Cherokee Vacation Rentals

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Our top choices for Cherokee vacation rentals

10.0 out of 10, Exceptional, (1)
"Room were great clean "
United States
Randy
$221 nightly
The price is $235
Jan 4 - Jan 5, 2026
Total with taxes and fees
10 Mi to Tennessee River: Blue Willow-themed Home

Vacation Home in East Florence

ReNew At JW's & bring your Dog too!
3.0 star property
10.0 out of 10, Exceptional, (1)
"Loved this little house. It had everything I needed and was close to my work. Majority of my stay I was alone and I felt totally safe. Definitely recommend this place!"
United States
Kim R.
$188 nightly
The price is $213
Jan 4 - Jan 5, 2026
Total with taxes and fees
ReNew At JW's & bring your Dog too!

Cottage in Tishomingo

Country Bliss
10.0 out of 10, Exceptional, (13)
"I have stayed several times here and always a pleasure very comfy and nicely appointed."
United States
Sherry B.
$159 nightly
The price is $170
Jan 1 - Jan 2, 2026
Total with taxes and fees
Country Bliss
9.6 out of 10, Exceptional, (23)
"Perfect for my trip. Great location. Quiet unit with adequate room. Unit was dated and could use a deep clean. "
United States
Hollis T.
$154 nightly
The price is $154
Jan 1 - Jan 2, 2026
Total with taxes and fees
501#C - Downtown 2BR Condo w/Modern Amenities
9.8 out of 10, Exceptional, (31)
"It was amazing will be going back "
United States
Michael T.
$254 nightly
The price is $272
Jan 3 - Jan 4, 2026
Total with taxes and fees
Fern Hollow Treehouse, rustic escape cozy romantic
2.0 star property
10.0 out of 10, Exceptional, (2)
"Totally recommend! I have stayed in alot of places over the years, and this warm and cozy little home did not disappoint!"
United States
Julie
$221 nightly
The price is $235
Jan 4 - Jan 5, 2026
Total with taxes and fees
10 Mi to Tennessee River: Blue Willow-Themed Home
2.0 star property
10.0 out of 10, Exceptional, (5)
"Adorable house, great location, awesome host, very comfortable "
United States
Jamie S.
$242 nightly
The price is $274
Jan 3 - Jan 4, 2026
Total with taxes and fees
Charming 2-bedroom house with AC, WiFi in wonderful Florence
9.2 out of 10, Wonderful, (5)
"Our family stayed here for a weekend getaway and it was great. The home was so cute and cozy! "
United States
Mercedes J.
$228 nightly
The price is $257
Jan 2 - Jan 3, 2026
Total with taxes and fees
NO PETS/NON SMOKING 3-bedroom home in Counce with WiFi, AC

Apartment in Red Bay

Stay on Main Street in Red Bay
2.0 star property
9.8 out of 10, Exceptional, (20)
"Great place to stay."
United States
Pamela H.
$130 nightly
The price is $141
Jan 4 - Jan 5, 2026
Total with taxes and fees
Stay on Main Street in Red Bay

Mobile Home in Florence

Cowboy Cottage
10.0 out of 10, Exceptional, (23)
"The whole property was super clean and the sweet treats were greatly appreciated!"
United States
Kristen D.
$155 nightly
The price is $170
Jan 7 - Jan 8, 2026
Total with taxes and fees
Cowboy Cottage

Cottage in Tishomingo

The Gypsy Queen
2.0 star property
10.0 out of 10, Exceptional, (1)
"Booked this place because my girlfriend wanted to stay “somewhere cute with charm” on a fishing trip to Pickwick. She absolutely loved it and I’m ashamed to admit how much I actually enjoyed the vibe. Weird, little, fun place out in the middle of nowhere all by yourself. Quiet and peaceful. The shower could be a bit warmer but aside from that it was perfect. Definitely worth a stay if you want something outside the box!"
United States
Jacob L.
$200 nightly
The price is $214
Jan 3 - Jan 4, 2026
Total with taxes and fees
The Gypsy Queen
2.0 star property
10.0 out of 10, Exceptional, (1)
"Very cozy place surrounded by nature. "
United States
Larry T.
$198 nightly
The price is $224
Jan 5 - Jan 6, 2026
Total with taxes and fees
Convenient to State Line Boat Ramp - Flintstone Cabin

