Cheap Flights from Knoxville (TYS) to St. Louis (CPS)

Popular airlines from McGhee Tyson Airport (TYS) to St. Louis, MO (CPS-St. Louis Downtown)

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Alternative airports near St. Louis

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Lambert-St. Louis Intl. STL. Cheapest option available. Average driving time to city center is 20 minutes. Flights from $259
STL
Lambert-St. Louis Intl.
Cheapest
Average driving time to city center20 min
Flights from $259

Frequently asked questions

How much does a flight from McGhee Tyson Airport (TYS) to St. Louis Downtown Airport (CPS) cost?
Grab a cheap one-way flight or cheap return flight from McGhee Tyson Airport (TYS) to St. Louis Downtown Airport (CPS) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from McGhee Tyson Airport (TYS) to St. Louis Downtown Airport (CPS)?
is the least expensive month to fly from TYS to CPS. Traveling during quieter months is often the key to scoring lower fares.
What is the cheapest airline that flies from McGhee Tyson Airport (TYS) to St. Louis Downtown Airport (CPS)?
Expedia's filter tool lets you easily compare different airlines, departure times and fares all in one place. Tailor the search to your trip, then sort by "Price (lowest to highest)" to see which carrier offers the cheapest TYS to CPS flight.
How many flights per day from McGhee Tyson Airport (TYS) to St. Louis Downtown Airport (CPS)?
You'll have to take a flight with a layover when traveling from McGhee Tyson Airport (TYS) to St. Louis Downtown Airport (CPS). Direct flights don't operate daily on this route. However, just filter your search to include one or two stops to discover an option that works for you.
What day of the week has the most flights from TYS to CPS?
Friday is typically the busiest day for flights, while Tuesday tends to be the quietest.* Keep in mind that flight schedules can vary depending on a range of factors, such as the season and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from McGhee Tyson Airport (TYS) to St. Louis Downtown Airport (CPS)?
Opt for a flight from McGhee Tyson Airport (TYS) to St. Louis Downtown Airport (CPS) that takes off before 3 PM to reduce the likelihood of delays. Departures after this hour are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from McGhee Tyson Airport (TYS) to St. Louis Downtown Airport (CPS) last-minute?
Waiting until just before your departure to book a ticket from TYS to CPS often results in higher prices. While it's possible to find some last-minute discounts, they aren't always guaranteed. Be flexible with your itinerary for the best chance of scoring a bargain.
Is it cheaper to book a TYS to CPS flight and hotel package?
You'll typically save money by booking a TYS to CPS flight and hotel package compared to booking separately. In fact, travelers could save hundreds of dollars by bundling with Expedia. And it's easy to manage everything in one place. Once you've selected your ideal flights and accommodations, you can add extras like tours, activities and car rentals.
Can I cancel or change the date of my flight from McGhee Tyson Airport (TYS) to St. Louis Downtown Airport (CPS)?
You can usually reschedule or cancel your TYS to CPS flight. However, if it's been more than 24 hours since booking, additional fees may apply. Refer to your airline's policies in your itinerary to see what changes are possible and if any costs are involved. You'll also find more details on our Customer Service portal.

Travel information

Origin airport
McGhee Tyson
Destination airport
St. Louis Downtown
Distance
389 mi

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Knoxville to St. Louis Flights

The cheapest times to fly from Knoxville to St. Louis

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Knoxville to St. Louis are during the month of . You can find some of the cheapest flights from Knoxville to St. Louis with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Knoxville to St. Louis

Sunday is one of the best days to book for cheap flights from Knoxville to St. Louis: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Knoxville to St. Louis

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Knoxville to St. Louis in 2025. You can also book with separate airlines for your outbound and return journeys, from one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Knoxville to St. Louis flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Knoxville to St. Louis airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Knoxville to St. Louis Flights

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*Available to One Key members.