Find 4 Star Hotels in De Soto, MO
Check availability on De Soto 4 Star Hotels
Compare De Soto 4 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.
Old Caledonian Bed and Breakfast
De Soto Four Star Hotel Information
When you need to book a room with luxurious amazing amenities and the best rates, the 4 star hotels in De Soto, Missouri are incredible options. Known for their extra perks, first-rate service, and fantastic locations, each of the De Soto 4 star hotels offers the ultimate experience for globe-trotting travelers. Relax in your expertly designed room. Kick back with around-the-clock room service.
Get a good night’s sleep with the ultra-plush bedding, and freshen up in the morning with designer-inspired body products. It’s all available when you stay at one of the top book a four star hotels in De Soto. What’s more, thanks to Expedia you might even score a cheap great deal on a 4 star hotel in De Soto, Missouri, areas near the hottest attractions, so you can plan a sightseeing adventure and take advantage of unbeatable discounts in one fell swoop.
Whether you’re putting together a serene getaway or want to revel in the most vibrant entertainment district, 4 star De Soto hotels offer everything your heart desires.
Frequently asked questions
De Soto Hotels by Star Rating
Stay near popular De Soto attractions
- Mississippi River
- Mark Twain National Forest
- Meramec State Park
- Bonne Terre Mine
- Meramec River
- St. Joe State Park
- Hawn State Park
- Pickle Springs Natural Area
- Washington State Park
- St. Francois State Park
- Crown Pointe Golf Club
- Big River
- Missouri Mines State Historic Site
- Weingarten Vineyard
- Mastodon State Historic Site
- Fort de Chartes
- Villa Antonio Winery
- Illinois Caverns State Natural Area
- Robertsville State Park
Explore more hotels
- WoodSpring Suites St. Louis Arnold
- La Quinta Inn & Suites by Wyndham Festus - St. Louis South
- Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS, an IHG Hotel
- Quality Inn Farmington
- Holiday Inn Express & Suites Farmington, an IHG Hotel
- Super 8 by Wyndham Potosi
- Super 8 by Wyndham Bonne Terre
- Crown Pointe Lodge, BW Signature Collection
- Hampton Inn Farmington
- Relax and enjoy the privacy
- Quality Inn Festus
- Hagood farms and trails
- Couples Retreat with hot tub (cabin2)
- Stewart Acres..."Big City Close, w/ Big Country Charm"
- ❤️ THE MAGIC TIPI RETREAT
- Lake Haven - Updated Mid Century Cabin Only 35 Mins from St. Louis
- Bluebird Meadows with In-ground Pool and Hot Tub! 125 ACRES TO EXPLORE
- Serenity Log Inn -Log out and Log Inn to Serenity
- Oakdale Primitive cabin (1)@Spring Lake Ranch