$80 Cheap Flights from St. Louis (STL) to San Diego (SAN)

View $80 flight on Thu, Oct 23, 2025Opens in a new window

Popular airlines from St. Louis Lambert Intl. Airport (STL) to San Diego Intl. Airport (SAN)

Cheap Flights from St. Louis to San Diego (STL-SAN)

Prices were available within the past 7 days and start at $80 for one-way flights and $160 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Frontier Airlines
Thu, Sep 18 - Sat, Sep 27
STL
St. Louis
SAN
San Diego
$160 Roundtrip, found 2 hours ago
$160
Roundtrip
found 2 hours ago
Select Frontier Airlines flight, departing Thu, Sep 18 from St. Louis to San Diego, returning Sat, Sep 27, priced at $160 found 2 hours ago
Frontier Airlines
Thu, Oct 23 - Sat, Nov 1
STL
St. Louis
SAN
San Diego
$175 Roundtrip, just found
$175
Roundtrip
just found
Select Frontier Airlines flight, departing Thu, Oct 23 from St. Louis to San Diego, returning Sat, Nov 1, priced at $175 just found
Frontier Airlines
Sun, Oct 19 - Sat, Oct 25
STL
St. Louis
SAN
San Diego
$176 Roundtrip, found 4 days ago
$176
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Sun, Oct 19 from St. Louis to San Diego, returning Sat, Oct 25, priced at $176 found 4 days ago
Frontier Airlines
Sun, Aug 31 - Thu, Oct 2
STL
St. Louis
SAN
San Diego
$190 Roundtrip, found 8 hours ago
$190
Roundtrip
found 8 hours ago
Select Frontier Airlines flight, departing Sun, Aug 31 from St. Louis to San Diego, returning Thu, Oct 2, priced at $190 found 8 hours ago
Frontier Airlines
Fri, Sep 19 - Sun, Sep 21
STL
St. Louis
SAN
San Diego
$191 Roundtrip, found 3 hours ago
$191
Roundtrip
found 3 hours ago
Select Frontier Airlines flight, departing Fri, Sep 19 from St. Louis to San Diego, returning Sun, Sep 21, priced at $191 found 3 hours ago
Frontier Airlines
Sat, Oct 18 - Sat, Oct 25
STL
St. Louis
SAN
San Diego
$194 Roundtrip, found 9 hours ago
$194
Roundtrip
found 9 hours ago
Select Frontier Airlines flight, departing Sat, Oct 18 from St. Louis to San Diego, returning Sat, Oct 25, priced at $194 found 9 hours ago
Southwest Airlines
Wed, Nov 12 - Sat, Nov 15
STL
St. Louis
SAN
San Diego
$225 Roundtrip, found 7 hours ago
$225
Roundtrip
found 7 hours ago
Select Southwest Airlines flight, departing Wed, Nov 12 from St. Louis to San Diego, returning Sat, Nov 15, priced at $225 found 7 hours ago
American Airlines
Mon, Oct 6 - Mon, Oct 13
STL
St. Louis
SAN
San Diego
$234 Roundtrip, found 6 hours ago
$234
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Mon, Oct 6 from St. Louis to San Diego, returning Mon, Oct 13, priced at $234 found 6 hours ago
Alaska Airlines
Sat, Sep 20 - Thu, Sep 25
STL
St. Louis
SAN
San Diego
$239 Roundtrip, found 7 hours ago
$239
Roundtrip
found 7 hours ago
Select Alaska Airlines flight, departing Sat, Sep 20 from St. Louis to San Diego, returning Thu, Sep 25, priced at $239 found 7 hours ago
Delta
Mon, Oct 6 - Mon, Oct 13
STL
St. Louis
SAN
San Diego
$244 Roundtrip, found 6 hours ago
$244
Roundtrip
found 6 hours ago
Select Delta flight, departing Mon, Oct 6 from St. Louis to San Diego, returning Mon, Oct 13, priced at $244 found 6 hours ago

Find the cheapest month to fly from St. Louis (STL) to San Diego (SAN)

November is typically the cheapest month to fly

From $118 - $391 per traveler.

