$217 Cheap Flights from Santo Domingo (SDQ) to Guayaquil (GYE)

View $217 flight on Tue, Mar 10, 2026Opens in a new window

Popular airlines from Las Americas Intl. Airport (SDQ) to Jose Joaquin de Olmedo Intl. Airport (GYE)

Cheap Flights from Santo Domingo to Guayaquil (SDQ-GYE)

Prices were available within the past 7 days and start at $217 for one-way flights and $440 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Copa
Wed, Dec 31 - Tue, Jan 6
SDQ
Santo Domingo
GYE
Guayaquil
$440 Roundtrip, found 6 hours ago
$440
Roundtrip
found 6 hours ago
Select Copa flight, departing Wed, Dec 31 from Santo Domingo to Guayaquil, returning Tue, Jan 6, priced at $440 found 6 hours ago
Copa
Wed, Dec 31 - Tue, Jan 6
SDQ
Santo Domingo
GYE
Guayaquil
$452 Roundtrip, found 6 hours ago
$452
Roundtrip
found 6 hours ago
Select Copa flight, departing Wed, Dec 31 from Santo Domingo to Guayaquil, returning Tue, Jan 6, priced at $452 found 6 hours ago
Copa
Wed, Dec 31 - Tue, Jan 6
SDQ
Santo Domingo
GYE
Guayaquil
$452 Roundtrip, found 6 hours ago
$452
Roundtrip
found 6 hours ago
Select Copa flight, departing Wed, Dec 31 from Santo Domingo to Guayaquil, returning Tue, Jan 6, priced at $452 found 6 hours ago
Copa
Wed, Dec 31 - Tue, Jan 6
SDQ
Santo Domingo
GYE
Guayaquil
$464 Roundtrip, found 6 hours ago
$464
Roundtrip
found 6 hours ago
Select Copa flight, departing Wed, Dec 31 from Santo Domingo to Guayaquil, returning Tue, Jan 6, priced at $464 found 6 hours ago
Copa
Wed, Dec 31 - Tue, Jan 6
SDQ
Santo Domingo
GYE
Guayaquil
$472 Roundtrip, found 6 hours ago
$472
Roundtrip
found 6 hours ago
Select Copa flight, departing Wed, Dec 31 from Santo Domingo to Guayaquil, returning Tue, Jan 6, priced at $472 found 6 hours ago
Copa
Mon, Jan 19 - Sat, Jan 24
SDQ
Santo Domingo
GYE
Guayaquil
$474 Roundtrip, found 7 hours ago
$474
Roundtrip
found 7 hours ago
Select Copa flight, departing Mon, Jan 19 from Santo Domingo to Guayaquil, returning Sat, Jan 24, priced at $474 found 7 hours ago
Copa
Sat, Feb 28 - Tue, Mar 3
SDQ
Santo Domingo
GYE
Guayaquil
$477 Roundtrip, found 1 day ago
$477
Roundtrip
found 1 day ago
Select Copa flight, departing Sat, Feb 28 from Santo Domingo to Guayaquil, returning Tue, Mar 3, priced at $477 found 1 day ago
avianca
Wed, Nov 12 - Sat, Nov 15
SDQ
Santo Domingo
GYE
Guayaquil
$487 Roundtrip, found 4 hours ago
$487
Roundtrip
found 4 hours ago
Select avianca flight, departing Wed, Nov 12 from Santo Domingo to Guayaquil, returning Sat, Nov 15, priced at $487 found 4 hours ago
JetBlue Airways
Sun, Nov 23 - Fri, Nov 28
SDQ
Santo Domingo
GYE
Guayaquil
$686 Roundtrip, found 1 day ago
$686
Roundtrip
found 1 day ago
Select JetBlue Airways flight, departing Sun, Nov 23 from Santo Domingo to Guayaquil, returning Fri, Nov 28, priced at $686 found 1 day ago
American Airlines
Mon, Apr 20 - Mon, Apr 27
SDQ
Santo Domingo
GYE
Guayaquil
$1,148 Roundtrip, found 2 hours ago
$1,148
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Mon, Apr 20 from Santo Domingo to Guayaquil, returning Mon, Apr 27, priced at $1,148 found 2 hours ago

Find the cheapest month to fly from Santo Domingo (SDQ) to Guayaquil (GYE)

January is typically the cheapest month to fly

From $346 - $829 per traveler.