Condo in Muscle Shoals

Stenson Hollow Lake Condo
9.6 out of 10, Exceptional, (82)
"Truly loved the place, very peaceful, clean, easy check-in and out"
United States
paula a.
$184 nightly
The price is $199
Jan 1 - Jan 2, 2026
Total with taxes and fees
Stenson Hollow Lake Condo
10.0 out of 10, Exceptional, (21)
"Beautiful cabin, great owner! Loved it here!"
United States
Jennifer A.
$176 nightly
The price is $188
Jan 1 - Jan 2, 2026
Total with taxes and fees
Crossroads to Pickwick Cabin SMOOTH SAILING

Vacation Home in Florence

The Cozy Cottage of Florence!
8.4 out of 10, Very Good, (10)
"Very nice house and close to everything. Thank you "
United States
LUCIAN R.
$253 nightly
The price is $286
Jan 6 - Jan 7, 2026
Total with taxes and fees
The Cozy Cottage of Florence!
9.6 out of 10, Exceptional, (44)
"Lovely home! Nice set up of rooms and the kids enjoyed the pool"
United States
christina j.
$267 nightly
The price is $293
Jan 5 - Jan 6, 2026
Total with taxes and fees
3-bedroom w/pool and all the comforts of home in Muscle Shoals-recording capital

Apartment in Belmont

The Loft on Main
9.8 out of 10, Exceptional, (8)
"The loft is beautiful! We enjoyed our stay."
United States
David A.
$169 nightly
The price is $181
Jan 1 - Jan 2, 2026
Total with taxes and fees
The Loft on Main
9.0 out of 10, Wonderful, (30)
"Nice property! We enjoyed our stay. "
United States
Joe S.
$245 nightly
The price is $262
Jan 1 - Jan 2, 2026
Total with taxes and fees
BIG parking lot for boats w/hookup, near boat ramp! Private Cabin at Goat Island

Condo in Florence

Downtown Vibes
2.0 star property
10.0 out of 10, Exceptional, (1)
"Absolutely precious place! Decorated so cute. Nice, neat and clean. Perfect location!! Walkable to campus and downtown! Will definitely stay here again! "
United States
Stacy
$202 nightly
The price is $228
Jan 5 - Jan 6, 2026
Total with taxes and fees
Downtown Vibes

Vacation Home in Florence

Lagniappe in Florence
9.8 out of 10, Exceptional, (29)
"Clean, new, and comfortable!!!!If I ever return to Florence, I will stay here for certain!"
United States
Alvie R.
$243 nightly
The price is $276
Jan 3 - Jan 4, 2026
Total with taxes and fees
Lagniappe in Florence
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Cherokee Hotel Reviews

Find out more about Cherokee

Everything you need to know about Cherokee vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Cherokee vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Cherokee vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Cherokee vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Cherokee. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Cherokee in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $133 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Cherokee rentals

At Expedia, we put the best Cherokee vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Cherokee rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Cherokee vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Cherokee. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Frequently asked questions

Can I find vacation rentals in Cherokee?

Yes, you can find vacation rentals near popular points of interest in Cherokee, or you can select a secluded option if you're looking for a relaxing stay.

What are some of the best vacation rentals in Cherokee?

Rustic Cabin overlooking Pickwick Lake: This Cherokee vacation home rental is located on a lake and offers a barbecue grill, air-conditioning, and laundry facilities to help you feel perfectly comfortable in your new surroundings. Kitchen amenities include a fridge, a stovetop, and a microwave. Our travelers also rate Driftwood Retreat on Tennessee River/Pickwick Lake as a favorite home for rent in Cherokee.

How many vacation rentals are there in Cherokee?

Choose from 5 Expedia vacation rentals in Cherokee for a memorable vacation.

What can I see and do in Cherokee?

Pickwick Lake and Tennessee River are a couple of lovely local spots to get outside and enjoy nature. Cane Creek Canyon Nature Preserve and Ivy Green are a couple of places you'll find in the larger area.

What are vacation rentals like in Cherokee?

Vacation rentals are privately owned accommodations you can reserve for several days or longer in Cherokee. Vacation rentals offer amenities like WiFi and washers and dryers so you'll have a home away from home. If you're concerned about a sanitized environment, a vacation rental can provide a sense of safety away from public hotel elevators and busy reception areas while still allowing you the excitement and enjoyment of travel. You'll also find more space in a vacation rental than in a standard hotel, which is another reason why a vacation rental is an attractive option for family trips.