,242 found 1 day ago
American Airlines
Fri, Jan 23 - Thu, Feb 5
MYR
Myrtle Beach
JNB
Johannesburg
$1,245 Roundtrip, found 1 hour ago
$1,245
Roundtrip
found 1 hour ago
Select American Airlines flight, departing Fri, Jan 23 from Myrtle Beach to Johannesburg, returning Thu, Feb 5, priced at $1,245 found 1 hour ago
American Airlines
Tue, Apr 28 - Wed, May 6
MYR
Myrtle Beach
JNB
Johannesburg
$1,250 Roundtrip, found 1 day ago
$1,250
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Apr 28 from Myrtle Beach to Johannesburg, returning Wed, May 6, priced at $1,250 found 1 day ago
American Airlines
Tue, Apr 28 - Wed, May 6
MYR
Myrtle Beach
JNB
Johannesburg
$1,251 Roundtrip, found 1 day ago
$1,251
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Apr 28 from Myrtle Beach to Johannesburg, returning Wed, May 6, priced at $1,251 found 1 day ago
United
Fri, Jan 23 - Thu, Feb 5
MYR
Myrtle Beach
JNB
Johannesburg
$1,392 Roundtrip, found 1 hour ago
$1,392
Roundtrip
found 1 hour ago
Select United flight, departing Fri, Jan 23 from Myrtle Beach to Johannesburg, returning Thu, Feb 5, priced at $1,392 found 1 hour ago
British Airways
Fri, Jan 23 - Thu, Feb 5
MYR
Myrtle Beach
JNB
Johannesburg
$1,452 Roundtrip, found 1 hour ago
$1,452
Roundtrip
found 1 hour ago
Select British Airways flight, departing Fri, Jan 23 from Myrtle Beach to Johannesburg, returning Thu, Feb 5, priced at $1,452 found 1 hour ago
Qatar Airways
Thu, Feb 5 - Fri, Feb 13
MYR
Myrtle Beach
JNB
Johannesburg
$1,553 Roundtrip, found 3 days ago
$1,553
Roundtrip
found 3 days ago
Select Qatar Airways flight, departing Thu, Feb 5 from Myrtle Beach to Johannesburg, returning Fri, Feb 13, priced at $1,553 found 3 days ago
Virgin Atlantic
Sat, Jan 10 - Sat, Jan 31
MYR
Myrtle Beach
JNB
Johannesburg
$1,782 Roundtrip, found 4 days ago
$1,782
Roundtrip
found 4 days ago
Select Virgin Atlantic flight, departing Sat, Jan 10 from Myrtle Beach to Johannesburg, returning Sat, Jan 31, priced at $1,782 found 4 days ago

Frequently asked questions

How much does a flight from Myrtle Beach Intl. Airport (MYR) to O.R. Tambo Intl. Airport (JNB) cost?
Lock in a cheap one-way flight from $720 or cheap return flight from $1,222 from Myrtle Beach Intl. Airport (MYR) to O.R. Tambo Intl. Airport (JNB) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Myrtle Beach Intl. Airport (MYR) to O.R. Tambo Intl. Airport (JNB)?
Flying in April may help you find better deals, as it's the cheapest month for flights between MYR and JNB. You'll usually find the lowest prices during off-peak months.
What is the cheapest airline that flies from Myrtle Beach Intl. Airport (MYR) to O.R. Tambo Intl. Airport (JNB)?
Expedia's filter tool lets you easily compare airlines, flight times and baggage options all in one place. Customize the search to your preferences, then sort by "Price (lowest to highest)" to find the carrier with the cheapest MYR to JNB flight.
How many flights per day from Myrtle Beach Intl. Airport (MYR) to O.R. Tambo Intl. Airport (JNB)?
There are no daily nonstop flights from Myrtle Beach Intl. Airport (MYR) to O.R. Tambo Intl. Airport (JNB). But you can choose flights with layovers. Filter your search on Expedia to include one or more stops, and you'll be cruising above the clouds in no time at all.
What day of the week has the most flights from MYR to JNB?
Friday is generally the busiest day for flights, while Tuesday is often the quietest.* Keep in mind that flight schedules can vary depending on various factors, including the carrier and season.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Myrtle Beach Intl. Airport (MYR) to O.R. Tambo Intl. Airport (JNB)?
Choose a flight from Myrtle Beach Intl. Airport (MYR) to O.R. Tambo Intl. Airport (JNB) that leaves before 3 PM to reduce the likelihood of delays and cancellations. Departures later than this are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Myrtle Beach Intl. Airport (MYR) to O.R. Tambo Intl. Airport (JNB) last-minute?
Waiting until just before your departure to book a flight from MYR to JNB often results in higher prices. While it's possible to find some last-minute deals, they aren't always guaranteed. Keep your travel schedule open to maximize your chances of snagging a bargain.
Is it cheaper to book a MYR to JNB flight and hotel package?
You'll generally save money by booking a MYR to JNB flight and hotel package compared to booking separately. In fact, travelers could save hundreds of dollars by bundling with Expedia. And it's easy to manage it all in one place. After selecting your ideal flights and accommodations, consider adding extras like car rentals, activities and tours.
Can I cancel or change the date of my flight from Myrtle Beach Intl. Airport (MYR) to O.R. Tambo Intl. Airport (JNB)?
If you booked your MYR to JNB flight within the last 24 hours, you may be able to cancel or modify it without any fees. Depending on the airline and the ticket type you purchased, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, visit our Customer Service portal if you'd like more information.

Travel information

Origin airport
Myrtle Beach Intl.
Destination airport
O.R. Tambo Intl.
Airlines serving
Air France, American Airlines, British Airways, Delta, KLM, Qatar Airways, United, Virgin Atlantic
Roundtrip price
$1,222
Distance
8130 mi

Book with confidence

Myrtle Beach to Johannesburg Flights

The cheapest times to fly from Myrtle Beach to Johannesburg

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Myrtle Beach to Johannesburg are during the month of April. You can find some of the cheapest flights from Myrtle Beach to Johannesburg with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Myrtle Beach to Johannesburg

Sunday is one of the best days to book for cheap flights from Myrtle Beach to Johannesburg: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Myrtle Beach to Johannesburg

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Myrtle Beach to Johannesburg in 2025. You can also book with separate airlines for your outbound and return journeys, from $720 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Myrtle Beach to Johannesburg flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Myrtle Beach to Johannesburg airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Myrtle Beach to Johannesburg Flights

Explore a world of travel with Expedia

*Available to One Key members.