Alternative airports near Guayaquil

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Jose Joaquin de Olmedo Intl. GYE. Cheapest and Closest option available. Average driving time to city center is 9 minutes. Flights from $509
GYE
Jose Joaquin de Olmedo Intl.
CheapestClosest
Average driving time to city center9 min
Flights from $509

Frequently asked questions

How much does a flight from Las Americas Intl. Airport (SDQ) to Jose Joaquin de Olmedo Intl. Airport (GYE) cost?
Grab a cheap one-way flight from $217 or cheap return flight from $440 from Las Americas Intl. Airport (SDQ) to Jose Joaquin de Olmedo Intl. Airport (GYE) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Las Americas Intl. Airport (SDQ) to Jose Joaquin de Olmedo Intl. Airport (GYE)?
December is the cheapest month to fly from SDQ to GYE. Avoiding peak travel times is often the key to better flight prices.
What is the cheapest airline that flies from Las Americas Intl. Airport (SDQ) to Jose Joaquin de Olmedo Intl. Airport (GYE)?
Expedia's filter tool lets you easily compare travel time, airlines and fares all in one place. Choose your preferences, then sort by "Price (lowest to highest)" to find out which carrier offers the cheapest SDQ to GYE flight.
How many flights per day from Las Americas Intl. Airport (SDQ) to Jose Joaquin de Olmedo Intl. Airport (GYE)?
You'll have to hop on a flight with a layover if you're traveling from Las Americas Intl. Airport (SDQ) to Jose Joaquin de Olmedo Intl. Airport (GYE). Direct flights don't operate daily on this route. However, simply filter your search to include one or two stops to discover the best option for your trip.
What day of the week has the most flights from SDQ to GYE?
Generally you'll find the widest variety of flight choices on a Friday. Tuesdays are often the quietest.* But this can change depending on the time of year, airline and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Las Americas Intl. Airport (SDQ) to Jose Joaquin de Olmedo Intl. Airport (GYE)?
To avoid possible delays on the Las Americas Intl. Airport (SDQ) to Jose Joaquin de Olmedo Intl. Airport (GYE) route, aim to fly before 3 PM. Departures after this hour have a 22% higher chance of being canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Las Americas Intl. Airport (SDQ) to Jose Joaquin de Olmedo Intl. Airport (GYE) last-minute?
Booking your flight from SDQ to GYE just before your trip is typically more expensive. However, if you're flexible with your travel times and dates, you could land a cheap last-minute fare.
Is it cheaper to book a SDQ to GYE flight and hotel package?
Compared with arranging flights and hotels separately, booking a SDQ to GYE flight and hotel package with Expedia could result in significant savings. Better yet, having everything in one place takes the hassle out of planning your trip. Just pick your flights and select from our wide range of stays, then personalize your trip with other add-ons like activities and car rentals.
Can I cancel or change the date of my flight from Las Americas Intl. Airport (SDQ) to Jose Joaquin de Olmedo Intl. Airport (GYE)?
It's generally possible to cancel or reschedule your SDQ to GYE flight. However, for bookings made more than 24 hours ago, additional fees may apply. Check your airline's policies in your itinerary to see what changes are possible and whether any costs are involved. You'll also find further details on our Customer Service portal.

Travel information

Origin airport
Las Americas Intl.
Destination airport
Jose Joaquin de Olmedo Intl.
Airlines serving
American Airlines, Copa, JetBlue Airways, avianca
Roundtrip price
$439
Distance
1582 mi

Book with confidence

Santo Domingo to Guayaquil Flights

The cheapest times to fly from Santo Domingo to Guayaquil

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Santo Domingo to Guayaquil are during the month of December. You can find some of the cheapest flights from Santo Domingo to Guayaquil with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Santo Domingo to Guayaquil

Sunday is one of the best days to book for cheap flights from Santo Domingo to Guayaquil: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Santo Domingo to Guayaquil

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Santo Domingo to Guayaquil in 2025. You can also book with separate airlines for your outbound and return journeys, from $217 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Santo Domingo to Guayaquil flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Santo Domingo to Guayaquil airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Santo Domingo to Guayaquil Flights

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*Available to One Key members.