Find 4 Star Hotels in Clayton, MO from $101

Compare Clayton 4 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Breakfast, lunch and dinner served
Live by Loews - St.Louis
4.0 star property
9.2 out of 10, Wonderful, (1003)
"Nice place "
The price is $169
$203 total
includes taxes & fees
May 12 - May 13
Live by Loews - St.Louis
Exterior
Moonrise Hotel
4.0 star property
9.0 out of 10, Wonderful, (1348)
"The location was great, the facility was great, the aesthetics were wonderful. "
The price is $159
$189 total
includes taxes & fees
May 14 - May 15
Moonrise Hotel
Exterior
21C Museum Hotel St Louis
4.5 star property
9.0 out of 10, Wonderful, (404)
"A few housekeeping issues, overall the staff were very helpful and hotel awesome."
The price is $152
$178 total
includes taxes & fees
May 27 - May 28
21C Museum Hotel St Louis
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Lobby
AC Hotel St. Louis Central West End
4.0 star property
9.0 out of 10, Wonderful, (398)
"Lovely clean hotel in the heart of St. Louis. Would stay there again. "
The price is $143
$169 total
includes taxes & fees
May 24 - May 25
AC Hotel St. Louis Central West End
Terrace/patio
Angad Arts Hotel
4.0 star property
8.8 out of 10, Excellent, (1021)
"This hotel was very neat. I was going to see a show at the Fox and the hotel is almost right across the street from the theatre so it was great for that purpose. There are some things I wish I had known prior to staying so I will share those here. Parking is in the back of the building for the hotel and there is a fee for parking. When I looked this up prior to booking it just stated "parking available". I think it was like $26. You enter the hotel in the back as well by hitting the ring...
The price is $135
$159 total
includes taxes & fees
Jun 2 - Jun 3
Angad Arts Hotel
Property entrance
River City Casino & Hotel
4.0 star property
8.8 out of 10, Excellent, (1005)
"Great hotel. So so location."
The price is $101
$128 total
includes taxes & fees
May 22 - May 23
River City Casino & Hotel
Outdoor pool
The Royal Sonesta Chase Park Plaza St. Louis
4.5 star property
8.8 out of 10, Excellent, (1002)
"Beautiful, classy hotel. Upscale restaurants and shopping nearby. Close proximity to Forest Park and the Muny, St Louis Zoo, Historical Museum and much more!"
The price is $227
$290 total
includes taxes & fees
May 27 - May 28
The Royal Sonesta Chase Park Plaza St. Louis
Lounge
Le Méridien St. Louis Clayton
4.0 star property
8.8 out of 10, Excellent, (460)
"The pool wasn’t open! The baseboard was quite dirty in bathroom of 1109…staff was phenomenal!"
The price is $188
$221 total
includes taxes & fees
May 19 - May 20
Le Méridien St. Louis Clayton
Exterior
The Pennywell St.Louis Downtown, a Hilton Hotel
4.0 star property
8.8 out of 10, Excellent, (354)
"Hotel is cleverly converted from a former bank building with the vault still visible in the lobby serving as an entrance to the store. "
The price is $130
$154 total
includes taxes & fees
May 27 - May 28
The Pennywell St.Louis Downtown, a Hilton Hotel
Outdoor pool
Hotel Saint Louis, Autograph Collection
4.0 star property
8.8 out of 10, Excellent, (315)
"Beautiful property I love that they have record players in the room"
The price is $169
$201 total
includes taxes & fees
May 27 - May 28
Hotel Saint Louis, Autograph Collection
Lobby
Hilton St. Louis Frontenac
4.0 star property
8.6 out of 10, Excellent, (1003)
"Outstanding "
The price is $135
$157 total
includes taxes & fees
May 19 - May 20
Hilton St. Louis Frontenac
Front of property
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
4.0 star property
8.6 out of 10, Excellent, (1003)
"Great all around experience "
The price is $115
$137 total
includes taxes & fees
May 27 - May 28
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
Exterior
DoubleTree by Hilton Hotel St. Louis - Chesterfield
4.0 star property
8.6 out of 10, Excellent, (1000)
"Very friendly staff"
The price is $142
$165 total
includes taxes & fees
May 19 - May 20
DoubleTree by Hilton Hotel St. Louis - Chesterfield
Exterior
Hyatt Regency St. Louis at The Arch
4.0 star property
8.4 out of 10, Very Good, (3006)
"We have stayed at this hotel several times. This particular stay, there happened to be a baseball game at the nearby stadium. The hotel parking was full, which caused an additional cost to park elsewhere. The desk attendant stated people often used their parking even though they are not hotel guess. My opinion, hotel guess should not have to pay for parking at other locations. Our room was on the 15th floor and the sheets were like sleeping on a brown paper bag (very crunchy). First time...
The price is $139
$164 total
includes taxes & fees
May 27 - May 28
Hyatt Regency St. Louis at The Arch
Outdoor pool
The Last Hotel
4.5 star property
8.4 out of 10, Very Good, (1002)
"This was my second time staying here and it was just as good as the first time. It was clean and was a cute hotel. "
The price is $198
$232 total
includes taxes & fees
Jun 3 - Jun 4
The Last Hotel
Lobby lounge
The Westin St. Louis
4.5 star property
8.4 out of 10, Very Good, (1003)
"Parking here is not free with the hotel stay. Rooms are at least 300.00 if not more a room but you have to pay 42.00 to park. Then you leave parking lot to go site seeing and dinner come back and have to park even further away from hotel but still paying 42.00. Its not right."
The price is $161
$188 total
includes taxes & fees
May 27 - May 28
The Westin St. Louis
Terrace/patio
The Cheshire
4.0 star property
8.4 out of 10, Very Good, (1002)
"Delicious breakfast with lovely fresh fruit. Staff was always accessible and helpful."
The price is $157
$187 total
includes taxes & fees
May 19 - May 20
The Cheshire
In-room safe, desk, blackout drapes, iron/ironing board
DoubleTree by Hilton St. Louis Forest Park
4.0 star property
8.4 out of 10, Very Good, (1004)
"The property was clean. The bed was comfortable. The location is great for being central to Forest Park, the Hill and downtown. We will stay again!"
The price is $131
$154 total
includes taxes & fees
May 27 - May 28
DoubleTree by Hilton St. Louis Forest Park
Exterior
Embassy Suites by Hilton St. Louis Downtown
4.0 star property
8.4 out of 10, Very Good, (1035)
"Very friendly, helpful staff. Everyone we had an encounter with that was part of the hotel staff was very happy, friendly and helpful! This is so refreshing! Clean, comfortable rooms in a unique building. We would definitely stay here again. "
The price is $152
$181 total
includes taxes & fees
May 22 - May 23
Embassy Suites by Hilton St. Louis Downtown
Exterior
Renaissance St. Louis Airport Hotel
4.0 star property
8.2 out of 10, Very Good, (1004)
"The staff was very personable and helpful! "
The price is $122
$144 total
includes taxes & fees
May 26 - May 27
Renaissance St. Louis Airport Hotel