Graph displaying average flight prices per month

Alternative airports near San Diego

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to General Abelardo L. Rodriguez Intl. TIJ. Average driving time to city center is 26 minutes. Flights from $766
TIJ
General Abelardo L. Rodriguez Intl.
Average driving time to city center26 min
Flights from $766
Select flight to McClellan-Palomar CLD. Cheapest option available. Average driving time to city center is 38 minutes. Flights from $360
CLD
McClellan-Palomar
Cheapest
Average driving time to city center38 min
Flights from $360
Flights from St. Louis (STL) to San Diego (SAN)
Origin airport
Lambert-St. Louis Intl.
Destination airport
San Diego Intl.
Airlines serving
Alaska Airlines, American Airlines, Delta, Frontier Airlines, Southwest Airlines, United
Roundtrip price
$160
Distance
1554 mi
Average flight time
1 hour 45 mins

St. Louis to San Diego Flights

The cheapest times to fly from St. Louis to San Diego

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from St. Louis to San Diego are during the month of September. You can find some of the cheapest flights from St. Louis to San Diego with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from St. Louis to San Diego

Sunday is one of the best days to book for cheap flights from St. Louis to San Diego: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from St. Louis to San Diego

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from St. Louis to San Diego in 2025. You can also book with separate airlines for your outbound and return journeys, from $80 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap St. Louis to San Diego flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your St. Louis to San Diego airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Lambert-St. Louis Intl. Airport (STL) to San Diego Intl. Airport (SAN) cost?
Grab a cheap one-way flight from $80 or cheap return flight from $160 from Lambert-St. Louis Intl. Airport (STL) to San Diego Intl. Airport (SAN) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Lambert-St. Louis Intl. Airport (STL) to San Diego Intl. Airport (SAN)?
September is the cheapest month to fly from STL to SAN. Timing your trip outside of the busy season is often the key to finding better deals on flights.
Which airlines fly direct from Lambert-St. Louis Intl. Airport (STL) to San Diego Intl. Airport (SAN)?
Hop on a nonstop flight with Southwest Airlines and journey straight from Lambert-St. Louis Intl. Airport (STL) to San Diego Intl. Airport (SAN).
What is the cheapest airline that flies from Lambert-St. Louis Intl. Airport (STL) to San Diego Intl. Airport (SAN)?
To find the cheapest airline that'll fly you from STL to SAN, use Expedia's filter tool. Tailor your search based on what matters most to you, such as preferred carriers and flight duration. You can then sort your results by "Price (lowest to highest)" to see the most affordable options first.
How many flights per day from Lambert-St. Louis Intl. Airport (STL) to San Diego Intl. Airport (SAN)?
On average, only 1 direct flight departs each day from Lambert-St. Louis Intl. Airport (STL) to San Diego Intl. Airport (SAN). Looking for more options? Use Expedia's filter tool to find flights with layovers and add an extra destination to your journey.
What are the most popular departure times for flights from Lambert-St. Louis Intl. Airport (STL) to San Diego Intl. Airport (SAN)?
The 11 AM departures from STL to SAN are the top choice for many travelers. They can also be more expensive. If you want to save on your fare, book during off-peak hours.
What day of the week has the most flights from STL to SAN?
Friday offers the most flights from Lambert-St. Louis Intl. Airport (STL) to San Diego Intl. Airport (SAN). Consider leaving on this day and you'll have a greater chance of finding a departure that fits your plans.
What is the earliest flight from Lambert-St. Louis Intl. Airport (STL) to San Diego Intl. Airport (SAN)?
Hop on the earliest flight at around 10:20AM UTC-6, departing from Lambert-St. Louis Intl. Airport (STL). You'll be flying for approximately 4h 10m, coming in to land at San Diego Intl. Airport (SAN) at approximately 12:30PM UTC-8.
How long does it take to fly from Lambert-St. Louis Intl. Airport (STL) to San Diego Intl. Airport (SAN)?
Flights from STL to SAN have an average travel time of 4 hours and 10 minutes. The total distance between the two airports is 1,550 mi.
What is the best time to fly from Lambert-St. Louis Intl. Airport (STL) to San Diego Intl. Airport (SAN)?
To touch down at San Diego Intl. Airport (SAN) on schedule, select a flight that leaves Lambert-St. Louis Intl. Airport (STL) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this time.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
What airports do you fly into for San Diego from Lambert-St. Louis Intl. Airport (STL)?
San Diego Intl. Airport (SAN) is the only airport in San Diego with direct flights from Lambert-St. Louis Intl. Airport (STL). Consider the options and find cheap fares on Expedia.
Is it cheaper to buy a plane ticket from Lambert-St. Louis Intl. Airport (STL) to San Diego Intl. Airport (SAN) last-minute?
Last-minute fares from STL to SAN are typically more expensive. For the lowest prices, start looking for flights well in advance. That being said, if you're flexible with your travel plans, it's possible to land a cheap ticket just before your departure.
Is it cheaper to book a STL to SAN flight and hotel package?
Securing a STL to SAN flight and hotel package is typically cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your trip in one place. Select from our wide range of accommodations and then add activities, flights and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Lambert-St. Louis Intl. Airport (STL) to San Diego Intl. Airport (SAN)?
If you booked your STL to SAN flight within the last 24 hours, you may be able to modify or cancel it without fees. Depending on the airline and the ticket type you purchased, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, visit our Customer Service portal for more details.

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*Available to One Key members.