Explore similar 5-star hotels

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

The beginning of any trip gets started with picking a fantastic spot. Clayton has become a popular local with guests because of all its local amenities. However, "location, location, location" applies to more than just what city where your plane lands. When you want a holiday that is great from start to finish, you need the ideal hotel.

Hotels as Picturesque as Clayton

Clayton saw its fair share of visitors in the last year. Our comment section provides tips and tricks on which hotel will fulfill your wishes for an unbelievable vacation. The resorts found here aim to make your vacation as pleasant as your evenings spent hanging out in Clayton. These hotels aim to make their facilities and grounds pleasing from the time you step onto the property. You'll never have to venture far to sustain your exercise schedule, enjoy an energizing spa treatment, or find a delicious lunch during your vacation with all that they offer.

Rooms have been designed to keep you as cozy as possible, with amenities like in-room tea or coffee, specially designed bathroom products, and, premium bedding. So, lay back and unwind. Moreover, if you find that you're need of anything more, you can be confident the staff will do their best to ensure you continue to be pleased during your time. These hotels are so nice that you'll regret the day you have to check-out.

Reserve a 4-Star Hotel in Clayton Today!

A getaway to Clayton should be one where you don't have to concern yourself about the little things. Expedia can get great rates on world-class accommodations to take your trip to the next level.

Frequently asked questions

What are the best 4-star hotels in Clayton?
Kick back and unwind in 4-star hotel comfort at Le Méridien St. Louis Clayton. Rated highly by many of our guests, it offers concierge services and premium bedding. Also check out The Cheshire. Egyptian-cotton sheets and a terrace help make this escape another popular choice in Clayton.
How much does it cost to stay in a 4-star hotel in Clayton?
We can help you easily locate the perfect 4-star hotel for your trip to Clayton. Use our filter tool to tailor your search by things like budget, amenities and star rating and get access to fabulous deals in a few clicks.

  • Search for the lowest price from $119

What's the difference between 5-star and 4-star hotels in Clayton?
Offering a welcoming guest experience and upscale décor, 4-star hotels are a fabulous option for your Clayton trip. These types of stays generally feature loads of useful amenities that make it easy to unpack and unwind — think 24-hour room service, gyms and pools. Or enjoy even more lavishness at a 5-star hotel designed to pamper with exclusive perks and amenities. 24-hour front desk, complimentary toiletries and gourmet dining are typically featured at these swanky properties.
Does Clayton have any 4-star all-inclusive resorts?
Use our filters to look for all-inclusive Clayton resorts where your room, food, daily entertainment and more are provided for in the purchase price. Can’t find anything available? You can also kick back and relax in sophisticated surroundings at other excellent 4-star stays in the city. The Cheshire and Le Méridien St. Louis Clayton are two popular options.
Are there any 4-star casino hotels in Clayton?
Spin the wheel and try your luck at River City Casino & Hotel. HoteLumiere at the Arch is one more sought-after 4-star option in Clayton where you can play your hand at the casino.
What are the top 4-star apartments in Clayton?
Prepare to enjoy Clayton like a local at one of our 4-star apartments. Featuring a garden and individually decorated rooms, Tower Grove Getaways By Namastay is a great pick in this amazing destination. Or spend your stay at Hickory B - 1 Bedroom Apts and make use of a fireplace and a deck.
What are the top 4-star hotels in downtown Clayton?
Book your stay at Le Méridien St. Louis Clayton and you’ll be in the perfect spot to explore downtown Clayton. Situated about 1 mi northwest from the center of town, this 4-star hotel also offers premium bedding and hypo-allergenic bedding.

Recent reviews of Clayton hotels
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